Mapping plasma structures in the high-latitude ionosphere using beacon satellite, incoherent scatter radar and ground-based magnetometer observations

In the autumn of the year 2000, four radio receivers capable of tracking various beacon satellites were set up along the southwestern coast of Greenland. They are used to reconstruct images of the ionospheric plasma density distribution via the tomographic method. In order to test and validate tomographic imaging under the highly variable conditions often prevailing in the high-latitude ionosphere, a time interval was selected when the Sondrestrom incoherent scatter radar conducted measurements of the ionospheric plasma density while the radio receivers tracked a number of beacon satellites. A comparison between two-dimensional images of the plasma density distribution obtained from the radar and the satellite receivers revealed generally good agreement between radar measurements and tomographic images. Observed discrepancies can be attributed to F region plasma patches moving through the field of view with a speed of several hundred meters per second, thereby smearing out the tomographic image. A notable mismatch occurred around local magnetic midnight when a magnetospheric substorm breakup occurred in the vicinity of southwest Greenland (identified from ground-based magnetometer observations). The breakup was associated with a sudden intensification of the westward auroral electrojet which was centered at about 69 and extended up to some 73 corrected geomagnetic latitude. Ground-based magnetometer data may thus have the potential of indicating when the tomographic method is at risk and may fail. We finally outline the application of tomographic imaging, when combined with magnetic field data, to estimate ionospheric Joule heating rates

Geomagnetic disturbances at high latitudes during very low solar wind density event

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94969/1/grl13480.pd

Photometric AGN reverberation mapping - an efficient tool for BLR sizes, black hole masses and host-subtracted AGN luminosities

Photometric reverberation mapping employs a wide bandpass to measure the AGN continuum variations and a suitable band, usually a narrow band (NB), to trace the echo of an emission line in the broad line region (BLR). The narrow band catches both the emission line and the underlying continuum, and one needs to extract the pure emission line light curve. We performed a test on two local AGNs, PG0003+199 (=Mrk335) and Ark120, observing well-sampled broad- (B, V) and narrow-band light curves with the robotic 15cm telescope VYSOS-6 on Cerro Armazones, Chile. In PG0003+199, H_alpha dominates the flux in the NB by 85%, allowing us to measure the time lag of H_alpha against B without the need to correct for the continuum contribution. In Ark120, H_beta contributes only 50% to the flux in the NB. The cross correlation of the B and NB light curves shows two distinct peaks of similar strength, one at lag zero from the autocorrelated continuum and one from the emission line at tau_cent = 47.5 +/- 3.4 days. We constructed a synthetic H_beta light curve, by subtracting a scaled V light curve, which traces the continuum, from the NB light curve. The cross correlation of this synthetic H_beta light curve with the B light curve shows only one major peak at tau_cent = 48.0 +/- 3.3 days, while the peak from the autocorrelated continuum at lag zero is absent. We conclude that, as long as the emission line contributes at least 50% to the bandpass, the pure emission line light curve can be reconstructed from photometric monitoring data so that the time lag can be measured. For both objects the lags we find are consistent with spectroscopic reverberation results. While the dense sampling (median 2 days) enables us to determine tau_cent with small (10%) formal errors, we caution that gaps in the light curves may lead to much larger systematic uncertainties. (Abstract shortened, see the manuscript.)Comment: 12 pages, 15 figures, accepted for publication in Astronomy and Astrophysic

Impact of the 26-30 May 2003 solar events on the earth ionosphere and thermosphere.

During the last week of May 2003, the solar active region AR 10365 produced a large number of flares, several of which were accompanied by Coronal Mass Ejections (CME). Specifically on 27 and 28 May three halo CMEs were observed which had a significant impact on geospace. On 29 May, upon their arrival at the L1 point, in front of the Earth's magnetosphere, two interplanetary shocks and two additional solar wind pressure pulses were recorded by the ACE spacecraft. The interplanetary magnetic field data showed the clear signature of a magnetic cloud passing ACE. In the wake of the successive increases in solar wind pressure, the magnetosphere became strongly compressed and the sub-solar magnetopause moved inside five Earth radii. At low altitudes the increased energy input to the magnetosphere was responsible for a substantial enhancement of Region-1 field-aligned currents. The ionospheric Hall currents also intensified and the entire high-latitude current system moved equatorward by about 10°. Several substorms occurred during this period, some of them - but not all - apparently triggered by the solar wind pressure pulses. The storm's most notable consequences on geospace, including space weather effects, were (1) the expansion of the auroral oval, and aurorae seen at mid latitudes, (2) the significant modification of the total electron content in the sunlight high-latitude ionosphere, (3) the perturbation of radio-wave propagation manifested by HF blackouts and increased GPS signal scintillation, and (4) the heating of the thermosphere, causing increased satellite drag. We discuss the reasons why the May 2003 storm is less intense than the October-November 2003 storms, although several indicators reach similar intensities

Performance of Different Diagnostic PD-L1 Clones in Head and Neck Squamous Cell Carcinoma

Background: The approval of immune checkpoint inhibitors in combination with specific diagnostic biomarkers presents new challenges to pathologists as tumor tissue needs to be tested for expression of programmed death-ligand 1 (PD-L1) for a variety of indications. As there is currently no requirement to use companion diagnostic assays for PD-L1 testing in Germany different clones are used in daily routine. While the correlation of staining results has been tested in various entities, there is no data for head and neck squamous cell carcinomas (HNSCC) so far. Methods: We tested five different PD-L1 clones (SP263, SP142, E1L3N, 22-8, 22C3) on primary HNSCC tumor tissue of 75 patients in the form of tissue microarrays. Stainings of both immune and tumor cells were then assessed and quantified by pathologists to simulate real-world routine diagnostics. The results were analyzed descriptively and the resulting staining pattern across patients was further investigated by principal component analysis and non-negative matrix factorization clustering. Results: Percentages of positive immune and tumor cells varied greatly. Both the resulting combined positive score as well as the eligibility for certain checkpoint inhibitor regimens was therefore strongly dependent on the choice of the antibody. No relevant co-clustering and low similarity of relative staining patterns across patients was found for the different antibodies. Conclusions: Performance of different diagnostic anti PD-L1 antibody clones in HNSCC is less robust and interchangeable compared to reported data from other tumor entities. Determination of PD-L1 expression is critical for therapeutic decision making and may be aided by back-to-back testing of different PD-L1 clones

Coordinated observation of field line resonance in the mid-tail

Standing Alfvén waves of 1.1 mHz (~15 min in period) were observed by the Cluster satellites in the mid-tail during 06:00-07:00 UT on 8 August 2003. Pulsations with the same frequency were also observed at several ground stations near Cluster's footpoint. The standing wave properties were determined from the electric and magnetic field measurements of Cluster. Data from the ground magnetometers indicated a latitudinal amplitude and phase structure consistent with the driven field line resonance (FLR) at 1.1 mHz. Simultaneously, quasi-periodic oscillations at different frequencies were observed in the post-midnight/early morning sector by GOES 12 (<i>l</i><sub>0</sub>≈8.7), Polar (<i>l</i><sub>0</sub>≈11-14) and Geotail (<i>l</i><sub>0</sub>≈9.8). The 8 August 2003 event yields rare and interesting datasets. It provides, for the first time, coordinated in situ and ground-based observations of a very low frequency FLR in the mid-tail on stretched field lines

Ground-based and satellite observations of high-latitude auroral activity in the dusk sector of the auroral oval

On 7 December 2000, during 13:30-15:30 UT the MIRACLE all-sky camera at Ny Alesund observed auroras at high-latitudes (MLAT similar to 76) simultaneously when the Cluster spacecraft were skimming the magnetopause in the same MLT sector (at similar to 16:00-18:00 MLT). The location of the auroras (near the ionospheric convection reversal boundary) and the clear correlation between their dynamics and IMF variations suggests their close relationship with R1 currents. Consequently, we can assume that the Cluster spacecraft were making observations in the magnetospheric region associated with the auroras, although exact magnetic conjugacy between the ground-based and satellite observations did not exist. The solar wind variations appeared to control both the behaviour of the auroras and the magnetopause dynamics. Auroral structures were observed at Ny Alesund especially during periods of negative IMF B-Z. In addition, the Cluster spacecraft experienced periodic (T similar to 4 - 6 min) encounters between magnetospheric and magnetosheath plasmas. These undulations of the boundary can be interpreted as a consequence of tailward propagating magnetopause surface waves. Simultaneous dusk sector ground-based observations show weak, but discernible magnetic pulsations (Pc 5) and occasionally periodic variations (T - 2 - 3 min) in the high-latitude auroras. In the dusk sector, Pc 5 activity was stronger and had characteristics that were consistent with a field line resonance type of activity. When IMF BZ stayed positive for a longer period, the auroras were dimmer and the spacecraft stayed at the outer edge of the magnetopause where they observed electromagnetic pulsations with T similar to 1 min. We find these observations interesting especially from the viewpoint of previously presented studies relating poleward-moving high-latitude auroras with pulsation activity and MHD waves propagating at the magnetospheric boundary layers

Implementing a system of quality-of-life diagnosis and therapy for breast cancer patients: results of an exploratory trial as a prerequisite for a subsequent RCT

A system for quality-of-life diagnosis and therapy (QoL system) was implemented for breast cancer patients. The system fulfilled the criteria for complex interventions (Medical Research Council). Following theory and modeling, this study contains the exploratory trial as a next step before the randomised clinical trial (RCT) answering three questions: (1) Are there differences between implementation sample and general population? (2) Which amount and type of disagreement exist between patient and coordinating practitioners (CPs) in assessed global QoL? (3) Are there empirical reasons for a cutoff of 50 points discriminating between healthy and diseased QoL? Implementation was successful: 74% of CPs worked along the care pathway. However, CPs showed preferences for selecting patients with lower age and UICC prognostic staging. Patients and CPs disagreed considerably in values of global QoL, despite education in QoL assessment by outreach visits, opinion leaders and CME: Zero values of QoL were only expressed by patients. Finally, the cutoff of 50 points was supported by the relationship between QoL in single items and global QoL: no patients with values above 50 dropped global QoL below 50, but values below 50 and especially at 0 points in single items, induced a dramatic fall of global QoL down to below 50. The exploratory trial was important for defining the complex intervention in the definitive RCT: control for age and prognostic stage grading, support for a QoL unit combining patient's and CP's assessment of QoL and support for the 50-point cutoff criterion between healthy and diseased QoL

The significance of trust in the political system and motivation for pupils' learning progress in politics lessons

Very little research has been conducted on the contribution of political education to learning progress in Germany. Hence, there is a need for intervention studies measuring performance against the theoretical background of a political competence model. This model comprises three constructs: subject knowledge, motivation and attitudes. According to this model, politics lessons should not only convey knowledge but also arouse subject interest, promote political attitudes and develop problem-solving skills. This study investigates how knowledge acquisition is influenced by intervention using theory-oriented teaching materials on the European Union, intervention using conventional textbooks on the European Union and politics lessons without any reference to the European Union. It further asks how the performance-related self-concept and subject interest in political issues impact political knowledge and whether civic virtue and trust in the system are related to it. The sample comprises 1071 pupils. Theory-oriented politics classes lead to greater growth of pupils’ knowledge than in the control group. As anticipated, this study proves that a positive subject-specific self-concept impacts knowledge. The examination of political attitudes reveals a positive correlation between civic virtue and knowledge. There is no connection between trust in the political system and knowledge