Human-centric zero-defect manufacturing: State-of-the-art review, perspectives, and challenges

Zero defect manufacturing (ZDM) aims at eliminating defects throughout the value stream as well as the cost of rework and scrap. The ambitious goal of zero defects requires the extensive utilization of emerging technologies. Amidst the major drive for technological advancement, humans are often kept out of the loop because they are perceived as the root cause of error. The report from the European Commission on Industry 5.0 emphasizes that human-centric is a key pillar in building a more resilient industry and is vital to incorporate the human component into the manufacturing sector. However, we did not find any publications that explain what human-centric ZDM is, nor what the roles of humans are in advancing ZDM. As a contribution to bridging this gap, a systematic literature review is conducted using different databases. We collected 36 publications and categorised them into 3 different human roles which are managers, engineers, and operators. From our search, we found out that managers play a vital role in cultivating ZDM in the entire organization to prevent errors despite the fact they often do not have direct contact with the production line as operators. Operators can help advance ZDM through knowledge capturing with feedback functions to the engineer to better design a corrective action to prevent errors. Assistive technologies such as extended reality are efficient tools used by operators to eliminate human errors in production environments. Human-centric is now a goal in the future manufacturing sector, but it could face barriers such as high technological investments and resistance to changes in their work tasks. This paper can contribute to paving the roadmap of human-centric ZDM to bring defects to zero and reposition the manufacturing sector to become more resilient.publishedVersio

Management Policy in Franchising Operations: A Preliminary Study

  During the past few decades franchising has emerged as one of the fastest growing methods doing business in the world . This article investigates the concept of climate in Franchising ores and how that relates to the stores' per formance. Work context, participation and orkgrou p were identified as important climate factors influencing store per formance: Pro­ r management .of the work climate should e.nhance Franchise store per formance. 

Paying attention to social media stocks

Social media has reshaped business models, economies, politics, and culture around the world. In this paper, we identified social media stocks from various sectors by using a strict, academic definition and then studied their performance and return characteristics. Multivariate regression results demonstrate that being recognized as a social media firm yields extra return. The performance of social media stocks is not associated with macro-level sentiment, but rather with firm-level attention paid by potential investors. Causality tests indicate that the default risk premium and volatility have incremental power in explaining the performance of social media stocks

Overview of milling techniques for improving the solubility of poorly water-soluble drugs

AbstractMilling involves the application of mechanical energy to physically break down coarse particles to finer ones and is regarded as a “top–down” approach in the production of fine particles. Fine drug particulates are especially desired in formulations designed for parenteral, respiratory and transdermal use. Most drugs after crystallization may have to be comminuted and this physical transformation is required to various extents, often to enhance processability or solubility especially for drugs with limited aqueous solubility. The mechanisms by which milling enhances drug dissolution and solubility include alterations in the size, specific surface area and shape of the drug particles as well as milling-induced amorphization and/or structural disordering of the drug crystal (mechanochemical activation). Technology advancements in milling now enable the production of drug micro- and nano-particles on a commercial scale with relative ease. This review will provide a background on milling followed by the introduction of common milling techniques employed for the micronization and nanonization of drugs. Salient information contained in the cited examples are further extracted and summarized for ease of reference by researchers keen on employing these techniques for drug solubility and bioavailability enhancement

Distinct transcriptome profiles of Gag-specific CD8+ T cells temporally correlated with the protection elicited by SIVΔnef live attenuated vaccine

The live attenuated vaccine (LAV) SIVmac239Δnef (SIVΔnef) confers the best protection among all the vaccine modalities tested in rhesus macaque model of HIV-1 infection. This vaccine has a unique feature of time-dependent protection: macaques are not protected at 3±5 weeks post vaccination (WPV), whereas immune protection emerges between 15 and 20 WPV. Although the exact mechanisms of the time-dependent protection remain incompletely understood, studies suggested that both cellular and humoral immunities contribute to this time-dependent protection. To further elucidate the mechanisms of protection induced by SIVΔnef, we longitudinally compared the global gene expression profiles of SIV Gag-CM9+ CD8+ (Gag-specific CD8+) T cells from peripheral blood of Mamu-A*01+ rhesus macaques at 3 and 20 WPV using rhesus microarray. We found that gene expression profiles of Gag-specific CD8+ T cells at 20 WPV are qualitatively different from those at 3 WPV. At 20 WPV, the most significant transcriptional changes of Gag-specific CD8+ T cells were genes involved in TCR signaling, differentiation and maturation toward central memory cells, with increased expression of CCR7, TCRα, TCRβ, CD28 and decreased expression of CTLA-4, IFN-γ, RANTES, granzyme A and B. Our study suggests that a higher quality of SIV-specific CD8+ T cells elicited by SIVΔnef over time contributes to the maturation of time-dependent protection

Towards an HCI model for eudaimonic growth - A phenomenological inquiry into travelers' serious leisure pursuits and cultivation of character strengths

Many people strive for a life characterized by self-growth and meaning, considered to be innate needs, by actualizing their authentic potentials during their lifespans. Positive psychology (PP) has termed this self-development process as eudaimonia—to live a virtuous life. From this perspective, such a life can be attained by individuals through cultivating key character strengths. On the other hand, the fields of leisure and tourism regard eudaimonia as the sustained pursuit of leisure activities that involve specific skills, knowledge, and experience. This study combines these two bodies of knowledge to propose a human-computer interaction (HCI) model that can facilitate individual eudaimonic growth through the serious pursuit of leisure activities applicable to the eTourism platform. By integrating concepts reported in the current literature with the results of our phenomenological investigation, we highlight three key findings to support the development of this model: 1. Individual eudaimonic development can be appreciated from both cross- sectional and developmental perspectives; 2. In addition to performance seeking behavior, individual satisfaction and fulfillment can emerge from the process of exercising one’s character strengths; 3. Goal formation and introspection are specific aspects that contribute to the meaning of an experience. The proposed HCI model comprises two interrelated components: a strength-based recommender system and personal reflective journaling informatics. The HCI model assumes that eudaimonic growth can occur when both systems are in action

Superconducting dome by tuning through a Van Hove singularity in a two-dimensional metal

Chemical substitution is a promising route for the exploration of a rich variety of doping- and/or disorder-dependent collective phenomena in low-dimensional quantum materials. Here we show that transition metal dichalcogenide alloys are ideal platforms to this purpose. In particular, we demonstrate the emergence of superconductivity in the otherwise metallic single-layer TaSe$_{2}$ by minute electron doping provided by substitutional W atoms. We investigate the temperature- and magnetic field-dependence of the superconducting state of Ta$_{1-\delta}$W$_\delta$Se$_2$ with electron doping ($\delta$) using variable temperature (0.34 K - 4.2 K) scanning tunneling spectroscopy (STS). We unveil the emergence of a superconducting dome spanning 0.003 < $\delta$ < 0.03 with a maximized critical temperature of 0.85 K, a significant increase from that of bulk TaSe$_{2}$ (T$_C$ = 0.14 K). Superconductivity emerges from an increase of the density of states (DOS) as the Fermi surface approaches a van Hove singularity due to doping. Once the singularity is reached, however, the DOS decreases with $\delta$, which gradually weakens the superconducting state, thus shaping the superconducting dome. Lastly, our doping-dependent measurements allow us to unambiguously track the development of a Coulomb glass phase triggered by disorder due to W dopants