Syndecan-3 in Inflammation and Angiogenesis

Syndecans are a four member multifunctional family of cell surface molecules with diverse biological roles. Syndecan-3 (SDC3) is the largest of these, but in comparison to the other family members relatively little is known about this molecule. SDC3 null mice grow and develop normally, all be it with subtle anatomical phenotypes in the brain. Roles for this molecule in both neuronal and brain tissue have been identified, and is associated with altered satiety responses. Recent studies suggest that SDC3 expression is not restricted to neuronal tissues and has important roles in inflammatory disorders such as rheumatoid arthritis, disease associated processes such as angiogenesis and in the facilitation of infection of dendritic cells by HIV. The purpose of this review article is to explore these new biological insights into SDC3 functions in inflammatory disease

Letters to the Editor

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66389/1/j.1600-0447.1989.tb03017.x.pd

Understanding service demand for mental health among Australians aged 16 to 64 years according to their possible need for treatment

Background: To inform decisions about mental health resource allocation, planners require reliable estimates of people who report service demand (i.e. people who use or want mental health services) according to their level of possible need. Methods: Using data on 6915 adults aged 16-64 years in Australia's 2007 National Survey of Mental Health and Wellbeing, we examined past-year service demand among respondents grouped into four levels of possible need: (a) 12-month mental disorder; (b) lifetime but no 12-month mental disorder; (c) any other indicator of possible need (12-month symptoms or reaction to stressful event, or lifetime hospitalisation); (d) no indicator of possible need. Multivariate logistic regression analyses examined correlates of service demand, separately for respondents in each of levels 1-3. Results: Sixteen per cent of Australian adults reported service demand, of whom one-third did not meet criteria for a 12-month mental disorder (equivalent to 5.7% of the adult population). Treatment patterns tended to follow a gradient defined by level of possible need. For example, service users with a 12-month disorder received, on average, 1.6-3.9 times more consultations than their counterparts in other levels of possible need, and had 1.9-2.2 times higher rates of psychologist consultation. Service users with a lifetime but not 12-month disorder or any other indicator of need consumed a similar average number of services to people with mild 12-month mental disorders, but received relatively fewer services involving the mental health sector. Service demand was associated with increased suicidality and psychological distress in all levels of possible need examined, and with poorer clinical and functional status for those with 12-month or lifetime disorders. Conclusions: Many Australians reporting service demand do not meet criteria for a current mental disorder, but may require services to maintain recovery following a past episode or because they are experiencing symptoms and significant psychological distress

Overestimation of thermal emittance in solenoid scans due to coupled transverse motion

The solenoid scan is a widely used method for the in-situ measurement of the thermal emittance in a photocathode gun. The popularity of this method is due to its simplicity and convenience since all rf photocathode guns are equipped with an emittance compensation solenoid. This paper shows that the solenoid scan measurement overestimates the thermal emittance in the ordinary measurement configuration due to a weak quadrupole field (present in either the rf gun or gun solenoid) followed by a rotation in the solenoid. This coupled transverse dynamics aberration introduces a correlation between the beam's horizontal and vertical motion leading to an increase in the measured 2D transverse emittance, thus the overestimation of the thermal emittance. This effect was systematically studied using both analytic expressions and numerical simulations. These studies were experimentally verified using an L-band 1.6-cell rf photocathode gun with a cesium telluride cathode, which shows a thermal emittance overestimation of 35% with a rms laser spot size of 2.7 mm. The paper concludes by showing that the accuracy of the solenoid scan can be improved by using a quadrupole magnet corrector, consisting of a pair of normal and skew quadrupole magnets.Comment: 12 pages, 13 figure

Spatial variations in snowpack chemistry, isotopic composition of NO3− and nitrogen deposition from the ice sheet margin to the coast of western Greenland

The relative roles of anthropogenic nitrogen (N) deposition and climate change in causing ecological change in remote Arctic ecosystems, especially lakes, have been the subject of debate over the last decade. Some palaeoecological studies have cited isotopic signals (δ(15N)) preserved in lake sediments as evidence linking N deposition with ecological change, but a key limitation has been the lack of co-located data on both deposition input fluxes and isotopic composition of deposited nitrate (NO3−). In Arctic lakes, including those in western Greenland, previous palaeolimnological studies have indicated a spatial variation in δ(15N) trends in lake sediments but data are lacking for deposition chemistry, input fluxes and stable isotope composition of NO3−. In the present study, snowpack chemistry, NO3− stable isotopes and net deposition fluxes for the largest ice-free region in Greenland were investigated to determine whether there are spatial gradients from the ice sheet margin to the coast linked to a gradient in precipitation. Late-season snowpack was sampled in March 2011 at eight locations within three lake catchments in each of three regions (ice sheet margin in the east, the central area near Kelly Ville and the coastal zone to the west). At the coast, snowpack accumulation averaged 181 mm snow water equivalent (SWE) compared with 36 mm SWE by the ice sheet. Coastal snowpack showed significantly greater concentrations of marine salts (Na+, Cl−, other major cations), ammonium (NH4+; regional means 1.4–2.7 µmol L−1), total and non-sea-salt sulfate (SO42−; total 1.8–7.7, non-sea-salt 1.0–1.8 µmol L−1) than the two inland regions. Nitrate (1.5–2.4 µmol L−1) showed significantly lower concentrations at the coast. Despite lower concentrations, higher precipitation at the coast results in greater net deposition for NO3− as well as NH4+ and non-sea-salt sulfate (nss-SO42−) relative to the inland regions (lowest at Kelly Ville 6, 4 and 3; highest at coast 9, 17 and 11 mol ha−1 a−1 of NO3−, NH4+ and nss-SO42− respectively). The δ(15N) of snowpack NO3− shows a significant decrease from inland regions (−5.7 ‰ at Kelly Ville) to the coast (−11.3 ‰). We attribute the spatial patterns of δ(15N) in western Greenland to post-depositional processing rather than differing sources because of (1) spatial relationships with precipitation and sublimation, (2) within-catchment isotopic differences between terrestrial snowpack and lake ice snowpack, and (3) similarities between fresh snow (rather than accumulated snowpack) at Kelly Ville and the coast. Hence the δ(15N) of coastal snowpack is most representative of snowfall in western Greenland, but after deposition the effects of photolysis, volatilization and sublimation lead to enrichment of the remaining snowpack with the greatest effect in inland areas of low precipitation and high sublimation losses

Atomic data from the IRON Project. I. Electron-impact scattering of Fe17+ using <I>R</I>-matrix theory with intermediate coupling

We present results for electron-impact excitation of F-like Fe calculated using R-matrix theory where an intermediate-coupling frame transformation (ICFT) is used to obtain level-resolved collision strengths. Two such calculations are performed, the first expands the target using 2s2 2p5, 2s 2p6, 2s2 2p4 3l, 2s 2p5 3l, and 2p6 3l configurations while the second calculation includes the 2s2 2p4 4l, 2s 2p5 4l, and 2p6 4l configurations as well. The effect of the additional structure in the latter calculation on the n=3 resonances is explored and compared with previous calculations. We find strong resonant enhancement of the effective collision strengths to the 2s2 2p4 3s levels. A comparison with a Chandra X-ray observation of Capella shows that the n=4 R-matrix calculation leads to good agreement with observation</p

The National Food Consumption Survey (NFCS): South Africa, 1999

Objective: The aim of the National Food Consumption Survey (NFCS) in South Africa was to determine the nutrient intakes and anthropometric status of children (1-9 years old), as well as factors that influence their dietary intake. Design: This was a cross-sectional survey of a nationally representative sample of all children aged 1-9 years in South Africa. A nationally representative sample with provincial representation was selected using 1996 Census information. Subjects: Of the 3120 children who were originally sampled data were obtained from 2894, a response rate of 93%. Methods: The sociodemographic status of each household was assessed by a questionnaire. Dietary intake was assessed by means of a 24-hour recall and a food-frequency questionnaire from the caregivers of the children. Food purchasing practices were determined by means of a food procurement questionnaire. Hunger was assessed by a modified hunger scale questionnaire. Nutritional status was determined by means of anthropometric measurements: height, weight, head circumference and arm circumference. Results: At the national level, stunting (height-for-age below minus two standard deviations (&lt; -2SD) from the reference median) was by far the most common nutritional disorder, affecting nearly one in five children. The children least affected (17%) were those living in urban areas. Even with regard to the latter, however, children living in informal urban areas were more severely affected (20%) compared with those living in formal urban areas (16%). A similar pattern emerged for the prevalence of underweight (weight-for-age &lt; -2SD), with one in 10 children being affected at the national level. Furthermore, one in 10 (13%) and one in four (26%) children aged 1-3 years had an energy intake less than half and less than two-thirds of their daily energy needs, respectively. For South African children as a whole, the intakes of energy, calcium, iron, zinc, selenium, vitamins A, D, C and E, riboflavin, niacin, vitamin B6 and folic acid were below two-thirds of the Recommended Dietary Allowances. At the national level, data from the 24-hour recalls indicated that the most commonly consumed food items were maize, sugar, tea, whole milk and brown bread. For South African children overall, one in two households (52%) experienced hunger, one in four (23%) were at risk of hunger and only one in four households (25%) appeared food-secure. Conclusion: The NFCS indicated that a large majority of households were food-insecure and that energy deficit and micronutrient deficiencies were common, resulting in a high prevalence of stunting. These results were used as motivation for the introduction of mandatory fortification in South Africa. © The Authors 2005.Conference Pape

The white‐rot fungus, Phanerochaete chrysosporium, under combinatorial stress produces variable oil profiles following analysis of secondary metabolites

From Wiley via Jisc Publications RouterHistory: received 2020-06-29, rev-recd 2020-11-10, accepted 2021-01-15, pub-electronic 2021-02-25, pub-print 2021-09Article version: VoRPublication status: PublishedFunder: Global Challenges Research Fund 2018‐19 GCRF Accelerator ‐ Adding value to agricultural waste through conversion to value added products; Grant(s): G.LFGC.001.EXPAbstract: Aims: The effects of combinatorial stress on lipid production in Phanerochaete chrysosporium remain understudied. This species of white‐rot fungi was cultivated on solid‐state media while under variable levels of known abiotic and biotic stressors to establish the effect upon fungal oil profiles. Methods and Results: Environmental stressors induced upon the fungus included the following: temperature, nutrient limitation and interspecies competition to assess impact upon oil profiles. Fatty acid type and its concentration were determined using analytical methods of gas chromatography and mass spectrometry. Growth rate under stress was established using high‐performance liquid chromatography with ergosterol as the biomarker. Fungi grown on solid‐state agar were able to simultaneously produce short‐ and long‐chain fatty acids which appeared to be influenced by nutritional composition as well as temperature. Addition of nitrogen supplements increased the growth rate, but lipid dynamics remained unchanged. Introducing competition‐induced stress had significantly altered the production of certain fatty acids beyond that of the monoculture while under nutrient‐limiting conditions. Linoleic acid concentrations, for example, increased from an average of 885 ng μl−1 at monoculture towards 13 820 ng μl−1 at co‐culture, following 7 days of incubation. Conclusions: Interspecies competition produced the most notable impact on lipid production for solid‐state media cultivated fungi while the addition of nitrogen supplementation presented growth and lipid accumulation to be uncorrelated. Combinatorial stress therefore influences the yield of overall lipid production as well as the number of intermediate fatty acids produced, deriving similar oil profiles to the composition of vegetable and fish oils. Significance and Impact of the Study: Fungal secondary metabolism remains highly sensitive following combinatorial stress. The outcome impacts the research towards optimizing fungal oil profiles for biomass and nutrition. Future investigations on fungal stress tolerance mechanisms need to address these environmental factors throughout the experimental design

Recombination Rate Coefficients for KLL Di-electronic Satellite Lines of Fe XXV and Ni XXVII

The unified method for total electron-ion recombination is extended to study the dielectronic satellite (DES) lines. These lines, formed from radiative decay of autoionizing states, are highly sensitive temperature diagnostics of astrophysical and laboratory plasma sources. The computation of the unified recombination rates is based on the relativistic Breit-Pauli R-matrix method and close coupling approximation. Extending the theoretical formulation developed earlier we present recombination rate coefficients for the 22 satellite lines of KLL complexes of helium-like Fe XXV and Ni XXVII. The isolated resonance approximation, commonly used throughout plasma modeling, treats these resonances essentially as bound features except for dielectronic capture into, and autoionization out of, these levels. A line profile or cross section shape is often assumed. On the other hand, by including the coupling between the autoionizing and continuum channels, the unified method gives the intrinsic spectrum of DES lines which includes not only the energies and strengths, but also the natural line or cross section shapes. A formulation is presented to derive autoionization rates from unified resonance strengths and enable correspondence with the isolated resonance approximation. While the rates compare very well with existing rates for the strong lines to <20%, the differences for weaker DES lines are larger. We also illustrate the application of the present results to the analysis of K ALPHA complexes observed in high-temperature X-ray emission spectra of Fe XXV and Ni XXVII. There are considerable differences with previous results in the total KLL intensity for Fe XXV at temperatures below the temperature of maximum abundance in coronal equilibrium. (Abbreviated Abstract)Comment: 21 pages, 5 figures, to appear in Physica Script