Critical Power Concept: Males vs. Females and the Impact of Muscle Fiber Composition

International Journal of Exercise Science 12(4): 277-286, 2019. CP describes the highest metabolic rate resulting in complete oxidative energy provision (steady state). Between the heavy and severe domain of exercise, CP will be surpassed, and the finite work capacity known as W\u27 will be used up. The purpose of the study is to test CP and W’ and its relationship in males and females, while assessing type I and II muscle fiber distribution in the leg. A 3 MT and isokinetic leg dynamometer muscle fiber typing protocol of 25 consecutive leg extensions were completed. W\u27 for the sample (n = 17) was 8381.64 ± 4556.72 joules [males (n = 9): 12086.22 ± 1851.39 joules; females (n = 8): 4214.00 ± 2459.07 joules]. Type II muscle fiber for the sample was 24.48% ± 12.92% (males: 20.83 ± 13.18%; females: 28.59 ± 12.10%). W\u27 was not significantly correlated to type II muscle fibers (r = -0.070, p = 0.790) but was significantly related when controlling for gender (r = 0.579, p = 0.024). W’ was correlated to Wpeak and BMI in the sample; when controlling for gender, it was correlated to Wpeak, Type I and Type II muscle fiber percentage and CP. Compared to females, males had higher W’ (p \u3c 0.001) and CP (p = 0.004). W’ was not correlated to type II muscle fibers but was when controlling for gender. Males were demonstrated to have significantly higher W’, CP, Wpeak and BMI compared to females suggesting potential muscle cross sectional area influences W’ and CP when comparing genders

A lunar explorer self-contained PicoRover

Postprint (published version

Reimagining the Juvenile Detention System

This group proposed to improve the juvenile detention system through policy as well as through change in the design of detention centers. Team members agreed to redesign the system in order to avoid dehumanizing adolescents and to introduce them to a new kind of community environment. The design of the prison will be based on a set of concentric circles. The inner circle will be the most restrictive in terms of freedoms and privileges. As the adolescent gains skills and trust, they move from the inner circle to the outer circles. The outer circles allow for more freedom and trust, physically demonstrated through the opening of the prison space into individual houses. With this increased trust and freedom, adolescents will also take on more responsibilities and become effective members of the prison community–working in the community garden for example

1965: Abilene Christian College Bible Lectures - Full Text

LIFT UP YOUR EYES” Being the Abilene Christian College Annual Bible Lectures 1965 Price: $3.95 Published by ABILENE CHRISTIAN COLLEGE STUDENTS EXCHANGE ACC Station Abilene. Texa

Diachronic modeling of the population within the medieval Greater Angkor Region settlement complex

9 pagesAngkor is one of the world’s largest premodern settlement complexes (9th to 15th centuries CE), but to date, no comprehensive demographic study has been completed, and key aspects of its population and demographic history remain unknown. Here, we combine lidar, archaeological excavation data, radiocarbon dates, and machine learning algorithms to create maps that model the development of the city and its population growth through time. We conclude that the Greater Angkor Region was home to approximately 700,000 to 900,000 inhabitants at its apogee in the 13th century CE. This granular, diachronic, paleodemographic model of the Angkor complex can be applied to any ancient civilization.We wish to thank the APSARA National Authority for permission to conduct remote sensing and collaborative field investigations. We thank M. So and M. Dana for administrative support. We thank E. Lustig and T. Lustig for comments and suggestions on aspects of economic geography and M. E. Smith and C. Isendahl for reading and offering comments on an earlier draft of this paper. Funding: Much of the work on research, planning, and writing of this manuscript was undertaken with the support of the University of Oregon Global Oregon Faculty Collaboration Fund, supported by the Global Studies Institute in the UO Office of International Affairs. Parts of this research have been funded by the Rust Family Foundation, the Social Sciences and Humanities Research Council of Canada Postdoctoral Fellowship, the National Science Foundation Doctoral Dissertation Research Improvement Awards (no. 1638137), the ACLS-Robert H. N. Ho Family Foundation Program in Buddhist Studies, Australian Research Council Discovery Grant DP1092663, Australian Research Council Discovery Early Career Researcher Award DE150100756, Australian Research Council Discovery Grant DP170102574, and the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement nos. 639828 and 866454). Author contributions: S.K. and A.K.C. contributed to the planning of this research. S.K., A.K.C., M.H., and S.O. drafted the manuscript. S.K., A.K.C., D.E., M.T.S., M.P., G.P.M., R.F., and P.H. edited the manuscript. S.K., A.A.L., M.H., J.N.-W., D.E., P.W., and S.O. contributed to the analysis. S.K., A.K.C., P.H., and M.P. compiled the data. S.K., A.K.C., P.H., G.P.M., R.F., D.E., C.P., and M.P. contributed data. S.K., M.H., and A.A.L. designed the figures. All authors discussed the results and commented on the manuscript. Competing interests: The authors declare that they have no competing interests. Data and materials availability: All data needed to evaluate the conclusions in the paper are present in the paper and/or the Supplementary Materials. Additional data related to this paper maybe requested from the authors

Intracellular Water Exchange for Measuring the Dry Mass, Water Mass and Changes in Chemical Composition of Living Cells

We present a method for direct non-optical quantification of dry mass, dry density and water mass of single living cells in suspension. Dry mass and dry density are obtained simultaneously by measuring a cell’s buoyant mass sequentially in an H[subscript 2]O-based fluid and a D[subscript 2]O-based fluid. Rapid exchange of intracellular H[subscript 2]O for D[subscript 2]O renders the cell’s water content neutrally buoyant in both measurements, and thus the paired measurements yield the mass and density of the cell’s dry material alone. Utilizing this same property of rapid water exchange, we also demonstrate the quantification of intracellular water mass. In a population of E. coli, we paired these measurements to estimate the percent dry weight by mass and volume. We then focused on cellular dry density – the average density of all cellular biomolecules, weighted by their relative abundances. Given that densities vary across biomolecule types (RNA, DNA, protein), we investigated whether we could detect changes in biomolecular composition in bacteria, fungi, and mammalian cells. In E. coli, and S. cerevisiae, dry density increases from stationary to exponential phase, consistent with previously known increases in the RNA/protein ratio from up-regulated ribosome production. For mammalian cells, changes in growth conditions cause substantial shifts in dry density, suggesting concurrent changes in the protein, nucleic acid and lipid content of the cell.National Cancer Institute (U.S.). Physical Sciences-Oncology Center (U54CA143874)National Institutes of Health (U.S.) (Center for Cell Division Process Grant P50GM6876)National Institutes of Health (U.S.) (Contract R01CA170592)United States. Army Research Office (Institute for Collaborate Biotechnologies Contract W911NF-09-D-0001

A study of the structure–activity relationship of GABAA–benzodiazepine receptor bivalent ligands by conformational analysis with low temperature NMR and X-ray analysis

The stable conformations of GABAA-benzodiazepine receptor bivalent ligands were determined by low temperature NMR spectroscopy and confirmed by single crystal X-ray analysis. The stable conformations in solution correlated well with those in the solid state. The linear conformation was important for these dimers to access the binding site and exhibit potent in vitro affinity and was illustrated for α5 subtype selective ligands. Bivalent ligands with an oxygen-containing linker folded back upon themselves both in solution and the solid state. Dimers which are folded do not bind to Bz receptors