Cryogenic Insulation Systems

The results of a comparative study of cryogenic insulation systems performed are presented. The key aspects of thermal insulation relative to cryogenic system design, testing, manufacturing, and maintenance are discussed. An overview of insulation development from an energy conservation perspective is given. Conventional insulation materials for cryogenic applications provide three levels of thermal conductivity. Actual thermal performance of standard multilayer insulation (MLI) is several times less than laboratory performance and often 10 times worse than ideal performance. The cost-effectiveness of the insulation system depends on thermal performance; flexibility and durability; ease of use in handling, installation, and maintenance; and overall cost including operations, maintenance, and life cycle. Results of comprehensive testing of both conventional and novel materials such as aerogel composites using cryostat boil-off methods are given. The development of efficient, robust cryogenic insulation systems that operate at a soft vacuum level is the primary focus of this paper

Relationship between muscular extensibility, strength and stability and the transmission of impacts during fatigued running.

The aim was to analyse the relationship between isokinetic strength, dynamic stability, muscular extensibility and impacts transmission during fatigued running. Low- and high-frequency impacts related to body movements and the severity of impacts, respectively were assessed in 17 male recreational runners, before and after a treadmill running fatigue protocol, using a triaxial accelerometry system. High-frequency impacts in the tibia were negatively correlated to the knee angle at which the quadriceps peak torque was reached (p = 0.014), and also to the extensibility of the hamstrings and soleus (p = 0.001 and p = 0.023, respectively). The increases of high-frequency impacts in tibia caused by fatigue were positively related to the knee angle at which the hamstrings peak torque was reached (p = 0.001) and to stability after landing (p = 0.007). The attenuation of high-frequency impacts was positively related to hamstrings/quadriceps ratio of strength (p = 0.010) and to stability (p = 0.006). Limiting possible deficits in hamstring and soleus range of motion, improving stability after landing, developing hamstring and quadriceps strength in elongated muscle range, and maintaining a balanced ratio of hamstring/quadriceps strength could help to reduce the injury risk in running

The Stripe Fortified GCT:A new GCT design for maximizing the controllable current

In this paper we introduce a new GCT design, namely the Stripe Fortified GCT, for the purpose of maximizing the controllable current by optimizing the current flow path in the device during turn-off. The main design of the new device along with variants are introduced. The MCC performance of this novel structure is assessed with a developed two dimensional model for full wafer simulations. Our results show that this new design is a very good candidate for increasing the MCC to values more than 5000A

Annihilation of NMSSM neutralinos in the Sun and neutrino telescope limits

We investigate neutralino dark matter in the framework of NMSSM performing a scan over its parameter space and calculating neutralino capture and annihilation rates in the Sun. We discuss the prospects of searches for neutralino dark matter in neutrino experiments depending on neutralino content and its main annihilation channel. We recalculate the upper limits on neutralino-proton elastic cross sections directly from neutrino telescopes upper bounds on annihilation rates in the Sun. This procedure has advantages as compared with corresponding recalcalations from the limits on muon flux, namely, it is independent on details of the experiment and the recalculation coefficients are universal for any kind of WIMP dark matter models. We derive 90% c.l. upper limits on neutralino-proton cross sections from the results of the Baksan Underground Scintillator Telescope.Comment: 28 pages, 16 figures, accepted for publication in JCAP, references adde

Loss of Liver Kinase B1 (LKB1) in Beta Cells Enhances Glucose-stimulated Insulin Secretion Despite Profound Mitochondrial Defects

The tumor suppressor liver kinase B1 (LKB1) is an important regulator of pancreatic β cell biology. LKB1-dependent phosphorylation of distinct AMPK (adenosine monophosphate-activated protein kinase) family members determines proper β cell polarity and restricts β cell size, total β cell mass, and glucose-stimulated insulin secretion (GSIS). However, the full spectrum of LKB1 effects and the mechanisms involved in the secretory phenotype remain incompletely understood. We report here that in the absence of LKB1 in β cells, GSIS is dramatically and persistently improved. The enhancement is seen both in vivo and in vitro and cannot be explained by altered cell polarity, increased β cell number, or increased insulin content. Increased secretion does require membrane depolarization and calcium influx but appears to rely mostly on a distal step in the secretion pathway. Surprisingly, enhanced GSIS is seen despite profound defects in mitochondrial structure and function in LKB1-deficient β cells, expected to greatly diminish insulin secretion via the classic triggering pathway. Thus LKB1 is essential for mitochondrial homeostasis in β cells and in parallel is a powerful negative regulator of insulin secretion. This study shows that β cells can be manipulated to enhance GSIS to supra-normal levels even in the face of defective mitochondria and without deterioration over months

Young people, crime and school exclusion: a case of some surprises

During the 1990s the number of young people being permanently excluded from schools in England and Wales increased dramatically from 2,910 (1990/91) to a peak of 12,700 (1996/97). Coinciding with this rise was a resurgence of the debate centring on lawless and delinquent youth. With the publication of Young People and Crime (Graham and Bowling 1995) and Misspent Youth (Audit Commission 1996) the 'common sense assumption' that exclusion from school inexorably promoted crime received wide support, with the school excludee portrayed as another latter day 'folk devil'. This article explores the link between school exclusion and juvenile crime, and offers some key findings from a research study undertaken with 56 young people who had experience of being excluded from school. Self-report interview questions reveal that whilst 40 of the young people had offended, 90% (36) reported that the onset of their offending commenced prior to their first exclusion. Moreover, 50 (89.2% of the total number of young people in the sample), stated that they were no more likely to offend subsequent to being excluded and 31 (55.4%) stated that they were less likely to offend during their exclusion period. Often, this was because on being excluded, they were 'grounded' by their parents