824 research outputs found
Guanosine nucleotides regulate B2 kinin receptor affinity of agonists but not of antagonists: Discussion of a model proposing receptor precoupling to G protein
The effect of nucleotides on binding of the B2 kinin (BK) receptor agonist {[}H-3]BK and the antagonist {[}H-3]NPC17731 to particulate fractions of human foreskin fibroblasts was studied. At 0 degrees C, particulate fractions exhibited a single class of binding sites with a Kd of 2.3 nM for {[}H-3]BK and a K-d Of 3.8 nM for the antagonist {[}H-3]NPC17731. Incubation with radioligands at 37 degrees C for 5 min gave a reduction of agonist, as well as antagonist, binding that was between 0-40% depending on the preparation, even in the absence of guanosine nucleotides. As shown by Scatchard analysis, this reduction in specific binding was due to a shift in the affinity of at least a fraction of the receptors. The presence at 37 degrees C of the guanine nucleotides GTP, GDP and their poorly hydrolyzable analogs left {[}H-3]-NPC17731 binding unaffected, but reduced the receptor affinity for {[}H-3]BK to a K-d Of about 15 nM. The maximal number of receptors, however, was unchanged. This affinity change was strongly dependent on the presence of bivalent cations, in particular Mg2+. It was reversed by incubation at 0 degrees C, The rank order of the guanosine nucleotides for {[}H-3]BK binding reduction was GTP{[}gamma S] = Gpp{[}NH]p > GTP = GDP > GDP{[}beta S]. GMP, ATP, ADP and AMP showed no influence on agonist binding. A model for the interaction of the B2 kinin receptor with G proteins is discussed
Dynamical System Approach to Cosmological Models with a Varying Speed of Light
Methods of dynamical systems have been used to study homogeneous and
isotropic cosmological models with a varying speed of light (VSL). We propose
two methods of reduction of dynamics to the form of planar Hamiltonian
dynamical systems for models with a time dependent equation of state. The
solutions are analyzed on two-dimensional phase space in the variables where is a function of a scale factor . Then we show how the
horizon problem may be solved on some evolutional paths. It is shown that the
models with negative curvature overcome the horizon and flatness problems. The
presented method of reduction can be adopted to the analysis of dynamics of the
universe with the general form of the equation of state .
This is demonstrated using as an example the dynamics of VSL models filled with
a non-interacting fluid. We demonstrate a new type of evolution near the
initial singularity caused by a varying speed of light. The singularity-free
oscillating universes are also admitted for positive cosmological constant. We
consider a quantum VSL FRW closed model with radiation and show that the
highest tunnelling rate occurs for a constant velocity of light if and . It is also proved that the considered class of
models is structurally unstable for the case of .Comment: 18 pages, 5 figures, RevTeX4; final version to appear in PR
Scenario of Accelerating Universe from the Phenomenological \Lambda- Models
Dark matter, the major component of the matter content of the Universe,
played a significant role at early stages during structure formation. But at
present the Universe is dark energy dominated as well as accelerating. Here,
the presence of dark energy has been established by including a time-dependent
term in the Einstein's field equations. This model is compatible with
the idea of an accelerating Universe so far as the value of the deceleration
parameter is concerned. Possibility of a change in sign of the deceleration
parameter is also discussed. The impact of considering the speed of light as
variable in the field equations has also been investigated by using a well
known time-dependent model.Comment: Latex, 9 pages, Major change
Electron transport through interacting quantum dots
We present a detailed theoretical investigation of the effect of Coulomb
interactions on electron transport through quantum dots and double barrier
structures connected to a voltage source via an arbitrary linear impedance.
Combining real time path integral techniques with the scattering matrix
approach we derive the effective action and evaluate the current-voltage
characteristics of quantum dots at sufficiently large conductances. Our
analysis reveals a reach variety of different regimes which we specify in
details for the case of chaotic quantum dots. At sufficiently low energies the
interaction correction to the current depends logarithmically on temperature
and voltage. We identify two different logarithmic regimes with the crossover
between them occurring at energies of order of the inverse dwell time of
electrons in the dot. We also analyze the frequency-dependent shot noise in
chaotic quantum dots and elucidate its direct relation to interaction effects
in mesoscopic electron transport.Comment: 21 pages, 4 figures. References added, discussion slightly extende
Grounding deep neural network predictions of human categorization behavior in understandable functional features: the case of face identity
Deep neural networks (DNNs) can resolve real-world categorization tasks with apparent human-level performance. However, true equivalence of behavioral performance between humans and their DNN models requires that their internal mechanisms process equivalent features of the stimulus. To develop such feature equivalence, our methodology leveraged an interpretable and experimentally controlled generative model of the stimuli (realistic three-dimensional textured faces). Humans rated the similarity of randomly generated faces to four familiar identities. We predicted these similarity ratings from the activations of five DNNs trained with different optimization objectives. Using information theoretic redundancy, reverse correlation, and the testing of generalization gradients, we show that DNN predictions of human behavior improve because their shape and texture features overlap with those that subsume human behavior. Thus, we must equate the functional features that subsume the behavioral performances of the brain and its models before comparing where, when, and how these features are processed
The Nature of Dark Matter
The observed strong dark-to-luminous matter coupling suggests the existence
of a some functional relation between visible and DM sources which leads to
biased Einstein equations. We show that such a bias appears in the case when
the topological structure of the actual Universe at very large distances does
not match properly that of the Friedman space. We introduce a bias operator
and show that the simple bias function
(the kernel of ) allows to account for all the variety of observed DM halos
in astrophysical systems. In galaxies such a bias forms the cored DM
distribution with the radius (which explains the recently
observed strong correlation between and ), while for a point
source it produces the logarithmic correction to the Newton's potential (which
explains the observed flat rotation curves in spirals). Finally, we show that
in the theory suggested the galaxy formation process leads to a specific
variation with time of all interaction constants and, in particular, of the
fine structure constant.Comment: 12 pages, essential revisio
Postmodern professions? The fragmentation of legal education and the legal profession
This article considers the institutional dimensions of professionalism and the legal profession's struggle with the challenges of post-modernity. An aspect of this is the Law Society's Training Framework Review (TFR) which promises changes to solicitors' education from 'cradle to grave'. The first part of the article analyses the structure and drivers of the TFR, their origins, and how they will be articulated. Secondly, the TFR is considered in the context of the political economy of higher education and its role in the new capitalism. Finally, we examine the potential effects of the TFR for the legal profession in the context of increasing practice segmentation and the threat of deprofessionalization, and also for the Law Society itself, whether it can retain a key role in the life course of the legal profession
On the structure and evolution of a polar crown prominence/filament system
Polar crown prominences are made of chromospheric plasma partially circling
the Suns poles between 60 and 70 degree latitude. We aim to diagnose the 3D
dynamics of a polar crown prominence using high cadence EUV images from the
Solar Dynamics Observatory (SDO)/AIA at 304 and 171A and the Ahead spacecraft
of the Solar Terrestrial Relations Observatory (STEREO-A)/EUVI at 195A. Using
time series across specific structures we compare flows across the disk in 195A
with the prominence dynamics seen on the limb. The densest prominence material
forms vertical columns which are separated by many tens of Mm and connected by
dynamic bridges of plasma that are clearly visible in 304/171A two-color
images. We also observe intermittent but repetitious flows with velocity 15
km/s in the prominence that appear to be associated with EUV bright points on
the solar disk. The boundary between the prominence and the overlying cavity
appears as a sharp edge. We discuss the structure of the coronal cavity seen
both above and around the prominence. SDO/HMI and GONG magnetograms are used to
infer the underlying magnetic topology. The evolution and structure of the
prominence with respect to the magnetic field seems to agree with the filament
linkage model.Comment: 24 pages, 14 figures, Accepted for publication in Solar Physics
Journal, Movies can be found at http://www2.mps.mpg.de/data/outgoing/panesar
Radiative Decay of a Long-Lived Particle and Big-Bang Nucleosynthesis
The effects of radiatively decaying, long-lived particles on big-bang
nucleosynthesis (BBN) are discussed. If high-energy photons are emitted after
BBN, they may change the abundances of the light elements through
photodissociation processes, which may result in a significant discrepancy
between the BBN theory and observation. We calculate the abundances of the
light elements, including the effects of photodissociation induced by a
radiatively decaying particle, but neglecting the hadronic branching ratio.
Using these calculated abundances, we derive a constraint on such particles by
comparing our theoretical results with observations. Taking into account the
recent controversies regarding the observations of the light-element
abundances, we derive constraints for various combinations of the measurements.
We also discuss several models which predict such radiatively decaying
particles, and we derive constraints on such models.Comment: Published version in Phys. Rev. D. Typos in figure captions correcte
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