A numerical study of the Southern Ocean including a thermodynamic active ice shelf - Part 1: Weddell Sea

There is a great amount of uncertainty regarding the understanding of the atmosphere-ocean-cryosphere interactions in the Southern Ocean despite the role that the region plays in our changing climate. With the aim of studying the relative importance of sea-ice and ice shelf processes in the Southern Ocean, a coupled ocean circulation sea-ice/ice shelf cavity model based on the Regional Ocean Model System (ROMS) is used in a periodic circumpolar domain with enhanced resolution in the Weddell Sea. A hierarchy of numerical experiments is performed where first a sea-ice model is used and then an ice shelf thermodynamic parameterization is included in order to evaluate the improvements resulting from each component. Results show that it is necessary to consider the formation and melting of sea-ice in order to adequately reproduce the observed hydrography and circulation. Inclusion of ice shelves cavities in the model only improves results if the ice shelf-ocean thermodynamic fluxes are active. Ice shelves and ocean interactions are an important process to be considered in order to obtain realistic hydrographic values under the ice shelf. The model framework presented in this work is a promising tool for analyzing the Southern Ocean response to future climate change scenarios

Enlightening the structure and dynamics of Abell 1942

We present a dynamical analysis of the galaxy cluster Abell 1942 based on a set of 128 velocities obtained at the European Southern Observatory. Data on individual galaxies are presented and the accuracy of the determined velocities is discussed as well as some properties of the cluster. We have also made use of publicly available Chandra X-ray data. We obtained an improved mean redshift value z = 0.22513 \pm 0.0008 and velocity dispersion sigma = 908^{+147}_{-139} km/s. Our analysis indicates that inside a radius of ~1.5 h_{70}^{-1} Mpc (~7 arcmin) the cluster is well relaxed, without any remarkable feature and the X-ray emission traces fairly well the galaxy distribution. Two possible optical substructures are seen at ~5 arcmin from the centre towards the Northwest and the Southwest direction, but are not confirmed by the velocity field. These clumps are however, kinematically bound to the main structure of Abell 1942. X-ray spectroscopic analysis of Chandra data resulted in a temperature kT = 5.5 \pm 0.5 keV and metal abundance Z = 0.33 \pm 0.15 Z_odot. The velocity dispersion corresponding to this temperature using the T_X-sigma scaling relation is in good agreement with the measured galaxies velocities. Our photometric redshift analysis suggests that the weak lensing signal observed at the south of the cluster and previously attributed to a "dark clump", is produced by background sources, possibly distributed as a filamentary structure.Comment: Accepted for publication in Astronomy & Astrophysics, 15 pages, 15 figures, table w/ positions, photometric data and redshift

The Cluster of Galaxies Abell 970

We present a dynamical analysis of the galaxy cluster Abell 970 based on a new set of radial velocities measured at ESO, Pic du Midi and Haute-Provence observatories. Our analysis indicates that this cluster has a substructure and is out of dynamical equilibrium. This conclusion is also supported by differences in the positions of the peaks of the surface density distribution and X-ray emission, as well as by the evidence of a large scale velocity gradient in the cluster. We also found a discrepancy between the masses inferred with the virial theorem and with the X-ray emission, what is expected if the galaxies and the gas inside the cluster are not in hydrostatic equilibrium. Abell 970 has a modest cooling flow, as is expected if it is out of equilibrium as suggested by Allen (1998). We propose that cooling flows may have an intermittent behavior, with phases of massive cooling flows being followed by phases without significant cooling flows after the acretion of a galaxy group massive enough to disrupt the dynamical equilibrium in the center of the clusters. A massive cooling flow will be established again, after a new equilibrium is achieved.Comment: 24 pages, 9 figures, submitted to A&

Coordinated analysis of age, sex, and education effects on change in MMSE scores

Objectives. We describe and compare the expected performance trajectories of older adults on the Mini-Mental Status Examination (MMSE) across six independent studies from four countries in the context of a collaborative network of longitudinal studies of aging. A coordinated analysis approach is used to compare patterns of change conditional on sample composition differences related to age, sex, and education. Such coordination accelerates evaluation of particular hypotheses. In particular, we focus on the effect of educational attainment on cognitive decline.Method. Regular and Tobit mixed models were fit to MMSE scores from each study separately. The effects of age, sex, and education were examined based on more than one centering point.Results. Findings were relatively consistent across studies. On average, MMSE scores were lower for older individuals and declined over time. Education predicted MMSE score, but, with two exceptions, was not associated with decline in MMSE over time.Conclusion. A straightforward association between educational attainment and rate of cognitive decline was not supported. Thoughtful consideration is needed when synthesizing evidence across studies, as methodologies adopted and sample characteristics, such as educational attainment, invariably differ. © 2012 The Author

Unexpected Consequences: Women’s experiences of a self-hypnosis intervention to help with pain relief during labour.

Background Self-hypnosis is becoming increasingly popular as a means of labour pain management. Previous studies have produced mixed results. There are very few data on women’s views and experiences of using hypnosis in this context. As part of a randomized controlled trial of self-hypnosis for intra-partum pain relief (the SHIP Trial) we conducted qualitative interviews with women randomized to the intervention arm to explore their views and experiences of using self-hypnosis during labour and birth. Methods Participants were randomly selected from the intervention arm of the study, which consisted of two antenatal self-hypnosis training sessions and a supporting CD that women were encouraged to listen to daily from 32 weeks gestation until the birth of their baby. Those who consented were interviewed in their own homes 8-12 weeks after birth. Following transcription, the interviews were analysed iteratively and emerging concepts were discussed amongst the authors to generate organizing themes. These were then used to develop a principal organizing metaphor or global theme, in a process known as thematic networks analysis. Results Of the 343 women in the intervention group, 48 were invited to interview, and 16 were interviewed over a 12 month period from February 2012 to January 2013. Coding of the data and subsequent analysis revealed a global theme of ‘unexpected consequences’, supported by 5 organising themes, ‘calmness in a climate of fear’, ‘from sceptic to believer’, ‘finding my space’, ‘delays and disappointments’ and ‘personal preferences’. Most respondents reported positive experiences of self-hypnosis and highlighted feelings of calmness, confidence and empowerment. They found the intervention to be beneficial and used a range of novel strategies to personalize their self-hypnosis practice. Occasionally women reported feeling frustrated or disappointed when their relaxed state was misinterpreted by midwives on admission or when their labour and birth experiences did not match their expectations. Conclusion The women in this study generally appreciated antenatal self-hypnosis training and found it to be beneficial during labour and birth. The state of focused relaxation experienced by women using the technique needs to be recognized by providers if the intervention is to be implemented into the maternity service

Polymorphism rs3088232 in the BRDT gene is associated with idiopathic male infertility in the West Siberian Region of Russia

Allelic variants of genes involved in spermatogenesis can contribute to the genetic predisposition to idiopathic male infertility. In the present study we investigated the association of polymorphism rs3088232 in the BRDT gene with the risk of this pathology on the sample of 105 infertile patients and 230 healthy controls. We revealed the association of allele G (OR = 1.80; CI 1.16—2.80; p = 0.008) and genotype GG (OR = 6.47; CI 1.23—34.15; p = 0.01) with idiopathic male infertility

Enantioselective liquid chromatography–mass spectrometry assay for the determination of ifosfamide and identification of the N-dechloroethylated metabolites of ifosfamide in human plasma

A sensitive and specific liquid chromatography-mass spectrometry (LC-MS) method has been developed and validated for the enantioselective determination of ifosfamide [(R)-IF and (S)-IF] in human plasma and for the detection of the N-dechloroethylated metabolites of IF, 2-N-dechloroethylifosfamide [(R)-2-DCl-IF and (S)-2-DCl-IF] and 3-N-dechloroethylifosfamide [(R)-3-DCl-IF and (S)-3-DCl-IF]. IF, 2-DCl-IF and 3-DCl-IF were extracted from plasma using solid-phase extraction and resolved by liquid chromatography on a column containing a Chirabiotic T chiral stationary phase. The enantioselective separations were achieved using a mobile phase composed of 2-propanol:methanol (60:40 v/v) and a flow rate of 0.5 ml/min. The observed enantioselectivities (α) for IF, 2-DCl-IF and 3-DCl-IF were 1.20, 1.17 and 1.20, respectively. The calibration curve was linear in the concentration range of 37.50-4800 ng/ml for each ifosfamide enantiomer (r2 > 0.997). The lower limit of detection (LLOD) was 5.00 ng/ml. The inter- and intra-day precision ranged from 3.63 to 15.8 % relative standard deviation (RSD) and 10.1 to 14.3 % RSD, respectively, and the accuracy ranged from 89.2 to 101.5 % of the nominal values. The method was applied to the analysis of plasma samples obtained from a cancer patient who received 3.75 g/m2/d dose of (R,S)-ifosfamide as a 96-h continuous infusion

On the Security of Delegation in Access Control Systems

Abstract. Delegation is a mechanism that allows a user A to act on another user B’s behalf by making B’s access rights available to A. It is well recognized as an important mechanism to provide resiliency and flexibility in access control systems, and has gained popularity in the research community. However, most existing literature focuses on modeling and managing delegations. Little work has been done on understanding the impact of delegation on the security of existing access control systems. In particular, no formal notion of security with respect to delegation has been proposed. Many existing access control systems are designed without having delegation in mind. Simply incorporating a delegation module into those systems may cause security breaches. This paper focuses on the security aspect of delegation in access control systems. We first give examples on how colluding users may abuse the delegation sup-port of access control systems to circumvent security policies, such as separation of duty. As a major contribution, we propose a formal notion of security with respect to delegation in access control systems. After that, we discuss potential mechanisms to enforce security. In particular, we design a novel source-based en-forcement mechanism for workflow authorization systems so as to achieve both security and efficiency.

Farming fit? Dispelling the Australian agrarian myth

Background: Rural Australians face a higher mental health and lifestyle disease burden (obesity, diabetes andcardiovascular disease) than their urban counterparts. Our ongoing research reveals that the Australian farmingcommunity has even poorer physical and mental health outcomes than rural averages. In particular, farm men andwomen have high rates of overweightness, obesity, abdominal adiposity, high blood pressure and psychologicaldistress when compared against Australian averages. Within our farming cohort we observed a significantassociation between psychological distress and obesity, abdominal adiposity and body fat percentage in thefarming population.Presentation of hypothesis: This paper presents a hypothesis based on preliminary data obtained from anongoing study that could potentially explain the complex correlation between obesity, psychological distress andphysical activity among a farming population. We posit that spasmodic physical activity, changing farm practicesand climate variability induce prolonged stress in farmers. This increases systemic cortisol that, in turn, promotesabdominal adiposity and weight gain.Testing the hypothesis: The hypothesis will be tested by anthropometric, biochemical and psychological analysismatched against systemic cortisol levels and the physical activity of the subjects.Implications of the hypothesis tested: Previous studies indicate that farming populations have elevated rates ofpsychological distress and high rates of suicide. Australian farmers have recently experienced challenging climaticconditions including prolonged drought, floods and cyclones. Through our interactions and through the media it isnot uncommon for farmers to describe the effect of this long-term stress with feelings of &lsquo;defeat&rsquo;. By gaining agreater understanding of the role cortisol and physical activity have on mental and physical health we maypositively impact the current rates of psychological distress in farmers.<br /