Supersoft X-ray Sources in M31: I. A Chandra Survey and an Extension to Quasisoft Sources

We report on very soft X-ray sources (VSSs) in M31. In a survey which was most sensitive to soft sources in four 8'x8' regions covered by Chandra's ACIS-S S3 CCD, we find 33 VSSs that appear to belong to M31. Fifteen VSSs have spectral characteristics mirroring the supersoft X-ray sources studied in the Magellanic Cloud and Milky Way ($k T_{eff} \leq 100$ eV); we therefore call these ``classical'' supersoft sources, or simply supersoft sources (SSSs). Eighteen VSSs may either have small (< 10%) hard components, or slightly higher effective temperatures (but still < 350 eV). We refer to these VSSs as quasisoft sources (QSSs). While hot white dwarf models may apply to SSSs, the effective temperatures of QSSs are too high, unless, e.g., the radiation emanates from only a small portion of surface. Two of the SSSs were first detected and identified as such through ROSAT observations. One SSS and one QSS may be identified with symbiotics, and 2 SSSs with supernova remnants. Both SSSs and QSSs in the disk are found near star-forming regions, possibly indicating that they are young. VSSs in the outer disk and halo are likely to be old systems; in these regions, there are more QSSs than SSSs, which is opposite to what is found in fields closer to the galaxy center. The largest density of bright VSSs is in the bulge; some of the bulge sources are close enough to the nucleus to be remnants of the tidal disruption of a giant by the massive central black hole. By using Chandra data in combination with ROSAT and XMM observations, we find most VSSs to be highly variable, fading from or brightening toward detectability on time scales of months. There is evidence for VSSs with low luminosities ($\sim 10^{36}$ erg s$^{-1}$).Comment: 14 pages, 4 figures. Accepted for publication in ApJ. Classification of supersoft and quasisoft sources is clarifie

Enhanced Temporal but Not Attentional Processing in Expert Tennis Players

In tennis, as in many disciplines of sport, fine spatio-temporal resolution is required to reach optimal performance. While many studies on tennis have focused on anticipatory skills or decision making, fewer have investigated the underlying visual perception abilities. In this study, we used a battery of seven visual tests that allowed us to assess which kind of visual information processing is performed better by tennis players than other athletes (triathletes) and non-athletes. We found that certain time-related skills, such as speed discrimination, are superior in tennis players compared to non-athletes and triathletes. Such tasks might be used to improve tennis performance in the future

Developing and implementing an integrated delirium prevention system of care:a theory driven, participatory research study

Background: Delirium is a common complication for older people in hospital. Evidence suggests that delirium incidence in hospital may be reduced by about a third through a multi-component intervention targeted at known modifiable risk factors. We describe the research design and conceptual framework underpinning it that informed the development of a novel delirium prevention system of care for acute hospital wards. Particular focus of the study was on developing an implementation process aimed at embedding practice change within routine care delivery. Methods: We adopted a participatory action research approach involving staff, volunteers, and patient and carer representatives in three northern NHS Trusts in England. We employed Normalization Process Theory to explore knowledge and ward practices on delirium and delirium prevention. We established a Development Team in each Trust comprising senior and frontline staff from selected wards, and others with a potential role or interest in delirium prevention. Data collection included facilitated workshops, relevant documents/records, qualitative one-to-one interviews and focus groups with multiple stakeholders and observation of ward practices. We used grounded theory strategies in analysing and synthesising data. Results: Awareness of delirium was variable among staff with no attention on delirium prevention at any level; delirium prevention was typically neither understood nor perceived as meaningful. The busy, chaotic and challenging ward life rhythm focused primarily on diagnostics, clinical observations and treatment. Ward practices pertinent to delirium prevention were undertaken inconsistently. Staff welcomed the possibility of volunteers being engaged in delirium prevention work, but existing systems for volunteer support were viewed as a barrier. Our evolving conception of an integrated model of delirium prevention presented major implementation challenges flowing from minimal understanding of delirium prevention and securing engagement of volunteers alongside practice change. The resulting Prevention of Delirium (POD) Programme combines a multi-component delirium prevention and implementation process, incorporating systems and mechanisms to introduce and embed delirium prevention into routine ward practices. Conclusions: Although our substantive interest was in delirium prevention, the conceptual and methodological strategies pursued have implications for implementing and sustaining practice and service improvements more broadly

A cross-national study on the antecedents of work–life balance from the fit and balance perspective

Drawing on the perceived work–family fit and balance perspective, this study investigates demands and resources as antecedents of work–life balance (WLB) across four countries (New Zealand, France, Italy and Spain), so as to provide empirical cross-national evidence. Using structural equation modelling analysis on a sample of 870 full time employees, we found that work demands, hours worked and family demands were negatively related to WLB, while job autonomy and supervisor support were positively related to WLB. We also found evidence that resources (job autonomy and supervisor support) moderated the relationships between demands and work–life balance, with high resources consistently buffering any detrimental influence of demands on WLB. Furthermore, our study identified additional predictors of WLB that were unique to some national contexts. For example, in France and Italy, overtime hours worked were negatively associated with WLB, while parental status was positively associated with WLB. Overall, the implications for theory and practice are discussed.Peer ReviewedPostprint (author's final draft

Attentional bias for threat: Evidence for delayed disengagement from emotional faces

The present paper reports three new experiments suggesting that the valence of a face cue can influence attentional effects in a cueing paradigm. Moreover, heightened trait anxiety resulted in increased attentional dwell-time on emotional facial stimuli, relative to neutral faces. Experiment 1 presented a cueing task, in which the cue was either an "angry", "happy", or "neutral" facial expression. Targets could appear either in the same location as the face (valid trials) or in a different location to the face (invalid trials). Participants did not show significant variations across the different cue types (angry, happy, neutral) in responding to a target on valid trials. However, the valence of the face did affect response times on invalid trials. Specifically, participants took longer to respond to a target when the face cue was "angry" or "happy" relative to neutral. In Experiment 2, the cue-target stimulus onset asynchrony (SOA) was increased and an overall inhibition of return (IOR) effect was found (i.e., slower responses on valid trials). However, the "angry" face cue eliminated the IOR effect for both high and low trait anxious groups. In Experiment 3, threat-related and jumbled facial stimuli reduced the magnitude of IOR for high, but not for low, trait-anxious participants. These results suggest that: (i) attentional bias in anxiety may reflect a difficulty in disengaging from threat-related and emotional stimuli, and (ii) threat-related and ambiguous cues can influence the magnitude of the IOR effect

Les Houches 2015: Physics at TeV Colliders Standard Model Working Group Report

This Report summarizes the proceedings of the 2015 Les Houches workshop on Physics at TeV Colliders. Session 1 dealt with (I) new developments relevant for high precision Standard Model calculations, (II) the new PDF4LHC parton distributions, (III) issues in the theoretical description of the production of Standard Model Higgs bosons and how to relate experimental measurements, (IV) a host of phenomenological studies essential for comparing LHC data from Run I with theoretical predictions and projections for future measurements in Run II, and (V) new developments in Monte Carlo event generators.Comment: Proceedings of the Standard Model Working Group of the 2015 Les Houches Workshop, Physics at TeV Colliders, Les Houches 1-19 June 2015. 227 page

μ\muSR studies of the frustrated quasi-2d square-lattice spin system Cu(Cl,Br)La(Nb,Ta)2_{2}O7_{7}: evolution from spin-gap to antiferromagnetic state

We report muon spin relaxation ($\mu$SR) and magnetic susceptibility measurements on Cu(Cl,Br)La(Nb,Ta)$_{2}$O$_{7}$, which demonstrate: (a) the absence of static magnetism in (CuCl)LaNb$_{2}$O$_{7}$ down to 15 mK confirming a spin-gapped ground state; (b) phase separation between partial volumes with a spin-gap and static magnetism in (CuCl)La(Nb,Ta)$_{2}$O$_{7}$; (c) history-dependent magnetization in the (Nb,Ta) and (Cl,Br) substitution systems; (d) a uniform long-range collinear antiferromagnetic state in (CuBr)LaNb$_{2}$O$_{7}$; and (e) a decrease of N\'eel temperature with decreasing Br concentration $x$ in Cu(Cl$_{1-x}$Br$_{x}$)LaNb$_{2}$O$_{7}$ with no change in the ordered Cu moment size for $0.33 \leq x \leq 1$. Together with several other $\mu$SR studies of quantum phase transitions in geometrically-frustrated spin systems, the present results reveal that the evolution from a spin-gap to a magnetically ordered state is often associated with phase separation and/or a first order phase transition.Comment: 10 pages 10 color figures; revised from letter paper style to full paper style; Figs. 2, 4, 5, 7c, 10 newly adde

The possibility of evidence-based psychiatry: depression as a case

Considering psychiatry as a medical discipline, a diagnosis identifying a disorder should lead to an effective therapy. Such presumed causality is the basis of evidence-based psychiatry. We examined the strengths and weaknesses of research onto the causality of relationship between diagnosis and therapy of major depressive disorder and suggest what could be done to strengthen eventual claims on causality. Four obstacles for a rational evidence-based psychiatry were recognised. First, current classification systems are scientifically nonfalsifiable. Second, cerebral processes are—at least to some extent—nondeterministic, i.e. they are random, stochastic and/or chaotic. Third, the vague or lack of relationship between therapeutic regimens and suspected pathogenesis. Fourth, the inadequacy of tools to diagnose and delineate a functional disorder. We suggest a strategy to identify diagnostic prototypes that are characterised by a limited number of parameters (symptoms, markers and other characteristics). A prototypical diagnosis that may either support or reject particular elements of current diagnostic systems. Nevertheless, one faces the possibility that psychiatry will remain a relatively weak evidence-based medical discipline

Recurrent Modification of a Conserved Cis-Regulatory Element Underlies Fruit Fly Pigmentation Diversity

The development of morphological traits occurs through the collective action of networks of genes connected at the level of gene expression. As any node in a network may be a target of evolutionary change, the recurrent targeting of the same node would indicate that the path of evolution is biased for the relevant trait and network. Although examples of parallel evolution have implicated recurrent modification of the same gene and cis-regulatory element (CRE), little is known about the mutational and molecular paths of parallel CRE evolution. In Drosophila melanogaster fruit flies, the Bric-à-brac (Bab) transcription factors control the development of a suite of sexually dimorphic traits on the posterior abdomen. Female-specific Bab expression is regulated by the dimorphic element, a CRE that possesses direct inputs from body plan (ABD-B) and sex-determination (DSX) transcription factors. Here, we find that the recurrent evolutionary modification of this CRE underlies both intraspecific and interspecific variation in female pigmentation in the melanogaster species group. By reconstructing the sequence and regulatory activity of the ancestral Drosophila melanogaster dimorphic element, we demonstrate that a handful of mutations were sufficient to create independent CRE alleles with differing activities. Moreover, intraspecific and interspecific dimorphic element evolution proceeded with little to no alterations to the known body plan and sex-determination regulatory linkages. Collectively, our findings represent an example where the paths of evolution appear biased to a specific CRE, and drastic changes in function were accompanied by deep conservation of key regulatory linkages. © 2013 Rogers et al

The Rho-Family GTPase Rac1 Regulates Integrin Localization in Drosophila Immunosurveillance Cells

BACKGROUND: When the parasitoid wasp Leptopilina boulardi lays an egg in a Drosophila larva, phagocytic cells called plasmatocytes and specialized cells known as lamellocytes encapsulate the egg. The Drosophila β-integrin Myospheroid (Mys) is necessary for lamellocytes to adhere to the cellular capsule surrounding L. boulardi eggs. Integrins are heterodimeric adhesion receptors consisting of α and β subunits, and similar to other plasma membrane receptors undergo ligand-dependent endocytosis. In mammalian cells it is known that integrin binding to the extracellular matrix induces the activation of Rac GTPases, and we have previously shown that Rac1 and Rac2 are necessary for a proper encapsulation response in Drosophila larvae. We wanted to test the possibility that Myospheroid and Rac GTPases interact during the Drosophila anti-parasitoid immune response. RESULTS: In the current study we demonstrate that Rac1 is required for the proper localization of Myospheroid to the cell periphery of haemocytes after parasitization. Interestingly, the mislocalization of Myospheroid in Rac1 mutants is rescued by hyperthermia, involving the heat shock protein Hsp83. From these results we conclude that Rac1 and Hsp83 are required for the proper localization of Mys after parasitization. SIGNIFICANCE: We show for the first time that the small GTPase Rac1 is required for Mysopheroid localization. Interestingly, the necessity of Rac1 in Mys localization was negated by hyperthermia. This presents a problem, in Drosophila we quite often raise larvae at 29°C when using the GAL4/UAS misexpression system. If hyperthermia rescues receptor endosomal recycling defects, raising larvae in hyperthermic conditions may mask potentially interesting phenotypes