Is left-handedness associated with a more pronounced age-related cognitive decline?

The effect of handedness on cognitive functioning has been the subject of much controversy. The influential "pathological left-handedness theory" posited by Coren and Halpern (1991) claims that left-handedness is probabilistically related to deviations from the neurological and cognitive norm. Many studies have failed to find negative effects of left-handedness on cognitive functioning, but most of these studies related handedness to cognition at one moment in time. Such studies do not exclude the possibility that sinistrality may be related to a more pronounced age-related longitudinal decline in cognitive functions. This hypothesis was tested in the present study. In a longitudinal study involving a large population sample of cognitively intact people aged at least 50 years at baseline, we evaluated the effect of handedness on age-related decline in four major cognitive domains: speed of information processing, verbal learning, long-term verbal memory, and executive functioning. The results failed to provide support for the hypothesis that sinistrality is associated with a more pronounced age-related cognitive decline. Recommendations for future studies are provided

Rey's verbal learning test: normative data for 1855 healthy participants aged 24-81 years and the influence of age, sex, education, and mode of presentation

The Verbal Learning Test (VLT; Rey, 1958) evaluates the declarative memory. Despite its extensive use, it has been difficult to establish normative data because test administration has not been uniform. The purpose of the present study was to gather normative data for the VLT for a large number (N = 1855) of healthy participants aged 24-81 years, using a procedure in which the words to be learned were presented either verbally or visually. The results showed that VLT performance decreased in an a.-e-dependent manner from an early age. The learning capacity of younger versus older adults differed quantitatively rather than qualitatively. Females and higher educated participants outperformed males and lower educated participants over the entire age range tested. Presentation mode affected VLT performance differently: auditory presentation resulted in a better recall on Trial 1 (a short-term or working memory measure), whereas visual presentation yielded a better performance on Trial 3, Trial 4, and Delta (a learning measure)

Association of cardiovascular risk factors with carotid intima media thickness in patients with rheumatoid arthritis with low disease activity compared to controls: A cross-sectional study

Objectives Rheumatoid arthritis (RA) has been identified as an independent cardiovascular risk factor. The importance of risk factors such as hypertension and hyperlipidemia in the generation of atherosclerosis in RA patients is unclear. This study analyzed clinical parameters associated with carotid intima media thickness (cIMT) in patients with RA. Methods Subjects with RA and healthy controls without RA, both without known cardiovascular disease, were included. Participants underwent a standard physical examination and laboratory measurements including a lipid profile. cIMT was measured semi-automatically by ultrasound. Results In total 243 RA patients and 117 controls were included. The median RA disease duration was 7 years (IQ

Lyman-alpha emission galaxies at a redshift of z = 5.7 in the FORS Deep Field

We present the results of a search for Lyman-alpha emission galaxies at z~ 5.7 in the FORS Deep Field. The objective of this study is to improve the faint end of the luminosity function of high-redshift Lyman-alpha emitting galaxies and to derive properties of intrinsically faint Lyman-alpha emission galaxies in the young universe. Using FORS2 at the ESO VLT and a set of special interference filters, we identified candidates for high-redshift Lyman-alpha galaxies. We then used FORS2 in spectroscopic mode to verify the identifications and to study their spectral properties. The narrow-band photometry resulted in the detection of 15 likely Lyman-alpha emission galaxies. Spectra with an adequate exposure time could be obtained for eight galaxies. In all these cases the presence of Lyman-alpha emission at z = 5.7 was confirmed spectroscopically. The line fluxes of the 15 candidates range between 3 and 16 * 10^-21 Wm^-2, which corresponds to star-formation rates not corrected for dust between 1 and 5 Msun/yr. The luminosity function derived for our photometrically identified objects extends the published luminosity functions of intrinsically brighter Lyman-alpha galaxies. With this technique the study of high-redshift Lyman-alpha emission galaxies can be extended to low intrinsic luminosities.Comment: 9 pages, 17 figures. Accepted by A&A. PDF version with higher resolution figures here: http://www.lsw.uni-heidelberg.de/users/jheidt/fdf/pubs/fdflae5_7_110406.pd

Current challenges in software solutions for mass spectrometry-based quantitative proteomics

This work was in part supported by the PRIME-XS project, grant agreement number 262067, funded by the European Union seventh Framework Programme; The Netherlands Proteomics Centre, embedded in The Netherlands Genomics Initiative; The Netherlands Bioinformatics Centre; and the Centre for Biomedical Genetics (to S.C., B.B. and A.J.R.H); by NIH grants NCRR RR001614 and RR019934 (to the UCSF Mass Spectrometry Facility, director: A.L. Burlingame, P.B.); and by grants from the MRC, CR-UK, BBSRC and Barts and the London Charity (to P.C.

A pan-chromatic view of the galaxy cluster XMMU J1230.3+1339 at z=0.975 - Observing the assembly of a massive system

We present a comprehensive galaxy cluster study of XMMU J1230.3+1339 based on a joint analysis of X-ray data, optical imaging and spectroscopy observations, weak lensing results, and radio properties for achieving a detailed multi-component view of this newly discovered system at z=0.975. We find an optically very rich and massive system with M200$\simeq$(4.2$\pm$0.8)$\times$10^14 M\sun, Tx$\simeq$5.3(+0.7--0.6)keV, and Lx$\simeq$(6.5$\pm$0.7)$\times$10^44 erg/s, for which various widely used mass proxies are measured and compared. We have identified multiple cluster-related components including a central fly-through group close to core passage with associated marginally extended 1.4GHz radio emission possibly originating from the turbulent wake region of the merging event. On the cluster outskirts we see evidence for an on-axis infalling group with a second Brightest Cluster Galaxy (BCG) and indications for an additional off-axis group accretion event. We trace two galaxy filaments beyond the nominal cluster radius and provide a tentative reconstruction of the 3D-accretion geometry of the system. In terms of total mass, ICM structure, optical richness, and the presence of two dominant BCG-type galaxies, the newly confirmed cluster XMMU J1230.3+1339 is likely the progenitor of a system very similar to the local Coma cluster, differing by 7.6 Gyr of structure evolution.Comment: 26 pages, 14 color figures, accepted for publication in A&

Predicting healthcare employees' participation in an office redesign program: Attitudes, norms and behavioral control

<p>Abstract</p> <p>Background</p> <p>The study examined the extent to which components based on a modified version of the theory of planned behavior explained employee participation in a new clinical office program designed to reduce patient waiting times in primary care clinics.</p> <p>Methods</p> <p>We regressed extent of employee participation on attitudes about the program, group norms, and perceived behavioral control along with individual and clinic characteristics using a hierarchical linear mixed model.</p> <p>Results</p> <p>Perceived group norms were one of the best predictors of employee participation. Attitudes about the program were also significant, but to a lesser degree. Behavioral control, however, was not a significant predictor. Respondents with at least one year of clinic tenure, or who were team leaders, first line supervisor, or managers had greater participation rates. Analysis at the clinic level indicated clinics with scores in the highest quartile clinic scores on group norms, attitudes, and behavioral control scores were significantly higher on levels of overall participation than clinics in the lowest quartile.</p> <p>Conclusion</p> <p>Findings suggest that establishing strong norms and values may influence employee participation in a change program in a group setting. Supervisory level was also significant with greater responsibility being associated with greater participation.</p