A Pilot Survey on the Licensing of DNA Inventions

Despite ethical concerns about gene patents, virtually no empirical evidence exists to support claims about either positive or negative effects, and extremely little is known about the intellectual property protection strategies of firms and universities. This article discusses the results of a pilot study to examine patenting and licensing philosophies, policies, and practices of different types of institutions and to describe the contractual conditions for licensing DNA sequence inventions

Exile Vol. VIII No. 1

FICTION Chance Encounter by Meredith Rose 5-12 The Chosen One by William Weaver 15-23 No Fuss, No Muss by Barbara Thiele 30-36 Easter Sunday by Christine Cooper 38-39 POETRY Two Poems by Barbara Purdy 12-13 Myself by Christine Cooper 24-25 The Kangaroo by Virginia Schott 27 Upon Remembering the Once-Novelty of Icicles by Barbara Purdy 27 Coming Awake by Janet Tallman 28 Poem by Christine Cooper 29 The Orb Weaver by Elizabeth Biggert 29 III Haiku by Robert Hoyt 37 GRAPHICS linocut by Beverly Erbacher 14 pen and ink by Jackie Sims 26 woodcut by Elizabeth Surbeck EDITORIAL A Sense of Finality by William Weaver 4 Awarded the EXILE-Denison Bookstore Writing Prize: The Chosen One by William Weaver 15-23 pen and ink 26 was originally credited to Elizabeth Surbeck. However the bound copy has Jackie Sims listed as the correct name in pencil. This interpretation is followed, though there is no Jackie Sims listed in the Contributors sectio

The Disk Substructures at High Angular Resolution Project (DSHARP). II. Characteristics of Annular Substructures

The Disk Substructures at High Angular Resolution Project (DSHARP) used ALMA to map the 1.25 mm continuum of protoplanetary disks at a spatial resolution of ~5 au. We present a systematic analysis of annular substructures in the 18 single-disk systems targeted in this survey. No dominant architecture emerges from this sample; instead, remarkably diverse morphologies are observed. Annular substructures can occur at virtually any radius where millimeter continuum emission is detected and range in widths from a few astronomical units to tens of astronomical units. Intensity ratios between gaps and adjacent rings range from near-unity to just a few percent. In a minority of cases, annular substructures coexist with other types of substructures, including spiral arms (3/18) and crescent-like azimuthal asymmetries (2/18). No clear trend is observed between the positions of the substructures and stellar host properties. In particular, the absence of an obvious association with stellar host luminosity (and hence the disk thermal structure) suggests that substructures do not occur preferentially near major molecular snowlines. Annular substructures like those observed in DSHARP have long been hypothesized to be due to planet–disk interactions. A few disks exhibit characteristics particularly suggestive of this scenario, including substructures in possible mean-motion resonance and double gap features reminiscent of hydrodynamical simulations of multiple gaps opened by a planet in a low-viscosity disk

Can incarcerated felons be (re)integrated into the political system? Results from a field experiment

How does America’s high rate of incarceration shape political participation? Few studies have examined the direct effects of incarceration on patterns of political engagement. Answering this question is particularly relevant for the 93% of formerly incarcerated individuals who are eligible to vote. Drawing on new administrative data from Connecticut, we present evidence from a field experiment showing that a simple informational outreach campaign to released felons can recover a large proportion of the reduction in participation observed following incarceration. The treatment effect estimates imply that efforts to reintegrate released felons into the political process can substantially reduce the participatory consequences of incarceration

The read-across hypothesis and environmental risk assessment of pharmaceuticals

This article is made available through the Brunel Open Access Publishing Fund. Copyright © 2013 American Chemical Society.Pharmaceuticals in the environment have received increased attention over the past decade, as they are ubiquitous in rivers and waterways. Concentrations are in sub-ng to low μg/L, well below acute toxic levels, but there are uncertainties regarding the effects of chronic exposures and there is a need to prioritise which pharmaceuticals may be of concern. The read-across hypothesis stipulates that a drug will have an effect in non-target organisms only if the molecular targets such as receptors and enzymes have been conserved, resulting in a (specific) pharmacological effect only if plasma concentrations are similar to human therapeutic concentrations. If this holds true for different classes of pharmaceuticals, it should be possible to predict the potential environmental impact from information obtained during the drug development process. This paper critically reviews the evidence for read-across, and finds that few studies include plasma concentrations and mode of action based effects. Thus, despite a large number of apparently relevant papers and a general acceptance of the hypothesis, there is an absence of documented evidence. There is a need for large-scale studies to generate robust data for testing the read-across hypothesis and developing predictive models, the only feasible approach to protecting the environment.BBSRC Industrial Partnership Award BB/ I00646X/1 and BBSRC Industrial CASE Partnership Studentship BB/I53257X/1 with AstraZeneca Safety Health and Environment Research Programme

A standardized, evidence-based protocol to assess clinical actionability of genetic disorders associated with genomic variation

Genome and exome sequencing can identify variants unrelated to the primary goal of sequencing. Detecting pathogenic variants associated with an increased risk of a medical disorder enables clinical interventions to improve future health outcomes in patients and their at-risk relatives. The Clinical Genome Resource, or ClinGen, aims to assess clinical actionability of genes and associated disorders as part of a larger effort to build a central resource of information regarding the clinical relevance of genomic variation for use in precision medicine and research

A tracer study of the Arctic Ocean's liquid freshwater export variability

We present an analysis of the variability of the liquid Arctic freshwater (FW) export, using a simulation from the Community Climate System Model Version 3 (CCSM3) that includes passive tracers for FW from different sources. It is shown that the FW exported through the western Canadian Arctic Archipelago (CAA) comes mainly from the Pacific and from North American runoff. The variability of the FW export from both of these sources is generally in phase, due to the strong influence of variations of the velocity anomaly on the CAA FW export variability. The velocity anomaly in the CAA is in turn mainly governed by variations in the large-scale atmospheric circulation (i.e., the Arctic Oscillation). In Fram Strait, the FW export is mainly composed of Eurasian runoff and FW of Pacific origin. The variability of the Fram Strait FW export is governed both by changes in the velocity and in the FW concentration, and the variability of the FW concentration from the two largest sources is not in phase. The Eurasian runoff export through Fram Strait depends strongly on the release of FW from the Eurasian shelf, which occurs during years with an anticyclonic circulation anomaly (negative Vorticity index) and takes 3 years to reach Fram Strait after leaving the shelf. In contrast, the variability of the Pacific FW export through Fram Strait is mainly controlled by changes in the Pacific FW storage in the Beaufort Gyre, with an increased export during years with a cyclonic circulation anomaly (positive Vorticity index)

SLO-2 Is Cytoprotective and Contributes to Mitochondrial Potassium Transport

Mitochondrial potassium channels are important mediators of cell protection against stress. The mitochondrial large-conductance “big” K+ channel (mBK) mediates the evolutionarily-conserved process of anesthetic preconditioning (APC), wherein exposure to volatile anesthetics initiates protection against ischemic injury. Despite the role of the mBK in cardioprotection, the molecular identity of the channel remains unknown. We investigated the attributes of the mBK using C. elegans and mouse genetic models coupled with measurements of mitochondrial K+ transport and APC. The canonical Ca2+-activated BK (or “maxi-K”) channel SLO1 was dispensable for both mitochondrial K+ transport and APC in both organisms. Instead, we found that the related but physiologically-distinct K+ channel SLO2 was required, and that SLO2-dependent mitochondrial K+ transport was triggered directly by volatile anesthetics. In addition, a SLO2 channel activator mimicked the protective effects of volatile anesthetics. These findings suggest that SLO2 contributes to protection from hypoxic injury by increasing the permeability of the mitochondrial inner membrane to K+

Shaping public opinion on the issue of childbirth; a critical analysis of articles published in an Australian newspaper

<p>Abstract</p> <p>Background</p> <p>The Australian government has announced a major program of reform with the move to primary maternity care, a program of change that appears to be at odds with current general public perceptions regarding how maternity care is delivered.</p> <p>Methods</p> <p>A critical discourse analysis of articles published in 'The Age', a newspaper with national distribution, subsequent to the release of the discussion paper by the Australian Government in 2008 was undertaken. The purpose was to identify how Australian maternity services are portrayed and what purpose is served by this representation to the general public.</p> <p>Results</p> <p>Findings from this critical discourse analysis revealed that Australian maternity services are being portrayed to the general public as an inflexible outdated service struggling to meets the needs of pregnant women and in desperate need of reform. The style of reporting employed in this newspaper involved presenting to the reader the range of expert opinion relevant to each topic, frequently involving polarised positions of the experts on the issue.</p> <p>Conclusions</p> <p>The general public are presented with a conflict, caught between the need for changes that come with the primary maternity model of care and fear that these change will undermine safe standards. The discourse; 'Australia is one of the safest countries in which to give birth or be born, what is must be best', represents the situation where despite major deficiencies in the system the general public may be too fearful of the consequences to consider a move away from reliance on traditional medical-led maternity care.</p