Reliability and Performance Improvement of PUC Converter Using a New Single-Carrier Sensor-Less PWM Method with Pseudo Reference Functions

A new single-carrier sensor-less pulsewidth modulation (PWM) method using suggested pseudo reference functions is proposed for packed U-cell (PUC) converter to improve performance and reliability of the PUC converter. It is composed of one PWM carrier signal and two suggested pseudo reference functions. By employing the proposed modulation method, the PUC dc capacitor voltage ripple is substantially decreased, and faster sensor-less capacitor voltage balancing is obtained. Moreover, the power losses are evenly distributed among all power switches. Consequently, notable reduction of the PUC dc capacitor voltage ripple and even distribution of the power loss among switches enhance the PUC converter\u27s reliability and lifetime. In addition, odd multiples of the switching harmonic clusters are eliminated from the output voltage; thus, the values of output passive filter components are halved. Hence, applying the proposed single-carrier sensor-less PWM method remarkably improves the performance, power density, reliability, and lifetime of the PUC converter and notably simplifies implementation of the switching pattern. Provided experimental results and comparisons as well as reliability analysis verify the viability and effectiveness of the proposed PWM method

Ectopic Noggin Blocks Sensory and Nonsensory Organ Morphogenesis in the Chicken Inner Ear

AbstractBone morphogenetic protein 4 (Bmp4) is expressed during multiple stages of development of the chicken inner ear. At the otocyst stage, Bmp4 is expressed in each presumptive sensory organ, as well as in the mesenchymal cells surrounding the region of the otocyst that is destined to form the semicircular canals. After the formation of the gross anatomy of the inner ear, Bmp4 expression persists in some sensory organs and restricted domains of the semicircular canals. To address the role of this gene in inner ear development, we blocked BMP4 function(s) by delivering one of its antagonists, Noggin, to the developing inner ear in ovo. Exogenous Noggin was delivered to the developing otocyst by using a replication-competent avian retrovirus encoding the Noggin cDNA (RCAS-N) or implanting beads coated with Noggin protein. Noggin treatment resulted in a variety of phenotypes involving both sensory and nonsensory components of the inner ear. Among the nonsensory structures, the semicircular canals were the most sensitive and the endolymphatic duct and sac most resistant to exogenous Noggin. Noggin affected the proliferation of the primordial canal outpouch, as well as the continual outgrowth of the canal after its formation. In addition, Noggin affected the structural patterning of the cristae, possibly via a decrease of Msx1 and p75NGFR expression. These results suggest that BMP4 and possibly other BMPs are required for multiple phases of inner ear development

Gradients of glucose metabolism regulate morphogen signalling required for specifying tonotopic organisation in the chicken cochlea

In vertebrates with elongated auditory organs, mechanosensory hair cells (HCs) are organised such that complex sounds are broken down into their component frequencies along a proximal-to-distal long (tonotopic) axis. Acquisition of unique morphologies at the appropriate position along the chick cochlea, the basilar papilla, requires that nascent HCs determine their tonotopic positions during development. The complex signalling within the auditory organ between a developing HC and its local niche along the cochlea is poorly understood. Using a combination of live imaging and NAD(P)H fluorescence lifetime imaging microscopy, we reveal that there is a gradient in the cellular balance between glycolysis and the pentose phosphate pathway in developing HCs along the tonotopic axis. Perturbing this balance by inhibiting different branches of cytosolic glucose catabolism disrupts developmental morphogen signalling and abolishes the normal tonotopic gradient in HC morphology. These findings highlight a causal link between graded morphogen signalling and metabolic reprogramming in specifying the tonotopic identity of developing HCs

From Kaon-Nuclear Interactions to Kaon Condensation

An effective chiral Lagrangian in heavy-fermion formalism whose parameters are constrained by kaon-nucleon and kaon-nuclear interactions next to the leading order in chiral expansion is used to describe kaon condensation in dense ``neutron star" matter. The critical density is found to be robust with respect to the parameters of the chiral Lagrangian and comes out to be $\rho_c\sim (3 - 4)\rho_0$. Once kaon condensation sets in, the system is no longer composed of neutron matter but of nuclear matter. Possible consequences on stellar collapse with the formation of compact ``nuclear stars" or light-mass black holes are pointed out.Comment: 20 pages, LaTeX, NORDITA-93/30 N, SUNY-NTG-93-

Fully Automatic Expression-Invariant Face Correspondence

We consider the problem of computing accurate point-to-point correspondences among a set of human face scans with varying expressions. Our fully automatic approach does not require any manually placed markers on the scan. Instead, the approach learns the locations of a set of landmarks present in a database and uses this knowledge to automatically predict the locations of these landmarks on a newly available scan. The predicted landmarks are then used to compute point-to-point correspondences between a template model and the newly available scan. To accurately fit the expression of the template to the expression of the scan, we use as template a blendshape model. Our algorithm was tested on a database of human faces of different ethnic groups with strongly varying expressions. Experimental results show that the obtained point-to-point correspondence is both highly accurate and consistent for most of the tested 3D face models

Online learning and fusion of orientation appearance models for robust rigid object tracking

We introduce a robust framework for learning and fusing of orientation appearance models based on both texture and depth information for rigid object tracking. Our framework fuses data obtained from a standard visual camera and dense depth maps obtained by low-cost consumer depth cameras such as the Kinect. To combine these two completely different modalities, we propose to use features that do not depend on the data representation: angles. More specifically, our framework combines image gradient orientations as extracted from intensity images with the directions of surface normals computed from dense depth fields. We propose to capture the correlations between the obtained orientation appearance models using a fusion approach motivated by the original Active Appearance Models (AAMs). To incorporate these features in a learning framework, we use a robust kernel based on the Euler representation of angles which does not require off-line training, and can be efficiently implemented online. The robustness of learning from orientation appearance models is presented both theoretically and experimentally in this work. This kernel enables us to cope with gross measurement errors, missing data as well as other typical problems such as illumination changes and occlusions. By combining the proposed models with a particle filter, the proposed framework was used for performing 2D plus 3D rigid object tracking, achieving robust performance in very difficult tracking scenarios including extreme pose variations. © 2014 Elsevier B.V. All rights reserved

Clinical Outcomes of Cochlear Reimplantation Due to Device Failure

ObjectivesThe aim of this study was to evaluate the clinical features of cochlear reimplantation due to device failure.MethodsThe medical records of 30 patients who had undergone a revision cochlear implantation were retrospectively reviewed. Causes of revision operations, number of electrode channels inserted, and postoperative speech performances were analyzed.ResultsDevice failure (N=12, 38.7%) and hematoma (N=3, 9.6%) were the two most common reasons for revision surgery. In patients with device failure, the number of electrode channels reinserted was equal to, or more than the number of channels inserted during initial implantation. Speech performance scores remained the same, or improved after reimplantation in patients with device failure.ConclusionDevice failure was the most common cause of revision operation in patients with cochlear implanttion. Contrary to expectation, new electrodes were fully inserted without difficulty in all reimplantation cases. Intracochlear damage due to reimplantation appeared to be clinically insignificant

A genetic algorithm

Castelli, M., Dondi, R., Manzoni, S., Mauri, G., & Zoppis, I. (2019). Top k 2-clubs in a network: A genetic algorithm. In J. J. Dongarra, J. M. F. Rodrigues, P. J. S. Cardoso, J. Monteiro, R. Lam, V. V. Krzhizhanovskaya, M. H. Lees, ... P. M. A. Sloot (Eds.), Computational Science. ICCS 2019: 19th International Conference, 2019, Proceedings (Vol. 5, pp. 656-663). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 11540 LNCS). Springer Verlag. https://doi.org/10.1007/978-3-030-22750-0_63The identification of cohesive communities (dense sub-graphs) is a typical task applied to the analysis of social and biological networks. Different definitions of communities have been adopted for particular occurrences. One of these, the 2-club (dense subgraphs with diameter value at most of length 2) has been revealed of interest for applications and theoretical studies. Unfortunately, the identification of 2-clubs is a computationally intractable problem, and the search of approximate solutions (at a reasonable time) is therefore fundamental in many practical areas. In this article, we present a genetic algorithm based heuristic to compute a collection of Top k 2-clubs, i.e., a set composed by the largest k 2-clubs which cover an input graph. In particular, we discuss some preliminary results for synthetic data obtained by sampling Erdös-Rényi random graphs.authorsversionpublishe

Au+Au Reactions at the AGS: Experiments E866 and E917

Particle production and correlation functions from Au+Au reactions have been measured as a function of both beam energy (2-10.7AGeV) and impact parameter. These results are used to probe the dynamics of heavy-ion reactions, confront hadronic models over a wide range of conditions and to search for the onset of new phenomena.Comment: 12 pages, 14 figures, Talk presented at Quark Matter '9