Serum Immunoglobulin in Scabies **From the Rupert Hallam Department of Dermatology. Hallamshire Hospital, and † the Department of Immunology, hallamshire Hospital Medical School. Sheffield, England. (Reprint requests to: Dr. Ward, Deapartment of Immunology, Hallamshire Hospital Medical School. Sheffield, S10 2RX, England.

Serum immunoglobulin levels were measured in 100 patients with scabies. White cell counts and erythrocyte sedimentation rates were measured in 62 of these patients and were normal in 59. The patients were divided into two groups according to whether their symptoms had been present for more or less than 3 weeks. The values for IgA were significantly lower in both early and late groups than in the normal. IgE levels were normal in both groups. The relationship between raised IgG and IgM and systemic infection and scabies sensitization is discussed. It is postulated that the low serum IgA may correlate with low secretory IgA in skin secretions, and may predispose to scabies infestation

Jupiter – friend or foe? I: the asteroids

The asteroids are a major source of potential impactors on the Earth today. It has long been assumed that the giant planet Jupiter acts as a shield, significantly lowering the impact rate on the Earth from both cometary and asteroidal bodies. Such shielding, it is claimed, enabled the development and evolution of life in a collisional environment, which is not overly hostile. The reduced frequency of impacts, and of related mass extinctions, would have allowed life the time to thrive, where it would otherwise have been suppressed. However, in the past, little work has been carried out to examine the validity of this idea. In the first of several papers, we examine the degree to which the impact risk resulting from a population representative of the asteroids is enhanced or reduced by the presence of a giant planet, in an attempt to understand fully the impact regime under which life on Earth developed. Our results show that the situation is far less clear cut that has previously been assumed, that is, the presence of a giant planet can act to enhance the impact rate of asteroids on the Earth significantly

Determining Habitability: Which exoEarths should we search for life?

Within the next few years, the first Earth-mass planets will be discovered around other stars. Some of those worlds will certainly lie within the classical "habitable zone" of their parent stars, and we will quickly move from knowing of no exoEarths to knowing many. For the first time, we will be in a position to carry out a detailed search for the first evidence of life beyond our Solar System. However, such observations will be hugely taxing and time consuming to perform, and it is almost certain that far more potentially habitable worlds will be known than it is possible to study. It is therefore important to catalogue and consider the various effects which make a promising planet more or less suitable for the development of life. In this work, we review the various planetary, dynamical and stellar influences that could influence the habitability of exoEarths. The various influences must be taken in concert when we attempt to decide where to focus our first detailed search for life. While there is no guarantee that any given planet will be inhabited, it is vitally important to ensure that we focus our time and effort on those planets most likely to yield a positive result.Comment: 32 pages, 2 figures, 1 table; Accepted to appear in the International Journal of Astrobiolog

Jupiter - friend or foe? III: the Oort cloud comets

It has long been assumed that the planet Jupiter acts as a giant shield, significantly lowering the impact rate of small bodies on the Earth. However, until recently, very little work had been carried out examining the role played by Jupiter in determining the frequency of such collisions. In this work, the third of a series of papers, we examine the degree to which the impact rate on Earth resulting from the Oort cloud comets is enhanced or lessened by the presence of a giant planet in a Jupiter-like orbit, in an attempt to more fully understand the impact regime under which life on Earth has developed. Our results show that the presence of a giant planet in a Jupiter-like orbit significantly alters the impact rate of Oort cloud comets on the Earth, decreasing the rate as the mass of the giant increases. The greatest bombardment flus is observed when no giant planet is present.Comment: 21 pages, 4 Figures. Accepted for publication in the International Journal of Astrobiolog

Neighborhood language isolation and depressive symptoms among elderly U.S. Latinos

Purpose: Neighborhood segregation related to cultural factors, such as language use, may influence elderly Latino depression. We examined the association between neighborhood-level Spanish language segregation and individual depressive symptoms among elderly Latinos. Methods: We linked U.S. Census language use data with geocoded population-based data from 1789 elderly Latinos (mean age = 70.6 years) participating in the Sacramento Area Latino Study on Aging (1998–2008). Neighborhood language segregation was measured with the Index of Concentration at the Extremes, which demonstrates the extent to which residents are concentrated at extremes of deprivation and privilege. We fit two-level generalized linear-mixed models with random intercepts for census tracts to quantify the association between neighborhood-level language segregation and depressive symptoms, adjusting for identified confounders. Results: After adjusting for age, sex, and nativity, residents of highly segregated Spanish-speaking neighborhoods had more depressive symptoms than those in highly segregated English-only-speaking neighborhoods (β = −4.410; 95% confidence interval [CI] = −6.851 to −1.970). This association was largely attenuated upon adjustment for individual-level education (β = −2.119; 95% CI = −4.650 to 0.413). Conclusions: Linguistically segregated communities may benefit from targeted outreach given the high depression prevalence in these neighborhoods. Furthermore, our findings suggest that limited access to fundamental social protections, such as education, may drive the segregation-depression association among U.S. Latinos. © 2018 Elsevier Inc

Educational mobility across generations and depressive symptoms over 10 years among US latinos

Few studies have collected intergenerational data to assess the association between educational mobility across multiple generations and offspring depression. Using data from the Sacramento Area Latino Study on Aging (1998-2008), we assessed the influence of intergenerational education on depressive symptoms over 10 years among 1,786 Latino individuals (mean age = 70.6 years). Educational mobility was classified as stable-low (low parental/low offspring education), upwardly mobile (low parental/high offspring education), stable-high (high parental/ high offspring education), or downwardly mobile (high parental/low offspring education). Depressive symptoms were measured with the Center for Epidemiological Studies-Depression Scale (CES-D); higher scores indicated more depressive symptoms. To quantify the association between educational mobility and CES-D scores over follow-up, we used generalized estimating equations to account for repeated CES-D measurements and adjusted for identified confounders. Within individuals, depressive symptoms remained relatively stable over follow-up. Compared with stable-low education, stable-high education and upward mobility were associated with significantly lower CES-D scores (β = -2.75 and -2.18, respectively). Downwardly mobile participants had slightly lower CES-D scores than stable-low participants (β = -0.77). Our results suggest that sustained, low educational attainment across generations may have adverse mental health consequences, and improved educational opportunities in underresourced communitiesmay counteract the adverse influence of low parental education on Latino depression

Space-time translational gauge identities in Abelian Yang-Mills gravity

We derive and calculate the space-time translational gauge identities in quantum Yang-Mills gravity with a general class of gauge conditions involving two arbitrary parameters. These identities of the Abelian group of translation are a generalization of Ward-Takahasi-Fradkin identities and important for general discussions of possible renormalization of Yang-Mills gravity with translational gauge symmetry. The gauge identities in Yang-Mills gravity with a general class of gauge conditions are substantiated by explicit calculations.Comment: 15 pages. To be published in The European Physical Journal - Plus (2012

The changing of the guard: groupwork with people who have intellectual disabilities

This paper considers the impact of service systems on group activities. It describes an inter-professional groupwork project facilitated by a social worker and a community nurse. The project provided an emancipatory experience for a group of adults who had intellectual disabilities. The group was charged with the task of reviewing and updating the recruitment and interview processes used by a 'Learning Disability Partnership Board', when employing new support workers. The paper begins with a brief history of intellectual disability and provides a context to the underpinning philosophical belief that people should be encouraged and supported to inhabit valued social roles no matter what disability they may have. It then identifies the ways in which the sponsoring health, education and social care services impacted on the creation and development of a groupwork project. It might have been expected that the nature of the intellectual disability would have been the major influence on group process. However the paper reveals that organisational constraints had a significant impact on group functioning. Issues including, staffing budgets and transport contracts impacted on group process and function. The results of the project show how, with adequate support, people with intellectual disability can make important decisions that have long-reaching impacts on the services

The status of GEO 600

The GEO 600 laser interferometer with 600m armlength is part of a worldwide network of gravitational wave detectors. GEO 600 is unique in having advanced multiple pendulum suspensions with a monolithic last stage and in employing a signal recycled optical design. This paper describes the recent commissioning of the interferometer and its operation in signal recycled mode

Measurement of the partial widths of the Z into up- and down-type quarks

Using the entire OPAL LEP1 on-peak Z hadronic decay sample, Z -> qbarq gamma decays were selected by tagging hadronic final states with isolated photon candidates in the electromagnetic calorimeter. Combining the measured rates of Z -> qbarq gamma decays with the total rate of hadronic Z decays permits the simultaneous determination of the widths of the Z into up- and down-type quarks. The values obtained, with total errors, were Gamma u = 300 ^{+19}_{-18} MeV and Gamma d = 381 ^{+12}_{-12} MeV. The results are in good agreement with the Standard Model expectation.Comment: 22 pages, 5 figures, Submitted to Phys. Letts.