Bostonia: The Boston University Alumni Magazine. Volume 20

Founded in 1900, Bostonia magazine is Boston University's main alumni publication, which covers alumni and student life, as well as university activities, events, and programs

Developing professional learning for staff working with children with speech, language and communication needs combined with moderate-to-severe learning difficulties

Children with speech, language and communication needs (SLCN) often present challenges in interaction where teachers may need specialist knowledge. In this article, Carolyn Anderson of the University of Strathclyde examines how teachers and classroom assistants (N=49) developed their professional learning for working with these pupils. A questionnaire revealed limited evidence of pre or post-qualification training in topics or number of hours teaching relating to SLCN. In the absence of formal learning opportunities, most teachers reported learning from others with experience or from reflecting on their own practice. They valued feedback from peers on their teaching practice. The results suggest that school teams should agree on definitions for reflective practice and feedback and how these contribute to professional learning. Lack of access to or availability of formal learning opportunities may be an important factor in shaping teachers' perceptions of their competence and confidence in working with children who have speech, language and communication needs

Thermal breakage of window glass in room fires conditions - Analysis of some important parameters

In a compartment fire, the breakage and possible fallout of a window glass has a significant impact on the fire dynamics. The thermal breakage of glass depends on various parameters such as glass type, edge shading, edges conditions and constraints on the glass. The purpose of the present study is to investigate some of the key parameters affecting the thermal breakage of window glass in fire conditions using a recently developed and validated computer tool. Fallout is not within the scope of this study. Different boundary conditions of the glass pane (unconstrained and constrained) subjected to fire radiant heat are investigated. The analysis shows that to prevent glass thermal breakage, it is important to provide enough spacing between the frame and glass pane to accommodate the thermal expansion, and constraints on the glass structure should be avoided. The zones where the glass is likely to crack first are shown. The study also quantifies the effects of glass edge conditions on its thermal breakage in fire conditions; such analysis has not been reported in the literature due to its complexity and the statistical nature of edge flaws. The results show that an ordinary float glass mostly used in windows, with the “as-cut” edge condition would break later and is stronger than a ground edge or polished edge glass for the scenarios investigated. The study demonstrates how a predictive tool could be employed for a better understanding of thermal breakage of window glass in fires and for design guidance

Patient stratification for determining optimal second-line and third-line therapy for type 2 diabetes:the TriMaster study

This is the author accepted manuscript. The final version is available from Nature Research via the DOI in this recordData availability: To minimize the risk of patient re-identification, de-identified individual patient-level clinical data are available under restricted access. Requests for access to anonymized individual participant data and study documents should be made to the corresponding author and will be reviewed by the Peninsula Research Bank Steering Committee. Access to data through the Peninsula Research Bank will be granted for requests with scientifically valid questions by academic teams with the necessary skills appropriate for the research. Data that can be shared will be released with the relevant transfer agreement.Code availability: Requests for access to code should be made to the corresponding author and will be reviewed by the Peninsula Research Bank Steering Committee. Access to code through the Peninsula Research Bank will be granted for requests with scientifically valid questions by academic teams with the necessary skills appropriate for the research. Code will be released by the lead statistician.Precision medicine aims to treat an individual based on their clinical characteristics. A differential drug response, critical to using these features for therapy selection, has never been examined directly in type 2 diabetes. In this study, we tested two hypotheses: (1) individuals with body mass index (BMI) > 30 kg/m2, compared to BMI ≤ 30 kg/m2, have greater glucose lowering with thiazolidinediones than with DPP4 inhibitors, and (2) individuals with estimated glomerular filtration rate (eGFR) 60-90 ml/min/1.73 m2, compared to eGFR >90 ml/min/1.73 m2, have greater glucose lowering with DPP4 inhibitors than with SGLT2 inhibitors. The primary endpoint for both hypotheses was the achieved HbA1c difference between strata for the two drugs. In total, 525 people with type 2 diabetes participated in this UK-based randomized, double-blind, three-way crossover trial of 16 weeks of treatment with each of sitagliptin 100 mg once daily, canagliflozin 100 mg once daily and pioglitazone 30 mg once daily added to metformin alone or metformin plus sulfonylurea. Overall, the achieved HbA1c was similar for the three drugs: pioglitazone 59.6 mmol/mol, sitagliptin 60.0 mmol/mol and canagliflozin 60.6 mmol/mol (P = 0.2). Participants with BMI > 30 kg/m2, compared to BMI ≤ 30 kg/m2, had a 2.88 mmol/mol (95% confidence interval (CI): 0.98, 4.79) lower HbA1c on pioglitazone than on sitagliptin (n = 356, P = 0.003). Participants with eGFR 60-90 ml/min/1.73 m2, compared to eGFR >90 ml/min/1.73 m2, had a 2.90 mmol/mol (95% CI: 1.19, 4.61) lower HbA1c on sitagliptin than on canagliflozin (n = 342, P = 0.001). There were 2,201 adverse events reported, and 447/525 (85%) randomized participants experienced an adverse event on at least one of the study drugs. In this precision medicine trial in type 2 diabetes, our findings support the use of simple, routinely available clinical measures to identify the drug class most likely to deliver the greatest glycemic reduction for a given patient. (ClinicalTrials.gov registration: NCT02653209 ; ISRCTN registration: 12039221 .).Medical Research Council (MRC)National Institute for Health and Care Research (NIHR

Protocol of a feasibility randomised controlled trial of Empowered Conversations: training family carers to enhance their relationships and communication with people living with dementia. [version 1; peer review: 3 approved]

Background: Communication difficulties can cause frustration, low mood, and stress for people living with dementia and their carer. Carers should be offered training on adapting their communication skills. However, it is not common for skills-based education to examine emotional aspects of care and the effect of dementia on relationships. The Empowered Conversations (EC) training course was developed in response to a gap in service provision and has been adapted to a virtual format (Zoom). It addresses the specific psychological, relationship, and communication needs of informal and family dementia carers. The primary aim of the study is to investigate the feasibility of conducting a multi-centre randomised controlled evaluation trial of EC.  Secondary aims include exploring the acceptability of delivering the intervention online and examining the optimum way of establishing cost-effectiveness. Methods: The feasibility trial uses a pragmatic data-collector blind parallel two-group RCT design with two arms (EC intervention plus treatment as usual, and treatment as usual waitlist control). There will be a 2:1 allocation in favour of the EC-training intervention arm. 75 participants will complete baseline outcome measures exploring their role as a carer, including their physical and mental health, attitudes to caring, quality of life, and use of health and social care services. These will be repeated after six-months. Participants allocated to the treatment group who complete the course will be invited to participate in a qualitative interview discussing their experience of EC. Discussion: The study will investigate recruitment pathways (including facilitators and barriers to recruitment), estimate retention levels and response rates to questionnaires, obtain additional evidence regarding proof of concept, and consider the most appropriate primary outcome measures and methods for evaluating cost-effectiveness. The results of the feasibility study will be used to inform the development of a multicentre randomised controlled trial in the United Kingdom. Registration: ISRCTN15261686 (02/03/2022

Tidal resource extraction in the Pentland Firth, UK : Potential impacts on flow regime and sediment transport in the Inner Sound of Stroma

Large-scale extraction of power from tidal streams within the Pentland Firth is expected to be underway in the near future. The Inner Sound of Stroma in particular has attracted significant commercial interest. To understand potential environmental impacts of the installation of a tidal turbine array a case study based upon the Inner Sound is considered. A numerical computational fluid dynamics model, Fluidity, is used to conduct a series of depth-averaged simulations to investigate velocity and bed shear stress changes due to the presence of idealised tidal turbine arrays. The number of turbines is increased from zero to 400. It is found that arrays in excess of 85 turbines have the potential to affect bed shear stress distributions in such a way that the most favourable sites for sediment accumulation migrate from the edges of the Inner Sound towards its centre. Deposits of fine gravel and coarse sand are indicated to occur within arrays of greater than 240 turbines with removal of existing deposits in the shallower channel margins also possible. The effects of the turbine array may be seen several kilometres from the site which has implications not only on sediment accumulation, but also on the benthic fauna

The habitability of Proxima Centauri b II. Possible climates and observability

International audienceRadial velocity monitoring has found the signature of a $M \sin i = 1.3$~M$_\oplus$ planet located within the Habitable Zone of Proxima Centauri, (Anglada-Escud\'e et al. 2016). Despite a hotter past and an active host star the planet Proxima~b could have retained enough volatiles to sustain surface habitability (Ribas et al. 2016). Here we use a 3D Global Climate Model to simulate Proxima b's atmosphere and water cycle for its two likely rotation modes (1:1 and 3:2 resonances) while varying the unconstrained surface water inventory and atmospheric greenhouse effect. We find that a broad range of atmospheric compositions can allow surface liquid water. On a tidally-locked planet with a surface water inventory larger than 0.6 Earth ocean, liquid water is always present, at least in the substellar region. Liquid water covers the whole planet for CO$_2$ partial pressures $\gtrsim 1$~bar. For smaller water inventories, water can be trapped on the night side, forming either glaciers or lakes, depending on the amount of greenhouse gases. With a non-synchronous rotation, a minimum CO$_2$ pressure is required to avoid falling into a completely frozen snowball state if water is abundant. If the planet is dryer, $\sim$0.5~bar of CO$_2$ would suffice to prevent the trapping of any arbitrary small water inventory into polar ice caps. More generally, any low-obliquity planet within the classical habitable zone of its star should be in one of the climate regimes discussed here. We use our GCM to produce reflection/emission spectra and phase curves. We find that atmospheric characterization will be possible by direct imaging with forthcoming large telescopes thanks to an angular separation of $7 \lambda/D$ at 1~$\mu$m (with the E-ELT) and a contrast of $\sim 10^{-7}$. The magnitude of the planet will allow for high-resolution spectroscopy and the search for molecular signatures

A simple model for the evolution of super-massive black holes and the quasar population

An empirically motivated model is presented for accretion-dominated growth of the super massive black holes (SMBH) in galaxies, and the implications are studied for the evolution of the quasar population in the universe. We investigate the core aspects of the quasar population, including space density evolution, evolution of the characteristic luminosity, plausible minimum masses of quasars, the mass function of SMBH and their formation epoch distribution. Our model suggests that the characteristic luminosity in the quasar luminosity function arises primarily as a consequence of a characteristic mass scale above which there is a systematic separation between the black hole and the halo merging rates. At lower mass scales, black hole merging closely tracks the merging of dark halos. When combined with a declining efficiency of black hole formation with redshift, the model can reproduce the quasar luminosity function over a wide range of redshifts. The observed space density evolution of quasars is well described by formation rates of SMBH above $\sim 10^8 M_\odot$. The inferred mass density of SMBH agrees with that found independently from estimates of the SMBH mass function derived empirically from the quasar luminosity function.Comment: 15 pages, 16 figure