1,459 research outputs found

    Case Studies of Beginning Teachers

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    Case Studies of Beginning Teachers offers a collection of 35 case studies of first-year teaching experiences — a mixture of true dilemmas and best solution scenarios — that bridge educational theory and practice to shed light on actual problems and challenges new teachers most often confront

    Case Studies on Teaching

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    Case Studies on Teaching is a unique book designed to infuse reality into the process of preparing teachers. The contents are based on real issues and needs faced by new teachers at they commence their professional careers in elementary and secondary school classrooms. The thirty-six cases offer myriad opportunities for utilizing the case method of instruction. This method has received acclaim in law, medicine, and business curricula. Regardless of the professional context, case studies create interactions that mandate active learning

    Increased parental care cost for nest-guarding fish in a lake with hyperabundant nest predators

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    Although parental care increases offspring survival, providing care is costly, reducing parental growth and survival and, thereby, compromising future reproductive success. To determine if an exotic benthic predator might be affecting parental care by nest-guarding smallmouth bass (Micropterus dolomieu), we compared nest-guarding behavior and energy expenditures in two systems, one with a hyperabundant recently introduced predator, the round goby (Neogobious melanostomus). In Lake Erie, USA, smallmouth bass vigorously defended their nests from benthic round gobies. In Lake Opeongo, Canada, smallmouth bass were exposed to fewer and predominantly open-water predators and were less active in their nest defense. From scuba and video observations, we documented that nest-guarding smallmouth bass chased predators (99% of which were round gobies) nine times more frequently in Lake Erie than in Lake Opeongo. This heightened activity resulted in a significant decline in weight and energetic content of guarding males in Lake Erie but no change in Lake Opeongo males. Bioenergetic simulations revealed that parental care increased smallmouth bass standard metabolic rate by 210% in Lake Erie but only by 28% in Lake Opeongo. As energy reserves declined and offspring became increasingly independent, males in both lakes consumed more prey and spent more time foraging away from their nests; however, nest-guarding smallmouth bass consumed few prey and, in Lake Erie, rarely consumed round gobies. Therefore, increased parental care costs owing to the presence of round gobies could affect future growth, reproduction, and survival if smallmouth bass approach critically low energy reserves.Funding for this project was provided by Federal Aid in Sport Fish Restoration Project F-69-P, administered jointly by United States Fish and Wildlife Service and Ohio Department of Natural Resources, Division of Wildlife, a Sigma Xi Grant-in-Aid awarded to G.B.S., and the Department of Evolution, Ecology, and Organismal Biology at The Ohio State University

    Renal revascularization in Takayasu arteritis–induced renal artery stenosis

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    AbstractPurposeThis study was undertaken to define the long-term effects of renal revascularization on blood pressure, and renal and cardiac function in patients with Takayasu arteritis–induced renal artery stenosis (TARAS).MethodsTwenty-seven patients (25 women; mean age, 27 years) with TARAS underwent intervention. Primary, primary assisted, and secondary patency rates were determined, and the late effects on blood pressure, renal and cardiac function, and survival were analyzed.ResultsAll patients had hypertension (mean blood pressure, 167/99 mm Hg; 2.5 antihypertensive medications per patient). Mean estimated glomerular filtration rate in patients not receiving hemodialysis was 76 mL/min, and in five patients serum creatinine concentration was greater than 1.5 mg/dL. Three patients were hemodialysis-dependent, and two had intractable congestive heart failure. Forty interventions were performed, including 32 aortorenal bypass procedures, two repeat implantations, four nephrectomies, and two transluminal angioplasty procedures. Postoperative morbidity was 19%. There were no deaths. During follow-up (mean, 68 months), three graft stenoses, all due to intimal hyperplasia, and three graft occlusions occurred. Two of three graft stenoses were successfully revised. At 1, 3, and 5 years of follow-up, primary patency was 87%, 79%, and 79%, respectively; primary assisted patency was 93%, 89%, 89%, respectively; and secondary patency was 93%, 89%, and 89%, respectively. Intervention resulted in a decrease in blood pressure to a mean of 132/79 mm Hg (P < .0001), and the need for antihypertensive medications was reduced to one per patient (P < .01). Mean glomerular filtration rate increased to 88 mL/min (P < .005), and two patients no longer required hemodialysis. Congestive heart failure resolved in both patients, and did not recur. There were three deaths during follow-up, with 5-year and 10-year actuarial survival of 96% and 80%, respectively.ConclusionsRenal revascularization to treat TARAS is durable, has a salutary effect on blood pressure, and enhances long-term renal and cardiac function. This response establishes renal revascularization as a successful and durable intervention for TARAS, and a benchmark to which other therapies should be compared

    Evaluating Student Volunteer and Service-Learning Programs: A Casebook for Practitioners

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    Today, evaluation concepts and methods are widely available to those who plan and administer student volunteer programs. Unfortunately, however, evaluation has all too often been carried out-and written about-in ways that have robbed it of its usefulness to people dealing with the realities of day-to-day program operation. Evaluation has thus acquired the reputation among practitioners of being too complex, too costly, too time-consuming, even too threatening to be of much practical value

    Physical properties of ESA Rosetta target asteroid (21) Lutetia: Shape and flyby geometry

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    Aims. We determine the physical properties (spin state and shape) of asteroid (21) Lutetia, target of the ESA Rosetta mission, to help in preparing for observations during the flyby on 2010 July 10 by predicting the orientation of Lutetia as seen from Rosetta. Methods. We use our novel KOALA inversion algorithm to determine the physical properties of asteroids from a combination of optical lightcurves, disk-resolved images, and stellar occultations, although the latter are not available for (21) Lutetia. Results. We find the spin axis of (21) Lutetia to lie within 5 degrees of ({\lambda} = 52 deg., {\beta} = -6 deg.) in Ecliptic J2000 reference frame (equatorial {\alpha} = 52 deg., {\delta} = +12 deg.), and determine an improved sidereal period of 8.168 270 \pm 0.000 001 h. This pole solution implies the southern hemisphere of Lutetia will be in "seasonal" shadow at the time of the flyby. The apparent cross-section of Lutetia is triangular as seen "pole-on" and more rectangular as seen "equator-on". The best-fit model suggests the presence of several concavities. The largest of these is close to the north pole and may be associated with large impacts.Comment: 17 pages, 5 figures, 3 tables, submitted to Astronomy and Astrophysic

    Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

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    Fibrosis compromises pancreatic ductal carcinoma (PDAC) treatment and contributes to patient mortality yet anti-stromal therapies are controversial. We found that human PDACs with impaired epithelial transforming growth factor β (TGF-β) signaling have elevated epithelial Stat3 activity and develop a stiffer, matricellular-enriched fibrosis associated with high epithelial tension and shorter patient survival. In several Kras-driven mouse models, both the loss of TGF-β signaling and elevated β1-integrin mechanosignaling engaged a positive feedback loop whereby Stat3 signaling promotes tumor progression by increasing matricellular fibrosis and tissue tension. In contrast, epithelial Stat3 ablation attenuated tumor progression by reducing the stromal stiffening and epithelial contractility induced by loss of TGF-β signaling. In PDAC patient biopsies, higher matricellular protein and activated Stat3 associated with SMAD4 mutation and shorter survival. The findings implicate epithelial tension and matricellular fibrosis in the aggressiveness of SMAD4 mutant pancreatic tumors, and highlight Stat3 and mechanics as key drivers of this phenotype

    A Study of Time-Dependent CP-Violating Asymmetries and Flavor Oscillations in Neutral B Decays at the Upsilon(4S)

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    We present a measurement of time-dependent CP-violating asymmetries in neutral B meson decays collected with the BABAR detector at the PEP-II asymmetric-energy B Factory at the Stanford Linear Accelerator Center. The data sample consists of 29.7 fb1{\rm fb}^{-1} recorded at the Υ(4S)\Upsilon(4S) resonance and 3.9 fb1{\rm fb}^{-1} off-resonance. One of the neutral B mesons, which are produced in pairs at the Υ(4S)\Upsilon(4S), is fully reconstructed in the CP decay modes J/ψKS0J/\psi K^0_S, ψ(2S)KS0\psi(2S) K^0_S, χc1KS0\chi_{c1} K^0_S, J/ψK0J/\psi K^{*0} (K0KS0π0K^{*0}\to K^0_S\pi^0) and J/ψKL0J/\psi K^0_L, or in flavor-eigenstate modes involving D()π/ρ/a1D^{(*)}\pi/\rho/a_1 and J/ψK0J/\psi K^{*0} (K0K+πK^{*0}\to K^+\pi^-). The flavor of the other neutral B meson is tagged at the time of its decay, mainly with the charge of identified leptons and kaons. The proper time elapsed between the decays is determined by measuring the distance between the decay vertices. A maximum-likelihood fit to this flavor eigenstate sample finds Δmd=0.516±0.016(stat)±0.010(syst)ps1\Delta m_d = 0.516\pm 0.016 {\rm (stat)} \pm 0.010 {\rm (syst)} {\rm ps}^{-1}. The value of the asymmetry amplitude sin2β\sin2\beta is determined from a simultaneous maximum-likelihood fit to the time-difference distribution of the flavor-eigenstate sample and about 642 tagged B0B^0 decays in the CP-eigenstate modes. We find sin2β=0.59±0.14(stat)±0.05(syst)\sin2\beta=0.59\pm 0.14 {\rm (stat)} \pm 0.05 {\rm (syst)}, demonstrating that CP violation exists in the neutral B meson system. (abridged)Comment: 58 pages, 35 figures, submitted to Physical Review

    Measurement of the Branching Fraction for B- --> D0 K*-

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    We present a measurement of the branching fraction for the decay B- --> D0 K*- using a sample of approximately 86 million BBbar pairs collected by the BaBar detector from e+e- collisions near the Y(4S) resonance. The D0 is detected through its decays to K- pi+, K- pi+ pi0 and K- pi+ pi- pi+, and the K*- through its decay to K0S pi-. We measure the branching fraction to be B.F.(B- --> D0 K*-)= (6.3 +/- 0.7(stat.) +/- 0.5(syst.)) x 10^{-4}.Comment: 7 pages, 1 postscript figure, submitted to Phys. Rev. D (Rapid Communications

    Evidence for the Rare Decay B -> K*ll and Measurement of the B -> Kll Branching Fraction

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    We present evidence for the flavor-changing neutral current decay BK+B\to K^*\ell^+\ell^- and a measurement of the branching fraction for the related process BK+B\to K\ell^+\ell^-, where +\ell^+\ell^- is either an e+ee^+e^- or μ+μ\mu^+\mu^- pair. These decays are highly suppressed in the Standard Model, and they are sensitive to contributions from new particles in the intermediate state. The data sample comprises 123×106123\times 10^6 Υ(4S)BBˉ\Upsilon(4S)\to B\bar{B} decays collected with the Babar detector at the PEP-II e+ee^+e^- storage ring. Averaging over K()K^{(*)} isospin and lepton flavor, we obtain the branching fractions B(BK+)=(0.650.13+0.14±0.04)×106{\mathcal B}(B\to K\ell^+\ell^-)=(0.65^{+0.14}_{-0.13}\pm 0.04)\times 10^{-6} and B(BK+)=(0.880.29+0.33±0.10)×106{\mathcal B}(B\to K^*\ell^+\ell^-)=(0.88^{+0.33}_{-0.29}\pm 0.10)\times 10^{-6}, where the uncertainties are statistical and systematic, respectively. The significance of the BK+B\to K\ell^+\ell^- signal is over 8σ8\sigma, while for BK+B\to K^*\ell^+\ell^- it is 3.3σ3.3\sigma.Comment: 7 pages, 2 postscript figues, submitted to Phys. Rev. Let
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