A negative answer to a question of Bass

In this companion paper to arXiv:0802.1928 we provide an example of an isolated surface singularity $R$ over a number field such that $K_0(R) = K_0(R[t])$ but $K_0(R) \neq K_0(R[t_1,t_2])$. This answers, negatively, a question of Bass.Comment: The paper was previously part of arXiv:0802.192

Bass’ \u3ci\u3eNK\u3c/i\u3e groups and \u3ci\u3ecd h\u3c/i\u3e-fibrant Hochschild homology

The K-theory of a polynomial ring R[t ] contains the K-theory of R as a summand. For R commutative and containing Q, we describe K∗(R[t ])/K∗(R) in terms of Hochschild homology and the cohomology of Kähler differentials for the cdh topology. We use this to address Bass’ question, whether Kn(R) = Kn(R[t ]) implies Kn(R) = Kn(R[t1, t2]). The answer to this question is affirmative when R is essentially of finite type over the complex numbers, but negative in general

Bass' NKNK groups and cdhcdh-fibrant Hochschild homology

The $K$-theory of a polynomial ring $R[t]$ contains the $K$-theory of $R$ as a summand. For $R$ commutative and containing \Q, we describe $K_*(R[t])/K_*(R)$ in terms of Hochschild homology and the cohomology of K\"ahler differentials for the $cdh$ topology. We use this to address Bass' question, on whether $K_n(R)=K_n(R[t])$ implies $K_n(R)=K_n(R[t_1,t_2])$. The answer is positive over fields of infinite transcendence degree; the companion paper arXiv:1004.3829 provides a counterexample over a number field.Comment: The article was split into two parts on referee's suggestion in 4/2010. This is the first part; the second can be found at arXiv:1004.382

Peripartum cardiomyopathy: diagnosis and management

No abstract available

TPL-2 restricts Ccl24-dependent immunity to Heligmosomoides polygyrus

Funding: This work was supported by the Francis Crick Institute which receives its core funding from Cancer Research UK (FC001220), the UK Medical Research Council (FC001220), and the Wellcome Trust (FC001200). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Acknowledgments We are indebted to The Francis Crick Institute Flow Cytometry facility, and in particular Bhavik Patel, Graham Preece, Wayne Turnbull and Phil Hobson. We would also like to thank The Francis Crick Institute Procedural Service Section for production of GA lines and Biological Services, especially Trisha Norton, Keith Williams and Adebambo Adekoya for animal husbandry and technical support; to Riccardo Guidi for constructive discussions and technical assistance. We would like to thank Gitta Stockinger and AhR Immunity Laboratory for providing technical support and reagents throughout this study. We also thank Richard Rance and the Wellcome Trust Sanger Institute’s 454 pyrosequencing team for generating 16S rRNA gene data.Peer reviewedPublisher PD

Optimum community energy storage for renewable energy and demand load management

While the management of PV generation is the prime application of residential batteries, they can deliver additional services in order to help systems to become cost-competitive. They can level-out the demand and potentially reduce the cost and emissions of the energy system by reducing demand peaks. In this study, community energy storage (CES) is optimised to perform both PV energy time-shift and demand load shifting (using retail tariffs with varying prices blocks) simultaneously. The optimisation method obtains the techno-economic benefits of CES systems as a function of the size of the community ranging from a single home to a 100-home community in two different scenarios for the United Kingdom: the year 2020 and a hypothetical zero emissions target. It is demonstrated that the levelised cost and levelised value of CES systems reach intermediate values to those achieved when both applications are performed independently. For the optimal performance of a battery system being charged from both local PV plants and the grid, our results suggest that the battery should be sized suitable to ensure it can fully discharge during the peak period

Supercritical fluid explosion process to aid fractionation of lipids from biomass

Disclosed are processes for development and recovery of lipids from biomass. A plant or microorganism-based biomass can be developed to encourage a desired lipid profile. Following development, ecologically friendly normally gaseous fluids such as carbon dioxide can be pressurized to a supercritical state followed by rapid expansion. The fluid is first contacted with a biomass source including oil-containing microorganisms and/or agricultural products. For instance, fungi or algae can be bioconverted from another biomass sources such as canola seed or corn syrup and then contacted with the high pressure fluid. During a contact period, the fluid can diffuse into the biomass, and in particular through the cell walls of the biomass. The fluid undergoes rapid release of pressure and opens the cell structure for improved release of oil. The fluid can optionally be utilized for extraction following the explosion process. For instance, the fluid can be re-pressurized in the same vessel for extraction processes

Rationale and design of the Clinical Evaluation of Magnetic Resonance Imaging in Coronary heart disease 2 trial (CE-MARC 2): a prospective, multicenter, randomized trial of diagnostic strategies in suspected coronary heart disease

Background: A number of investigative strategies exist for the diagnosis of coronary heart disease (CHD). Despite the widespread availability of noninvasive imaging, invasive angiography is commonly used early in the diagnostic pathway. Consequently, approximately 60% of angiograms reveal no evidence of obstructive coronary disease. Reducing unnecessary angiography has potential financial savings and avoids exposing the patient to unnecessary risk. There are no large-scale comparative effectiveness trials of the different diagnostic strategies recommended in international guidelines and none that have evaluated the safety and efficacy of cardiovascular magnetic resonance.<p></p> Trial Design: CE-MARC 2 is a prospective, multicenter, 3-arm parallel group, randomized controlled trial of patients with suspected CHD (pretest likelihood 10%-90%) requiring further investigation. A total of 1,200 patients will be randomized on a 2:2:1 basis to receive 3.0-T cardiovascular magnetic resonance–guided care, single-photon emission computed tomography–guided care (according to American College of Cardiology/American Heart Association appropriate-use criteria), or National Institute for Health and Care Excellence guidelines–based management. The primary (efficacy) end point is the occurrence of unnecessary angiography as defined by a normal (>0.8) invasive fractional flow reserve. Safety of each strategy will be assessed by 3-year major adverse cardiovascular event rates. Cost-effectiveness and health-related quality-of-life measures will be performed.<p></p> Conclusions: The CE-MARC 2 trial will provide comparative efficacy and safety evidence for 3 different strategies of investigating patients with suspected CHD, with the intension of reducing unnecessary invasive angiography rates. Evaluation of these management strategies has the potential to improve patient care, health-related quality of life, and the cost-effectiveness of CHD investigation

'Another, More Sinister Reality': Class, Youth and Psychopathology from Saturday Night and Sunday Morning to Endless Night

This article analyses how the protagonists of films such as Saturday Night and Sunday Morning (1959), The Collector (1965), Blow Up (1966), Twisted Nerve (1968) and Endless Night (1972) were understood in relation to debates over the supposed perils of the new affluence and the erosion of class distinctions that it was presumed to entail. In particular it examines the terms in which these issues were discussed within contemporaneous reviews of the films, terms that were insistently psychological. These protagonists, as well as, to a certain extent, the actors who played them, were seen as representing a nightmare image of a ‘new’ working class that no longer ‘knew its place’, and as manifesting psychological problems that were associated with this intermediate status. Their psychologies were interpreted by many critics as being distinguished by a sense of isolation from external reality and by a hostile relationship to the world characterised by a psychopathic lack of empathy. Such concerns could be seen as establishing certain parallels between working-class realism and the contemporaneous horror film, and indeed the reviews cited in this article demonstrate that working-class realism and horror were seen as having shared points of interest in the 1960s, points that have often been repressed by the tendency to compartmentalise British cinema history into separate or even opposed ‘traditions’

Observations from the Basin and Range Province (Western United States) Pertinent to the Interpretation of Regional Detachment Faults

This paper summarizes the results of completed and ongoing research in three areas of the Basin and Range Province of the western United States that casts doubt on the interpretation of specific regional detachment faults and the large extensional strains with which such faults are commonly associated. Given that these examples were influential in the development of ideas about low-angle normal faults, and particularly in making the case for frictional slip at dips of appreciably less than the 30° lock-up angle for μ ≈ 0.6 (where μ is the coefficient of friction), we advocate a critical re-examination of interpreted detachments elsewhere in the Basin and Range Province and in other extensional and passive margin settings. The Sevier Desert ‘detachment’ of west-central Utah is reinterpreted as a Palaeogene unconformity that has been traced to depth west of the northern Sevier Desert basin along an unrelated seismic reflection (most probably a splay of the Cretaceous-age Pavant thrust). The absence of evidence in well cuttings and cores for either brittle deformation (above) or ductile deformation (below) is inconsistent with the existence of a fault with as much as 40 km of displacement. The Pavant thrust and the structurally higher Canyon Range thrust are erosionally truncated at the western margin of the southern Sevier Desert basin, and are not offset by the ‘detachment’ in the manner assumed by those inferring large extension across the basin. The Mormon Peak detachment of SE Nevada is reinterpreted as a series of slide blocks on the basis of detachment characteristics and spatially variable kinematic indicators that are more closely aligned with the modern dip direction than the inferred regional extension direction. A particularly distinctive feature of the detachment is a basal layer of up to several tens of centimetres of polymictic conglomerate that was demonstrably involved in the deformation, with clastic dykes of the same material extending for several metres into overlying rocks in a manner remarkably similar to that observed at rapidly emplaced slide blocks. The Castle Cliff detachment in the nearby Beaver Dam Mountains of SW Utah is similarly regarded as a surficial feature, as originally interpreted, and consistent with its conspicuous absence in seismic reflection profiles from the adjacent sedimentary basin. The middle Miocene Eagle Mountain Formation of eastern California, interpreted on the basis of facies evidence and distinctive clast provenance to have been moved tectonically more than 80 km ESE from a location close to the Jurassic-age Hunter Mountain batholith of the Cottonwood Mountains, is reinterpreted as having accumulated in a fluvial–lacustrine rather than alluvial fan–lacustrine setting, with no bearing on either the amount or direction of tectonic transport. The conglomeratic rocks upon which the provenance argument was based are pervasively channelized, with erosional relief of less than 1 m to as much as 15 m, fining-upwards successions at the same scale and abundant trough cross-stratification – all characteristic features of fluvial sedimentation and not of alluvial fans. The interpretation of the Eagle Mountain Formation as having been deposited within a few kilometres of the Hunter Mountain batholith, which depends strongly on assumptions about the dimensions of alluvial fans, is therefore not required. The result is important because the Eagle Mountain offset has been viewed as representing the strongest evidence for extreme extension in this part of California, and for the existence of detachment faults of regional dimensions