Bromotryptophans and their incorporation in cyclic and bicyclic privileged peptides

While revisiting biologically active natural peptides, the importance of the tryptophan residue became clear. In this article, the incorporation of this amino acid, brominated at different positions of the indole ring, into cyclic peptides was successfully achieved. These products demonstrated improved properties in terms of passive diffusion, permeability across membranes, biostability in human serum and cytotoxicity. Moreover, these brominated tryptophans at positions 5, 6, or 7 proved to be compatible as building blocks to prepare bicyclic stapled peptides by performing on‐resin Suzuki‐Miyaura cross‐coupling reactions

Rat-to-Human Transmission of Cowpox Infection

We isolated Cowpox virus (CPXV) from the ulcerative eyelid lesions of a 14-year-old girl, who had cared for a clinically ill wild rat that later died. CPXV isolated from the rat (Rattus norvegicus) showed complete homology with the girl’s virus. Our case is the first proven rat-to-human transmission of cowpox

Global wealth disparities drive adherence to COVID-safe pathways in head and neck cancer surgery

Peer reviewe

The IDENTIFY study: the investigation and detection of urological neoplasia in patients referred with suspected urinary tract cancer - a multicentre observational study

Objective To evaluate the contemporary prevalence of urinary tract cancer (bladder cancer, upper tract urothelial cancer [UTUC] and renal cancer) in patients referred to secondary care with haematuria, adjusted for established patient risk markers and geographical variation. Patients and Methods This was an international multicentre prospective observational study. We included patients aged ≥16 years, referred to secondary care with suspected urinary tract cancer. Patients with a known or previous urological malignancy were excluded. We estimated the prevalence of bladder cancer, UTUC, renal cancer and prostate cancer; stratified by age, type of haematuria, sex, and smoking. We used a multivariable mixed-effects logistic regression to adjust cancer prevalence for age, type of haematuria, sex, smoking, hospitals, and countries. Results Of the 11 059 patients assessed for eligibility, 10 896 were included from 110 hospitals across 26 countries. The overall adjusted cancer prevalence (n = 2257) was 28.2% (95% confidence interval [CI] 22.3–34.1), bladder cancer (n = 1951) 24.7% (95% CI 19.1–30.2), UTUC (n = 128) 1.14% (95% CI 0.77–1.52), renal cancer (n = 107) 1.05% (95% CI 0.80–1.29), and prostate cancer (n = 124) 1.75% (95% CI 1.32–2.18). The odds ratios for patient risk markers in the model for all cancers were: age 1.04 (95% CI 1.03–1.05; P < 0.001), visible haematuria 3.47 (95% CI 2.90–4.15; P < 0.001), male sex 1.30 (95% CI 1.14–1.50; P < 0.001), and smoking 2.70 (95% CI 2.30–3.18; P < 0.001). Conclusions A better understanding of cancer prevalence across an international population is required to inform clinical guidelines. We are the first to report urinary tract cancer prevalence across an international population in patients referred to secondary care, adjusted for patient risk markers and geographical variation. Bladder cancer was the most prevalent disease. Visible haematuria was the strongest predictor for urinary tract cancer

Le Foot-Core : la panacée pour remédier à la faiblesse des muscles intrinsèques du pied ?

Revue de littérature systématique de type thérapeutique et étiologique Le but de ce mémoire a démontré l’implication de la faiblesse des muscles intrinsèques du pied dans l’apparitions de pathologie ascendante et d’étudier les bénéfices du foot-core.Cette thérapeutique est basée sur un renforcement des intrinsèques, une mobilisation des articulations du pied et sur l’étirement de structure intrinsèque au pied.L’implication des intrinsèques est implicite, on retrouve chez des sujets souffrant de pathologies du membre inférieur une constante qui est une faiblesse des muscles intrinsèques du pied.Le foot-core est une rééducation majoritairement pratiquée chez les coureurs, mais elle est bénéfique pour tous les sujets, sportif ou non

Search algorithms for . . .

AbstractA novel search technique called highway search is introduced. The search technique relies on a highway simulation which takes several homogeneous walks through a (possibly infinite) state space. Furthermore, we provide a memory-efficient algorithm that approximates a highway search and we prove that, under particular conditions, they coincide. The effectiveness of highway search is compared to two mainstream search techniques, viz. random search and randomised depth-first search. Our results demonstrate that randomised depth-first search explores the least amount of states in the effort of finding states of interest, whereas a highways search yields the shortest witnessing traces to such states