4,527 research outputs found
Effect of Layer-Stacking on the Electronic Structure of Graphene Nanoribbons
The evolution of electronic structure of graphene nanoribbons (GNRs) as a
function of the number of layers stacked together is investigated using
\textit{ab initio} density functional theory (DFT) including interlayer van der
Waals interactions. Multilayer armchair GNRs (AGNRs), similar to single-layer
AGNRs, exhibit three classes of band gaps depending on their width. In zigzag
GNRs (ZGNRs), the geometry relaxation resulting from interlayer interactions
plays a crucial role in determining the magnetic polarization and the band
structure. The antiferromagnetic (AF) interlayer coupling is more stable
compared to the ferromagnetic (FM) interlayer coupling. ZGNRs with the AF
in-layer and AF interlayer coupling have a finite band gap while ZGNRs with the
FM in-layer and AF interlayer coupling do not have a band gap. The ground state
of the bi-layer ZGNR is non-magnetic with a small but finite band gap. The
magnetic ordering is less stable in multilayer ZGNRs compared to single-layer
ZGNRs. The quasipartcle GW corrections are smaller for bilayer GNRs compared to
single-layer GNRs because of the reduced Coulomb effects in bilayer GNRs
compared to single-layer GNRs.Comment: 10 pages, 5 figure
Improving Phase Change Memory Performance with Data Content Aware Access
A prominent characteristic of write operation in Phase-Change Memory (PCM) is
that its latency and energy are sensitive to the data to be written as well as
the content that is overwritten. We observe that overwriting unknown memory
content can incur significantly higher latency and energy compared to
overwriting known all-zeros or all-ones content. This is because all-zeros or
all-ones content is overwritten by programming the PCM cells only in one
direction, i.e., using either SET or RESET operations, not both. In this paper,
we propose data content aware PCM writes (DATACON), a new mechanism that
reduces the latency and energy of PCM writes by redirecting these requests to
overwrite memory locations containing all-zeros or all-ones. DATACON operates
in three steps. First, it estimates how much a PCM write access would benefit
from overwriting known content (e.g., all-zeros, or all-ones) by
comprehensively considering the number of set bits in the data to be written,
and the energy-latency trade-offs for SET and RESET operations in PCM. Second,
it translates the write address to a physical address within memory that
contains the best type of content to overwrite, and records this translation in
a table for future accesses. We exploit data access locality in workloads to
minimize the address translation overhead. Third, it re-initializes unused
memory locations with known all-zeros or all-ones content in a manner that does
not interfere with regular read and write accesses. DATACON overwrites unknown
content only when it is absolutely necessary to do so. We evaluate DATACON with
workloads from state-of-the-art machine learning applications, SPEC CPU2017,
and NAS Parallel Benchmarks. Results demonstrate that DATACON significantly
improves system performance and memory system energy consumption compared to
the best of performance-oriented state-of-the-art techniques.Comment: 18 pages, 21 figures, accepted at ACM SIGPLAN International Symposium
on Memory Management (ISMM
Id-1 and Id-2 are markers for metastasis and prognosis in oesophageal squamous cell carcinoma
Id protein family consists of four members namely Id-1 to Id-4. Different from other basic helix–loop–helix transcription factors, they lack the DNA binding domain. Id proteins have been shown to be dysregulated in many different cancer types and their prognostic value has also been demonstrated. Recently, Id-1 has been shown to be upregulated in oesophageal squamous cell carcinoma (ESCC). However, the prognostic implications of Id proteins in ESCC have not been reported. We examined the expression of the Id proteins in ESCC cell lines and clinical ESCC specimens and found that Id protein expressions were dysregulated in both the ESCC cell lines and specimens. By correlating the expression levels of Id proteins and the clinicopathological data of our patient cohort, we found that M1 stage tumours had significantly higher nuclear Id-1 expression (P=0.012) while high nuclear Id-1 expression could predict development of distant metastasis within 1 year of oesophagectomy (P=0.005). In addition, high levels of Id-2 expression in both cytoplasmic and nuclear regions predicted longer patient survival (P=0.041). Multivariate analysis showed that high-level expression of Id-2 in both cytoplasmic and nuclear regions and lower level of nuclear Id-1 expression were independent favourable predictors of survival in our ESCC patients. Our results suggest that Id-1 may promote distant metastasis in ESCC, and both Id-1 and Id-2 may be used for prognostication for ESCC patients
The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a.
p53 and its major E3 ligase Mdm2 are both ubiquitinated and targeted to the proteasome for degradation. Despite the importance of this in regulating the p53 pathway, little is known about the mechanisms of proteasomal recognition of ubiquitinated p53 and Mdm2. In this study, we show that knockdown of the proteasomal ubiquitin receptor S5a/PSMD4/Rpn10 inhibits p53 protein degradation and results in the accumulation of ubiquitinated p53. Overexpression of a dominant-negative deletion of S5a lacking its ubiquitin-interacting motifs (UIM)s, but which can be incorporated into the proteasome, also causes the stabilization of p53. Furthermore, small-interferring RNA (siRNA) rescue experiments confirm that the UIMs of S5a are required for the maintenance of low p53 levels. These observations indicate that S5a participates in the recognition of ubiquitinated p53 by the proteasome. In contrast, targeting S5a has no effect on the rate of degradation of Mdm2, indicating that proteasomal recognition of Mdm2 can be mediated by an S5a-independent pathway. S5a knockdown results in an increase in the transcriptional activity of p53. The selective stabilization of p53 and not Mdm2 provides a mechanism for p53 activation. Depletion of S5a causes a p53-dependent decrease in cell proliferation, demonstrating that p53 can have a dominant role in the response to targeting S5a. This study provides evidence for alternative pathways of proteasomal recognition of p53 and Mdm2. Differences in recognition by the proteasome could provide a means to modulate the relative stability of p53 and Mdm2 in response to cellular signals. In addition, they could be exploited for p53-activating therapies. This work shows that the degradation of proteins by the proteasome can be selectively dependent on S5a in human cells, and that this selectivity can extend to an E3 ubiquitin ligase and its substrate
Measurement of Two-Particle Correlations of Hadrons in e⁺ e⁻ Collisions at Belle
The measurement of two-particle angular correlation functions in high-multiplicity e+e− collisions at √s=10.52 GeV is reported. In this study, the 89.5 fb−1 of hadronic e+e− annihilation data collected by the Belle detector at KEKB are used. Two-particle angular correlation functions are measured in the full relative azimuthal angle (Δϕ) and three units of pseudorapidity (Δη), defined by either the electron beam axis or the event-shape thrust axis, and are studied as a function of charged-particle multiplicity. The measurement in the thrust axis analysis, with mostly outgoing quark pairs determining the reference axis, is sensitive to the region of additional soft gluon emissions. No significant anisotropic collective behavior is observed with either coordinate analyses. Near-side jet correlations appear to be absent in the thrust axis analysis. The measurements are compared to predictions from various event generators and are expected to provide new constraints to the phenomenological models in the low-energy regime
Evidence for at Belle
We search for the decay with , where the is not measured, using a data
sample corresponding to an integrated luminosity of 711 which
contains 772 pairs, collected around the
(4S) resonance with the Belle detector at the KEKB asymmetric-energy
collider. We measure for the first time the branching fraction to be with a significance of . We simultaneously measure
the branching fraction for the related channel
with much improved precision.Comment: 7 pages, 5 figures, 4 tables. To be submitted to PR
Measurement of the cross section in the energy range from to GeV using inclusive and production
We report the first measurement of the inclusive and cross sections in the
energy range from to . Based on these results, we determine
and
in the same energy range. We measure the fraction of events at
to be . We determine also
the ratio of the inclusive branching fractions .
The results are obtained using the data collected with the Belle detector at
the KEKB asymmetric-energy collider
Precision Measurement of the Mass Difference
We have measured the vector-pseudoscalar mass splitting , significantly more precise than the previous
world average. We minimize the systematic errors by also measuring the
vector-pseudoscalar mass difference using the radiative
decay , obtaining
. This is
then combined with our previous high-precision measurement of
, which used the decay . We also
measure the mass difference MeV, using the
decay modes of the and mesons.Comment: 18 pages uuencoded compressed postscript (process with uudecode then
gunzip). hardcopies with figures can be obtained by sending mail to:
[email protected]
Search for charged lepton flavor violating decays of ϒ (1S)
We present a search for the charged lepton-flavor-violating decays ϒ(1S) → ℓ±ℓ′∓ and radiative charged lepton-flavour-violating decays ϒ(1S) → γℓ±ℓ′∓ [ℓ,ℓ′ = e, μ, τ] using the 158 million ϒ(2S) sample collected by the Belle detector at the KEKB collider. This search uses ϒ(1S) mesons produced in ϒ(2S) → π+π− ϒ(1S) transitions. We do not find any significant signal, so we provide upper limits on the branching fractions at the 90% confidence level
Measurements of differential cross sections of Z/gamma*+jets+X events in proton anti-proton collisions at sqrt{s}=1.96 TeV
We present cross section measurements for Z/gamma*+jets+X production,
differential in the transverse momenta of the three leading jets. The data
sample was collected with the D0 detector at the Fermilab Tevatron proton
anti-proton collider at a center-of-mass energy of 1.96 TeV and corresponds to
an integrated luminosity of 1 fb-1. Leading and next-to-leading order
perturbative QCD predictions are compared with the measurements, and agreement
is found within the theoretical and experimental uncertainties. We also make
comparisons with the predictions of four event generators. Two
parton-shower-based generators show significant shape and normalization
differences with respect to the data. In contrast, two generators combining
tree-level matrix elements with a parton shower give a reasonable description
of the the shapes observed in data, but the predicted normalizations show
significant differences with respect to the data, reflecting large scale
uncertainties. For specific choices of scales, the normalizations for either
generator can be made to agree with the measurements.Comment: Published in PLB. 11 pages, 3 figure
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