6,082 research outputs found

    The polar temperature of Venus

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    Interferometric and polarization measurements of polar regions of Venu

    FM1-43 dye behaves as a permeant blocker of the hair-cell mechanotransducer channel

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    Hair cells in mouse cochlear cultures are selectively labeled by brief exposure to FM1-43, a styryl dye used to study endocytosis and exocytosis. Real-time confocal microscopy indicates that dye entry is rapid and via the apical surface. Cooling to 4°C and high extracellular calcium both reduce dye loading. Pretreatment with EGTA, a condition that breaks tip links and prevents mechanotransducer channel gating, abolishes subsequent dye loading in the presence of calcium. Dye loading recovers after calcium chelation with a time course similar to that described for tip-link regeneration. Myo7a mutant hair cells, which can transduce but have all mechanotransducer channels normally closed at rest, do not label with FM1-43 unless the bundles are stimulated by large excitatory stimuli. Extracellular perfusion of FM1-43 reversibly blocks mechanotransduction with half-blocking concentrations in the low micromolar range. The block is reduced by high extracellular calcium and is voltage dependent, decreasing at extreme positive and negative potentials, indicating that FM1-43 behaves as a permeant blocker of the mechanotransducer channel. The time course for the relief of block after voltage steps to extreme potentials further suggests that FM1-43 competes with other cations for binding sites within the pore of the channel. FM1-43 does not block the transducer channel from the intracellular side at concentrations that would cause complete block when applied extracellularly. Calcium chelation and FM1-43 both reduce the ototoxic effects of the aminoglycoside antibiotic neomycin sulfate, suggesting that FM1-43 and aminoglycosides enter hair cells via the same pathway

    Elliptic flow of thermal dileptons in relativistic nuclear collisions

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    We calculate the transverse momentum and invariant mass dependence of elliptic flow of thermal dileptons for Au+Au collisions at the Relativistic Heavy Ion Collider. The system is described using hydrodynamics, with the assumption of formation of a thermalized quark-gluon plasma at some early time, followed by cooling through expansion, hadronization and decoupling. Dileptons are emitted throughout the expansion history: by annihilation of quarks and anti-quarks inthe early quark-gluon plasma stage and through a set of hadronic reactions during the late hadronic stage. The resulting differential elliptic flow exhibits a rich structure, with different dilepton mass windows providing access to different stages of the expansion history. Elliptic flow measurements for dileptons,combined with those of hadrons and direct photons, are a powerful tool for mapping the time-evolution of heavy-ion collisions.Comment: Latex 8 pages including a total of 13 postscript figures. Added 2 figures, additional references, and expanded discussions. Figures modified for better viewing. To appear in Phys. Rev.

    ρ\rho meson broadening and dilepton production in heavy ion collisions

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    The modification of the width of the rho meson due to in-medium decays and collisions is evaluated. In high temperature and/or high density hadronic matter, the collision width is much larger than the one-loop decay width. The large width of the ρ\rho meson in matter seems to be consistent with some current interpretations of the e+ee^+ e^- mass spectra measured at the CERN/SPS.Comment: 4 pages, LaTeX, including 4 Postscript figures, to appear in Proc. of QM'99, Nucl. Phys.
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