Charm as a domain wall fermion in quenched lattice QCD

We report a study describing the charm quark by a domain-wall fermion (DWF) in lattice quantum chromodynamics (QCD). Our study uses a quenched gauge ensemble with the DBW2 rectangle-improved gauge action at a lattice cutoff of $a^{-1} \sim 3$ GeV. We calculate masses of heavy-light (charmed) and heavy-heavy (charmonium) mesons with spin-parity $J^P = 0^\mp$ and $1^\mp$, leptonic decay constants of the charmed pseudoscalar mesons ($D$ and $D_s$), and the $D^0$-$\bar{D^0}$ mixing parameter. The charm quark mass is found to be $m^{\bar{\rm MS}}_{c}(m_{c})=1.24(1)(18)$ GeV. The mass splittings in charmed-meson parity partners $\Delta_{q,J=0}$ and $\Delta_{q, J=1}$ are degenerate within statistical errors, in accord with experiment, and they satisfy a relation $\Delta_{q=ud, J} > \Delta_{q=s, J}$, also consistent with experiment. A C-odd axial vector charmonium state, $h_c), lies 22(11) MeV above the$\chi_{c1}$meson, or$m_{h_{c}} = 3533(11)_{\rm stat.}$MeV using the experimental$\chi_{c1}) mass. However, in this regard, we emphasize significant discrepancies in the calculation of hyperfine splittings on the lattice. The leptonic decay constants of $D$ and $D_s$ mesons are found to be $f_D=232(7)_{\rm stat.}(^{+6}_{-0})_{\rm chiral}(11)_{\rm syst.}$ MeV and $f_{D_s}/f_{D} = 1.05(2)_{\rm stat.}(^{+0}_{-2})_{\rm chiral}(2)_{\rm syst.}$, where the first error is statistical, the second a systematic due to chiral extrapolation and the third error combination of other known systematics. The $D^0$-$\bar{D^0}$ mixing bag parameter, which enters the $\Delta C = 2$ transition amplitude, is found to be $B_D(2{GeV})=0.845(24)_{\rm stat.}(^{+24}_{-6})_{\rm chiral}(105)_{\rm syst.}$.Comment: 49 pages, 15 figure

Heavy-Quark Symmetry and the Electromagnetic Decays of Excited Charmed Strange Mesons

Heavy-hadron chiral perturbation theory (HH$\chi$PT) is applied to the decays of the even-parity charmed strange mesons, D_{s0}(2317) and D_{s1}(2460). Heavy-quark spin symmetry predicts the branching fractions for the three electromagnetic decays of these states to the ground states D_s and D_s^* in terms of a single parameter. The resulting predictions for two of the branching fractions are significantly higher than current upper limits from the CLEO experiment. Leading corrections to the branching ratios from chiral loop diagrams and spin-symmetry violating operators in the HH$\chi$PT Lagrangian can naturally account for this discrepancy. Finally the proposal that the D_{s0}(2317) (D_{s1}(2460)) is a hadronic bound state of a D (D^*) meson and a kaon is considered. Leading order predictions for electromagnetic branching ratios in this molecular scenario are in very poor agreement with existing data.Comment: 25 pages, 3 figure

An estimate of the flavour singlet contributions to the hyperfine splitting in charmonium

We explore the splitting between flavour singlet and non-singlet mesons in charmonium. This has implications for the hyperfine splitting in charmonium

Exact Absorption Probability in the Extremal Six-Dimensional Dyonic String Background

We show that the minimally coupled massless scalar wave equation in the background of an six-dimensional extremal dyonic string (or D1-D5 brane intersection) is exactly solvable, in terms of Mathieu functions. Using this fact, we calculate absorption probabilities for these scalar waves, and present the explicit results for the first few low energy corrections to the leading-order expressions. For a specific tuning of the dyonic charges one can reach a domain where the low energy absorption probability goes to zero with inverse powers of the logarithm of the energy. This is a dividing domain between the regime where the low energy absorption probability approaches zero with positive powers of energy and the regime where the probability is an oscillatory function of the logarithm of the energy. By the conjectured AdS/CFT correspondence, these results shed novel light on the strongly coupled two-dimensional field theory away from its infrared conformally invariant fixed point (the strongly coupled ``non-critical'' string).Comment: Latex (3 times), 23 page

Excited Charmed Mesons: Observations, Analyses and Puzzles

We review the status of recently observed positive parity charmed resonances, both in the non-strange and in the strange sector. We describe the experimental findings, the main theoretical analyses and the open problems deserving further investigations.Comment: LaTeX, 25 pages, 5 figures. Invited revie

Waiting for Precise Measurements of K^+->pi^+ nu nu and K_L->pi^0 nu nu

In view of future plans for accurate measurements of the theoretically clean branching ratios Br(K+ -> pi+ nu nu) and Br(KL -> pi0 nu nu), that should take place in the next decade, we collect the relevant formulae for quantities of interest and analyze their theoretical and parametric uncertainties. We point out that in addition to the angle beta in the unitarity triangle (UT) also the angle gamma can in principle be determined from these decays with respectable precision and emphasize in this context the importance of the recent NNLO QCD calculation of the charm contribution to K+ -> pi+ nu nu and of the improved estimate of the long distance contribution by means of chiral perturbation theory. In addition to known expressions we present several new ones that should allow transparent tests of the Standard Model (SM) and of its extensions. While our presentation is centered around the SM, we also discuss models with minimal flavour violation and scenarios with new complex phases in decay amplitudes and meson mixing. We give a brief review of existing results within specific extensions of the SM, in particular the Littlest Higgs Model with T-parity, Z' models, the MSSM and a model with one universal extra dimension. We derive a new "golden" relation between B and K systems that involves (beta,gamma) and Br(KL -> pi0 nu nu) and investigate the virtues of (R_t,beta), (R_b,gamma), (beta,gamma) and (etabar,gamma) strategies for the UT in the context of K -> pi nu nu decays with the goal of testing the SM and its extensions.Comment: 56 pages, 18 figures, Section on Long Distance Contributions, 2 Figures and few References added, Uses Rev Mod Phys Style; Includes new results of NNLO calculation as well as matrix elements, extended and modified sections on new physic

A survey of prolapse practice in UK women’s health physiotherapists: what has changed in the last decade?

INTRODUCTION AND HYPOTHESIS: Prolapse is a common female problem, and conservative treatments such as pelvic floor muscle training (PFMT) are important options for women. Evidence supporting the effectiveness of PFMT for prolapse has grown over the last decade, and it was hypothesised that practice and practice guidelines would have developed in line with the evidence. To assess this, up-to-date information about the practice of physiotherapists working in women’s health regarding their treatment of prolapse was required. METHODS: An online survey sent to members of the Association of Chartered Physiotherapists in Women’s Health and the Chartered Physiotherapists Promoting Continence. Results were compared with those of an earlier survey undertaken in 2002. RESULTS: A 49 % response rate was achieved. The majority of respondents were senior physiotherapists (55 %) and had worked in women’s health for more than 10 years. Respondents were treating significantly more women with prolapse than a decade before: 36 % vs 14 % treated more than 50 women per year in 2002 and 2013 respectively (p < 0.001). Individualised PFMT (93 %), lifestyle advice (92 %) and biofeedback-assisted PFMT (83 %) were the most common treatment elements, with four being the average number of appointments. Forty-eight percent had changed their practice as a result of recent research; however, scepticism amongst medics, the referral of women directly for surgery, and constraints on resources were thought to be barriers to wider implementation of the evidence of PFMT for prolapse. CONCLUSIONS: There has been uptake of evidence-based prolapse practice by UK specialist physiotherapists in the last decade. Further research targeting the implementation of this evidence would be valuable in addressing potential barriers, and in supporting the need for physiotherapy in the treatment of prolapse

The establishment of a WHO Reference Reagent for anti-malaria (Plasmodium falciparum) human serum

BACKGROUND: At a World Health Organization (WHO) sponsored meeting it was concluded that there is an urgent need for a reference preparation that contains antibodies against malaria antigens in order to support serology studies and vaccine development. It was proposed that this reference would take the form of a lyophilized serum or plasma pool from a malaria-endemic area. In response, an immunoassay standard, comprising defibrinated human plasma has been prepared and evaluated in a collaborative study. RESULTS: A pool of human plasma from a malaria endemic region was collected from 140 single plasma donations selected for reactivity to Plasmodium falciparum apical membrane antigen-1 (AMA-1) and merozoite surface proteins (MSP-119, MSP-142, MSP-2 and MSP-3). This pool was defibrinated, filled and freeze dried into a single batch of ampoules to yield a stable source of naturally occurring antibodies to P. falciparum. The preparation was evaluated by an enzyme-linked immunosorbent assay (ELISA) in a collaborative study with sixteen participants from twelve different countries. This anti-malaria human serum preparation (NIBSC Code: 10/198) was adopted by the WHO Expert Committee on Biological Standardization (ECBS) in October 2014, as the first WHO reference reagent for anti-malaria (Plasmodium falciparum) human serum with an assigned arbitrary unitage of 100 units (U) per ampoule. CONCLUSION: Analysis of the reference reagent in a collaborative study has demonstrated the benefit of this preparation for the reduction in inter- and intra-laboratory variability in ELISA. Whilst locally sourced pools are regularly use for harmonization both within and between a few laboratories, the presence of a WHO-endorsed reference reagent should enable optimal harmonization of malaria serological assays either by direct use of the reference reagent or calibration of local standards against this WHO reference. The intended uses of this reference reagent, a multivalent preparation, are (1) to allow cross-comparisons of results of vaccine trials performed in different centres/with different products; (2) to facilitate standardization and harmonization of immunological assays used in epidemiology research; and (3) to allow optimization and validation of immunological assays used in malaria vaccine development

Study of DJ meson decays to D+π−, D0π+ and D∗+π− final states in pp collisions

A study of D+π−, D0π+ and D∗+π− final states is performed using pp collision data, corresponding to an integrated luminosity of 1.0 fb−1, collected at a centre-of-mass energy of 7 TeV with the LHCb detector. The D1(2420)0 resonance is observed in the D∗+π− final state and the D∗2(2460) resonance is observed in the D+π−, D0π+ and D∗+π− final states. For both resonances, their properties and spin-parity assignments are obtained. In addition, two natural parity and two unnatural parity resonances are observed in the mass region between 2500 and 2800 MeV. Further structures in the region around 3000 MeV are observed in all the D∗+π−, D+π− and D0π+ final states

Enhanced Protective Efficacy of a Chimeric Form of the Schistosomiasis Vaccine Antigen Sm-TSP-2

The large extracellular loop of the Schistosoma mansoni tetraspanin, Sm-TSP-2, when fused to a thioredoxin partner and formulated with Freund's adjuvants, has been shown to be an efficacious vaccine against murine schistosomiasis. Moreover, Sm-TSP-2 is uniquely recognised by IgG1 and IgG3 from putatively resistant individuals resident in S. mansoni endemic areas in Brazil. In the present study, we expressed Sm-TSP-2 at high yield and in soluble form in E. coli without the need for a solubility enhancing fusion partner. We also expressed in E. coli a chimera called Sm-TSP-2/5B, which consisted of Sm-TSP-2 fused to the immunogenic 5B region of the hookworm aspartic protease and vaccine antigen, Na-APR-1. Sm-TSP-2 formulated with alum/CpG showed significant reductions in adult worm and liver egg burdens in two separate murine schistosomiasis challenge studies. Sm-TSP-2/5B afforded significantly greater protection than Sm-TSP-2 alone when both antigens were formulated with alum/CpG. The enhanced protection obtained with the chimeric fusion protein was associated with increased production of anti-Sm-TSP-2 antibodies and IL-4, IL-10 and IFN-γ from spleen cells of vaccinated animals. Sera from 666 individuals from Brazil who were infected with S. mansoni were screened for potentially deleterious IgE responses to Sm-TSP-2. Anti-Sm-TSP-2 IgE to this protein was not detected (also shown previously for Na-APR-1), suggesting that the chimeric antigen Sm-TSP-2/5B could be used to safely and effectively vaccinate people in areas where schistosomes and hookworms are endemic