1,209 research outputs found
Energy Implications of Photonic Networks With Speculative Transmission
Speculative transmission has been proposed to overcome the high latency of setting up end-to-end paths through photonic networks for computer systems. However, speculative transmission has implications for the energy efficiency of the network, in particular, control circuits are more complex and power hungry and failed speculative transmissions must be repeated. Moreover, in future chip multiprocessors (CMPs) with integrated photonic network end points, a large proportion of the additional energy will be dissipated on the CMP. This paper compares the energy characteristics of scheduled and speculative chip-to-chip networks for shared memory computer systems on the scale of a rack. For this comparison, we use a novel speculative control plane which reduces energy consumption by eliminating duplicate packets from the allocation process. In addition, we consider photonic power gating to reduce processor chip energy dissipation and the energy impact of the choice between semiconductor optical amplifier and ring resonator switching technologies. We model photonic network elements using values from the published literature as well as determine the power consumption of the allocator and network adapter circuits, implemented in a commercial low leakage 45 nm CMOS process. The power dissipated on the CMP using speculative networks is shown to be roughly double that of scheduled networks at saturation load and an order of magnitude higher at low loads
Reconfigurable network systems and software-defined networking
Modern high-speed networks have evolved from relatively static networks to highly adaptive networks facilitating dynamic reconfiguration. This evolution has influenced all levels of network design and management, introducing increased programmability and configuration flexibility. This influence has extended from the lowest level of physical hardware interfaces to the highest level of network management by software. A key representative of this evolution is the emergence of softwaredefined networking (SDN). In this paper, we review the current state of the art in reconfigurable network systems, covering hardware reconfiguration, SDN, and the interplay between them. We take a top-down approach, starting with a tutorial on software-defined networks. We then continue to discuss programming languages as the linking element between different levels of software and hardware in the network. We review electronic switching systems, highlighting programmability and reconfiguration aspects, and describe the trends in reconfigurable network elements. Finally, we describe the state of the art in the integration of photonic transceiver and switching elements with electronic technologies, and consider the implications for SDN and reconfigurable network systems.This work was jointly supported by the UKs Engineering and Physical Sciences Research Council (EPSRC) Internet Project EP/H040536/1, an EPSRC Research Fellowship grant to Philip Watts (EP/I004157/2), and DARPA and AFRL under contract FA8750-11-C-0249.This is the final version of the article. It first appeared from IEEE via http://dx.doi.org/10.1109/JPROC.2015.243573
Effect of microplastic on the gills of the Shore Crab Carcinus maenas
This is a âJust Acceptedâ manuscript. "Just Accepted manuscripts" have been peer-reviewed and accepted for publication. They are posted
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or consequences arising from the use of information contained in these âJust Acceptedâ manuscripts.Microscopic plastic debris (microplastics, <5mm in diameter) is ubiquitous in the marine environment. Previous work has shown that microplastics may be ingested and inhaled by the shore crab Carcinus maenas although the biological consequences are unknown. Here, we show that acute aqueous exposure to polystyrene microspheres (8Îźm) with different surface coatings had significant but transient effects on branchial function. Microspheres inhaled into the gill chamber had a small but significant dose dependent effect on oxygen consumption after 1 hour of exposure, returning to normal levels after 16 h. Ion exchange was also affected, with a small but significant decrease in hemolymph sodium ions and an increase in calcium ions after 24 h post exposure. To further asses the effects on osmoregulation, crabs were challenged with reduced salinity after microplastic exposure. Neither microspheres nor natural sediments altered the crabâs response to osmotic stress, regardless of plastic concentration added. Carboxylated (COOH) and aminated (NH2) polystyrene microspheres were distributed differently across the gill surface, although neither had a significant adverse impact on gill function. These results illustrate the extent of the physiological effects of microplastics, compared to the physiological resilience of shore crabs in maintaining osmoregulatory and respiratory function after acute exposure to both anthropogenic plastics and natural particles.W, CL and TG acknowledge funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement n° 308370. The contents of this publication are the responsibility of the CleanSea project and can in no way be taken to reflect the views of the European Union. TG and CL acknowledge additional support from NERC NE/L007010/1
Hyperon interaction with dense nuclear matter and link to neutron stars
The theoretical status of the hyperon-nucleon and hyperon-hyperon
interactions is reviewed, paying a special attention to chiral effective field
theories. Results on hyperons in dense matter are presented and the
consequences for the properties of neutron stars are analyzed.Comment: 6 pages, 2 figures, invited plenary talk, published In: Elia D.,
Bruno G.E., Colangelo P., Cosmai L. (eds). The XVIII International Conference
on Strangeness in Quark Matter (SQM 2019
Low Power Optical Transceivers for Switched Interconnect Networks
The power-consumption of network equipment is under ever-increasing scrutiny. As part of an ensemble project seeking to reduce power-consumption within data-centers1, this work focuses on reducing the power consumption of photonic transceivers for future fast power gated and/or optical switching networks. Utilising an open-source toolkit, we show that Serializer/Deserializer (SERDES) dominates power consumption of traditional optical transceivers. This result has particular implications for the modulation format of future interconnects. At 25 Gb/s line rate, SERDES blocks of PAM-16 and 4-wavelength WDM are shown to have 53% and 79% lower power respectively compared with SERDES of serial NRZ as well as reduced power gating restoration time and energy
Power Optimized Transceivers for Future Switched Networks
Network equipment power consumption is under increased scrutiny. To understand and decompose transceiver power consumption, we have created a toolkit incorporating a library of transceiver circuits in 45-nm CMOS and MOS current mode logic (MCML) and characterize power consumption using representative network traffic traces with digital synthesis and SPICE tools. Our toolkit includes all the components required to construct a library of different transceivers: line coding, frame alignment, channel bonding, serialization and deserialization, clockâdata recovery, and clock generation. For optical transceivers, we show that photonic components and front end drivers only consume a small fraction (<22%) of total serial transceiver power. This implies that major reductions in optical transceiver power can only be obtained by paying attention to the physical layer circuits such as clock recovery and serialâparallel conversions. We propose a burst-mode physical layer protocol suitable for optically switched links that retains the beneficial transmission characteristics of 8b/10b, but, even without power gating and voltage controlled oscillator power optimization, reduces the power consumption during idle periods by 29% compared with a conventional 8b/10b transceiver. We have made the toolkit available to the community at large in the hope of stimulating work in this field
Nuclei in Strongly Magnetised Neutron Star Crusts
We discuss the ground state properties of matter in outer and inner crusts of
neutron stars under the influence of strong magnetic fields. In particular, we
demonstrate the effects of Landau quantization of electrons on compositions of
neutron star crusts. First we revisit the sequence of nuclei and the equation
of state of the outer crust adopting the Baym, Pethick and Sutherland (BPS)
model in the presence of strong magnetic fields and most recent versions of the
theoretical and experimental nuclear mass tables. Next we deal with nuclei in
the inner crust. Nuclei which are arranged in a lattice, are immersed in a
nucleonic gas as well as a uniform background of electrons in the inner crust.
The Wigner-Seitz approximation is adopted in this calculation and each lattice
volume is replaced by a spherical cell. The coexistence of two phases of
nuclear matter - liquid and gas, is considered in this case. We obtain the
equilibrium nucleus corresponding to each baryon density by minimizing the free
energy of the cell. We perform this calculation using Skyrme nucleon-nucleon
interaction with different parameter sets. We find nuclei with larger mass and
charge numbers in the inner crust in the presence of strong magnetic fields
than those of the zero field case for all nucleon-nucleon interactions
considered here. However, SLy4 interaction has dramatic effects on the proton
fraction as well as masses and charges of nuclei. This may be attributed to the
behaviour of symmetry energy with density in the sub-saturation density regime.
Further we discuss the implications of our results to shear mode oscillations
of magnetars.Comment: presented in "Exciting Physics Symposium" held in Makutsi, South
Africa in November, 2011 and to be published in a book by Springer Verla
Design, Construction and Cloning of Truncated ORF2 and tPAsp-PADRE-Truncated ORF2 Gene Cassette From Hepatitis E Virus in the pVAX1 Expression Vector
Background: Hepatitis E Virus (HEV) is the causative agent of enterically transmitted acute hepatitis and has high mortality rate of up to 30% among pregnant women. Therefore, development of a novel vaccine is a desirable goal.
Objectives: The aim of this study was to construct tPAsp-PADRE-truncated open reading frame 2 (ORF2) and truncated ORF2 DNA plasmid, which can assist future studies with the preparation of an effective vaccine against Hepatitis E Virus.
Materials and Methods: A synthetic codon-optimized gene cassette encoding tPAsp-PADRE-truncated ORF2 protein was designed, constructed and analyzed by some bioinformatics software. Furthermore, a codon-optimized truncated ORF2 gene was amplified by the polymerase chain reaction (PCR), with a specific primer from the previous construct. The constructs were sub-cloned in the pVAX1 expression vector and finally expressed in eukaryotic cells.
Results: Sequence analysis and bioinformatics studies of the codon-optimized gene cassette revealed that codon adaptation index (CAI), GC content, and frequency of optimal codon usage (Fop) value were improved, and performance of the secretory signal was confirmed. Cloning and sub-cloning of the tPAsp-PADRE-truncated ORF2 gene cassette and truncated ORF2 gene were confirmed by colony PCR, restriction enzymes digestion and DNA sequencing of the recombinant plasmids pVAX-tPAsp-PADRE-truncated ORF2 (aa 112-660) and pVAX-truncated ORF2 (aa 112-660). The expression of truncated ORF2 protein in eukaryotic cells was approved by an Immunofluorescence assay (IFA) and the reverse transcriptase polymerase chain reaction (RT-PCR) method.
Conclusions: The results of this study demonstrated that the tPAsp-PADRE-truncated ORF2 gene cassette and the truncated ORF2 gene in recombinant plasmids are successfully expressed in eukaryotic cells. The immunogenicity of the two recombinant plasmids with different formulations will be evaluated as a novel DNA vaccine in future investigations
Structural subnetwork evolution across the life-span: rich-club, feeder, seeder
The impact of developmental and aging processes on brain connectivity and the
connectome has been widely studied. Network theoretical measures and certain
topological principles are computed from the entire brain, however there is a
need to separate and understand the underlying subnetworks which contribute
towards these observed holistic connectomic alterations. One organizational
principle is the rich-club - a core subnetwork of brain regions that are
strongly connected, forming a high-cost, high-capacity backbone that is
critical for effective communication in the network. Investigations primarily
focus on its alterations with disease and age. Here, we present a systematic
analysis of not only the rich-club, but also other subnetworks derived from
this backbone - namely feeder and seeder subnetworks. Our analysis is applied
to structural connectomes in a normal cohort from a large, publicly available
lifespan study. We demonstrate changes in rich-club membership with age
alongside a shift in importance from 'peripheral' seeder to feeder subnetworks.
Our results show a refinement within the rich-club structure (increase in
transitivity and betweenness centrality), as well as increased efficiency in
the feeder subnetwork and decreased measures of network integration and
segregation in the seeder subnetwork. These results demonstrate the different
developmental patterns when analyzing the connectome stratified according to
its rich-club and the potential of utilizing this subnetwork analysis to reveal
the evolution of brain architectural alterations across the life-span
An analytical solution for the settlement of stone columns beneath rigid footings
This paper presents a new approximate solution to study the settlement of rigid footings resting on a soft soil improved with groups of stone columns. The solution development is fully analytical, but finite element analyses are used to verify the validity of some assumptions, such as a simplified geometric model, load distribution with depth and boundary conditions. Groups of stone columns are converted to equivalent single columns with the same cross-sectional area. So, the problem becomes axially symmetric. Soft soil is assumed as linear elastic but plastic strains are considered in the column using the Mohr-Coulomb yield criterion and a non-associated flow rule, with a constant dilatancy angle. Soil profile is divided into independent horizontal slices and equilibrium of stresses and compatibility of deformations are imposed in the vertical and horizontal directions. The solution is presented in a closed form and may be easily implemented in a spreadsheet. Comparisons of the proposed solution with numerical analyses show a good agreement for the whole range of common values, which
confirms the validity of the solution and its hypotheses. The solution also compares well with a small scale laboratory test available in literature
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