Shock-Driven Periodic Variability in a Low-Mass-Ratio Supermassive Black Hole Binary

We investigate the time-varying electromagnetic emission of a low-mass-ratio supermassive black hole binary (SMBHB) embedded in a circumprimary disk, with a particular interest in variability of shocks driven by the binary. We perform a 2D, locally isothermal hydrodynamics simulation of a SMBHB with mass ratio $q=0.01$ and separation $a=100\;R_g$, using a physically self-consistent steady disk model. We estimate the electromagnetic variability from the system by monitoring accretion onto the secondary and using an artificial viscosity scheme to capture shocks and monitor the energy dissipated. The SMBHB produces a wide, eccentric gap in the disk, previously only observed for larger mass ratios, which we attribute to our disk model being much thinner ($H/R\approx0.01$ near the secondary) than is typical of previous works. The eccentric gap drives periodic accretion onto the secondary SMBH on a timescale matching the orbital period of the binary, $t_{\rm{bin}}\approx0.1\;\rm{yr}$, implying that the variable accretion regime of the SMBHB parameter space extends to lower mass ratios than previously established. Shocks driven by the binary are periodic, with a period matching the orbital period, and the shocks are correlated with the accretion rate, with peaks in the shock luminosity lagging peaks in the accretion rate by $0.43\;t_{\rm{bin}}$. We propose that the correlation of these quantities represents a useful identifier of SMBHB candidates, via observations of correlated variability in X-ray and UV monitoring of AGN, rather than single-waveband periodicity alone.Comment: 12 pages, 8 figures, accepted by MNRA

Space Station Freedom environmental control and life support system phase 3 simplified integrated test detailed report

A description of the phase 3 simplified integrated test (SIT) conducted at the Marshall Space Flight Center (MSFC) Core Module Integration Facility (CMIF) in 1989 is presented. This was the first test in the phase 3 series integrated environmental control and life support systems (ECLSS) tests. The basic goal of the SIT was to achieve full integration of the baseline air revitalization (AR) subsystems for Space Station Freedom. Included is a description of the SIT configuration, a performance analysis of each subsystem, results from air and water sampling, and a discussion of lessons learned from the test. Also included is a full description of the preprototype ECLSS hardware used in the test

Midazolam Efficacy Against Acute Hydrogen Sulfide-Induced Mortality and Neurotoxicity.

Hydrogen sulfide (H2S) is a colorless, highly neurotoxic gas. It is not only an occupational and environmental hazard but also of concern to the Department of Homeland Security for potential nefarious use. Acute high-dose H2S exposure causes death, while survivors may develop neurological sequelae. Currently, there is no suitable antidote for treatment of acute H2S-induced neurotoxicity. Midazolam (MDZ), an anti-convulsant drug recommended for treatment of nerve agent intoxications, could also be of value in treating acute H2S intoxication. In this study, we tested the hypothesis that MDZ is effective in preventing/treating acute H2S-induced neurotoxicity. This proof-of-concept study had two objectives: to determine whether MDZ prevents/reduces H2S-induced mortality and to test whether MDZ prevents H2S-induced neurological sequelae. MDZ (4 mg/kg) was administered IM in mice, 5 min pre-exposure to a high concentration of H2S at 1000 ppm or 12 min post-exposure to 1000 ppm H2S followed by 30 min of continuous exposure. A separate experiment tested whether MDZ pre-treatment prevented neurological sequelae. Endpoints monitored included assessment of clinical signs, mortality, behavioral changes, and brain histopathological changes. MDZ significantly reduced H2S-induced lethality, seizures, knockdown, and behavioral deficits (p < 0.01). MDZ also significantly prevented H2S-induced neurological sequelae, including weight loss, behavior deficits, neuroinflammation, and histopathologic lesions (p < 0.01). Overall, our findings show that MDZ is a promising drug for reducing H2S-induced acute mortality, neurotoxicity, and neurological sequelae

Broad spectrum proteomics analysis of the inferior colliculus following acute hydrogen sulfide exposure.

Acute exposure to high concentrations of H2S causes severe brain injury and long-term neurological disorders, but the mechanisms involved are not known. To better understand the cellular and molecular mechanisms involved in acute H2S-induced neurodegeneration we used a broad-spectrum proteomic analysis approach to identify key molecules and molecular pathways involved in the pathogenesis of acute H2S-induced neurotoxicity and neurodegeneration. Mice were subjected to acute inhalation exposure of up to750 ppm of H2S. H2S induced behavioral deficits and severe lesions including hemorrhage in the inferior colliculus (IC). The IC was microdissected for proteomic analysis. Tandem mass tags (TMT) liquid chromatography mass spectrometry (LC-MS/MS)-based quantitative proteomics was applied for protein identification and quantitation. LC-MS/MS identified 598, 562, and 546 altered proteomic changes at 2 h, and on days 2 and 4 post-H2S exposure, respectively. Of these, 77 proteomic changes were statistically significant at any of the 3 time points. Mass spectrometry data were subjected to Perseus 1.5.5.3 statistical analysis, and gene ontology heat map clustering. Expressions of several key molecules were verified to confirm H2S-dependent proteomics changes. Webgestalt pathway overrepresentation enrichment analysis with Panther engine revealed H2S exposure disrupted several biological processes including metabotropic glutamate receptor group 1 and inflammation mediated by chemokine and cytokine signaling pathways among others. Further analysis showed that energy metabolism, integrity of blood-brain barrier, hypoxic, and oxidative stress signaling pathways were also implicated. Collectively, this broad-spectrum proteomics data has provided important clues to follow up in future studies to further elucidate mechanisms of H2S-induced neurotoxicity

Relocation of the Salvador Camarena Burial: Historical and Bioarcheological Investigations of a Mexican Migrant Worker Grave (41MV372) in Maverick County, Texas

F rom 2011 through 2014, the Texas Department of Transportation collaborated with Prewitt and Associates, Inc., to investigate an isolated grave in a remote area alongside FM 481 in Maverick County, Texas. An initial archeological investigation confirmed that the location was a historic grave, and archival records revealed that it contained the remains of Salvador Camarena, a Mexican citizen who died in Texas in January 1950. Additional research identified Camarena’s son and other family members living in Mexico, California, and Texas. With the family’s permission, the burial remains were exhumed, examined, and reinterred at La Marque Cemetery in Galveston County, Texas, where Camarena’s mother and two sisters are buried. The bioarcheological analysis of the skeletal remains corroborates the historical information. Together, the bioarcheological and historical data provide a rare glimpse into the life and death of a migrant laborer. The burial of one immigrant worker may seem insignificant. However, the Camarena case represents a sad but common theme in the history of migrant labor. Like many before him and even more since, Camarena probably died in a foreign country seeking a means to support his family when traveling to seasonal agricultural work

Investigating Differences between Graphical and Textual Declarative Process Models

Declarative approaches to business process modeling are regarded as well suited for highly volatile environments, as they enable a high degree of flexibility. However, problems in understanding declarative process models often impede their adoption. Particularly, a study revealed that aspects that are present in both imperative and declarative process modeling languages at a graphical level-while having different semantics-cause considerable troubles. In this work we investigate whether a notation that does not contain graphical lookalikes, i.e., a textual notation, can help to avoid this problem. Even though a textual representation does not suffer from lookalikes, in our empirical study it performed worse in terms of error rate, duration and mental effort, as the textual representation forces the reader to mentally merge the textual information. Likewise, subjects themselves expressed that the graphical representation is easier to understand

Fitness function distributions over generalized search neighborhoods in the q-ary hypercube

Evolutionary Computation, 21(4): 561-590, 2013The frequency distribution of a fitness function over regions of its domain is an important quantity for understanding the behavior of algorithms that employ randomized sampling to search the function. In general, exactly characterizing this distribution is at least as hard as the search problem, since the solutions typically live in the tails of the distribution. However, in some cases it is possible to efficiently retrieve a collection of quantities (called moments) that describe the distribution. In this paper, we consider functions of bounded epistasis that are defined over length-n strings from a finite alphabet of cardinality q. Many problems in combinatorial optimization can be specified as search problems over functions of this type. Employing Fourier analysis of functions over finite groups, we derive an efficient method for computing the exact moments of the frequency distribution of fitness functions over Hamming regions of the q-ary hypercube. We then use this approach to derive equations that describe the expected fitness of the offspring of any point undergoing uniform mutation. The results we present provide insight into the statistical structure of the fitness function for a number of combinatorial problems. For the graph coloring problem, we apply our results to efficiently compute the average number of constraint violations that lie within a certain number of steps of any coloring. We derive an expression for the mutation rate that maximizes the expected fitness of an offspring at each fitness level. We also apply the results to the slightly more complex frequency assignment problem, a relevant application in the domain of the telecommunications industry. As with the graph coloring problem, we provide formulas for the average value of the fitness function in Hamming regions around a solution and the expectation-optimal mutation rate.Spanish Ministry of Science and Innovation and FEDER under contract TIN2008-06491-C04-01 (the M∗ project). Andalusian Government under contract P07-TIC-03044 (DIRICOM project). Air Force Office of Scientific Re- search, Air Force Materiel Command, USAF, under grant number FA9550-08-1-0422