Prevençao Secundária da Morte Súbita: Importância do Marcapasso Definitivo Prévio ao Implante de Cardioversor-desfibrilador Implantável (CDI) na Sobrevida de Pacientes com Miocardiopatia Chagásica

Objetivo: Avaliar a importância clínica da presença de marcapasso definitivo (MPD) previamente ao implante de CDI, considerando variáveis clínicas e epidemiológicas. Métodos: Dos 321 pacientes do banco de dados de CDI de nossa instituiçao, foram selecionados 275 submetidos a implante de CDI para prevençao secundária de morte súbita cardíaca (MSC), agrupados de acordo com a cardiomiopatia de base e a presença de MPD prévio ao implante de CDI. As variáveis analisadas foram: sexo, idade, CF-NYHA, medicaçoes, ritmo cardíaco, FEVE e TVNS. Para análise estatística, utilizou-se o método de Kaplan-Meier e o teste de log-rank. Resultados: A amostra reduzida de pacientes com cardiomiopatia nao chagásica e MPD prévio ao implante de CDI (N=6) nao permitiu análises estatísticas consistentes. Nos pacientes com cardiomiopatia chagásica (CCH), as características de base nos subgrupos com e sem MPD prévio foram estatisticamente semelhantes, exceto pela maior prevalência de TVNS no subgrupo sem MPD prévio. Nos pacientes com CCH, a comparaçao das curvas de sobrevida dos subgrupos com e sem MPD prévio evidenciou uma diferença significativa (p&0,05). A probabilidade de sobrevida no final do primeiro e terceiro anos foi de 78% e 39% nos pacientes com MPD prévio (N=18) e 87% e 58% nos pacientes sem MPD prévio (N=72). Conclusoes: Nos pacientes com CCH submetidos a implante de CDI para prevençao secundária de MSC, a presença de MPD previamente ao implante de CDI apresentou prevalência elevada (20%) e associou-se a um pior prognóstico

Prevençao Secundária da Morte Súbita: Importância do Marcapasso Definitivo Prévio ao Implante de Cardioversor-desfibrilador Implantável (CDI) na Sobrevida de Pacientes com Miocardiopatia Chagásica

Objetivo: Avaliar a importância clínica da presença de marcapasso definitivo (MPD) previamente ao implante de CDI, considerando variáveis clínicas e epidemiológicas. Métodos: Dos 321 pacientes do banco de dados de CDI de nossa instituiçao, foram selecionados 275 submetidos a implante de CDI para prevençao secundária de morte súbita cardíaca (MSC), agrupados de acordo com a cardiomiopatia de base e a presença de MPD prévio ao implante de CDI. As variáveis analisadas foram: sexo, idade, CF-NYHA, medicaçoes, ritmo cardíaco, FEVE e TVNS. Para análise estatística, utilizou-se o método de Kaplan-Meier e o teste de log-rank. Resultados: A amostra reduzida de pacientes com cardiomiopatia nao chagásica e MPD prévio ao implante de CDI (N=6) nao permitiu análises estatísticas consistentes. Nos pacientes com cardiomiopatia chagásica (CCH), as características de base nos subgrupos com e sem MPD prévio foram estatisticamente semelhantes, exceto pela maior prevalência de TVNS no subgrupo sem MPD prévio. Nos pacientes com CCH, a comparaçao das curvas de sobrevida dos subgrupos com e sem MPD prévio evidenciou uma diferença significativa (p&0,05). A probabilidade de sobrevida no final do primeiro e terceiro anos foi de 78% e 39% nos pacientes com MPD prévio (N=18) e 87% e 58% nos pacientes sem MPD prévio (N=72). Conclusoes: Nos pacientes com CCH submetidos a implante de CDI para prevençao secundária de MSC, a presença de MPD previamente ao implante de CDI apresentou prevalência elevada (20%) e associou-se a um pior prognóstico

Carbon Dioxide Utilisation -The Formate Route

UIDB/50006/2020 CEEC-Individual 2017 Program Contract.The relentless rise of atmospheric CO2 is causing large and unpredictable impacts on the Earth climate, due to the CO2 significant greenhouse effect, besides being responsible for the ocean acidification, with consequent huge impacts in our daily lives and in all forms of life. To stop spiral of destruction, we must actively reduce the CO2 emissions and develop new and more efficient “CO2 sinks”. We should be focused on the opportunities provided by exploiting this novel and huge carbon feedstock to produce de novo fuels and added-value compounds. The conversion of CO2 into formate offers key advantages for carbon recycling, and formate dehydrogenase (FDH) enzymes are at the centre of intense research, due to the “green” advantages the bioconversion can offer, namely substrate and product selectivity and specificity, in reactions run at ambient temperature and pressure and neutral pH. In this chapter, we describe the remarkable recent progress towards efficient and selective FDH-catalysed CO2 reduction to formate. We focus on the enzymes, discussing their structure and mechanism of action. Selected promising studies and successful proof of concepts of FDH-dependent CO2 reduction to formate and beyond are discussed, to highlight the power of FDHs and the challenges this CO2 bioconversion still faces.publishersversionpublishe

Open data from the third observing run of LIGO, Virgo, KAGRA and GEO

The global network of gravitational-wave observatories now includes five detectors, namely LIGO Hanford, LIGO Livingston, Virgo, KAGRA, and GEO 600. These detectors collected data during their third observing run, O3, composed of three phases: O3a starting in April of 2019 and lasting six months, O3b starting in November of 2019 and lasting five months, and O3GK starting in April of 2020 and lasting 2 weeks. In this paper we describe these data and various other science products that can be freely accessed through the Gravitational Wave Open Science Center at https://gwosc.org. The main dataset, consisting of the gravitational-wave strain time series that contains the astrophysical signals, is released together with supporting data useful for their analysis and documentation, tutorials, as well as analysis software packages.Comment: 27 pages, 3 figure

Search for Eccentric Black Hole Coalescences during the Third Observing Run of LIGO and Virgo

Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass $M>70$ $M_\odot$) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities $0 < e \leq 0.3$ at $0.33$ Gpc$^{-3}$ yr$^{-1}$ at 90\% confidence level.Comment: 24 pages, 5 figure

Open data from the third observing run of LIGO, Virgo, KAGRA, and GEO

The global network of gravitational-wave observatories now includes five detectors, namely LIGO Hanford, LIGO Livingston, Virgo, KAGRA, and GEO 600. These detectors collected data during their third observing run, O3, composed of three phases: O3a starting in 2019 April and lasting six months, O3b starting in 2019 November and lasting five months, and O3GK starting in 2020 April and lasting two weeks. In this paper we describe these data and various other science products that can be freely accessed through the Gravitational Wave Open Science Center at https://gwosc.org. The main data set, consisting of the gravitational-wave strain time series that contains the astrophysical signals, is released together with supporting data useful for their analysis and documentation, tutorials, as well as analysis software packages