Surgical Treatment or Irradiation of Cervical Carcinoma

All in all, the various methods, surgical with or without lymphadenectomy and irradiation, including supervolt therapy, permit marked individualization according to the age of the patient, her general condition, her operability, and according to the histological findings. It may be said for all methods that the best results are still obtained in the early stages of carcinoma. By surgery as well as irradiation, 90% or more permanent cures may be achieved. This, in view of the nature of cancerous disease, is an important fact

Keratin K15 as a Biomarker of Epidermal Stem Cells

Keratin 15 (K15) is type I keratin protein co-expressed with the K5/K14 pair present in the basal keratinocytes of all stratified epithelia. Although it is a minor component of the cytoskeleton with a variable expression pattern, nonetheless its expression has been reported as a stem cell marker in the bulge of hair follicles. Conversely, suprabasal expression of K15 has also been reported in both normal and diseased tissues, which is inconsistent with its role as a stem cell marker. Our recently published work has given evidence of the molecular pathways that seem to control the expression of K15 in undifferentiated and differentiated cells. In this article, we have critically reviewed the published work to establish the reliability of K15 as an epidermal stem cell marker