157 research outputs found
Convex Rank Tests and Semigraphoids
Convex rank tests are partitions of the symmetric group which have desirable
geometric properties. The statistical tests defined by such partitions involve
counting all permutations in the equivalence classes. Each class consists of
the linear extensions of a partially ordered set specified by data. Our methods
refine existing rank tests of non-parametric statistics, such as the sign test
and the runs test, and are useful for exploratory analysis of ordinal data. We
establish a bijection between convex rank tests and probabilistic conditional
independence structures known as semigraphoids. The subclass of submodular rank
tests is derived from faces of the cone of submodular functions, or from
Minkowski summands of the permutohedron. We enumerate all small instances of
such rank tests. Of particular interest are graphical tests, which correspond
to both graphical models and to graph associahedra
Assessing the Positional Planimetric Accuracy of DBpedia Georeferenced Resources
International audienceAssessing the quality of the main linked data sources on the Web like DBpedia or Yago is an important research topic. The existing approaches for quality assessment mostly focus on determining whether data sources are compliant with Web of data best practices or on their completeness, semantic accuracy, consistency, relevancy or trustworthi-ness. In this article, we aim at assessing the accuracy of a particular type of information often associated with Web of data resources: direct spatial references. We present the approaches currently used for assessing the planimetric accuracy of geographic databases. We explain why they cannot be directly applied to the resources of the Web of data. Eventually , we propose an approach for assessing the planimetric accuracy of DBpedia resources, adapted to the open nature of this knowledge base
177Lu-rhPSMA-10.1 induces tumor response in a patient with mCRPC after PSMA-directed radioligand therapy with 177Lu-PSMA-I AND T
Excess resource use and costs of physical comorbidities in individuals with mental health disorders: A systematic literature review and meta-analysis
Individuals with mental health disorders (MHDs) have worse physical health than the general population, utilise healthcare resources more frequently and intensively, incurring higher costs. We provide a first comprehensive overview and quantitative synthesis of literature on the mag- nitude of excess resource use and costs for those with MHDs and comorbid physical health condi- tions (PHCs). This systematic review (PROSPERO CRD42017075319) searched studies comparing resource use or costs of individuals with MHDs and comorbid PHCs versus individuals without co- morbid conditions published between 2007 and 2021. We conducted narrative and quantitative syntheses, using random-effects meta-analyses to explore ranges of excess resource use and costs across care segments, comparing to MHD only, PHC only, or general population controls (GPC). Of 20,075 records, 228 and 100 were eligible for narrative and quantitative syntheses, respectively. Most studies were from the US, covered depression or schizophrenia, reporting endocrine/metabolic or circulatory comorbidities. Frequently investigated healthcare segments were inpatient, outpatient, emergency care and medications. Evidence on lost productivity, long-term and informal care was rare. Substantial differences exist between MHDs, with depressive disorder tending towards lower average excess resource use and cost estimates, while excess resource use ranges between +6% to +320% and excess costs between +14% to +614%. PHCs are major drivers of resource use and costs for individuals with MHDs, affecting care segments differently. Significant physical health gains and cost savings are potentially achievable through prevention, earlier identification, management and treatment, using more integrated care approaches. Current international evidence, however, is heterogeneous with limited geographical representativeness and comparability
Cooperation in Microbial Populations: Theory and Experimental Model Systems
Cooperative behavior, the costly provision of benefits to others, is common
across all domains of life. This review article discusses cooperative behavior
in the microbial world, mediated by the exchange of extracellular products
called public goods. We focus on model species for which the production of a
public good and the related growth disadvantage for the producing cells are
well described. To unveil the biological and ecological factors promoting the
emergence and stability of cooperative traits we take an interdisciplinary
perspective and review insights gained from both mathematical models and
well-controlled experimental model systems. Ecologically, we include crucial
aspects of the microbial life cycle into our analysis and particularly consider
population structures where an ensemble of local communities (sub populations)
continuously emerge, grow, and disappear again. Biologically, we explicitly
consider the synthesis and regulation of public good production. The discussion
of the theoretical approaches includes general evolutionary concepts,
population dynamics, and evolutionary game theory. As a specific but generic
biological example we consider populations of Pseudomonas putida and its
regulation and utilization of pyoverdines, iron scavenging molecules. The
review closes with an overview on cooperation in spatially extended systems and
also provides a critical assessment of the insights gained from the
experimental and theoretical studies discussed. Current challenges and
important new research opportunities are discussed, including the biochemical
regulation of public goods, more realistic ecological scenarios resembling
native environments, cell to cell signalling, and multi-species communities.Comment: Review article, 88 pages, 14 figure
From intensive care to rehabilitation: survey on the satisfaction with care received during prolonged hospitalization for COVID-19 at a northern Italian university hospital
Objective: Investigating the experiences perceived by COVID-19 inpatients is a fundamental research area that is starting to be explored. For this reason, our objective was to provide the first Italian survey on COVID-19 inpatients' satisfaction, obtained through a self-completed questionnaire previously used in a reference study in a UK cohort of COVID-19 patients.
Subjects and methods: Hospitalized COVID-19 patients (>20 days) admitted to Ferrara University Hospital who underwent rehabilitation during their hospital stay were invited to complete an anonymous questionnaire. The survey's questions explored the patients' satisfaction with the health services received, and their completion took place approximately one year after hospitalization. Information on sex, number of wards, ICU stays, and hospital discharge dates was collected.
Results: Sixty-two completed questionnaires were analyzed. The average overall satisfaction score obtained from the answers indicated by the participants in the tenth question was 4.7 out of 5.0. Very positive responses were observed for information about discharge plans, privacy, management of pain, sleep quality, and feeling of safety. The possibility of being consulted about medications and side effects received a very low satisfaction score. Considering overall satisfaction, no significant differences were noted for sex or ICU stay. The obtained results were almost superimposable to those reported in the cohort of COVID-19 patients of the reference study.
Conclusions: This survey suggested that COVID-19 patients' healthcare satisfaction was high. Nevertheless, some areas must be improved, such as the communication and involvement of the patients in the decision-making of care and the discussion about medications or possible side effects
Tomato: a crop species amenable to improvement by cellular and molecular methods
Tomato is a crop plant with a relatively small DNA content per haploid genome and a well developed genetics. Plant regeneration from explants and protoplasts is feasable which led to the development of efficient transformation procedures.
In view of the current data, the isolation of useful mutants at the cellular level probably will be of limited value in the genetic improvement of tomato. Protoplast fusion may lead to novel combinations of organelle and nuclear DNA (cybrids), whereas this technique also provides a means of introducing genetic information from alien species into tomato. Important developments have come from molecular approaches. Following the construction of an RFLP map, these RFLP markers can be used in tomato to tag quantitative traits bred in from related species. Both RFLP's and transposons are in the process of being used to clone desired genes for which no gene products are known. Cloned genes can be introduced and potentially improve specific properties of tomato especially those controlled by single genes. Recent results suggest that, in principle, phenotypic mutants can be created for cloned and characterized genes and will prove their value in further improving the cultivated tomato.
In vivo and in vitro synthesis of CM-proteins (A-hordeins) from barley (Hordeum vulgare L.)
CM-proteins from barley endosperm (CMa, CMb, CMc, CMd), which are the main components of the A-hordein fraction, are synthesized most actively 10 to 30 d after anthesis (maximum at 15–20 d). They are synthesized by membranebound polysomes as precursors of higher apparent molecular weight (13,000–21,000) than the mature proteins (12,000–16,000). The largest in vitro product (21,000) is the putative precursor of protein CMd (16,000), as it is selected with anti-CMd monospecific IgG's, and is coded by an mRNA of greater sedimentation coefficient (9 S) than those encoding the other three proteins (7.5 S). CM-proteins always appear in the soluble fraction, following different homogenization and subcellular fractionation procedures, indicating that these proteins are transferred to the soluble fraction after processing
Practical Classification Guidelines for Diabetes in patients treated with insulin: a cross-sectional study of the accuracy of diabetes diagnosis.
Differentiating between type 1 and type 2 diabetes is fundamental to ensuring appropriate management of patients, but can be challenging, especially when treating with insulin. The 2010 UK Practical Classification Guidelines for Diabetes were developed to help make the differentiation.This article is freely available via Open Access. Click on the Additional Link above to access the full-text via the publisher's site.Published (Open Access
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