Synthesis of substituted benzooxaborinin-1-ols via palladium-catalysed cyclisation of alkenyl- and alkynyl-boronic acids

Two new palladium-catalysed reactions have been developed for the synthesis of stable 4-substituted benzooxaborinin-1-ols. A palladium-catalysed cyclisation of ortho-alkenylbenzene boronic acids can be used to access 4-chlorobenzooxaborinin-1-ols via a Wacker-type oxidation and chlorination. Alternatively, ortho-alkynylbenzene boronic acids undergo a palladium-catalysed oxyallylation reaction to provide 4-allylbenzooxaborinin-1-ols

Dyspepsia prevalence and impact on quality of life among Rwandan healthcare workers: A cross-sectional survey

Background. Dyspepsia has been demonstrated worldwide to have major personal and societal  impacts, but data on the burden of this disease in Africa are lacking.Objective. To document the prevalence of dyspepsia and its quality-of-life impact among healthcare  workers (HCWs) at Butare University Teaching Hospital (BUTH), Rwanda.Methods. A cross-sectional survey among consenting HCWs at BUTH was conducted. Multilingual  interviewers guided participants through validated questionnaires, including the Short-Form Leeds Dyspepsia Questionnaire (SF-LDQ), to detect the presence and frequency of dyspeptic symptoms, and the Short-Form Nepean Dyspepsia Index (SF-NDI), to examine the impact of dyspepsia on quality of life.Results. The study included 378 enrolled HCWs, all of whom provided responses to the SF-LDQ and 356 of whom responded to the SF-NDI. The prevalence of dyspepsia in the study population was 38.9% (147/378). Of these 147 HCWs, 79 (53.7%) had very mild dyspepsia, 33 (22.4%) had mild dyspepsia, 20 (13.6%) had moderate dyspepsia and 15 (10.2%) had severe dyspepsia. Females were more likely to complain of dyspepsia than males (98/206 v. 49/172; odds ratio (OR) 2.3; 95% confidence interval (CI) 1.5 - 3.5; p<0.001). Participants with dyspepsia of at least mild severity had SF-NDI scores reflecting reduced quality of life when compared with non-dyspeptic participants (OR 17.0; 95% CI 5.0 - 57.1; p<0.001), with most marked effects on the ‘tension’ and ‘eating and drinking’ subdomains of theSF-NDI.Conclusion. The prevalence of dyspepsia among HCWs in Rwanda is high and is associated with lowered quality of life

Ocean processes at the Antarctic continental slope

The Antarctic continental shelves and slopes occupy relatively small areas, but, nevertheless, are important for global climate, biogeochemical cycling and ecosystem functioning. Processes of water mass transformation through sea ice formation/melting and ocean-atmosphere interaction are key to the formation of deep and bottom waters as well as determining the heat flux beneath ice shelves. Climate models, however, struggle to capture these physical processes and are unable to reproduce water mass properties of the region. Dynamics at the continental slope are key for correctly modelling climate, yet their small spatial scale presents challenges both for ocean modelling and for observational studies. Cross-slope exchange processes are also vital for the flux of nutrients such as iron from the continental shelf into the mixed layer of the Southern Ocean. An iron-cycling model embedded in an eddy-permitting ocean model reveals the importance of sedimentary iron in fertilizing parts of the Southern Ocean. Ocean gliders play a key role in improving our ability to observe and understand these small-scale processes at the continental shelf break. The Gliders: Excellent New Tools for Observing the Ocean (GENTOO) project deployed three Seagliders for up to two months in early 2012 to sample the water to the east of the Antarctic Peninsula in unprecedented temporal and spatial detail. The glider data resolve small-scale exchange processes across the shelf-break front (the Antarctic Slope Front) and the front\u27s biogeochemical signature. GENTOO demonstrated the capability of ocean gliders to play a key role in a future multi-disciplinary Southern Ocean observing system

Reference to index of the High School of Hobart town

The High School was founded in 1848 by a group of leading Presbyterians and Free Churchmen, including Rev. John Lillie, Minister of St. Andrews Church, Hobart, G.W.Walker, R. Officer t T.D.Chapman, etc. A grant of land on the Domain was received from the Crown and a building designed by A. Dawson was begun in 1848 by Messrs. Cleghorn and Anderson, costing about $3600. By 1851 there were already 81 pupils, by 1859 boarders were taken and a junior department had been started. Dr. Lillie was the first Rector. In 1857 Rev. R.D.P. Harris took up the appointment of Rector and remained until 1885, leasing the school from the shareholders from 1862. In 1885 the rights were handed over to Christ College and the building sold to the University of Tasmania in 1892. Other papers relating to the High School held by F.C.Wolfhagen were not received. These include some correspondence relating to the land grant, 1846-50, and a printed copy of the petition to the Legislative Council to allow the High School to vest the premises in the University of Tasmania, which includes a note of the history of the school. Other material is held by the Mitchell Library, Sydney, and Christ College Trust. The object of the High School, as originally described, was 'the instruction of youth in the higher branches of learning, as taught in superior classical and mathematical schools in England', the ultimate object being 'to confer on Australian youth the inestimable advantages of an European University'. The school opened in 1850 and 56 boys were enrolled in the first quarter. The number had increased to 81 at the beginning of 1851. By 1859 boarders were being taken and a junior department had been started iIn 1857 Rev. R.D.P. Harris took up the appointment of Rector and remained until 1885, leasing the school from the shareholders from 1862. In 1885 the rights were handed over to Christ College and the building sold to the University of Tasmania in 1892

Character building in childrens’ online information behaviours: applying a virtue epistemology perspective to information literacy.

This paper advances our understanding of the theoretical and practical challenges of developing intellectual character in children’s online information behaviours. We argue that widely reported issues such as misinformation and disinformation extend IL education beyond considerations of ability to considerations of disposition, and highlight this as an understudied topic within IL education. We introduce the classical concept of intellectual character and discuss virtues traits in the IL context. Applying Baehr’s nine intellectual virtues to two commonly cited IL models, we evidence limited presence of virtues in IL models, and propose an important agenda for future research

Surface and Temporal Biosignatures

Recent discoveries of potentially habitable exoplanets have ignited the prospect of spectroscopic investigations of exoplanet surfaces and atmospheres for signs of life. This chapter provides an overview of potential surface and temporal exoplanet biosignatures, reviewing Earth analogues and proposed applications based on observations and models. The vegetation red-edge (VRE) remains the most well-studied surface biosignature. Extensions of the VRE, spectral "edges" produced in part by photosynthetic or nonphotosynthetic pigments, may likewise present potential evidence of life. Polarization signatures have the capacity to discriminate between biotic and abiotic "edge" features in the face of false positives from band-gap generating material. Temporal biosignatures -- modulations in measurable quantities such as gas abundances (e.g., CO2), surface features, or emission of light (e.g., fluorescence, bioluminescence) that can be directly linked to the actions of a biosphere -- are in general less well studied than surface or gaseous biosignatures. However, remote observations of Earth's biosphere nonetheless provide proofs of concept for these techniques and are reviewed here. Surface and temporal biosignatures provide complementary information to gaseous biosignatures, and while likely more challenging to observe, would contribute information inaccessible from study of the time-averaged atmospheric composition alone.Comment: 26 pages, 9 figures, review to appear in Handbook of Exoplanets. Fixed figure conversion error