1,337 research outputs found
Seeing motion and apparent motion
In apparent motion experiments, participants are presented with what is in fact a succession of two brief stationary stimuli at two different locations, but they report an impression of movement. Philosophers have recently debated whether apparent motion provides evidence in favour of a particular account of the nature of temporal experience. I argue that the existing discussion in this area is premised on a mistaken view of the phenomenology of apparent motion and, as a result, the space of possible philosophical positions has not yet been fully explored. In particular, I argue that the existence of apparent motion is compatible with an account of the nature of temporal experience that involves a version of direct realism. In doing so, I also argue against two other claims often made about apparent motion, viz. that apparent motion is the psychological phenomenon that underlies motion experience in the cinema, and that apparent motion is subjectively indistinguishable from real motion
Impact of human bladder cancer cell architecture on autologous T-lymphocyte activation
To investigate the influence of tumor cell architecture on T-cell activation, we used an autologous human model based on 2 bladder tumor cell lines as targets for cytotoxic tumor-infiltrating lymphocytes (TILs). These tumor cell lines were grown in vitro as either standard 2-dimensional (2D) monolayers or 3-dimensional (3D) spheroids. T-cell activation was determined by measuring the production of three major cytokines (tumor necrosis factor, granulocyte/macrophage colony-stimulating factor and interferon-gamma), known to be secreted by most activated TILs. Changes in the architecture of target cells from 2D to 3D induced a dramatic decrease in their capacity for stimulating TILs. Interestingly, neither TIL infiltration nor MHC class I, B7.1 costimulatory or lymphocyte function-associated factor-3 adhesion molecule downregulation played a major role in this decrease. These findings demonstrate that tumor architecture has a major impact on T-cell activation and might be implicated in the escape of tumor cells from the immune system
Suppression of Superconducting Critical Current Density by Small Flux Jumps in Thin Films
By doing magnetization measurements during magnetic field sweeps on thin
films of the new superconductor , it is found that in a low temperature
and low field region small flux jumps are taking place. This effect strongly
suppresses the central magnetization peak leading to reduced nominal
superconducting critical current density at low temperatures. A borderline for
this effect to occur is determined on the field-temperature (H-T) phase
diagram. It is suggested that the small size of the flux jumps in films is due
to the higher density of small defects and the relatively easy thermal
diffusion in thin films in comparison with bulk samples.Comment: 7 figures Phys. Rev. B accepted scheduled issue: 01 Feb 200
Pharmacists in Pharmacovigilance: Can Increased Diagnostic Opportunity in Community Settings Translate to Better Vigilance?
The pharmacy profession has undergone substantial change over the last two to three decades. Whilst medicine supply still remains a central function, pharmacistâs roles and responsibilities have become more clinic and patient focused. In the community (primary care), pharmacists have become important providers of healthcare as Western healthcare policy advocates patient self-care. This has resulted in pharmacists taking on greater responsibility in managing minor illness and the delivery of public health interventions. These roles require pharmacists to more fully use their clinical skills, and often involve diagnosis and therapeutic management. Community pharmacists are now, more than ever before, in a position to identify, record and report medication safety incidents. However, current research suggests that diagnostic ability of community pharmacists is questionable and they infrequently report to local or national schemes. The aim of this paper is to highlight current practice and suggest ways in which community pharmacy can more fully contribute to patient safety
Local threshold field for dendritic instability in superconducting MgB2 films
Using magneto-optical imaging the phenomenon of dendritic flux penetration in
superconducting films was studied. Flux dendrites were abruptly formed in a 300
nm thick film of MgB2 by applying a perpendicular magnetic field. Detailed
measurements of flux density distributions show that there exists a local
threshold field controlling the nucleation and termination of the dendritic
growth. At 4 K the local threshold field is close to 12 mT in this sample,
where the critical current density is 10^7 A/cm^2. The dendritic instability in
thin films is believed to be of thermo-magnetic origin, but the existence of a
local threshold field, and its small value are features that distinctly
contrast the thermo-magnetic instability (flux jumps) in bulk superconductors.Comment: 6 pages, 6 figures, submitted to Phys. Rev.
A Spitzer IRAC Imaging Survey for T Dwarf Companions Around M, L, and T Dwarfs: Observations, Results, and Monte Carlo Population Analyses
We report observational techniques, results, and Monte Carlo population
analyses from a Spitzer Infrared Array Camera imaging survey for substellar
companions to 117 nearby M, L, and T dwarf systems (median distance of 10 pc,
mass range of 0.6 to \sim0.05 M\odot). The two-epoch survey achieves typical
detection sensitivities to substellar companions of [4.5 {\mu}m] \leq 17.2 mag
for angular separations between about 7" and 165". Based on common proper
motion analysis, we find no evidence for new substellar companions. Using Monte
Carlo orbital simulations (assuming random inclination, random eccentricity,
and random longitude of pericenter), we conclude that the observational
sensitivities translate to an ability to detect 600-1100K brown dwarf
companions at semimajor axes greater than ~35 AU, and to detect 500-600K
companions at semimajor axes greater than ~60 AU. The simulations also estimate
a 600-1100K T dwarf companion fraction of < 3.4% for 35-1200 AU separations,
and < 12.4% for the 500-600K companions, for 60-1000 AU separations.Comment: 35 pages, 6 figure
Optimal measurement of visual motion across spatial and temporal scales
Sensory systems use limited resources to mediate the perception of a great
variety of objects and events. Here a normative framework is presented for
exploring how the problem of efficient allocation of resources can be solved in
visual perception. Starting with a basic property of every measurement,
captured by Gabor's uncertainty relation about the location and frequency
content of signals, prescriptions are developed for optimal allocation of
sensors for reliable perception of visual motion. This study reveals that a
large-scale characteristic of human vision (the spatiotemporal contrast
sensitivity function) is similar to the optimal prescription, and it suggests
that some previously puzzling phenomena of visual sensitivity, adaptation, and
perceptual organization have simple principled explanations.Comment: 28 pages, 10 figures, 2 appendices; in press in Favorskaya MN and
Jain LC (Eds), Computer Vision in Advanced Control Systems using Conventional
and Intelligent Paradigms, Intelligent Systems Reference Library,
Springer-Verlag, Berli
Local biases drive, but do not determine, the perception of illusory trajectories
When a dot moves horizontally across a set of tilted lines of alternating orientations, the dot appears to be moving up and down along its trajectory. This perceptual phenomenon, known as the slalom illusion, reveals a mismatch between the veridical motion signals and the subjective percept of the motion trajectory, which has not been comprehensively explained. In the present study, we investigated the empirical boundaries of the slalom illusion using psychophysical methods. The phenomenon was found to occur both under conditions of smooth pursuit eye movements and constant fixation, and to be consistently amplified by intermittently occluding the dot trajectory. When the motion direction of the dot was not constant, however, the stimulus display did not elicit the expected illusory percept. These findings confirm that a local bias towards perpendicularity at the intersection points between the dot trajectory and the tilted lines cause the illusion, but also highlight that higher-level cortical processes are involved in interpreting and amplifying the biased local motion signals into a global illusion of trajectory perception
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