195 research outputs found
The impact of leadership and leadership development in higher education : a review of the literature and evidence
Leadership development and its effectiveness has not been explored in depth across university settings. Few studies link leadership development programmes to organisational outcomes in Higher Education (HE) or performance assessment exercises, such as the UK Research Excellence Framework (REF). This review explores what is known in the area of the impact of leadership development in HE settings and offers a contribution to further thinking in this field
Activation of an Endogenous Retrovirus-Associated Long Non-Coding RNA in Human Adenocarcinoma
Background
Long non-coding RNAs (lncRNAs) are emerging as molecules that significantly impact many cellular processes and have been associated with almost every human cancer. Compared to protein-coding genes, lncRNA genes are often associated with transposable elements, particularly with endogenous retroviral elements (ERVs). ERVs can have potentially deleterious effects on genome structure and function, so these elements are typically silenced in normal somatic tissues, albeit with varying efficiency. The aberrant regulation of ERVs associated with lncRNAs (ERV-lncRNAs), coupled with the diverse range of lncRNA functions, creates significant potential for ERV-lncRNAs to impact cancer biology.
Methods
We used RNA-seq analysis to identify and profile the expression of a novel lncRNA in six large cohorts, including over 7,500 samples from The Cancer Genome Atlas (TCGA).
Results
We identified the tumor-specific expression of a novel lncRNA that we have named Endogenous retroViral-associated ADenocarcinoma RNA or ‘EVADR’, by analyzing RNA-seq data derived from colorectal tumors and matched normal control tissues. Subsequent analysis of TCGA RNA-seq data revealed the striking association of EVADR with adenocarcinomas, which are tumors of glandular origin. Moderate to high levels of EVADR were detected in 25 to 53% of colon, rectal, lung, pancreas and stomach adenocarcinomas (mean = 30 to 144 FPKM), and EVADR expression correlated with decreased patient survival (Cox regression; hazard ratio = 1.47, 95% confidence interval = 1.06 to 2.04, P = 0.02). In tumor sites of non-glandular origin, EVADR expression was detectable at only very low levels and in less than 10% of patients. For EVADR, a MER48 ERV element provides an active promoter to drive its transcription. Genome-wide, MER48 insertions are associated with nine lncRNAs, but none of the MER48-associated lncRNAs other than EVADR were consistently expressed in adenocarcinomas, demonstrating the specific activation of EVADR. The sequence and structure of the EVADR locus is highly conserved among Old World monkeys and apes but not New World monkeys or prosimians, where the MER48 insertion is absent. Conservation of the EVADR locus suggests a functional role for this novel lncRNA in humans and our closest primate relatives.
Conclusions
Our results describe the specific activation of a highly conserved ERV-lncRNA in numerous cancers of glandular origin, a finding with diagnostic, prognostic and therapeutic implications
Electron Neutrino Mass Measurement by Supernova Neutrino Bursts and Implications on Hot Dark Matter
We present a new strategy for measuring the electron neutrino mass (\mnue)
by future detection of a Galactic supernova in large underground detectors such
as the Super-Kamiokande (SK). This method is nearly model-independent and one
can get a mass constraint in a straightforward way from experimental data
without specifying any model parameters for profiles of supernova neutrinos. We
have tested this method using virtual data generated from a numerical model of
supernova neutrino emission by realistic Monte-Carlo simulations of the SK
detection. It is shown that this method is sensitive to \mnue of 3 eV
for a Galactic supernova, and this range is as low as the prediction of the
cold+hot dark matter scenario with a nearly degenerate mass hierarchy of
neutrinos, which is consistent with the current observations of solar and
atmospheric neutrino anomalies and density fluctuations in the universe.Comment: 4 pages including 1 figure, accepted by Phys. Rev. Let
Detection of a glitch in the pulsar J1709-4429
We report the detection of a glitch event in the pulsar J17094429 (also
known as B170644) during regular monitoring observations with the Molonglo
Observatory Synthesis Telescope (UTMOST). The glitch was found during timing
operations, in which we regularly observe over 400 pulsars with up to daily
cadence, while commensally searching for Rotating Radio Transients, pulsars,
and FRBs. With a fractional size of ,
the glitch reported here is by far the smallest known for this pulsar,
attesting to the efficacy of glitch searches with high cadence using UTMOST.Comment: 3 pages, 1 figur
1 Versus 2-cm Excision Margins for pT2-pT4 Primary Cutaneous Melanoma (MelMarT): A Feasibility Study
Abstract
Background
There is a lack of consensus regarding optimal surgical excision margins for primary cutaneous melanoma > 1 mm in Breslow thickness (BT). A narrower surgical margin is expected to be associated with lower morbidity, improved quality of life (QoL), and reduced cost. We report the results of a pilot international study (MelMarT) comparing a 1 versus 2-cm surgical margin for patients with primary melanoma > 1 mm in BT.
Methods
This phase III, multicentre trial [NCT02385214] administered by the Australia & New Zealand Medical Trials Group (ANZMTG 03.12) randomised patients with a primary cutaneous melanoma > 1 mm in BT to a 1 versus 2-cm wide excision margin to be performed with sentinel lymph node biopsy. Surgical closure technique was at the discretion of the treating surgeon. Patients’ QoL was measured (FACT-M questionnaire) at baseline, 3, 6, and 12 months after randomisation.
Results
Between January 2015 and June 2016, 400 patients were randomised from 17 centres in 5 countries. A total of 377 patients were available for analysis. Primary melanomas were located on the trunk (56.9%), extremities (35.6%), and head and neck (7.4%). More patients in the 2-cm margin group required reconstruction (34.9 vs. 13.6%; p < 0.0001). There was an increased wound necrosis rate in the 2-cm arm (0.5 vs. 3.6%; p = 0.036). After 12 months’ follow-up, no differences were noted in QoL between groups.
Discussion
This pilot study demonstrates the feasibility of a large international RCT to provide a definitive answer to the optimal excision margin for patients with intermediate- to high-risk primary cutaneous melanoma.
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Searches For High-Frequency Variations In The B-8 Solar Neutrino Flux At The Sudbury Neutrino Observatory
We have performed three searches for high-frequency signals in the solar neutrino flux measured by the Sudbury Neutrino Observatory, motivated by the possibility that solar g-mode oscillations could affect the production or propagation of solar B-8 neutrinos. The first search looked for any significant peak in the frequency range 1-144 day(-1), with a sensitivity to sinusoidal signals with amplitudes of 12% or greater. The second search focused on regions in which g-mode signals have been claimed by experiments aboard the Solar and Heliospheric Observatory satellite, and was sensitive to signals with amplitudes of 10% or greater. The third search looked for extra power across the entire frequency band. No statistically significant signal was detected in any of the three searches.Natural Sciences and Engineering Research Council, CanadaIndustry Canada, CanadaNational Research Council, CanadaNorthern Ontario Heritage Fund, CanadaAtomic Energy of Canada, Ltd., CanadaOntario Power Generation, CanadaHigh Performance Computing Virtual Laboratory, CanadaCanada Foundation for InnovationDept. of Energy, USNational Energy Research Scientific Computing Center, USScience and Technologies Facilities Council, UKAstronom
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Low-Multiplicity Burst Search At The Sudbury Neutrino Observatory
Results are reported from a search for low-multiplicity neutrino bursts in the Sudbury Neutrino Observatory. Such bursts could indicate the detection of a nearby core-collapse supernova explosion. The data were taken from Phase I (1999 November-2001 May), when the detector was filled with heavy water, and Phase II (2001 July-2003 August), when NaCl was added to the target. The search was a blind analysis in which the potential backgrounds were estimated and analysis cuts were developed to eliminate such backgrounds with 90% confidence before the data were examined. The search maintained a greater than 50% detection probability for standard supernovae occurring at a distance of up to 60 kpc for Phase I and up to 70 kpc for Phase II. No low-multiplicity bursts were observed during the data-taking period.Natural Sciences and Engineering Research Council, CanadaIndustry Canada, CanadaNational Research Council, CanadaNorthern Ontario Heritage Fund, CanadaAtomic Energy of Canada, Ltd., CanadaOntario Power Generation, CanadaHigh Performance Computing Virtual Laboratory, CanadaCanada Foundation for Innovation, CanadaCanada Research Chairs, CanadaDepartment of Energy, USNational Energy Research Scientific Computing Center, USAlfred P. Sloan Foundation, USScience and Technology Facilities Council, UKFundacao para a Ciencia e a Technologia, PortugalAstronom
Low Multiplicity Burst Search at the Sudbury Neutrino Observatory
Results are reported from a search for low-multiplicity neutrino bursts in
the Sudbury Neutrino Observatory (SNO). Such bursts could indicate detection of
a nearby core-collapse supernova explosion. The data were taken from Phase I
(November 1999 - May 2001), when the detector was filled with heavy water, and
Phase II (July 2001 - August 2003), when NaCl was added to the target. The
search was a blind analysis in which the potential backgrounds were estimated
and analysis cuts were developed to eliminate such backgrounds with 90%
confidence before the data were examined. The search maintained a greater than
50% detection probability for standard supernovae occurring at a distance of up
to 60 kpc for Phase I and up to 70 kpc for Phase II. No low-multiplicity bursts
were observed during the data-taking period.Comment: 11 pages, 4 figures, submitted to Ap
A Search for Neutrinos from the Solar hep Reaction and the Diffuse Supernova Neutrino Background with the Sudbury Neutrino Observatory
A search has been made for neutrinos from the hep reaction in the Sun and from the diffus
Combined Analysis of all Three Phases of Solar Neutrino Data from the Sudbury Neutrino Observatory
We report results from a combined analysis of solar neutrino data from all
phases of the Sudbury Neutrino Observatory. By exploiting particle
identification information obtained from the proportional counters installed
during the third phase, this analysis improved background rejection in that
phase of the experiment. The combined analysis resulted in a total flux of
active neutrino flavors from 8B decays in the Sun of (5.25 \pm
0.16(stat.)+0.11-0.13(syst.))\times10^6 cm^{-2}s^{-1}. A two-flavor neutrino
oscillation analysis yielded \Deltam^2_{21} = (5.6^{+1.9}_{-1.4})\times10^{-5}
eV^2 and tan^2{\theta}_{12}= 0.427^{+0.033}_{-0.029}. A three-flavor neutrino
oscillation analysis combining this result with results of all other solar
neutrino experiments and the KamLAND experiment yielded \Deltam^2_{21} =
(7.41^{+0.21}_{-0.19})\times10^{-5} eV^2, tan^2{\theta}_{12} =
0.446^{+0.030}_{-0.029}, and sin^2{\theta}_{13} =
(2.5^{+1.8}_{-1.5})\times10^{-2}. This implied an upper bound of
sin^2{\theta}_{13} < 0.053 at the 95% confidence level (C.L.)
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