A bibliography of six years (1951-1956) research in arithmetic

Thesis (Ed.M.)--Boston Universit

Fomento del pensamiento crítico a través del desarrollo curricular en contextos interculturales de los estudiantes de grado 11° de Educación Media Técnica en la Institución Educativa Técnica Agropecuaria de Guataca en el Municipio de Mompós.

La investigación buscó responder, por una parte, a la necesidad de viabilizar el fomento del pensamiento crítico de manera transversal al desarrollo curricular. Y, por otra, a la necesidad de integrar más eficaz y proactivamente el contexto social desde su dimensión intercultural rural-urbana. Para tal fin se propuso examinar la incidencia del desarrollo curricular en el fomento del pensamiento crítico de los estudiantes de Educación Media Técnica de una institución educativa rural. La propuesta se sustentó en el estudio del desarrollo curricular en contextos interculturales, y en la comprensión contextualizada de las habilidades y disposiciones que definen la capacidad de pensamiento crítico. El proceso investigativo se basó en técnicas de Investigación Acción Participativa, y comprendió las siguientes acciones: la caracterización del contexto, el autodiagnóstico sobre la praxis docente, y, la construcción colaborativa de un plan de acción integral. Encontrándose que, es posible construir colaborativamente estrategias metodológicas que, integradas a las políticas institucionales de desarrollo curricular, contribuyan a la subsanación de esta problemática. Concluyéndose así que, si el desarrollo curricular resulta poco favorable al fomento del pensamiento crítico, es posible revertir esta situación partiendo de una revisión de la forma como la praxis docente puede incidir en esta situación y, buscando cómo integrar el contexto sociocultural a estos procesos. De esta manera, se estará propiciando no sólo instancias de innovación curricular favorables al fomento del pensamiento crítico, sino también a la valoración de la identidad y de la diversidad cultural más allá del aula y los contextos inmediatos.The research sought to respond, on the one hand, to the need to make possible the promotion of critical thinking in a transversal way to curricular development. And, on the other hand, to the need to integrate more effectively and proactively the social context from its rural-urban intercultural dimension. For this proposed to examine the incidence of curricular development in the promotion of critical thinking of the students of Technical Secondary Education of rural educational institution. The proposal was based on the study of curricular development in intercultural contexts, and on the contextualized understanding of the skills and dispositions that define the capacity for critical thinking. The investigative process was based on Participatory Action Research techniques, and included the following actions: the characterization of the context, the self-diagnostic of teaching praxis, and the collaborative construction of a comprehensive action plan. Finding that it is possible to collaboratively build methodological strategies that, integrated into the institutional policies of curricular development, contribute to the correction of this problem. Thus, concluding that, if the curricular development is unfavorable to the promotions of critical thinking, it is possible to reverse this situation starting from a review of the way in which the teaching praxis can affect this situation and, looking for how to integrate the sociocultural context to these processes. In this way, not only instances of curricular innovation favorable to the promotion of critical thinking will be fostered, but also the appreciation of identity and cultural diversity beyond the classroom and immediate contexts

Tyrosine metabolism: Urinary excretion studies in parkinsonism

Vanilmandelic, homogentisic and homovanillic acid excretions were studied in parkinsonian patients on and off -dopa.Vanilmandelic acid excretions were quantitated both by gas-chromatographic and colorimetric methods. A marked increase in the excretion of this acid was demonstrated in the parkinsonian patient as compared to controls. Although Vanilmandelic excretion rises under the influence of -dopa, the increase is much smaller than that of free homovanillic acid. The latter consistently accounts for some 18-20% of the administered -dopa dose. While vanilmandelic acid excretions even under the influence of -dopa correlate well with the patients' weight, no such correlation could be obtained with homovanillic acid.Homogentisic acid could not be detected in urine specimens of patients either on or off -dopa. No correlation was observed between the clinical status or response to -dopa of the patients and their excretion of acidic urinary catabolites.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/33538/1/0000037.pd

Platelets of patients with chronic kidney disease demonstrate deficient platelet reactivity in vitro

<p>Abstract</p> <p>Background</p> <p>In patients with chronic kidney disease studies focusing on platelet function and properties often are non-conclusive whereas only few studies use functional platelet tests. In this study we evaluated a recently developed functional flow cytometry based assay for the analysis of platelet function in chronic kidney disease.</p> <p>Methods</p> <p>Platelet reactivity was measured using flow cytometric analysis. Platelets in whole blood were triggered with different concentrations of agonists (TRAP, ADP, CRP). Platelet activation was quantified with staining for P-selectin, measuring the mean fluorescence intensity. Area under the curve and the concentration of half-maximal response were determined.</p> <p>Results</p> <p>We studied 23 patients with chronic kidney disease (9 patients with cardiorenal failure and 14 patients with end stage renal disease) and 19 healthy controls. Expression of P-selectin on the platelet surface measured as mean fluorescence intensity was significantly less in chronic kidney disease patients compared to controls after maximal stimulation with TRAP (9.7 (7.9-10.8) vs. 11.4 (9.2-12.2), P = 0.032), ADP (1.6 (1.2-2.1) vs. 2.6 (1.9-3.5), P = 0.002) and CRP (9.2 (8.5-10.8) vs. 11.5 (9.5-12.9), P = 0.004). Also the area under the curve was significantly different. There was no significant difference in half-maximal response between both groups.</p> <p>Conclusion</p> <p>In this study we found that patients with chronic kidney disease show reduced platelet reactivity in response of ADP, TRAP and CRP compared to controls. These results contribute to our understanding of the aberrant platelet function observed in patients with chronic kidney disease and emphasize the significance of using functional whole blood platelet activation assays.</p

Gliese 12 b, a temperate Earth-sized planet at 12 parsecs discovered with TESS and CHEOPS

We report on the discovery of Gliese 12 b, the nearest transiting temperate, Earth-sized planet found to date. Gliese 12 is a bright (V = 12.6 mag, K = 7.8 mag) metal-poor M4V star only 12.162 ± 0.005 pc away from the Solar system with one of the lowest stellar activity levels known for M-dwarfs. A planet candidate was detected by TESS based on only 3 transits in sectors 42, 43, and 57, with an ambiguity in the orbital period due to observational gaps. We performed follow-up transit observations with CHEOPS and ground-based photometry with MINERVA-Australis, SPECULOOS, and Purple Mountain Observatory, as well as further TESS observations in sector 70. We statistically validate Gliese 12 b as a planet with an orbital period of 12.76144 ± 0.00006 d and a radius of 1.0 ± 0.1 R⊕, resulting in an equilibrium temperature of ∼315 K. Gliese 12 b has excellent future prospects for precise mass measurement, which may inform how planetary internal structure is affected by the stellar compositional environment. Gliese 12 b also represents one of the best targets to study whether Earth-like planets orbiting cool stars can retain their atmospheres, a crucial step to advance our understanding of habitability on Earth and across the galaxy

Gliese 12 b, a temperate Earth-sized planet at 12 parsecs discovered with TESS and CHEOPS

We report on the discovery of Gliese 12 b, the nearest transiting temperate, Earth-sized planet found to date. Gliese 12 is a bright (V = 12.6 mag, K = 7.8 mag) metal-poor M4V star only 12.162 ± 0.005 pc away from the Solar system with one of the lowest stellar activity levels known for M-dwarfs. A planet candidate was detected by TESS based on only 3 transits in sectors 42, 43, and 57, with an ambiguity in the orbital period due to observational gaps. We performed follow-up transit observations with CHEOPS and ground-based photometry with MINERVA-Australis, SPECULOOS, and Purple Mountain Observatory, as well as further TESS observations in sector 70. We statistically validate Gliese 12 b as a planet with an orbital period of 12.76144 ± 0.00006 d and a radius of 1.0 ± 0.1 R⊕, resulting in an equilibrium temperature of ∼315 K. Gliese 12 b has excellent future prospects for precise mass measurement, which may inform how planetary internal structure is affected by the stellar compositional environment. Gliese 12 b also represents one of the best targets to study whether Earth-like planets orbiting cool stars can retain their atmospheres, a crucial step to advance our understanding of habitability on Earth and across the galaxy

Prevalencia de Obesidad en estudiantes de primaria del colegio Raimondi

Con el objetivo de determinar la prevalencia de sobrepeso obesidad en escolares de 3º a 6º año de primaria del colegio Raimondi. Material y métodos: entre julio noviembre del 2015 fueron evaluados 371 de 3º a 6º de primaria del colegio de varones Raimondi en quienes se determinó el IMC el cual con ayuda del Z-escore se determinó la prevalencia de sobrepeso obesidad. Resultados: se encontró que el 66.3% de niños tuvieron un IMC &gt; del percentil 85 considerado como sobrepeso obesidad y de estos el 37.5% fueron obesos. Se concluye que la obesidad es una condición relacionada a los hábitos alimentarios inadecuados que compromete a más de un tercio de la población escolar de primaria en el colegio Raimondi. Palabras Clave: Obesidad en escolares

Erratum to: A systematic review of the characteristics and validity of monitoring technologies to assess Parkinson’s disease

This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated."Background: There is growing interest in having objective assessment of health-related outcomes using technology-based devices that provide unbiased measurements which can be used in clinical practice and scientific research. Many studies have investigated the clinical manifestations of Parkinson’s disease using such devices. However, clinimetric properties and clinical validation vary among the different devices. Methods: Given such heterogeneity, we sought to perform a systematic review in order to (i) list, (ii) compare and (iii) classify technological-based devices used to measure motor function in individuals with Parkinson's disease into three groups, namely wearable, non-wearable and hybrid devices. A systematic literature search of the PubMed database resulted in the inclusion of 168 studies. These studies were grouped based on the type of device used. For each device we reviewed availability, use, reliability, validity, and sensitivity to change. The devices were then classified as (i) ‘recommended’, (ii) ‘suggested’ or (iii) ‘listed’ based on the following criteria: (1) used in the assessment of Parkinson’s disease (yes/no), (2) used in published studies by people other than the developers (yes/no), and (3) successful clinimetric testing (yes/no). Results: Seventy-three devices were identified, 22 were wearable, 38 were non-wearable, and 13 were hybrid devices. In accordance with our classification method, 9 devices were ‘recommended’, 34 devices were ‘suggested’, and 30 devices were classified as ‘listed’. Within the wearable devices group, the Mobility Lab sensors from Ambulatory Parkinson’s Disease Monitoring (APDM), Physilog®, StepWatch 3, TriTrac RT3 Triaxial accelerometer, McRoberts DynaPort, and Axivity (AX3) were classified as ‘recommended’. Within the non-wearable devices group, the Nintendo Wii Balance Board and GAITRite® gait analysis system were classified as ‘recommended’. Within the hybrid devices group only the Kinesia® system was classified as ‘recommended’."The present research is part of the EU project SENSE-PARK, funded under the Seventh Framework Programme, Cooperation – ICT, Grant Agreement no. 288557