227 research outputs found
Effective field theory interpretation of searches for dark matter annihilation in the Sun with the IceCube Neutrino Observatory
We present a model-independent interpretation of searches for dark matter
annihilation in the Sun using an effective field theory approach. We identify a
set of effective operators contributing to spin-dependent scattering of dark
matter with protons in the non-relativistic limit and explore simple new
physics models which would give rise to such operators. Using the limits on the
spin-dependent scattering cross-section set by the IceCube collaboration in
their search for dark matter annihilation in the Sun, we derive limits on
effective couplings and corresponding masses of mediating particles. We show
that the effective field theory interpretation of the IceCube searches provides
constraints on dark matter complementary to those from relic density
observations and searches at the LHC. Finally, we discuss the impact of
astrophysical uncertainties on our results.Comment: 16 pages, 6 figures; Added references in v
Effective field theory interpretation of searches for dark matter annihilation in the Sun with the IceCube Neutrino Observatory
Cattle Raiding, Cultural Survival, and Adaptability of East African Pastoralists
This is the published version. Also found here http://www.jstor.org/stable/359710
Cattle Raiding, Cultural Survival, and Adaptability of East African Pastoralists
This is the published version. Also found here http://www.jstor.org/stable/359710
The Hydrogen Atom in Combined Electric and Magnetic Fields with Arbitrary Mutual Orientations
For the hydrogen atom in combined magnetic and electric fields we investigate
the dependence of the quantum spectra, classical dynamics, and statistical
distributions of energy levels on the mutual orientation of the two external
fields. Resonance energies and oscillator strengths are obtained by exact
diagonalization of the Hamiltonian in a complete basis set, even far above the
ionization threshold. At high excitation energies around the Stark saddle point
the eigenenergies exhibit strong level repulsions when the angle between the
fields is varied. The large avoided crossings occur between states with the
same approximately conserved principal quantum number, n, and this
intramanifold mixing of states cannot be explained, not even qualitatively, by
conventional perturbation theory. However, it is well reproduced by an extended
perturbation theory which takes into account all couplings between the angular
momentum and Runge-Lenz vector. The large avoided crossings are interpreted as
a quantum manifestation of classical intramanifold chaos. This interpretation
is supported by both classical Poincar\'e surfaces of section, which reveal a
mixed regular-chaotic intramanifold dynamics, and the statistical analysis of
nearest-neighbor-spacingComment: two-column version, 10 pages, REVTeX, 10 figures, uuencoded,
submitted to Rhys. Rev.
The History of Astrophysics in Antarctica
We examine the historical development of astrophysical science in Antarctica
from the early 20th century until today. We find three temporally overlapping
eras, each having a rather distinct beginning. These are the astrogeological
era of meteorite discovery, the high energy era of particle detectors, and the
photon astronomy era of microwave, sub--mm and infrared telescopes, sidelined
by a few niche experiments at optical wavelengths. The favourable atmospheric
and geophysical conditions are briefly examined, followed by an account of the
major experiments and a summary of their results.Comment: 29 pages, 10 figures, 1 table Submitted to PASA in April 200
The Human Cytomegalovirus Major Immediate-Early Proteins as Antagonists of Intrinsic and Innate Antiviral Host Responses
The major immediate-early (IE) gene of human cytomegalovirus (CMV) is believed to have a decisive role in acute infection and its activity is an important indicator of viral reactivation from latency. Although a variety of gene products are expressed from this region, the 72-kDa IE1 and the 86-kDa IE2 nuclear phosphoproteins are the most abundant and important. Both proteins have long been recognized as promiscuous transcriptional regulators. More recently, a critical role of the IE1 and IE2 proteins in counteracting non-adaptive host cell defense mechanisms has been revealed. In this review we will briefly summarize the available literature on IE1- and IE2-dependent mechanisms contributing to CMV evasion from intrinsic and innate immune responses
Differential limit on the extremely-high-energy cosmic neutrino flux in the presence of astrophysical background from nine years of IceCube data
We report a quasi-differential upper limit on the extremely-high-energy (EHE)
neutrino flux above GeV based on an analysis of nine years of
IceCube data. The astrophysical neutrino flux measured by IceCube extends to
PeV energies, and it is a background flux when searching for an independent
signal flux at higher energies, such as the cosmogenic neutrino signal. We have
developed a new method to place robust limits on the EHE neutrino flux in the
presence of an astrophysical background, whose spectrum has yet to be
understood with high precision at PeV energies. A distinct event with a
deposited energy above GeV was found in the new two-year sample, in
addition to the one event previously found in the seven-year EHE neutrino
search. These two events represent a neutrino flux that is incompatible with
predictions for a cosmogenic neutrino flux and are considered to be an
astrophysical background in the current study. The obtained limit is the most
stringent to date in the energy range between and GeV. This result constrains neutrino models predicting a three-flavor
neutrino flux of $E_\nu^2\phi_{\nu_e+\nu_\mu+\nu_\tau}\simeq2\times 10^{-8}\
{\rm GeV}/{\rm cm}^2\ \sec\ {\rm sr}10^9\ {\rm GeV}$. A significant part
of the parameter-space for EHE neutrino production scenarios assuming a
proton-dominated composition of ultra-high-energy cosmic rays is excluded.Comment: The version accepted for publication in Physical Review
Divergent Effects of Human Cytomegalovirus and Herpes Simplex Virus-1 on Cellular Metabolism
Viruses rely on the metabolic network of the host cell to provide energy and macromolecular precursors to fuel viral replication. Here we used mass spectrometry to examine the impact of two related herpesviruses, human cytomegalovirus (HCMV) and herpes simplex virus type-1 (HSV-1), on the metabolism of fibroblast and epithelial host cells. Each virus triggered strong metabolic changes that were conserved across different host cell types. The metabolic effects of the two viruses were, however, largely distinct. HCMV but not HSV-1 increased glycolytic flux. HCMV profoundly increased TCA compound levels and flow of two carbon units required for TCA cycle turning and fatty acid synthesis. HSV-1 increased anapleurotic influx to the TCA cycle through pyruvate carboxylase, feeding pyrimidine biosynthesis. Thus, these two related herpesviruses drive diverse host cells to execute distinct, virus-specific metabolic programs. Current drugs target nucleotide metabolism for treatment of both viruses. Although our results confirm that this is a robust target for HSV-1, therapeutic interventions at other points in metabolism might prove more effective for treatment of HCMV
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