The thinning of orchard fruits

Thesis (B.S.)--University of Illinois, 1906.Typescript

Mariachi as a music education genre: a study of the program status, pedagogical practices, and activities

Thesis (D.M.A.)--Boston UniversityIn recent years, public schools and higher education institutions in Texas have placed a growing emphasis on mariachi music programs. The purpose of this study was to gather data regarding the status of mariachi programs and the pedagogical practices and activities of selected mariachi instructors in kindergarten through 12th grade (K12) schools in Texas. The researcher examined the pedagogical practices, content knowledge bases, and specific skill sets that selected mariachi instructors considered to be important determinants of effectiveness in teaching mariachi music. Descriptive data about the selected mariachi instructors' class activities was also collected. The sample used for this study comprised 14 selected mariachi music instructors. The sampling process included compiling a list of mariachi programs throughout the state of Texas, organizing the list according to the seven All-State Area alignments recognized by the Texas Music Educators Association, and selecting two instructors-one from a junior high school and one from a high school-in each All-State Area. The method for gathering information on pedagogical practices and class activities included tape-recorded interviews and on-site observations ofthe selected mariachi instructors. Data from both the interviews and the observation sessions were aggregated for further analysis and for the development of categories and themes, as appropriate. The study and its reported outcomes constitute a status of mariachi programs across Texas. Data gathered from selected mariachi instructors provided information regarding program content and program scheduling in K12 schools and an overview of the instructors' backgrounds and bases of knowledge of the mariachi genre. Further, specific skills and skill sets regarding performance practices of the mariachi ensemble are discussed. It is anticipated that this accumulation of pedagogical information will be used by music educators currently involved in the mariachi genre and by other music educators in the development of their programs

William R. Palmer to Sarah Sabina Kean, April 26, 1830

William R. Palmer wrote from West Point Foundry to Sarah Sabina Kean, his God mother, addressed to Ursino, Elizabethtown, NJ. He sent Sarah some information regarding the Highland School which she was considering sending her son, John Kean to.https://digitalcommons.kean.edu/lhc_1830s/1027/thumbnail.jp

Polarimetric measurements of sea surface brightness temperatures using an aircraft K-band radiometer

This paper presents the first experimental evidence that the polarimetric brightness temperatures of sea surfaces are sensitive to ocean wind direction in the incidence angle range of 30 to 50 degrees. Our experimental data were collected by a K-band (19.35 GHz) polarimetric wind radiometer (WINDRAD) mounted on the NASA DC-8 aircraft. A set of aircraft radiometer flights was successfully completed in November 1993. We performed circle flights over National Data Buoy Center (NDBC) moored buoys deployed off the northern California coast, which provided ocean wind measurements. The first WINDRAD flight was made on November 4, 1993. There was clear weather with a wind speed of 12 m/s at 330 degrees around the Pt. Arena buoy. We circled the buoy at three incidence angles, and all data when plotted as functions of azimuth angles show clear modulations of several Kelvin. At 40 degrees incidence angle, there is a 5 Kelvin peak-to-peak signal in the second Stokes parameter Q and the third Stokes parameter U. The Q data maximum is in the upwind direction and U has a 45 degrees phase shift in azimuth as predicted by theory. There is also an up/downwind asymmetry of 2 Kelvin in the Q data, and 1 Kelvin in the U data. At 50 degrees incidence angle, the collected data show very similar wind direction signatures to the SSM/I model function. Additional flights were made on other days under cloudy conditions. Data taken at a wind speed of 8 m/s show that at 40 degrees incidence Q and U have a smaller azimuthal modulation of 3 Kelvin, probably due to the lower wind speed. Additionally, the simultaneously recorded video images of sea surfaces suggested that Q and U data were less sensitive to unpolarized geophysical variations, such as clouds and whitecaps, while the T(v) and T(h) increased by a few Kelvin when the radiometer beam crossed over clouds, or there was a sudden increase of whitecaps in the radiometer footprint. The results of our aircraft flights indicate that passive polarimetric radiometry has a strong potential for global ocean wind speed and direction measurements from space

Impact of fatigue as the primary determinant of functional limitations among patients with post-COVID-19 syndrome: a cross-sectional observational study

OBJECTIVES: To describe self-reported characteristics and symptoms of treatment-seeking patients with post-COVID-19 syndrome (PCS). To assess the impact of symptoms on health-related quality of life (HRQoL) and patients' ability to work and undertake activities of daily living. DESIGN: Cross-sectional single-arm service evaluation of real-time user data. SETTING: 31 post-COVID-19 clinics in the UK. PARTICIPANTS: 3754 adults diagnosed with PCS in primary or secondary care deemed suitable for rehabilitation. INTERVENTION: Patients using the Living With Covid Recovery digital health intervention registered between 30 November 2020 and 23 March 2022. PRIMARY AND SECONDARY OUTCOME MEASURES: The primary outcome was the baseline Work and Social Adjustment Scale (WSAS). WSAS measures the functional limitations of the patient; scores of ≥20 indicate moderately severe limitations. Other symptoms explored included fatigue (Functional Assessment of Chronic Illness Therapy-Fatigue), depression (Patient Health Questionnaire-Eight Item Depression Scale), anxiety (Generalised Anxiety Disorder Scale, Seven-Item), breathlessness (Medical Research Council Dyspnoea Scale and Dyspnoea-12), cognitive impairment (Perceived Deficits Questionnaire, Five-Item Version) and HRQoL (EQ-5D). Symptoms and demographic characteristics associated with more severe functional limitations were identified using logistic regression analysis. RESULTS: 3541 (94%) patients were of working age (18-65); mean age (SD) 48 (12) years; 1282 (71%) were female and 89% were white. 51% reported losing ≥1 days from work in the previous 4 weeks; 20% reported being unable to work at all. Mean WSAS score at baseline was 21 (SD 10) with 53% scoring ≥20. Factors associated with WSAS scores of ≥20 were high levels of fatigue, depression and cognitive impairment. Fatigue was found to be the main symptom contributing to a high WSAS score. CONCLUSION: A high proportion of this PCS treatment-seeking population was of working age with over half reporting moderately severe or worse functional limitation. There were substantial impacts on ability to work and activities of daily living in people with PCS. Clinical care and rehabilitation should address the management of fatigue as the dominant symptom explaining variation in functionality

Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B

Background: Canine osteosarcoma is clinically nearly identical to the human disease, but is common and highly heritable, making genetic dissection feasible. Results: Through genome-wide association analyses in three breeds (greyhounds, Rottweilers, and Irish wolfhounds), we identify 33 inherited risk loci explaining 55% to 85% of phenotype variance in each breed. The greyhound locus exhibiting the strongest association, located 150 kilobases upstream of the genes CDKN2A/B, is also the most rearranged locus in canine osteosarcoma tumors. The top germline candidate variant is found at a >90% frequency in Rottweilers and Irish wolfhounds, and alters an evolutionarily constrained element that we show has strong enhancer activity in human osteosarcoma cells. In all three breeds, osteosarcoma-associated loci and regions of reduced heterozygosity are enriched for genes in pathways connected to bone differentiation and growth. Several pathways, including one of genes regulated by miR124, are also enriched for somatic copy-number changes in tumors. Conclusions: Mapping a complex cancer in multiple dog breeds reveals a polygenic spectrum of germline risk factors pointing to specific pathways as drivers of disease

Managed Care for Elderly People: A Compendium of Findings

Although managed care seems to serve well the in terests of non-elderly enrollees and their payers, elderly people face more risks. Chronic conditions, multiple prob lems, and more limited resources make them more vul nerable, whereas multiple payer sources make them more complicated to cover. This synthesis of managed care de livered in Medicare and Medicaid demonstration projects serving elderly beneficiaries shows that managed care plans either select or attract enrollees who suffer fewer frailties than those served in fee-for-service settings, ex hibit reluctance to enter rural markets, provide a broad range of elderly-specific services, offer more compre hensive coverage and services, and result in greater per ceived access problems, particularly for vulnerable subgroups. Plans operate more cheaply by using fewer resources, even after adjusting for case mix differences. Managed care enrollees tend to be more satisfied with financial and coverage aspects, whereas fee-for-service enrollees report higher satisfaction on other dimensions. In acute care settings, process of care findings were mixed, whereas clinical and self-reported outcome indi cators were no better and in some instances worse in managed care. Long-term care enrollees, in the few stud ies reported, consistently faired worse in both the processes and outcomes of care. These findings suggest that further research on the effects of managed care in its rapidly changing incarnations is needed, particularly with respect to how to improve the quality of acute and long-term care delivered to elderly people and the proper role of government and other key actors in the health care system.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66514/2/10.1177_106286069801300304.pd

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.

Multiple sclerosis is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically results in intermittent neurological disturbance followed by progressive accumulation of disability. Epidemiological studies have shown that genetic factors are primarily responsible for the substantially increased frequency of the disease seen in the relatives of affected individuals, and systematic attempts to identify linkage in multiplex families have confirmed that variation within the major histocompatibility complex (MHC) exerts the greatest individual effect on risk. Modestly powered genome-wide association studies (GWAS) have enabled more than 20 additional risk loci to be identified and have shown that multiple variants exerting modest individual effects have a key role in disease susceptibility. Most of the genetic architecture underlying susceptibility to the disease remains to be defined and is anticipated to require the analysis of sample sizes that are beyond the numbers currently available to individual research groups. In a collaborative GWAS involving 9,772 cases of European descent collected by 23 research groups working in 15 different countries, we have replicated almost all of the previously suggested associations and identified at least a further 29 novel susceptibility loci. Within the MHC we have refined the identity of the HLA-DRB1 risk alleles and confirmed that variation in the HLA-A gene underlies the independent protective effect attributable to the class I region. Immunologically relevant genes are significantly overrepresented among those mapping close to the identified loci and particularly implicate T-helper-cell differentiation in the pathogenesis of multiple sclerosis