Quasidegeneracy of Majorana Neutrinos and the Origin of Large Leptonic Mixing

We propose that the observed large leptonic mixing may just reflect a quasidegeneracy of three Majorana neutrinos. The limit of exact degeneracy of Majorana neutrinos is not trivial, as leptonic mixing and even CP violation may occur. We conjecture that the smallness of $|U_{13}|$, when compared to the other elements of $U_{PMNS}$, may just reflect the fact that, in the limit of exact mass degeneracy, the leptonic mixing matrix necessarily has a vanishing element. We show that the lifting of the mass degeneracy can lead to the measured value of $|U_{13}|$ while at the same time accommodating the observed solar and atmospheric mixing angles. In the scenario we consider for the breaking of the mass degeneracy there is only one CP violating phase, already present in the limit of exact degeneracy, which upon the lifting of the degeneracy generates both Majorana and Dirac-type CP violation in the leptonic sector. We analyse some of the correlations among physical observables and point out that in most of the cases considered, the implied strength of leptonic Dirac-type CP violation is large enough to be detected in the next round of experiments.Comment: 16 pages, 4 figures. Matches published version, references added, improved discussion, results unchange

‘A truly sublime appearance’: using GIS to find the traces of pre-colonial landscapes and land use

When the British landed on the island of Van Diemen’s Land in1803, they found lands seemingly prepared for them. Abundantopen plains drew the newcomers further inland, attracted by theprospects of further pastoral and agricultural success. What theyneither understood nor acknowledged was the thousands of yearsof cultivation prior to their arrival. As the custodians of the island,the Tasmanian Aboriginal people used fire to manage and maintain a landscape that nourished them. This article proposes thatanalysis of land-use continuities can reveal new understandings ofpre-colonial landscapes. This article uses two case studies to demonstrate two complementary approaches for uncovering thisstory. The first study follows a traditional approach that relies onhistoric sources such as maps, artwork and journals. The secondmethodology incorporates modern resources to build aGeographic Information System (GIS) from environmental and historic spatial data. The GIS compensates for an absence of traditional sources, thus enabling researchers to investigate areas ofcolonial expansion that have previously been undervalued. UsingGIS to understand this continuity of land use gives historiansanother tool for researching landscapes that have been obscuredby subsequent occupiers

Association Between Acute Kidney Injury Hospital Visits and Environmental Heat Stress at a Nicaraguan Sugarcane Plantation

Background: Mesoamerican sugarcane cutters are at a high risk of chronic kidney disease of non-traditional origin, a disease likely linked to heat-related acute kidney injury (AKI). Studies in general populations have described a positive association between high environmental temperatures and clinically assessed kidney outcomes, but there are no studies in occupational settings. Method: We accessed routine records of clinically diagnosed AKI (AKI-CD) and wet bulb globe temperatures (WBGT) at a large Nicaraguan sugarcane plantation and modeled the relationship between these using negative binomial regression. A rest-shade-hydration intervention was gradually enhanced during the study period, and efforts were made to increase the referral of workers with suspected AKI to healthcare. Results: Each 1°C WBGT was associated with an 18% (95% confidence interval [CI]: [4, 33%]) higher AKI-CD rate on the same day and a 14% (95% CI [−5, 37%]) higher rate over a week. AKI-CD rates and severity, and time between symptoms onset and diagnosis decreased during the study period, that is, with increasing rest-shade-hydration intervention. Symptoms and biochemical signs of systemic inflammation were common among AKI-CD cases. Discussion: Occupational heat stress, resulting from heavy work in environmental heat, was associated with a higher rate of clinically diagnosed AKI in a population at risk of CKDnt. Promoting rest-shade-hydration may have contributed to reducing AKI rates during the study period. Occupational health and safety personnel have key roles to play in enforcing rest, shade, and hydration practices, referring workers with suspected AKI to healthcare as well as collecting and analyzing the data needed to support workplace heat stress interventions

Quantum authentication with key recycling

We show that a family of quantum authentication protocols introduced in [Barnum et al., FOCS 2002] can be used to construct a secure quantum channel and additionally recycle all of the secret key if the message is successfully authenticated, and recycle part of the key if tampering is detected. We give a full security proof that constructs the secure channel given only insecure noisy channels and a shared secret key. We also prove that the number of recycled key bits is optimal for this family of protocols, i.e., there exists an adversarial strategy to obtain all non-recycled bits. Previous works recycled less key and only gave partial security proofs, since they did not consider all possible distinguishers (environments) that may be used to distinguish the real setting from the ideal secure quantum channel and secret key resource.Comment: 38+17 pages, 13 figures. v2: constructed ideal secure channel and secret key resource have been slightly redefined; also added a proof in the appendix for quantum authentication without key recycling that has better parameters and only requires weak purity testing code

Relationships between CYP2D6 phenotype, breast cancer and hot flushes in women at high risk of breast cancer receiving prophylactic tamoxifen: results from the IBIS-I trial

Licensed under a Creative Commons Attribution Non-Commercial Share Alike Licens

Author correction : a global database for metacommunity ecology, integrating species, traits, environment and space

Correction to: Scientific Data https://doi.org/10.1038/s41597-019-0344-7, published online 08 January 202

Author correction : a global database for metacommunity ecology, integrating species, traits, environment and space

Correction to: Scientific Data https://doi.org/10.1038/s41597-019-0344-7, published online 08 January 202

Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer

INTRODUCTION: Tamoxifen therapy reduces the risk of recurrence and prolongs the survival of oestrogen-receptor-positive patients with breast cancer. Even if most patients benefit from tamoxifen, many breast tumours either fail to respond or become resistant. Because tamoxifen is extensively metabolised by polymorphic enzymes, one proposed mechanism underlying the resistance is altered metabolism. In the present study we investigated the prognostic and/or predictive value of functional polymorphisms in cytochrome P450 3A5 CYP3A5 (*3), CYP2D6 (*4), sulphotransferase 1A1 (SULT1A1; *2) and UDP-glucuronosyltransferase 2B15 (UGT2B15; *2) in tamoxifen-treated patients with breast cancer. METHODS: In all, 677 tamoxifen-treated postmenopausal patients with breast cancer, of whom 238 were randomised to either 2 or 5 years of tamoxifen, were genotyped by using PCR with restriction fragment length polymorphism or PCR with denaturing high-performance liquid chromatography. RESULTS: The prognostic evaluation performed in the total population revealed a significantly better disease-free survival in patients homozygous for CYP2D6*4. For CYP3A5, SULT1A1 and UGT2B15 no prognostic significance was observed. In the randomised group we found that for CYP3A5, homozygous carriers of the *3 allele tended to have an increased risk of recurrence when treated for 2 years with tamoxifen, although this was not statistically significant (hazard ratio (HR) = 2.84, 95% confidence interval (CI) = 0.68 to 11.99, P = 0.15). In the group randomised to 5 years' tamoxifen the survival pattern shifted towards a significantly improved recurrence-free survival (RFS) among CYP3A5*3-homozygous patients (HR = 0.20, 95% CI = 0.07 to 0.55, P = 0.002). No reliable differences could be seen between treatment duration and the genotypes of CYP2D6, SULT1A1 or UGT2B15. The significantly improved RFS with prolonged tamoxifen treatment in CYP3A5*3 homozygotes was also seen in a multivariate Cox model (HR = 0.13, CI = 0.02 to 0.86, P = 0.03), whereas no differences could be seen for CYP2D6, SULT1A1 and UGT2B15. CONCLUSION: The metabolism of tamoxifen is complex and the mechanisms responsible for the resistance are unlikely to be explained by a single polymorphism; instead it is a combination of several mechanisms. However, the present data suggest that genetic variation in CYP3A5 may predict response to tamoxifen therapy

On the Computational Overhead of MPC with Dishonest Majority

We consider the situation where a large number $n$ of players want to securely compute a large function $f$ with security against an adaptive, malicious adversary which might corrupt $t < cn$ of the parties for some given $c \in [0,1)$. In other words, only some arbitrarily small constant fraction of the parties are assumed to be honest. For any fixed $c$, we consider the asymptotic complexity as $n$ and the size of $f$ grows. We are in particular interested in the computational overhead, defined as the total computational complexity of all parties divided by the size of $f$. We show that it is possible to achieve poly-logarithmic computational overhead for all $c < 1$. Prior to our result it was only known how to get poly-logarithmic overhead for $c < \frac{1}{2}$. We therefore significantly extend the area where we can do secure multiparty computation with poly-logarithmic overhead. Since we allow that more than half the parties are corrupted, we can only get security with abort, i.e., the adversary might make the protocol abort before all parties learn their outputs. We can, however, for all $c$ make a protocol for which there exists $d > 0$ such that if at most $d n$ parties are actually corrupted in a given execution, then the protocol will not abort. Our result is solely of theoretical interest