1,617 research outputs found
Rationale, design and methods of the Study of Work and Pain (SWAP): a cluster randomised controlled trial testing the addition of a vocational advice service to best current primary care for patients with musculoskeletal pain (ISRCTN 52269669)
Background
Musculoskeletal pain is a major contributor to short and long term work absence. Patients
seek care from their general practitioner (GP) and yet GPs often feel ill-equipped to deal with
work issues. Providing a vocational case management service in primary care, to support
patients with musculoskeletal problems to remain at or return to work, is one potential
solution but requires robust evaluation to test clinical and cost-effectiveness.
Methods/Design
This protocol describes a cluster randomised controlled trial, with linked qualitative
interviews, to investigate the effect of introducing a vocational advice service into general
practice, to provide a structured approach to managing work related issues in primary care
patients with musculoskeletal pain who are absent from work or struggling to remain in work.
General practices (n = 6) will be randomised to offer best current care or best current care
plus a vocational advice service. Adults of working age who are absent from or struggling to
remain in work due to a musculoskeletal pain problem will be invited to participate and 330
participants will be recruited. Data collection will be through patient completed
questionnaires at baseline, 4 and 12 months. The primary outcome is self-reported work
absence at 4 months. Incremental cost-utility analysis will be undertaken to calculate the cost
per additional QALY gained and incremental net benefits. A linked interview study will
explore the experiences of the vocational advice service from the perspectives of GPs, nurse
practitioners (NPs), patients and vocational advisors.
Discussion
This paper presents the rationale, design, and methods of the Study of Work And Pain
(SWAP) trial. The results of this trial will provide evidence to inform primary care practice
and guide the development of services to provide support for musculoskeletal pain patients
with work-related issues.
Trial registration
Current Controlled Trials ISRCTN52269669
Comparison between resistive and collisionless double tearing modes for nearby resonant surfaces
The linear instability and nonlinear dynamics of collisional (resistive) and
collisionless (due to electron inertia) double tearing modes (DTMs) are
compared with the use of a reduced cylindrical model of a tokamak plasma. We
focus on cases where two q = 2 resonant surfaces are located a small distance
apart. It is found that regardless of the magnetic reconnection mechanism,
resistivity or electron inertia, the fastest growing linear eigenmodes may have
high poloidal mode numbers m ~ 10. The spectrum of unstable modes tends to be
broader in the collisionless case. In the nonlinear regime, it is shown that in
both cases fast growing high-m DTMs lead to an annular collapse involving small
magnetic island structures. In addition, collisionless DTMs exhibit multiple
reconnection cycles due to reversibility of collisionless reconnection and
strong ExB flows. Collisionless reconnection leads to a saturated stable state,
while in the collisional case resistive decay keeps the system weakly dynamic
by driving it back towards the unstable equilibrium maintained by a source
term.Comment: 15 pages, 9 figure
Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis
Oesophageal adenocarcinoma (EAC) incidence is rapidly increasing in Western countries. A better understanding of EAC underpins efforts to improve early detection and treatment outcomes. While large EAC exome sequencing efforts to date have found recurrent loss-offunction mutations, oncogenic driving events have been underrepresented. Here we use a combination of whole-genome sequencing (WGS) and single-nucleotide polymorphism-array profiling to show that genomic catastrophes are frequent in EAC, with almost a third (32%, nÂĽ40/123) undergoing chromothriptic events. WGS of 22 EAC cases show that catastrophes may lead to oncogene amplification through chromothripsis-derived double-minute chromosome formation (MYC and MDM2) or breakage-fusion-bridge (KRAS, MDM2 and RFC3). Telomere shortening is more prominent in EACs bearing localized complex rearrangements. Mutational signature analysis also confirms that extreme genomic instability in EAC can be driven by somatic BRCA2 mutations. These findings suggest that genomic catastrophes have a significant role in the malignant transformation of EAC
Use of DNA–Damaging Agents and RNA Pooling to Assess Expression Profiles Associated with BRCA1 and BRCA2 Mutation Status in Familial Breast Cancer Patients
A large number of rare sequence variants of unknown clinical significance have been identified in the breast cancer susceptibility genes, BRCA1 and BRCA2. Laboratory-based methods that can distinguish between carriers of pathogenic mutations and non-carriers are likely to have utility for the classification of these sequence variants. To identify predictors of pathogenic mutation status in familial breast cancer patients, we explored the use of gene expression arrays to assess the effect of two DNA–damaging agents (irradiation and mitomycin C) on cellular response in relation to BRCA1 and BRCA2 mutation status. A range of regimes was used to treat 27 lymphoblastoid cell-lines (LCLs) derived from affected women in high-risk breast cancer families (nine BRCA1, nine BRCA2, and nine non-BRCA1/2 or BRCAX individuals) and nine LCLs from healthy individuals. Using an RNA–pooling strategy, we found that treating LCLs with 1.2 µM mitomycin C and measuring the gene expression profiles 1 hour post-treatment had the greatest potential to discriminate BRCA1, BRCA2, and BRCAX mutation status. A classifier was built using the expression profile of nine QRT–PCR validated genes that were associated with BRCA1, BRCA2, and BRCAX status in RNA pools. These nine genes could distinguish BRCA1 from BRCA2 carriers with 83% accuracy in individual samples, but three-way analysis for BRCA1, BRCA2, and BRCAX had a maximum of 59% prediction accuracy. Our results suggest that, compared to BRCA1 and BRCA2 mutation carriers, non-BRCA1/2 (BRCAX) individuals are genetically heterogeneous. This study also demonstrates the effectiveness of RNA pools to compare the expression profiles of cell-lines from BRCA1, BRCA2, and BRCAX cases after treatment with irradiation and mitomycin C as a method to prioritize treatment regimes for detailed downstream expression analysis
Illness behavior in patients on long-term sick leave due to chronic musculoskeletal pain
Background and purpose Methods for identification of patients with illness behavior in orthopedic settings are still being debated. The purpose of this study was to test the association between illness behavior, depressed mood, pain intensity, self-rated disability, and clinical status in patients with chronic musculoskeletal pain (CMP)
Some Like It Fat: Comparative Ultrastructure of the Embryo in Two Demosponges of the Genus Mycale (Order Poecilosclerida) from Antarctica and the Caribbean
0000-0002-7993-1523© 2015 Riesgo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License [4.0], which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The attached file is the published version of the article
New Mechanics of Spinal Injury
The prediction and prevention of spinal injury is an important aspect of
preventive health science. The spine, or vertebral column, represents a chain
of 26 movable vertebral bodies, joint together by transversal viscoelastic
intervertebral discs and longitudinal elastic tendons. This paper proposes a
new locally-coupled loading-rate hypothesis}, which states that the main cause
of both soft- and hard-tissue spinal injury is a localized Euclidean jolt, or
SE(3)-jolt, an impulsive loading that strikes a localized spine in several
coupled degrees-of-freedom simultaneously. To show this, based on the
previously defined covariant force law, we formulate the coupled Newton-Euler
dynamics of the local spinal motions and derive from it the corresponding
coupled SE(3)-jolt dynamics. The SE(3)-jolt is the main cause of two basic
forms of spinal injury: (i) hard-tissue injury of local translational
dislocations; and (ii) soft-tissue injury of local rotational disclinations.
Both the spinal dislocations and disclinations, as caused by the SE(3)-jolt,
are described using the Cosserat multipolar viscoelastic continuum model.
Keywords: localized spinal injury, coupled loading-rate hypothesis, coupled
Newton-Euler dynamics, Euclidean jolt dynamics, spinal dislocations and
disclinationsComment: 14 pages, 1 figure, Late
The Luminosity Function of Galaxies in SDSS Commissioning Data
During commissioning observations, the Sloan Digital Sky Survey (SDSS) has
produced one of the largest existing galaxy redshift samples selected from CCD
images. Using 11,275 galaxies complete to r^* = 17.6 over 140 square degrees,
we compute the luminosity function of galaxies in the r^* band over a range -23
< M < -16 (for h=1). The result is well-described by a Schechter function with
parameters phi_* = 0.0146 +/- 0.0012 h^3 Mpc^{-3}, M_* = -20.83 +/- 0.03, and
alpha = -1.20 +/- 0.03. The implied luminosity density in r^* is j = (2.6 +/-
0.3) x 10^8 h L_sun Mpc^{-3}. The surface brightness selection threshold has a
negligible impact for M < -18. We measure the luminosity function in the u^*,
g^*, i^*, and z^* bands as well; the slope at low luminosities ranges from
alpha=-1.35 to alpha=-1.2. We measure the bivariate distribution of r^*
luminosity with half-light surface brightness, intrinsic color, and morphology.
High surface brightness, red, highly concentrated galaxies are on average more
luminous than low surface brightness, blue, less concentrated galaxies. If we
synthesize results for R-band or b_j-band using the Petrosian magnitudes with
which the SDSS measures galaxy fluxes, we obtain luminosity densities 2.0 times
that found by the Las Campanas Redshift Survey in R and 1.4 times that found by
the Two-degree Field Galaxy Redshift Survey in b_j. We are able to reproduce
the luminosity functions obtained by these surveys if we also mimic their
isophotal limits for defining galaxy magnitudes, which are shallower and more
redshift dependent than the Petrosian magnitudes used by the SDSS. (Abridged)Comment: 49 pages, including 23 figures, accepted by AJ; some minor textual
changes, plus an important change in comparison to LCR
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