Response of mouse epidermal cells to single doses of heavy-particles

The survival of mouse epidermal cells to heavy-particles has been studied In Vivo by the Withers clone technique. Experiments with accelerated helium, lithium and carbon ions were performed. The survival curve for the helium ion irradiations used a modified Bragg curve method with a maximum tissue penetration of 465 microns, and indicated that the dose needed to reduce the original cell number to 1 surviving cell/square centimeters was 1525 rads with a D sub o of 95 rads. The LET at the basal cell layer was 28.6 keV per micron. Preliminary experiments with lithium and carbon used treatment doses of 1250 rads with LET's at the surface of the skin of 56 and 193 keV per micron respectively. Penetration depths in skin were 350 and 530 microns for the carbon and lithium ions whose Bragg curves were unmodified. Results indicate a maximum RBE for skin of about 2 using the skin cloning technique. An attempt has been made to relate the epidermal cell survival curve to mortality of the whole animal for helium ions

Macartney Rose Control Systems.

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Anomalous increase in nematic-isotropic transition temperature in dimer molecules induced by magnetic field

We have determined the nematic-isotropic transition temperature as a function of applied magnetic field in three different thermotropic liquid crystalline dimers. These molecules are comprised of two rigid calamitic moieties joined end to end by flexible spacers with odd numbers of methylene groups. They show an unprecedented magnetic field enhancement of nematic order in that the transition temperature is increased by up to 15K when subjected to 22T magnetic field. The increase is conjectured to be caused by a magnetic field-induced decrease of the average bend angle in the aliphatic spacers connecting the rigid mesogenic units of the dimers

BIMA and Keck Imaging of the Radio Ring PKS 1830-211

We discuss BIMA (Berkeley Illinois Maryland Association) data and present new high quality optical and near-IR Keck images of the bright radio ring PKS 1830-211. Applying a powerful new deconvolution algorithm we have been able to identify both images of the radio source. In addition we recover an extended source in the optical, consistent with the expected location of the lensing galaxy. The source counterparts are very red, I-K=7, suggesting strong Galactic absorption with additional absorption by the lensing galaxy at z=0.885, and consistent with the detection of high redshift molecules in the lens.Comment: To be published in the ASP Conference Proceedings, 'Highly Redshifted Radio Lines', Greenbank, W

Primary Beam Shape Calibration from Mosaicked, Interferometric Observations

Image quality in mosaicked observations from interferometric radio telescopes is strongly dependent on the accuracy with which the antenna primary beam is calibrated. The next generation of radio telescope arrays such as the Allen Telescope Array (ATA) and the Square Kilometer Array (SKA) have key science goals that involve making large mosaicked observations filled with bright point sources. We present a new method for calibrating the shape of the telescope's mean primary beam that uses the multiple redundant observations of these bright sources in the mosaic. The method has an analytical solution for simple Gaussian beam shapes but can also be applied to more complex beam shapes through $\chi^2$ minimization. One major benefit of this simple, conceptually clean method is that it makes use of the science data for calibration purposes, thus saving telescope time and improving accuracy through simultaneous calibration and observation. We apply the method both to 1.43 GHz data taken during the ATA Twenty Centimeter Survey (ATATS) and to 3.14 GHz data taken during the ATA's Pi Gigahertz Sky Survey (PiGSS). We find that the beam's calculated full width at half maximum (FWHM) values are consistent with the theoretical values, the values measured by several independent methods, and the values from the simulation we use to demonstrate the effectiveness of our method on data from future telescopes such as the expanded ATA and the SKA. These results are preliminary, and can be expanded upon by fitting more complex beam shapes. We also investigate, by way of a simulation, the dependence of the accuracy of the telescope's FWHM on antenna number. We find that the uncertainty returned by our fitting method is inversely proportional to the number of antennas in the array.Comment: Accepted by PASP. 8 pages, 8 figure

Light scattering study of the “pseudo-layer” compression elastic constant in a twist-bend nematic liquid crystal

The nematic twist-bend (TB) phase, exhibited by certain achiral thermotropic liquid crystalline (LC) dimers, features a nanometer-scale, heliconical rotation of the average molecular long axis (director) with equally probable left- and right-handed domains. On meso to macroscopic scales, the TB phase may be considered as a stack of equivalent slabs or “pseudo-layers”, each one helical pitch in thickness. The long wavelength fluctuation modes should then be analogous to those of a smectic-A phase, and in particular the hydrodynamic mode combining “layer” compression and bending ought to be characterized by an effective layer compression elastic constant Beff and average director splay constant Keff1. The magnitude of Keff1 is expected to be similar to the splay constant of an ordinary nematic LC, but due to the absence of a true mass density wave, Beff could differ substantially from the typical value of ∼10⁶ Pa in a conventional smectic-A. Here we report the results of a dynamic light scattering study, which confirms the “pseudo-layer” structure of the TB phase with Beff in the range 10³–10⁴ Pa. We show additionally that the temperature dependence of Beff at the TB to nematic transition is accurately described by a coarse-grained free energy density, which is based on a Landau-deGennes expansion in terms of a heli-polar order parameter that characterizes the TB state and is linearly coupled to bend distortion of the director

Space Shuttle main engine, powerhead structural modeling, stress and fatigue life analysis. Volume 4: Summary of investigation of unscheduled events and special tasks

Low pressure fuel turbopump turbine labyrinth send tip rubbing analysis, gas dynamic analysis, and HPFTP blade crack and blade impact are presented

Second harmonic light scattering induced by defects in the twist-bend nematic phase of liquid crystal dimers

The nematic twist-bend (NTB) phase, exhibited by certain thermotropic liquid crystalline (LC) dimers, represents a new orientationally ordered mesophase -- the first distinct nematic variant discovered in many years. The NTB phase is distinguished by a heliconical winding of the average molecular long axis (director) with a remarkably short (nanoscale) pitch and, in systems of achiral dimers, with an equal probability to form right- and left-handed domains. The NTB structure thus provides another fascinating example of spontaneous chiral symmetry breaking in nature. The order parameter driving the formation of the heliconical state has been theoretically conjectured to be a polarization field, deriving from the bent conformation of the dimers, that rotates helically with the same nanoscale pitch as the director field. It therefore presents a significant challenge for experimental detection. Here we report a second harmonic light scattering (SHLS) study on two achiral, NTB-forming LCs, which is sensitive to the polarization field due to micron-scale distortion of the helical structure associated with naturally-occurring textural defects. These defects are parabolic focal conics of smectic-like ``pseudo-layers", defined by planes of equivalent phase in a coarse-grained description of the NTB state. Our SHLS data are explained by a coarse-grained free energy density that combines a Landau-deGennes expansion of the polarization field, the elastic energy of a nematic, and a linear coupling between the two

Evasion of autophagy mediated by Rickettsia surface protein OmpB is critical for virulence.

Rickettsia are obligate intracellular bacteria that evade antimicrobial autophagy in the host cell cytosol by unknown mechanisms. Other cytosolic pathogens block different steps of autophagy targeting, including the initial step of polyubiquitin-coat formation. One mechanism of evasion is to mobilize actin to the bacterial surface. Here, we show that actin mobilization is insufficient to block autophagy recognition of the pathogen Rickettsia parkeri. Instead, R. parkeri employs outer membrane protein B (OmpB) to block ubiquitylation of the bacterial surface proteins, including OmpA, and subsequent recognition by autophagy receptors. OmpB is also required for the formation of a capsule-like layer. Although OmpB is dispensable for bacterial growth in endothelial cells, it is essential for R. parkeri to block autophagy in macrophages and to colonize mice because of its ability to promote autophagy evasion in immune cells. Our results indicate that OmpB acts as a protective shield to obstruct autophagy recognition, thereby revealing a distinctive bacterial mechanism to evade antimicrobial autophagy