Bold Responses to Inhibition in Cannabis Using Adolescents and Emerging Adults

Cannabis use has been associated with increased blood oxygen level dependent (BOLD) responses absent of behavioral deficits during a response inhibition task compared to controls. We investigated whether gender and cannabis use result in differences in BOLD responses and behavioral performance during a Go-NoGo task. Participants included eighty-three 16-26 year olds (MJ=36, Controls=46). An emotion based Go-NoGo task required participants to inhibit their response during a “neutral” face. A whole-brain analysis looked at differences between cannabis group, gender, and their interaction. Significant increased BOLD responses were observed in cannabis users compared to controls in the left frontal cortex, left cingulate cortex, and the left thalamus during correct response inhibitions. There were no significant differences on task performance or group by gender interactions. Supporting previous research, cannabis users showed increased BOLD responses in core areas associated with response inhibition during a Go-NoGo task further elucidating the relationships between cannabis and brain-behavior

Bold Responses to Inhibition in Cannabis Using Adolescents and Emerging Adults

Cannabis use has been associated with increased blood oxygen level dependent (BOLD) responses absent of behavioral deficits during a response inhibition task compared to controls. We investigated whether gender and cannabis use result in differences in BOLD responses and behavioral performance during a Go-NoGo task. Participants included eighty-three 16-26 year olds (MJ=36, Controls=46). An emotion based Go-NoGo task required participants to inhibit their response during a “neutral” face. A whole-brain analysis looked at differences between cannabis group, gender, and their interaction. Significant increased BOLD responses were observed in cannabis users compared to controls in the left frontal cortex, left cingulate cortex, and the left thalamus during correct response inhibitions. There were no significant differences on task performance or group by gender interactions. Supporting previous research, cannabis users showed increased BOLD responses in core areas associated with response inhibition during a Go-NoGo task further elucidating the relationships between cannabis and brain-behavior

ADAPTION IMPACTS OF ENTRY PYRAMID MARKETING TECHNOLOGY ON COMPETITIVE ADVANTAGE

This study aims at show the impact of Entry pyramid marketing echnology oncompetitive advantage social structure by analyzing the impact depending on views of the study population of ZAIN LTD.The problem of this study formulated as it’s main question “ What is the impact of entry pyramid marketing technology on ZAIN LTD competitive advantage”. From this main question we’re branching sub questions circulated on this study to give a methodology answers .Considering this methodology of collecting and analyzing (12) of Senior and executive management depending on positions : General Director, Deputy Director, Branch Manager and Section Head. Collecting data by building a questionnaire as a tool for measuring model study and using statistical methods to test the study hypothesis

Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death.

Glutamate is the dominant excitatory neurotransmitter in the brain, but under conditions of metabolic stress it can accumulate to excitotoxic levels. Although pharmacologic modulation of excitatory amino acid receptors is well studied, minimal consideration has been given to targeting mitochondrial glutamate metabolism to control neurotransmitter levels. Here we demonstrate that chemical inhibition of the mitochondrial pyruvate carrier (MPC) protects primary cortical neurons from excitotoxic death. Reductions in mitochondrial pyruvate uptake do not compromise cellular energy metabolism, suggesting neuronal metabolic flexibility. Rather, MPC inhibition rewires mitochondrial substrate metabolism to preferentially increase reliance on glutamate to fuel energetics and anaplerosis. Mobilizing the neuronal glutamate pool for oxidation decreases the quantity of glutamate released upon depolarization and, in turn, limits the positive-feedback cascade of excitotoxic neuronal injury. The finding links mitochondrial pyruvate metabolism to glutamatergic neurotransmission and establishes the MPC as a therapeutic target to treat neurodegenerative diseases characterized by excitotoxicity

Effective low-energy theory for correlated carbon nanotubes

The low-energy theory for single-wall carbon nanotubes including Coulomb interactions is derived and analyzed. It describes two fermion chains without interchain hopping but coupled in a specific way by the interaction. The strong-coupling properties are studied by bosonization, and consequences for experiments on single armchair nanotubes are discussed.Comment: 5 pages REVTeX, includes one figur

Accretion in the Rho-Oph pre-main sequence stars

The aim of this paper is to provide a measurement of the mass accretion rate in a large, complete sample of objects in the core of the star forming region Rho-Oph. The sample includes most of the objects (104 out of 111) with evidence of a circumstellar disk from mid-infrared photometry; it covers a stellar mass range from about 0.03 to 3 Msun and it is complete to a limiting mass of ~0.05 Msun. We used J and K-band spectra to derive the mass accretion rate of each object from the intensity of the hydrogen recombination lines, Pab or Brg. For comparison, we also obtained similar spectra of 35 diskless objects. The results show that emission in these lines is only seen in stars with disks, and can be used as an indicator of accretion. However, the converse does not hold, as about 50% of our disk objects do not have detectable line emission. The measured accretion rates show a strong correlation with the mass of the central object (Macc ~ Mstar^1.8+-0.2) and a large spread, of two orders of magnitude at least, for any interval of Mstar. A comparison with existing data for Taurus shows that the objects in the two regions have similar behaviour, at least for objects more massive than ~0.1Msun. The implications of these results are briefly discussed.Comment: A&A in press, 16 pages including tables, 5 figure

Adolescent Experiences with Self-Asphyxial Behaviors and Problematic Drinking in Emerging Adulthood

Self-asphyxial behavior to achieve a euphoric high (The Choking Game; TCG), occurs most often during early adolescence. Participants in TCG often engage in other risky behaviors. This study investigated the relationship between prior experience with TCG and problematic drinking behaviors in emerging adulthood. Emerging adults, 18 to 25 years old (N = 1248), 56% female, and 78% Caucasian completed an online survey regarding knowledge of and prior engagement in TCG and current drinking behaviors. Participants who personally engaged in TCG during childhood/adolescence or were familiar with TCG reported significantly more problematic drinking behaviors during emerging adulthood. Those present when others engaged in TCG but resisted participation themselves reported significantly less current problematic drinking behaviors than those who participated, but significantly more current problematic drinking behaviors than those never present. Emerging adults with increased social familiarity with TCG during adolescence endorsed greater problematic drinking behaviors. Results suggest resistance skills may generalize across time/activities