Patterns in Galápagos Magmatism Arising from the Upper Mantle Dynamics of Plume-Ridge Interaction

The origin of various patterns seen in Galápagos magmatism is investigated using numerical simulations of mantle plume-ridge interaction with the realistic geometry and evolution of the Galapágos Spreading Center (GSC). Models predict magma generation and composition from a mantle composed of fusible veins of material enriched in incompatible elements, and a more refractory depleted matrix. Model 1 simulates a low-viscosity plume, owing to a temperature-dependent mantle rheology; Model 2 includes the added dependence on water content, which leads to high viscosities in the dehydrated, shallow upper mantle. Model 1 produces the most favorable results. It shows how a modest crustal thickness anomaly observed along the Western GSC can arise from a plume with large excess temperatures (greater than 100°C). Model 1 also predicts geographic patterns in magma isotopic compositions broadly resembling those observed along the GSC as well as around the Galapágos Archipelago. These patterns are predicted to arise out of the differences in melting depths between the enriched veins and depleted matrix, coupled with spatial variations in the rate of mantle upwelling and decompression melting. The results provide an alternative to traditional explanations involving the plume mixing with or entraining the ambient mantle. The models are still missing some essential factors, as indicated by the predicted increases, rather than the observed decrease in incompatible element concentration away from the hotspot along the GSC. Possible factors include a regional-scale zoning in incompatible element and water content within the plume, or melt migration that delivers a larger flux of incompatible-element-rich melts to the GSC

Acceptance and Commitment Therapy for people living with motor neuron disease: an uncontrolled feasibility study

Background: Motor neuron disease (MND) is a fatal, progressive neurodegenerative disease that causes progressive weakening and wasting of limb, bulbar, thoracic and abdominal muscles. Clear evidence-based guidance on how psychological distress should be managed in people living with MND (plwMND) is lacking. Acceptance and Commitment Therapy (ACT) is a form of psychological therapy that may be particularly suitable for this population. However, to the authors' knowledge, no study to date has evaluated ACT for plwMND. Consequently, the primary aim of this uncontrolled feasibility study was to examine the feasibility and acceptability of ACT for improving the psychological health of plwMND. Methods: PlwMND aged ≥ 18 years were recruited from 10 UK MND Care Centres/Clinics. Participants received up to 8 one-to-one ACT sessions, developed specifically for plwMND, plus usual care. Co-primary feasibility and acceptability outcomes were uptake (≥ 80% of the target sample [N = 28] recruited) and initial engagement with the intervention (≥ 70% completing ≥ 2 sessions). Secondary outcomes included measures of quality of life, anxiety, depression, disease-related functioning, health status and psychological flexibility in plwMND and quality of life and burden in caregivers. Outcomes were assessed at baseline and 6 months. Results: Both a priori indicators of success were met: 29 plwMND (104%) were recruited and 76% (22/29) attended ≥ 2 sessions. Attrition at 6-months was higher than anticipated (8/29, 28%), but only two dropouts were due to lack of acceptability of the intervention. Acceptability was further supported by good satisfaction with therapy and session attendance. Data were possibly suggestive of small improvements in anxiety and psychological quality of life from baseline to 6 months in plwMND, despite a small but expected deterioration in disease-related functioning and health status. Conclusions: There was good evidence of acceptability and feasibility. Limitations included the lack of a control group and small sample size, which complicate interpretation of findings. A fully powered RCT to evaluate the clinical and cost-effectiveness of ACT for plwMND is underway

Conserved BK Channel-Protein Interactions Reveal Signals Relevant to Cell Death and Survival

The large-conductance Ca2+-activated K+ (BK) channel and its β-subunit underlie tuning in non-mammalian sensory or hair cells, whereas in mammals its function is less clear. To gain insights into species differences and to reveal putative BK functions, we undertook a systems analysis of BK and BK-Associated Proteins (BKAPS) in the chicken cochlea and compared these results to other species. We identified 110 putative partners from cytoplasmic and membrane/cytoskeletal fractions, using a combination of coimmunoprecipitation, 2-D gel, and LC-MS/MS. Partners included 14-3-3γ, valosin-containing protein (VCP), stathmin (STMN), cortactin (CTTN), and prohibitin (PHB), of which 16 partners were verified by reciprocal coimmunoprecipitation. Bioinformatics revealed binary partners, the resultant interactome, subcellular localization, and cellular processes. The interactome contained 193 proteins involved in 190 binary interactions in subcellular compartments such as the ER, mitochondria, and nucleus. Comparisons with mice showed shared hub proteins that included N-methyl-D-aspartate receptor (NMDAR) and ATP-synthase. Ortholog analyses across six species revealed conserved interactions involving apoptosis, Ca2+ binding, and trafficking, in chicks, mice, and humans. Functional studies using recombinant BK and RNAi in a heterologous expression system revealed that proteins important to cell death/survival, such as annexinA5, γ-actin, lamin, superoxide dismutase, and VCP, caused a decrease in BK expression. This revelation led to an examination of specific kinases and their effectors relevant to cell viability. Sequence analyses of the BK C-terminus across 10 species showed putative binding sites for 14-3-3, RAC-α serine/threonine-protein kinase 1 (Akt), glycogen synthase kinase-3β (GSK3β) and phosphoinositide-dependent kinase-1 (PDK1). Knockdown of 14-3-3 and Akt caused an increase in BK expression, whereas silencing of GSK3β and PDK1 had the opposite effect. This comparative systems approach suggests conservation in BK function across different species in addition to novel functions that may include the initiation of signals relevant to cell death/survival

PROSPECT-II Physics Opportunities

The Precision Reactor Oscillation and Spectrum Experiment, PROSPECT, has made world-leading measurements of reactor antineutrinos at short baselines. In its first phase, conducted at the High Flux Isotope Reactor (HFIR) at Oak Ridge National Laboratory, PROSPECT produced some of the strongest limits on eV-scale sterile neutrinos, made a precision measurement of the reactor antineutrino spectrum from $^{235}$U, and demonstrated the observation of reactor antineutrinos in an aboveground detector with good energy resolution and well-controlled backgrounds. The PROSPECT collaboration is now preparing an upgraded detector, PROSPECT-II, to probe yet unexplored parameter space for sterile neutrinos and contribute to a full resolution of the Reactor Antineutrino Anomaly, a longstanding puzzle in neutrino physics. By pressing forward on the world's most precise measurement of the $^{235}$U antineutrino spectrum and measuring the absolute flux of antineutrinos from $^{235}$U, PROSPECT-II will sharpen a tool with potential value for basic neutrino science, nuclear data validation, and nuclear security applications. Following a two-year deployment at HFIR, an additional PROSPECT-II deployment at a low enriched uranium reactor could make complementary measurements of the neutrino yield from other fission isotopes. PROSPECT-II provides a unique opportunity to continue the study of reactor antineutrinos at short baselines, taking advantage of demonstrated elements of the original PROSPECT design and close access to a highly enriched uranium reactor core

Note on arXiv:2005.05301, 'Preparation of the Neutrino-4 experiment on search for sterile neutrino and the obtained results of measurements'

We comment on the claimed observation [arXiv:arXiv:2005.05301] of sterileneutrino oscillations by the Neutrino-4 collaboration. Such a claim, whichrequires the existence of a new fundamental particle, demands a level of rigorcommensurate with its impact. The burden lies with the Neutrino-4 collaborationto provide the information necessary to prove the validity of their claim tothe community. In this note, we describe aspects of both the data and analysismethod that might lead to an oscillation signature arising from a nullexperiment and describe additional information needed from the Neutrino-4collaboration to support the oscillation claim. Additionally, as opposed to theassertion made by the Neutrino-4 collaboration, we also show that the method of'coherent summation' using the $L/E$ parameter produces similar results to themethods used by the PROSPECT and the STEREO collaborations.<br

The LUX-ZEPLIN (LZ) Experiment

We describe the design and assembly of the LUX-ZEPLIN experiment, a direct detection search for cosmic WIMP dark matter particles. The centerpiece of the experiment is a large liquid xenon time projection chamber sensitive to low energy nuclear recoils. Rejection of backgrounds is enhanced by a Xe skin veto detector and by a liquid scintillator Outer Detector loaded with gadolinium for efficient neutron capture and tagging. LZ is located in the Davis Cavern at the 4850' level of the Sanford Underground Research Facility in Lead, South Dakota, USA. We describe the major subsystems of the experiment and its key design features and requirements