Response of mouse epidermal cells to single doses of heavy-particles

The survival of mouse epidermal cells to heavy-particles has been studied In Vivo by the Withers clone technique. Experiments with accelerated helium, lithium and carbon ions were performed. The survival curve for the helium ion irradiations used a modified Bragg curve method with a maximum tissue penetration of 465 microns, and indicated that the dose needed to reduce the original cell number to 1 surviving cell/square centimeters was 1525 rads with a D sub o of 95 rads. The LET at the basal cell layer was 28.6 keV per micron. Preliminary experiments with lithium and carbon used treatment doses of 1250 rads with LET's at the surface of the skin of 56 and 193 keV per micron respectively. Penetration depths in skin were 350 and 530 microns for the carbon and lithium ions whose Bragg curves were unmodified. Results indicate a maximum RBE for skin of about 2 using the skin cloning technique. An attempt has been made to relate the epidermal cell survival curve to mortality of the whole animal for helium ions

Lumbar puncture for the generalist

The safe and successful performance of a lumbar puncture demands a working and yet specific knowledge as well as competency in performance. This review aims to aid understanding of the knowledge framework, the pitfalls and complications of lumbar puncture. It includes special reference to three dimensional relationships, functional anatomy, imaging anatomy, normal variation and living anatomy. A lumbar puncture is a commonly performed procedure for diagnostic and therapeutic purposes. Epidural and spinal anaesthesia, for example, are common in obstetric practice and involve the same technique as a lumbar puncture except for the endpoint of the needle being in the epidural space and subarachnoid space respectively. The procedure is by no means innocuous and some anatomical pitfalls include inability to find the correct entry site for placement of the lumbar puncture needle and lack of awareness of structures in relation to the advancing needle. Headache is the most common complication and it is important to avoid traumatic and dry taps, herniation syndromes and injury to the terminal end of the spinal cord. With a thorough knowledge of the contraindications, the regional anatomy and rationale of the technique and adequate prior skills practice, a lumbar puncture can be performed safely and successfully

SSME structural dynamic model development

A mathematical model of the Space Shuttle Main Engine (SSME) as a complete assembly, with detailed emphasis on LOX and High Fuel Turbopumps is developed. The advantages of both complete engine dynamics, and high fidelity modeling are incorporated. Development of this model, some results, and projected applications are discussed

Macartney Rose Control Systems.

4 p

Bayesian total evidence dating reveals the recent crown radiation of penguins

The total-evidence approach to divergence-time dating uses molecular and morphological data from extant and fossil species to infer phylogenetic relationships, species divergence times, and macroevolutionary parameters in a single coherent framework. Current model-based implementations of this approach lack an appropriate model for the tree describing the diversification and fossilization process and can produce estimates that lead to erroneous conclusions. We address this shortcoming by providing a total-evidence method implemented in a Bayesian framework. This approach uses a mechanistic tree prior to describe the underlying diversification process that generated the tree of extant and fossil taxa. Previous attempts to apply the total-evidence approach have used tree priors that do not account for the possibility that fossil samples may be direct ancestors of other samples. The fossilized birth-death (FBD) process explicitly models the diversification, fossilization, and sampling processes and naturally allows for sampled ancestors. This model was recently applied to estimate divergence times based on molecular data and fossil occurrence dates. We incorporate the FBD model and a model of morphological trait evolution into a Bayesian total-evidence approach to dating species phylogenies. We apply this method to extant and fossil penguins and show that the modern penguins radiated much more recently than has been previously estimated, with the basal divergence in the crown clade occurring at ~12.7 Ma and most splits leading to extant species occurring in the last 2 million years. Our results demonstrate that including stem-fossil diversity can greatly improve the estimates of the divergence times of crown taxa. The method is available in BEAST2 (v. 2.4) www.beast2.org with packages SA (v. at least 1.1.4) and morph-models (v. at least 1.0.4).Comment: 50 pages, 6 figure

Macartney Rose Control Systems.

4 p

Single-Scattering Optical Tomography: Simultaneous Reconstruction of Scattering and Absorption

We demonstrate that simultaneous reconstruction of scattering and absorption of a mesoscopic system using angularly-resolved measurements of scattered light intensity is possible. Image reconstruction is realized based on the algebraic inversion of a generalized Radon transform relating the scattering and absorption coefficients of the medium to the measured light intensity and derived using the single-scattering approximation to the radiative transport equation.Comment: This is a sequel to physics/070311

Threshold Photo/Electro Pion Production - Working Group Summary

We summarize the pertinent experimental and theoretical developments in the field of pion photo- and electroproduction in the threshold region. We discuss which experiments and which calculations should be done/performed in the future.Comment: plain TeX (macro included), 6pp, summary talk presented at the workshop on "Chiral Dynamics: Theory and Experiments", MIT, July 25-29, 199

A Bayesian approach to the follow-up of candidate gravitational wave signals

Ground-based gravitational wave laser interferometers (LIGO, GEO-600, Virgo and Tama-300) have now reached high sensitivity and duty cycle. We present a Bayesian evidence-based approach to the search for gravitational waves, in particular aimed at the followup of candidate events generated by the analysis pipeline. We introduce and demonstrate an efficient method to compute the evidence and odds ratio between different models, and illustrate this approach using the specific case of the gravitational wave signal generated during the inspiral phase of binary systems, modelled at the leading quadrupole Newtonian order, in synthetic noise. We show that the method is effective in detecting signals at the detection threshold and it is robust against (some types of) instrumental artefacts. The computational efficiency of this method makes it scalable to the analysis of all the triggers generated by the analysis pipelines to search for coalescing binaries in surveys with ground-based interferometers, and to a whole variety of signal waveforms, characterised by a larger number of parameters.Comment: 9 page