Historical mystery solved: A multi-analytical approach to the identification of a key marker for the historical use of brazilwood (Caesalpinia spp.) in paintings and textiles

Brazilwood-derived pigments and dyes are found in many historical objects, from European paintings to North American First Nations textiles.</p

No Sex Differences in Use of Dopaminergic Medication in Early Parkinson Disease in the US and Canada - Baseline Findings of a Multicenter Trial

Background: Sex differences in Parkinson disease clinical features have been reported, but few studies have examined sex influences on use of dopaminergic medication in early Parkinson disease. The objective of this study was to test if there are differences in the type of dopaminergic medication used and levodopa equivalent daily dose between men and women with early Parkinson disease enrolled in a large multicenter study of Creatine as a potential disease modifying therapy – the National Institute of Neurological Disorders and Stroke Exploratory Trials in Parkinson Disease Long-Term Study-1. Methods: Baseline data of 1,741 participants from 45 participating sites were analyzed. Participants from the United States and Canada were enrolled within five years of Parkinson Disease diagnosis. Two outcome variables were studied: type of dopaminergic medication used and levodopa equivalent daily dose at baseline in the Long-Term Study-1. Chi-square statistic and linear regression models were used for statistical analysis. Results: There were no statistically significant differences in the frequency of use of different types of dopaminergic medications at baseline between men and women with Parkinson Disease. A small but statistically significant difference was observed in the median unadjusted levodopa equivalent daily dose at baseline between women (300 mg) and men (325 mg), but this was not observed after controlling for disease duration (years since Parkinson disease diagnosis), disease severity (Unified Parkinson's Disease Rating Scale Motor and Activities of Daily Living Scores), and body weight. Conclusions: In this large multicenter study, we did not observe sex differences in the type and dose of dopaminergic medications used in early Parkinson Disease. Further research is needed to evaluate the influence of male or female sex on use of dopaminergic medication in mid- and late-stage Parkinson Disease

Non-linear susceptibilities of spherical models

The static and dynamic susceptibilities for a general class of mean field random orthogonal spherical spin glass models are studied. We show how the static and dynamical properties of the linear and nonlinear susceptibilities depend on the behaviour of the density of states of the two body interaction matrix in the neighbourhood of the largest eigenvalue. Our results are compared with experimental results and also with those of the droplet theory of spin glasses.Comment: 20 pages, 2 fig

Blueberry Advisory Committee Research Report

The 1985 edition of the Blueberry Progress Reports was prepared for the Maine Blueberry Commission and the University of Maine Blueberry Advisory Committee by researchers with the Maine Agricultural Experiment Station and Maine Cooperative Extension Service at the University of Maine, Orono. Projects in this report include: 1. Control of secondary blueberry pest insects 2. Effect of pruning practices on blueberry insect abundance 3. Effect of hexazinone on species distribution in lowbush blueberry fields 4. Dichlobenil for control of bunchberry 5. Evaluation of postemergence herbicides for grass control 6. Hand-wiper applications of herbicides on woody weeds 7. Evaluation of steam as a pruning practice for lowbush blueberry fields 8. Evaluation of glyphosate and 2,4-D applied with a commercial weed roller to control woody weeds 9. Hand-wiping and cutting treatments for dogbane 9. Evaluation of airblast-sprayer application of asulam for bracken fern control 10. Spot treatment of woody weeds with 2,4-D in oil 11. Chemical control of Botrytis blossom blight 12. Evaluation of preliminary steam treatments (1984) at Blueberry Hill Farm 13. Long term effects of N and NPK fertilizer on plant growth and yield 14. Nutritional survey of selected lowbush blueberry fields 15. Interaction of fertility and pruning practices on soil characteristics and lowbush blueberry growth and yield 16. Frequency of fertility application for establishment of lowbush blueberry seedlings 17. Slow release vs. liquid fertilizer for establishment of lowbush blueberry seedlings 18. The effect of several mulches on frost heaving, soil moisture, soil temperature and rhizome development 19. Blueberry product development: raisin-type blueberries 20. Blueberry product development: blueberry puree 21. Addendum: 1985 Report from Moody Trevet

Wind-driven evolution of the North Pacific subpolar gyre over the last deglaciation

North Pacific atmospheric and oceanic circulations are key missing pieces in our understanding of the reorganisation of the global climate system since the Last Glacial Maximum (LGM). Here, using a basin-wide compilation of planktic foraminiferal δ18O, we show that the North Pacific subpolar gyre extended ~3 degrees further south during the LGM, consistent with sea surface temperature and productivity proxy data. Analysis of an ensemble of climate models indicates that the expansion of the subpolar gyre was associated with a substantial gyre strengthening. These gyre circulation changes were driven by a southward shift in the mid-latitude westerlies and increased wind-stress from the polar easterlies. Using single-forcing model runs, we show these atmospheric circulation changes are a non-linear response to the combined topographic and albedo effects of the Laurentide Ice Sheet. Our reconstruction suggests the gyre boundary (and thus westerly winds) began to migrate northward at ~17-16 ka, during Heinrich Stadial 1

The Hard X-ray Luminosity of OB Star Populations: Implications for the Contribution of Star Formation to the Cosmic X-ray Background

We present an empirical analysis of the integrated X-ray luminosity arising from populations of OB stars. In particular, we utilize results from the All-Sky Monitor on RXTE, along with archival data from previous missions, to assess the mean integrated output of X-rays in the 2-10 keV band from accreting early-type binaries within 3 kpc of the Sun. Using a recent OB star census of the Solar neighborhood, we then calculate the specific X-ray luminosity per O star from accretion-powered systems. We also assess the contribution to the total X-ray luminosity of an OB population from associated T Tauri stars, stellar winds, and supernovae. We repeat this exercise for the major Local Group galaxies, concluding that the total X-ray luminosity per O star spans a broad range from 2 to 20e34 erg/s. Contrary to previous results, we do not find a consistent trend with metallicity; in fact, the specific luminosities for M31 and the SMC are equal, despite having metallicities which differ by an order of magnitude. In light of these results, we assess the fraction of the observed 2-10 keV emission from starburst galaxies that arises directly from their OB star populations, concluding that, while binaries can explain most of the hard X-ray emission in many local starbursts, a significant additional component or components must be present in some systems. A discussion of the nature of this additional emission, along with its implications for the contribution of starbursts to the cosmic X-ray background, concludes our report.Comment: aastex, 30 pages including 2 tables and 1 figure. To appear in Ap

Failure to Detect the Novel Retrovirus XMRV in Chronic Fatigue Syndrome

BACKGROUND:In October 2009 it was reported that 68 of 101 patients with chronic fatigue syndrome (CFS) in the US were infected with a novel gamma retrovirus, xenotropic murine leukaemia virus-related virus (XMRV), a virus previously linked to prostate cancer. This finding, if confirmed, would have a profound effect on the understanding and treatment of an incapacitating disease affecting millions worldwide. We have investigated CFS sufferers in the UK to determine if they are carriers of XMRV. METHODOLOGY:Patients in our CFS cohort had undergone medical screening to exclude detectable organic illness and met the CDC criteria for CFS. DNA extracted from blood samples of 186 CFS patients were screened for XMRV provirus and for the closely related murine leukaemia virus by nested PCR using specific oligonucleotide primers. To control for the integrity of the DNA, the cellular beta-globin gene was amplified. Negative controls (water) and a positive control (XMRV infectious molecular clone DNA) were included. While the beta-globin gene was amplified in all 186 samples, neither XMRV nor MLV sequences were detected. CONCLUSION:XMRV or MLV sequences were not amplified from DNA originating from CFS patients in the UK. Although we found no evidence that XMRV is associated with CFS in the UK, this may be a result of population differences between North America and Europe regarding the general prevalence of XMRV infection, and might also explain the fact that two US groups found XMRV in prostate cancer tissue, while two European studies did not

Tauopathic Changes in the Striatum of A53T α-Synuclein Mutant Mouse Model of Parkinson's Disease

Tauopathic pathways lead to degenerative changes in Alzheimer's disease and there is evidence that they are also involved in the neurodegenerative pathology of Parkinson's disease [PD]. We have examined tauopathic changes in striatum of the α-synuclein (α-Syn) A53T mutant mouse. Elevated levels of α-Syn were observed in striatum of the adult A53T α-Syn mice. This was accompanied by increases in hyperphosphorylated Tau [p-Tau], phosphorylated at Ser202, Ser262 and Ser396/404, which are the same toxic sites also seen in Alzheimer's disease. There was an increase in active p-GSK-3β, hyperphosphorylated at Tyr216, a major and primary kinase known to phosphorylate Tau at multiple sites. The sites of hyperphosphorylation of Tau in the A53T mutant mice were similar to those seen in post-mortem striata from PD patients, attesting to their pathophysiological relevance. Increases in p-Tau were not due to alterations on protein phosphatases in either A53T mice or in human PD, suggesting lack of involvement of these proteins in tauopathy. Extraction of striata with Triton X-100 showed large increases in oligomeric forms of α-Syn suggesting that α-Syn had formed aggregates the mutant mice. In addition, increased levels of p-GSK-3β and pSer396/404 were also found associated with aggregated α-Syn. Differential solubilization to measure protein binding to cytoskeletal proteins demonstrated that p-Tau in the A53T mutant mouse were unbound to cytoskeletal proteins, consistent with dissociation of p-Tau from the microtubules upon hyperphosphorylation. Interestingly, α-Syn remained tightly bound to the cytoskeleton, while p-GSK-3β was seen in the cytoskeleton-free fractions. Immunohistochemical studies showed that α-Syn, pSer396/404 Tau and p-GSK-3β co-localized with one another and was aggregated and accumulated into large inclusion bodies, leading to cell death of Substantia nigral neurons. Together, these data demonstrate an elevated state of tauopathy in striata of the A53T α-Syn mutant mice, suggesting that tauopathy is a common feature of synucleinopathies