Effect of protection status on mammal richness and abundance in Afromontane forests of the Udzungwa Mountains, Tanzania

The effectiveness of Protected Areas (PAs) in reducing hunting pressure on mammal populations in tropical forests has rarely been examined at a community-wide level. In African forests, commercial and subsistence hunting are widespread, but assessments of mammal abundance and distribution patterns are often lacking. We investigated patterns of occupancy and abundance for 27 species of medium- to large-bodied mammals (>2 kg) within Tanzania's Udzungwa Mountains Afromontane forests, a global biodiversity hotspot. We sampled 22 forest sites within 10 forests under varying degrees of protection, elevation, distance to extractive communities, and levels of law enforcement. We sampled 251.7 km of recce line transects during dry seasons (July–November) between September 2007 and July 2010. We found a strong positive effect of protection status on species richness and on encounter rates of the most commonly encountered species. Consistent with the levels of resources and enforcement within each PA category, there was a significant progression in species richness and abundance from Forest Reserves through Nature Reserves to sites within Udzungwa Mountains National Park. Protective status closely reflected levels of disturbance. Snaring activity, and distance to ranger posts were identified as significant predictors of overall species richness and encounter rates for mammal species, including endemics. The species-area relationship for our study species was found to be largely overridden by levels of protection. Our findings demonstrate PA effectiveness in Afromontane forests and reinforce concerns over hunting pressures particularly the threat posed by snares

Structural and spectroscopic insights on the coordination chemistry of the rigid heterotopic chelating ligand 1H-pyrazolo[4,3-h]quinoline

In this work we report the coordination chemistry of a rigid heterotopic ligand 1H-pyrazolo[4,3-h]quinoline HL1 in copper(II) and zinc(II) complexes for the first time, and examine both the structural properties and solution-phase behaviour of these species. On reaction with zinc(II) nitrate in acetonitrile, a mononuclear complex [Zn(HL1)2(OH2)2](NO3)2 1 is generated, where a size mismatch between the metal ion and the binding pocket leads to an anomalously long Zn-N bond to the pyrazole nitrogen atom. This is consistent with solution-state absorption and fluorescence measurements which indicate a relatively low stability constant logß of 9.1(3) in acetonitrile. The reaction of HL1 with copper(II) nitrate in methanol gave four new crystalline phases, the major forms of which being two polymorphs of the complex [Cu2(µ2-L1)2(NO3)2(MeOH)2] 2a and 2ß which also constitutes the dominant solution-phase behaviour of this mixture. Additionally, trace amounts of the nitric acid salt of HL1 were crystallised, along with the slow formation of a tetranuclear species [Cu4(µ2-L1)6(OH2)2](NO3)2·2MeOH 3 which also features anomalously long bridging distances from the L1 ligand as a result of its backbone rigidity

Chiral symmetry breaking in dimensionally regularized nonperturbative quenched QED

In this paper we study dynamical chiral symmetry breaking in dimensionally regularized quenched QED within the context of Dyson-Schwinger equations. In D < 4 dimensions the theory has solutions which exhibit chiral symmetry breaking for all values of the coupling. To begin with, we study this phenomenon both numerically and, with some approximations, analytically within the rainbow approximation in the Landau gauge. In particular, we discuss how to extract the critical coupling alpha_c = pi/3 relevant in four dimensions from the D dimensional theory. We further present analytic results for the chirally symmetric solution obtained with the Curtis-Pennington vertex as well as numerical results for solutions exhibiting chiral symmetry breaking. For these we demonstrate that, using dimensional regularization, the extraction of the critical coupling relevant for this vertex is feasible. Initial results for this critical coupling are in agreement with cut-off based work within the currently achievable numerical precision.Comment: 24 pages, including 5 figures; submitted to Phys. Rev.

Association Between Chronic Hepatitis C Virus Infection and Myocardial Infarction Among People Living With HIV in the United States.

Hepatitis C virus (HCV) infection is common among people living with human immunodeficiency virus (PLWH). Extrahepatic manifestations of HCV, including myocardial infarction (MI), are a topic of active research. MI is classified into types, predominantly atheroembolic type 1 MI (T1MI) and supply-demand mismatch type 2 MI (T2MI). We examined the association between HCV and MI among patients in the Centers for AIDS Research (CFAR) Network of Integrated Clinical Systems, a US multicenter clinical cohort of PLWH. MIs were centrally adjudicated and categorized by type using the Third Universal Definition of Myocardial Infarction. We estimated the association between chronic HCV (RNA+) and time to MI while adjusting for demographic characteristics, cardiovascular risk factors, clinical characteristics, and history of injecting drug use. Among 23,407 PLWH aged ≥18 years, there were 336 T1MIs and 330 T2MIs during a median of 4.7 years of follow-up between 1998 and 2016. HCV was associated with a 46% greater risk of T2MI (adjusted hazard ratio (aHR)&nbsp;=&nbsp;1.46, 95% confidence interval (CI): 1.09, 1.97) but not T1MI (aHR&nbsp;=&nbsp;0.87, 95% CI: 0.58, 1.29). In an exploratory cause-specific analysis of T2MI, HCV was associated with a 2-fold greater risk of T2MI attributed to sepsis (aHR&nbsp;=&nbsp;2.01, 95% CI: 1.25, 3.24). Extrahepatic manifestations of HCV in this high-risk population are an important area for continued research

Evidence of strong small-scale population structure in the Antarctic freshwater copepod Boeckella poppei in lakes on Signy Island, South Orkney Islands

Environmental conditions were particularly severe during the Last Glacial Maximum, altering the distribution of the Southern Hemisphere biota, particularly at higher latitudes. The copepod Boeckella poppei is the only macroscopic continental invertebrate species known to be distributed today across the three main biogeographic regions in Antarctica as well as in southern South America. Signy Island (South Orkney Islands) is a unique location for the study of Antarctic freshwater ecosystems due to its location and geographic isolation; it contains 17 lakes in several low altitude catchments. We conducted phylogeographic and demographic analyses using the cox1 gene on 84 individuals of B. poppei from seven lakes across Signy Island. We recorded low levels of genetic diversity and a strong genetic differentiation signal between the eastern and western valleys within the island. Phylogeographic structure and demographic inference analyses suggested at least one asymmetrical dispersal event from west to east. Demographic inference detected a strong signal of population growth during the deglaciation process, which may have followed either (1) a strong genetic bottleneck due to a reduction in population size during the last glacial period, or (2) a founder effect associated with postglacial recolonization of Signy Island from elsewhere. The genetic architecture of this island's populations of B. poppei shows that historical events, rather than continuous dispersal events, likely played a major role in the species' current distribution. Finally, our study considers possible mechanisms for dispersal and colonization success of the most dominant species in the Antarctic freshwater community

Chiral Symmetry Breaking in Quenched Massive Strong-Coupling QED4_4

We present results from a study of subtractive renormalization of the fermion propagator Dyson-Schwinger equation (DSE) in massive strong-coupling quenched QED$_4$. Results are compared for three different fermion-photon proper vertex {\it Ans\"{a}tze\/}: bare $\gamma^\mu$, minimal Ball-Chiu, and Curtis-Pennington. The procedure is straightforward to implement and numerically stable. This is the first study in which this technique is used and it should prove useful in future DSE studies, whenever renormalization is required in numerical work.Comment: REVTEX 3.0, 15 pages plus 7 uuencoded PostScript figure

Multicore and FPGA implementations of emotional-based agent architectures

The final publication is available at Springer via http://dx.doi.org/10.1007/s11227-014-1307-6.Control architectures based on Emotions are becoming promising solutions for the implementation of future robotic agents. The basic controllers of the architecture are the emotional processes that decide which behaviors of the robot must activate to fulfill the objectives. The number of emotional processes increases (hundreds of millions/s) with the complexity level of the application, reducing the processing capacity of the main processor to solve complex problems (millions of decisions in a given instant). However, the potential parallelism of the emotional processes permits their execution in parallel on FPGAs or Multicores, thus enabling slack computing in the main processor to tackle more complex dynamic problems. In this paper, an emotional architecture for mobile robotic agents is presented. The workload of the emotional processes is evaluated. Then, the main processor is extended with FPGA co-processors through Ethernet link. The FPGAs will be in charge of the execution of the emotional processes in parallel. Different Stratix FPGAs are compared to analyze their suitability to cope with the proposed mobile robotic agent applications. The applications are set up taking into account different environmental conditions, robot dynamics and emotional states. Moreover, the applications are run also on Multicore processors to compare their performance in relation to the FPGAs. Experimental results show that Stratix IV FPGA increases the performance in about one order of magnitude over the main processor and solves all the considered problems. Quad-Core increases the performance in 3.64 times, allowing to tackle about 89 % of the considered problems. Quad-Core has a lower cost than a Stratix IV, so more adequate solution but not for the most complex application. Stratix III could be applied to solve problems with around the double of the requirements that the main processor could support. Finally, a Dual-Core provides slightly better performance than stratix III and it is relatively cheaper.This work was supported in part under Spanish Grant PAID/2012/325 of "Programa de Apoyo a la Investigacion y Desarrollo. Proyectos multidisciplinares", Universitat Politecnica de Valencia, Spain.Domínguez Montagud, CP.; Hassan Mohamed, H.; Crespo, A.; Albaladejo Meroño, J. (2015). Multicore and FPGA implementations of emotional-based agent architectures. Journal of Supercomputing. 71(2):479-507. https://doi.org/10.1007/s11227-014-1307-6S479507712Malfaz M, Salichs MA (2010) Using MUDs as an experimental platform for testing a decision making system for self-motivated autonomous agents. Artif Intell Simul Behav J 2(1):21–44Damiano L, Cañamero L (2010) Constructing emotions. 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Asymptotic Scaling and Infrared Behavior of the Gluon Propagator

The Landau gauge gluon propagator for the pure gauge theory is evaluated on a 32^3x64 lattice with a physical volume of (3.35^3x6.7)fm^4. Comparison with two smaller lattices at different lattice spacings allows an assessment of finite volume and finite lattice spacing errors. Cuts on the data are imposed to minimize these errors. Scaling of the gluon propagator is verified between beta=6.0 and beta=6.2. The tensor structure is evaluated and found to be in good agreement with the Landau gauge form, except at very small momentum values, where some small finite volume errors persist. A number of functional forms for the momentum dependence of the propagator are investigated. The form D(q^2)=D_ir+D_uv, where D_ir(q^2) ~ (q^2+M^2)^-\eta and D_uv is an infrared regulated one-loop asymptotic form, is found to provide an adequate description of the data over the entire momentum region studied - thereby bridging the gap between the infrared confinement region and the ultraviolet asymptotic region. The best estimate for the exponent \eta is 3.2(+0.1/-0.2)(+0.2/-0.3), where the first set of errors represents the uncertainty associated with varying the fitting range, while the second set of errors reflects the variation arising from different choices of infrared regulator in D_uv. Fixing the form of D_uv, we find that the mass parameter M is (1020+/-100)MeV.Comment: 37 pages, RevTeX, 16 postscript figures, 7 gif figures. Revised version accepted for publication in Phys. Rev. D. Model functions and discussion of asymptotic behaviour modified; all model fits have been redone. This paper, including postscript version of all figures, can be found at http://www.physics.adelaide.edu.au/~jskuller/papers

Mutations of the BRAF gene in human cancer

Cancers arise owing to the accumulation of mutations in critical genes that alter normal programmes of cell proliferation, differentiation and death. As the first stage of a systematic genome-wide screen for these genes, we have prioritized for analysis signalling pathways in which at least one gene is mutated in human cancer. The RAS RAF MEK ERK MAP kinase pathway mediates cellular responses to growth signals. RAS is mutated to an oncogenic form in about 15% of human cancer. The three RAF genes code for cytoplasmic serine/threonine kinases that are regulated by binding RAS. Here we report BRAF somatic missense mutations in 66% of malignant melanomas and at lower frequency in a wide range of human cancers. All mutations are within the kinase domain, with a single substitution (V599E) accounting for 80%. Mutated BRAF proteins have elevated kinase activity and are transforming in NIH3T3 cells. Furthermore, RAS function is not required for the growth of cancer cell lines with the V599E mutation. As BRAF is a serine/threonine kinase that is commonly activated by somatic point mutation in human cancer, it may provide new therapeutic opportunities in malignant melanoma

Freezing of the QCD coupling constant and solutions of Schwinger-Dyson equations

We compare phenomenological values of the frozen QCD running coupling constant ($\alpha_s$) with two classes of solutions obtained through nonperturbative Schwinger-Dyson equations. We use these same solutions with frozen coupling constants as well as their respective nonperturbative gluon propagators to compute the QCD prediction for the asymptotic pion form factor. Agreement between theory and experiment on $\alpha_s(0)$ and $F_\pi (Q^2)$ is found only for one of the solutions Schwinger-Dyson equations.Comment: 6 pages, 4 figures, RevTeX, axodra