Permintaan Pangan Hewani Rumah Tangga di Provinsi Jawa Barat

Indonesian's consumption of food derived from animal products is relatively low. In general, the consumption behaviour depends not only on prices and total expenditure, but also on some household characteristics. Households with different characteristics have different spending patterns reflecting the level of welfare of each household. This study analyzed the food consumption of households using the LA system (AIDS) of five groups of animal based food. The data used in this research are the National Socio-Economic Survey (NSES) in 2012 in West Java Province. The result show that the consumption of animal based food is influenced by household income and also by other factors including socio-demographic household size, type of area and level of education of household head. The value of own price elasticity showed that all commodities are inelastic. Based on the values of cross elasticity, all animal based food commodities are complement to each other except that fish are substitutes for eggs. Fish and egg are categorized as normal good, whereas meat, poultry and milk are categorized as luxury goods

Perancangan Media Iklan sebagai Penunjang Informasi dan Promosi pada Hotel Sitamiang 2 Bogor

Perkembangan dunia perhotelan yang makin pesat, menuntut kebutuhan akan informasi dan promosi agar Hotel Sitamiang 2 Bogor semakin diminati oleh customer. Tujuan dari penelitian ini adalah merancang media berbasis audio visual agar dapat menarik dan efektif, terutama dalam penyampaian informasi dan promosi mengenai hal – hal yang berkaitan dengan Hotel Sitamiang 2 Bogor. Permasalahan yang ada yaitu kurangnya media promosi dan informasi yang digunakan pada Hotel Sitamiang 2 Bogor, karena dalam melakukan suatu promosi dan memberikan informasi masih menggunakan media cetak yaitu berupa brosur,  untuk itu dibuatlah suatu teknik promosi baru untuk Hotel Sitamiang 2 yaitu dengan menggunakan media iklan yang mampu menginformasikan dan mempromosikan seluruh aset dan keunggulan yang dimiliki Perusahaan, dengan harapan akan menarik minat calon customer, menjalin relasi atau kerjasama baik dengan klien perseorangan, klien Perusahaan, instansi atau lembaga terkait, dan sebagai media informasi untuk meningkatkan image Hotel Sitamiang 2 agar lebih dikenal lagi di masyarakat khususnya di daerah Bogor dan sekitarnya. Adapun metodologi yang digunakan dalam penelitian ini diantaranya metode analisa permasalahan, metode pengumpulan data, metode analisa perancangan dan metode konsep produksi mavib (KPM) yang meliputi : pre production, production, dan post production. Dengan menggunakan media iklan maka Perusahaan akan lebih menarik dalam menyampaikan informasi dan promosi suatu produk dan jasa yang di tawarkan, sehingga perancangan media video iklan Hotel Sitamiang 2 Bogor, diharapkan dapat menjadi solusi dalam pemecahan masalah pada media promosi dan informasinya. Kata Kunci: media iklan, informasi, promosi

POTENSI LAHAN PENGEMBANGAN PERTANIAN HORTIKULTURA BUAH NANAS UNTUK PENGEMBANGAN WILAYAH DI KABUPATEN SUBANG

Subang Regency has the main sector in the field of agriculture that is pineapple fruit horticulture. According to Subang Spatial Planning Regulation of 2011 - 2031 agricultural potential that has the opportunity to increase the financing capacity of regional development is pineapple fruit. The objectives of this study were to: (1) delineate the available land for pineapple fruit, (2) evaluate the suitability of the land for pineapple fruit cultivation, (3) determine the potential land location for pineapple fruit development. The methodology used in this study was an analysis of Geographic Information System and land evaluation based on limiting factor to compare the characteristics of the land with the requirements of growing plants. The results showed that of potential land for the development of pineapple fruit is spread over the south side of Subang Regency. Sub-district prioritized the recommended for development is sub-district which have the area of available land and have the widest suitability, namely Cijambe Sub-district with an area of 2,124 hectares and Jalancagak sub-district with an area of 1,135 hectares

PEMBUATAN DAN KARAKTERISASI ARANG AKTIF DARI BATANG LIMBAH TANAMAN GUMITIR DENGAN AKTIVATOR ZnCl2

The agricultural waste of gumitir plants stem can be used as an ingredient in producing an activated carbon. Some researchers have reported that the additions of phosphoric acid and NaOH as chemical activators have resulted in an activated carbon that met the SNI (Indonesian National Standard) 06-3730-1995 about technical activated carbon. The purpose of this study was to produce and characterize the activated carbon from the stem of gumitir plants carbonized at 300oC for 90 minutes with the use of ZnCl2 as the activator. The activation was carried out by adding ZnCl2 to an amount of carbon in various mole ratios. The characteristics of the activated carbon obtained were compared to the SNI. It was evident that the addition of 0.1 mole of ZnCl2 to 1 gram of the carbon produced an activated carbon that met the SNI standard, namely, water content of 5.00%, as content of 8.33%, volatile content of 950oC of heating  of  7.36%, carbon content of 79,30%, iodine absorption capacity of 788.1271 mg/g, and methylene blue absorption capacity of 260.7917 mg/g. The surface area and surfae acidity of this carbon was of 677,6270 mg2/g and 0.3396 mmol/g, respectively. The functional group analysis of this activated carbon showed the presence of O-H, COOH, C-O aldehyde, alkaline C-C and C-H groups

Development of monoclonal antibodies and quantitative ELISAs targeting insulin-degrading enzyme

<p>Abstract</p> <p>Background</p> <p>Insulin-degrading enzyme (IDE) is a widely studied zinc-metalloprotease implicated in the pathogenesis of type 2 diabetes mellitus, Alzheimer disease (AD) and varicella zoster virus infection. Despite more than six decades of research on IDE, progress has been hampered by the lack of well-characterized reagents targeting this biomedically important protease. To address this important need, we generated and characterized new mouse monoclonal antibodies (mAbs) targeting natively folded human and rodent IDE.</p> <p>Results</p> <p>Eight monoclonal hybridoma cell lines were derived in house from mice immunized with full-length, natively folded, recombinant human IDE. The mAbs derived from these lines were shown to detect IDE selectively and sensitively by a wide range of methods. Two mAbs in particular—designated 6A1 and 6H9—proved especially selective for IDE in immunocytochemical and immunohistochemical applications. Using a variety of methods, we show that 6A1 selectively detects both human and rodent IDE, while 6H9 selectively detects human, but not rodent, IDE, with both mAbs showing essentially no cross reactivity with other proteins in these applications. Using these novel anti-IDE mAbs, we also developed sensitive and quantitative sandwich ELISAs capable of quantifying IDE levels present in human brain extracts.</p> <p>Conclusion</p> <p>We succeeded in developing novel mAbs that selectively detect rodent and/or human IDE, which we have shown to be suitable for a wide range of applications, including western blotting, immunoprecipitation, immunocytochemistry, immunohistochemistry, and quantitative sandwich ELISAs. These novel anti-IDE mAbs and the assays derived from them constitute important new tools for addressing many unresolved questions about the basic biology of IDE and its role in multiple highly prevalent human diseases.</p

Usefulness of Microcatheters Inserted Overnight for Additional Injection of Sclerosant after Initial Balloon-Occluded Retrograde Transvenous Obliteration of Gastric Varices

In patients with large gastric varices, dose limitation of the sclerosant can cause difficulties in achieving complete thrombosis of varices during a single balloon-occluded retrograde transvenous obliteration (BRTO) procedure. For patients with incomplete variceal thrombosis after the first BRTO, additional sclerosant must be injected in a second BRTO. We report a successful case of BRTO for large gastric varices in whom additional sclerosant was injected through a microcatheter that remained inserted overnight. To achieve complete variceal thrombosis in a patient with incomplete thrombosis of large gastric varices after a first BRTO, a retained microcatheter can be used to inject additional sclerosant in a second BRTO the next day

Exogenous WNT5A and WNT11 proteins rescue CITED2 dysfunction in mouse embryonic stem cells and zebrafish morphants

Mutations and inadequate methylation profiles of CITED2 are associated with human congenital heart disease (CHD). In mouse, Cited2 is necessary for embryogenesis, particularly for heart development, and its depletion in embryonic stem cells (ESC) impairs cardiac differentiation. We have now determined that Cited2 depletion in ESC affects the expression of transcription factors and cardiopoietic genes involved in early mesoderm and cardiac specification. Interestingly, the supplementation of the secretome prepared from ESC overexpressing CITED2, during the onset of differentiation, rescued the cardiogenic defects of Cited2-depleted ESC. In addition, we demonstrate that the proteins WNT5A and WNT11 held the potential for rescue. We also validated the zebrafish as a model to investigate cited2 function during development. Indeed, the microinjection of morpholinos targeting cited2 transcripts caused developmental defects recapitulating those of mice knockout models, including the increased propensity for cardiac defects and severe death rate. Importantly, the co-injection of anti-cited2 morpholinos with either CITED2 or WNT5A and WNT11 recombinant proteins corrected the developmental defects of Cited2-morphants. This study argues that defects caused by the dysfunction of Cited2 at early stages of development, including heart anomalies, may be remediable by supplementation of exogenous molecules, offering the opportunity to develop novel therapeutic strategies aiming to prevent CHD.Agência financiadora: Fundação para a Ciência e a Tecnologia (FCT) Comissão de Coordenação e Desenvolvimento Regional do Algarve (CCDR Algarve) ALG-01-0145-FEDER-28044; DFG 568/17-2 Algarve Biomedical Center (ABC) Municipio de Louléinfo:eu-repo/semantics/publishedVersio

Evaluation of the ACS NSQIP Surgical Risk Calculator in Elderly Patients Undergoing Hepatectomy for Hepatocellular Carcinoma

Background: The American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) surgical risk calculator (SRC) aims to help predict patient-specific risk for morbidity and mortality. The performance of the SRC among an elderly population undergoing curative-intent hepatectomy for hepatocellular carcinoma (HCC) remains unknown. Methods: Patients > 70 years of age who underwent hepatectomy for HCC between 1998 and 2017 were identified using a multi-institutional international database. To estimate the performance of SRC, 12 observed postoperative outcomes were compared with median SRC-predicted risk, and C-statistics and Brier scores were calculated. Results: Among 500 patients, median age was 75 years (IQR 72-78). Most patients (n = 324, 64.8%) underwent a minor hepatectomy, while 35.2% underwent a major hepatectomy. The observed incidence of venous thromboembolism (VTE) (3.2%) and renal failure (RF) (4.4%) exceeded the median predicted risk (VTE, 1.8%; IQR 1.5-3.1 and RF, 1.0%; IQR 0.5-2.0). In contrast, the observed incidence of 30-day readmission (7.0%) and non-home discharge (2.5%) was lower than median-predicted risk (30-day readmission, 9.4%; IQR 7.4-12.8 and non-home discharge, 5.7%; IQR 3.3-11.7). Only 57.8% and 71.2% of patients who experienced readmission (C-statistic, 0.578; 95%CI 0.468-0.688) or mortality (C-statistic, 0.712; 95%CI 0.508-0.917) were correctly identified by the model. Conclusion: Among elderly patients undergoing hepatectomy for HCC, the SRC underestimated the risk of complications such as VTE and RF, while being no better than chance in estimating the risk of readmission. The ACS SRC has limited clinical applicability in estimating perioperative risk among elderly patients being considered for hepatic resection of HCC.info:eu-repo/semantics/publishedVersio

The balance between cathepsin C and cystatin F controls remyelination in the brain of Plp1-overexpressing mouse, a chronic demyelinating disease model

In demyelinating diseases such as multiple sclerosis (MS), an imbalance between the demyelination and remyelination rates underlies the degenerative processes. Microglial activation is observed in demyelinating lesions; however, the molecular mechanism responsible for the homeostatic/environmental change remains elusive. We previously found that cystatin F (CysF), a cysteine protease inhibitor, is selectively expressed in microglia only in actively demyelinating/remyelinating lesions but ceases expression in chronic lesions, suggesting its role in remyelination. Here, we report the effects of manipulating the expression of CysF and cathepsin C (CatC), a key target of CysF, in a murine model of transgenic demyelinating disease, Plp4e/-. During the active remyelinating phase, both CysF knockdown (CysFKD) and microglial-selective CatC overexpression (CatCOE) showed a worsening of the demyelination in Plp4e/- transgenic mice. Conversely, during the chronic demyelinating phase, CatC knockdown (CatCKD) ameliorated the demyelination. Our results suggest that the balance between CatC and CysF expression controls the demyelination and remyelination process