Distribution of testate amoebae in salt marshes along the North American East Coast

Reproduced with permission of the publisher. © 2006 Cushman Foundation for Foraminiferal ResearchThis study describes the distribution of testate amoebae in three North American East Coast salt marshes (Leipsic River marsh, Delaware, USA; Little River marsh, Maine, USA; and Little Dipper Harbour marsh, New Brunswick, Canada). Five zones are recognized in the high salt marsh. With increasing marine influence, these zones are characterized by the following succession of dominant taxa: Valkanovia elegans, Tracheleuglypha dentata, Centropyxis cassis type, C. platystoma type and Difflugia pristis type. Most species occur in all three marshes, and their general vertical distribution is comparable. The results are also comparable with those obtained from British salt marshes, suggesting that salt-marsh testate amoebae have similar distributions on both sides of the Atlantic Ocean. The precision of the sea-level indicative value of testate amoebae in fossil salt-marsh sediments is a function of the local mean tidal range (MTR). Results of this study show that testate amoebae can indicate former sea levels with a precision of ±0.04 m in the Leipsic River marsh (MTR = 1.75 m), ±0.09 m in the Little River marsh (MTR = 2.6 m), and ±0.18 m in the Little Dipper marsh (MTR = 5.8 m)

Transforming Pharmacy and Pharmaceutical Sciences Education in the Context of Workforce Development

KEY MESSAGES: 1.1 The continued development of pharmacy services and the pharmaceutical sciences relies on a well educated, competent, sufficient and well distributed pharmaceutical workforce. 1.2 There is no workforce without education. It is fundamental for the international community to agree on how pharmaceutical workforce competency is developed and assured through initial and subsequent professional education. 1.3 The concept of a continuously competent workforce is of fundamental interest for professional leadership bodies and stakeholders. 1.4 As FIP member organisations drive the development of the profession at the national level, they should always consider encompassing an education component [initial education and Continuing Professional Development (CPD)/Continuing Education (CE)] into their strategies. 1.5 FIP brought together global health and pharmacy leaders from across the world to set the future milestones for pharmaceutical education in the context of workforce development during an exceptional event, which took place in Nanjing, China, on 7 and 8 November 2016: the Global Conference on Pharmacy and Pharmaceutical Sciences Education — "Creating a global vision for a global workforce". 1.6 The conference set the future milestones for education and workforce development of pharmacists and pharmaceutical scientists, and created a global vision for transformative pharmacy and pharmaceutical sciences education. 2. PRINCIPAL OUTCOMES: Following extensive consultation, three milestone documents were presented and adopted at the global conference. Participants at the conference were able to influence and contribute to them. These are: 2.1 A Global Vision for Education and Workforce that provides a description of the future directions of our profession and how education can support the evolution of science and practice. 2.2 A set of 13 Pharmaceutical Workforce Development Goals (PWDGs) which aim to facilitate the implementation of the global vision through a series of measurable, feasible and tangible goals. 2.3 A set of 67 statements on Pharmacy and Pharmaceutical Sciences Education ("the Nanjing Statements") that describe an envisioned future for education, to enable the enhancement of professional education standards worldwide

Reconstruction of recent sea-level change using testate amoebae

Reproduced with permission of the publisher. Copyright © 2009 University of Washington Published by Elsevier Inc.Proxy-based sea-level reconstructions place the instrumentally observed rates of recent sea-level rise in a longer term context by providing data that extend the instrumental sea-level record into past centuries. This paper presents the first sea-level reconstructions based on analyses of testate amoebae, to test their ability to produce high-precision reconstructions of past sea level. We present two reconstructions for the past 100 yr from sites in Maine (USA) and Nova Scotia (Canada) based on short cores from salt marshes, and modern training data from North America and the United Kingdom. These are compared with tide-gauge records and reconstructions based on foraminifera from the same cores. The reconstructions show good agreement with both the tide-gauge data and the foraminifera-based reconstructions. The UK data perform well in predicting known elevations of North American surface samples and produce sea-level reconstructions very similar to those based on the North American data, suggesting the methodology is robust across large geographical areas. We conclude that testate amoebae have the potential to provide robust, higher precision sea-level reconstructions for the past few centuries if modern transfer functions are improved and core sites are located within the main zone of testate amoebae occurrence on the salt marsh

Changes in dynamics of accommodation after accommodative facility training in myopes and emmetropes

This study evaluates the effect of accommodative facility training in myopes and emmetropes. Monocular accommodative facility was measured in nine myopes and nine emmetropes for distance and near. Subjective facility was recorded with automated flippers and objective measurements were simultaneously taken with a PowerRefractor. Accommodative facility training (a sequence of 5 min monocular right eye, 5 min monocular left eye, 5 min binocular) was given on three consecutive days and facility was re-assessed on the fifth day. The results showed that training improved the facility rate in both groups. The improvement in facility rates were linked to the time constants and peak velocity of accommodation. Some changes in amplitude seen in emmetropes indicate an improvement in facility rate at the expense of an accurate accommodation response

Salt-marsh testate amoebae as precise and widespread indicators of sea-level change

This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record.Salt-marsh sediments are routinely used to reconstruct sea-level changes over past millennia. These reconstructions bridge an important gap between geological and instrumental sea-level records, and provide insights into the role of atmospheric, oceanic, climatic and anthropogenic sea-level drivers, thereby improving understanding of contemporary and future sea-level changes. Salt-marsh foraminifera, diatoms and testate amoebae are three of the proxies capable of accurately reconstructing former sea level over decadal to millennial timescales. Datasets of surface assemblages are collated along elevational gradients to provide modern analogues that can be used to infer former marsh-surface elevations from fossil assemblages. Testate amoebae are the most recently developed proxy and existing studies suggest that they are at least as precise as the two other proxies. This study provides a synthesis of sea-level research using testate amoebae and collates and analyses existing surface datasets of intertidal salt-marsh testate amoebae from sites throughout the North Atlantic. We test the hypothesis that intertidal testate amoebae demonstrate cosmopolitan intertidal zonation across wide geographical areas in a way that is unique to this proxy. Testate amoebae assemblages are harmonised under a unified taxonomy and standardised into a single basin-wide training set suitable for reconstructing sea-level changes from salt-marsh sediments across the North Atlantic. Transfer functions are developed using regression modelling and show comparable performance values to published local training sets of foraminifera, diatoms and testate amoebae. When used to develop recent (last 100 years) sea-level reconstructions for sites in Norway and Quebec, Canada, the testate amoebae-based transfer function demonstrated prediction uncertainties of ± 0.26 m and ± 0.10 m respectively. These uncertainties equate to 10% and 11% of the tidal ranges at each site, which is of comparable precision to other published sea-level reconstructions based on foraminifera or diatoms. There is great scope for further developing intertidal testate amoebae as precise sea-level indicators and their application should be tested at sites beyond the North Atlantic.Our work on salt-marsh testate amoebae was funded by the Natural Environment Research Council (grant GR9/03426 to WRG and DJC) and by Plymouth University studentships (to RLB and TLN). Datasets from the Magdalen Islands were originally collected using funding from the Coastal Geoscience Research Chair at the Université du Québec à Rimouski

Prodrugs: Do They Have Advantages in Clinical Practice?

This is the published version, also available from the publisher at http://adisonline.com/drugs/Abstract/1985/29050/Prodrugs__Do_They_Have_Advantages_in_Clinical.2.aspxProdrugs are pharmacologically inactive chemical derivatives of a drug molecule that require a transformation within the body in order to release the active drug. They are designed to overcome pharmaceutical and/or pharmacokinetically based problems associated with the parent drug molecule that would otherwise limit the clinical usefulness of the drug. The scientific rationale, based on clinical pharmaceutical and chemical experience, for the design of various currently used prodrugs is presented in this review. The examples presented are by no means comprehensive, but are representative of the different ways in which the prodrug approach has been used to enhance the clinical efficacy of various drug molecules

Vertical zonation of testate amoebae in the Elatia Mires, northern Greece : palaeoecological evidence for a wetland response to recent climate change or autogenic processes?

The Elatia Mires of northern Greece are unique ecosystems of high conservation value. The mires are climatically marginal and may be sensitive to changing hydroclimate, while northern Greece has experienced a significant increase in aridity since the late twentieth century. To investigate the impact of recent climatic change on the hydrology of the mires, the palaeoecological record was investigated from three near-surface monoliths extracted from two sites. Testate amoebae were analysed as sensitive indicators of hydrology. Results were interpreted using transfer function models to provide quantitative reconstructions of changing water table depth and pH. AMS radiocarbon dates and 210Pb suggest the peats were deposited within the last c. 50 years, but do not allow a secure chronology to be established. Results from all three profiles show a distinct shift towards a more xerophilic community particularly noted by increases in Euglypha species. Transfer function results infer a distinct lowering of water tables in this period. A hydrological response to recent climate change is a tenable hypothesis to explain this change; however other possible explanations include selective test decay, vertical zonation of living amoebae, ombrotrophication and local hydrological change. It is suggested that a peatland response to climatic change is the most probable hypothesis, showing the sensitivity of marginal peatlands to recent climatic change

Refractive changes associated with oblique viewing and reading in myopes and emmetropes

The effect of brief periods of monocular oblique viewing on axial refractive error in myopes and emmetropes was studied in 20 normal subjects. Refractive error and higher order aberrations were measured either with the subject's head positioned such that the subject looked straight into an aberrometer with the right eye or the subject's head rotated to the right or left by approximately 30-so that the subject had to make an eye rotation of the same angle to see the aberrometer's fixation target. In the first experiment, 10 measurements of wavefront aberration were taken over a period of 3 min at each head position. The refractive changes with oblique viewing showed high levels of intersubject variability. Some subjects showed evidence of systematic change in refraction with oblique viewing. All subjects showed pupil constriction. In the second experiment, after the initial measurement of central and oblique refraction, subjects were made to binocularly read a text placed at 25 cm for 20 min, and the refraction measurements were repeated. No systematic changes in refraction were noted during oblique viewing after 20 min of reading. The data from Experiment 1 give some support for the view that shortterm pressures from structures external to the eye may affect its axial refraction. However, the results from Experiment 2 suggest that any such pressures during short-term reading tasks have no significant impact on the axial refraction

A Search for Isolated Radio Pulses from the Crab Nebula at 151.5 MHz

A search has been made for large bursts of radio emission at 151.5 MHz from the direction of the Crab Nebula. In 605 hr of observation, no events exceeding a flux of 1.4 × 10^(−22) W m^(−2) Hz^(−1) were detected. This therefore sets an upper limit for the energy in radio pulses from the direction of the Crab Nebula which might be associated with the events recorded in the gravitational wave experiments of Weber. Implications of the results with regard to ‘strong pulses’ and phase fluctuations in the periodic emissions from the pulsar NP 0532 are also examined

Cultural basis of social ‘deficits’ in autism spectrum disorders

There is very little research that specifically looks at how autism spectrum disorders are perceived in various communities. This qualitative research was conducted with parents who had children on the autistic spectrum belonging to four different ethnic communities (White British, Somali, West African and South Asian- 63 in total) and living in the UK. The study found that the importance that the parents give to various social skills varied on the basis of their cultural background and the gender of the parent. This is an important aspect to consider while providing support and services to individuals on the autism spectrum and their family members if the services have to be appropriate for their needs. This consideration would also enable the individuals on the autism spectrum to develop appropriate social skills required within their cultural groups. This is a preliminary study and further research on the topic is required