E2 strengths and transition radii difference of one-phonon 2+ states of 92Zr from electron scattering at low momentum transfer

Background: Mixed-symmetry 2+ states in vibrational nuclei are characterized by a sign change between dominant proton and neutron valence-shell components with respect to the fully symmetric 2+ state. The sign can be measured by a decomposition of proton and neutron transition radii with a combination of inelastic electron and hadron scattering [C. Walz et al., Phys. Rev. Lett. 106, 062501 (2011)]. For the case of 92Zr, a difference could be experimentally established for the neutron components, while about equal proton transition radii were indicated by the data. Method: Differential cross sections for the excitation of one-phonon 2+ and 3- states in 92Zr have been measured with the (e,e') reaction at the S-DALINAC in a momentum transfer range q = 0.3-0.6 fm^(-1). Results: Transition strengths B(E2;2+_1 -> 0+_1) = 6.18(23), B(E2; 2+_2 -> 0+_1) = 3.31(10) and B(E3; 3-_1 -> 0+_1) = 18.4(11) Weisskopf units are determined from a comparison of the experimental cross sections to quasiparticle-phonon model (QPM) calculations. It is shown that a model-independent plane wave Born approximation (PWBA) analysis can fix the ratio of B(E2) transition strengths to the 2+_(1,2) states with a precision of about 1%. The method furthermore allows to extract their proton transition radii difference. With the present data -0.12(51) fm is obtained. Conclusions: Electron scattering at low momentum transfers can provide information on transition radii differences of one-phonon 2+ states even in heavy nuclei. Proton transition radii for the 2+_(1,2) states in 92Zr are found to be identical within uncertainties. The g.s. transition probability for the mixed-symmetry state can be determined with high precision limited only by the available experimental information on the B(E2; 2+_1 -> 0+_1) value.Comment: 14 pages, 5 figures, submitted to Phys. Rev. C, revised manuscrip

Differential role of entorhinal and hippocampal nerve growth factor in short- and long-term memory modulation

Afghanistan - Primitive wellColorVolume 33, Page

Respiratory protein interactions in Dehalobacter sp. strain 8M revealed through genomic and native proteomic analyses

Dehalobacter (Firmicutes) encompass obligate organohalide-respiring bacteria used for bioremediation of groundwater contaminated with halogenated organics. Various aspects of their biochemistry remain unknown, including the identities and interactions of respiratory proteins. Here, we sequenced the genome of Dehalobacter sp. strain 8M and analysed its protein expression. Strain 8M encodes 22 reductive dehalogenase homologous (RdhA) proteins. RdhA D8M_v2_40029 (TmrA) was among the two most abundant proteins during growth with trichloromethane and 1,1,2-trichloroethane. To examine interactions of respiratory proteins, we used blue native gel electrophoresis together with dehalogenation activity tests and mass spectrometry. The highest activities were found in gel slices with the highest abundance of TmrA. Protein distributions across gel lanes provided biochemical evidence that the large and small subunits of the membrane-bound [NiFe] uptake hydrogenase (HupL and HupS) interacted strongly and that HupL/S interacted weakly with RdhA. Moreover, the interaction of RdhB and membrane-bound b-type cytochrome HupC was detected. RdhC proteins, often encoded in rdh operons but without described function, migrated in a protein complex not associated with HupL/S or RdhA. This study provides the first biochemical evidence of respiratory protein interactions in Dehalobacter, discusses implications for the respiratory architecture and advances the molecular comprehension of this unique respiratory chain

Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription.

Deregulated expression of MYC induces a dependence on the NUAK1 kinase, but the molecular mechanisms underlying this dependence have not been fully clarified. Here, we show that NUAK1 is a predominantly nuclear protein that associates with a network of nuclear protein phosphatase 1 (PP1) interactors and that PNUTS, a nuclear regulatory subunit of PP1, is phosphorylated by NUAK1. Both NUAK1 and PNUTS associate with the splicing machinery. Inhibition of NUAK1 abolishes chromatin association of PNUTS, reduces spliceosome activity, and suppresses nascent RNA synthesis. Activation of MYC does not bypass the requirement for NUAK1 for spliceosome activity but significantly attenuates transcription inhibition. Consequently, NUAK1 inhibition in MYC-transformed cells induces global accumulation of RNAPII both at the pause site and at the first exon-intron boundary but does not increase mRNA synthesis. We suggest that NUAK1 inhibition in the presence of deregulated MYC traps non-productive RNAPII because of the absence of correctly assembled spliceosomes

Practical application of AAPM Report 270 in display quality assurance: A report of Task Group 270

Published in January 2019, AAPM Report 270 provides an update to the recommendations of the AAPM\u27s TG18 report. Report 270 provides new definitions of display types, updated testing patterns, and revised performance standards for the modern, flat-panel displays used as part of medical image acquisition and review. The focus of the AAPM report is on consistent image quality and appearance, and how to establish a quality assurance program to achieve those two goals. This work highlights some of the key takeaways of AAPM Report 270 and makes comparisons with existing recommendations from other references. It also provides guidance for establishing a display quality assurance program for different-sized institutions. Finally, it describes future challenges for display quality assurance and what work remains

Electron Beam-Induced Writing of Nanoscale Iron Wires on a Functional Metal Oxide

Electron beam-induced surface activation (EBISA) has been used to grow wires of iron on rutile TiO2(110)-(1 × 1) in ultrahigh vacuum. The wires have a width down to ∼20 nm and hence have potential utility as interconnects on this dielectric substrate. Wire formation was achieved using an electron beam from a scanning electron microscope to activate the surface, which was subsequently exposed to Fe(CO)5. On the basis of scanning tunneling microscopy and Auger electron spectroscopy measurements, the activation mechanism involves electron beam-induced surface reduction and restructuring

Effects of climate extremes on the terrestrial carbon cycle : concepts, processes and potential future impacts

This article is protected by copyright. All rights reserved. Acknowledgements This work emerged from the CARBO-Extreme project, funded by the European Community’s 7th framework programme under grant agreement (FP7-ENV-2008-1-226701). We are grateful to the Reviewers and the Subject Editor for helpful guidance. We thank to Silvana Schott for graphic support. Mirco Miglivacca provided helpful comments on the manuscript. Michael Bahn acknowledges support from the Austrian Science Fund (FWF; P22214-B17). Sara Vicca is a postdoctoral research associate of the Fund for Scientific Research – Flanders. Wolfgang Cramer contributes to the Labex OT-Med (n° ANR-11- LABX-0061) funded by the French government through the A*MIDEX project (n° ANR-11-IDEX-0001-02). Flurin Babst acknowledges support from the Swiss National Science Foundation (P300P2_154543).Peer reviewedPublisher PD