Methodology to compare costs of sanitation options for low-income peri-urban areas in Lusaka, Zambia

Urban slums and low-income peri-urban areas in developing countries are characterised by a lack of infrastructure. The absence of sustainable sanitation systems is one of the causes that can lead to a high level of water-borne diseases in these areas, especially during the rainy season. This paper presents a methodology for cost comparisons of sanitation system options with a focus on excreta management (a sanitation system consists of the household toilets, collection and transport of excreta, treatment and storage, and transport of sanitised excreta to reuse sites). Greywater collection and treatment are excluded from the analysis for simplicity reasons. We used three low-income peri-urban areas in Lusaka, Zambia, to demonstrate our proposed methodology. The population density in the three peri-urban areas ranges from 104 to 244 people/ha. Unlined pit latrines are the most common form of excreta management, even though drilled boreholes and shallow wells are used as sources for drinking water in the same areas. Based on four selection criteria (no use of water for transporting the waste, low costs, waste sanitisation, and no contribution to groundwater pollution from stored excreta), we have short-listed two options which meet most or all of the criteria: A conventional low-cost option (Option 5: VIP latrines with downstream processing) and an ecological sanitation option (Option 6: urine-diversion dehydrating (UDD) toilets with downstream processing). The concept designs for both options are based on the entire peri-urban population in Lusaka of approximately 1.23 m. people, and on the assumption that 12 residents who live on the same plot (or ‘compound’) would share one toilet. The paper details the assumptions used to create a set of default model input parameters which are used in the cost equations to calculate capital costs, annual operating costs and net present values (NVP). Based on this basic financial analysis, we calculated the following indicative costs: capital costs of 31 €/cap and 39 €/cap for Option 5 and Option 6, respectively. Annual operating costs per capita were estimated to be 2.3 €/a·cap and 2.1 €/a·cap) for Option 5 and Option 6, respectively. The NPV for Option 6 is about 14% higher than for Option 5 but the difference is not significant, given the accuracy of the cost estimate (about ± 25%). Overall, this paper shows that the two options are difficult to differentiate based on cost alone. The financial model allows examination of the relative contributions of the different components to the overall cost of the sanitation system. For example, the costs of urine storage and transport are significant contributors to the capital and operating costs of the Ecosan option, and ways to reduce these costs should be investigated.Keywords: NPV, millennium development goals, groundwater, ecological sanitation, Ecosan, VIP latrine, UDD toilet, financial model, reuse, excret

Constraints on the ICM velocity power spectrum from the X-ray lines width and shift

Future X-ray observations of galaxy clusters by high spectral resolution missions will provide spatially resolved measurements of the energy and width for the brightest emission lines in the intracluster medium (ICM) spectrum. In this paper we discuss various ways of using these high resolution data to constrain velocity power spectrum in galaxy clusters. We argue that variations of these quantities with the projected distance R in cool core clusters contain important information on the velocity field length scales in the ICM. The effective length $l_{\rm eff}$ along the line of sight, which provides dominant contribution to the line flux, increases with R, allowing one to probe the amplitude of the velocity variations at different spatial scales. In particular, we show that the width of the line as a function of R is closely linked to the structure function of the 3D velocity field. Yet another easily obtainable proxy of the velocity field length scales is the ratio of the amplitude of the projected velocity field (line energy) variations to the dispersion of the velocity along the line of sight (line width). Finally the projected velocity field can be easily converted into 3D velocity field, especially for clusters like Coma with an extended flat core in the surface brightness. Under assumption of a homogeneous isotropic Gaussian 3D velocity field we derived simple expressions relating the power spectrum of the 3D velocity field (or structure function) and the observables. The uncertainties in the observables, caused by stochastic nature of the velocity field, are estimated by making multiple realizations of the random Gaussian velocity field and evaluating the scatter in observables. If large scale motions are present in the ICM these uncertainties may dominate the statistical errors of line width and shift measurements.Comment: 15 pages, 10 figures, accepted to MNRA

Premodern debasement: a messy affair

The paper argues that in premodern Europe, the practice of debasement was far more ‘messy’ than research has generally recognised. First, high information costs often prevented the effective control of mint officials who could exploit their resulting autonomy in order to debase coins on their own account. Second, these costs made it impossible to monitor markets closely enough to enforce regulations. Attempts by governments to debase coins by increasing their nominal value therefore ‘worked’ only if they conformed to the market rates of these coins. Finally, high information costs prevented the creation of closed areas where the domestic currency enjoyed a monopoly. The resulting trade in coinage created incentives for governments to issue inferior copies of their neighbour’s coins – a practice that had the same consequences as a debasement – and forced the affected governments to follow suit by debasing their own coinage, too

Destabilization of light NREM sleep by thalamic PLC beta 4 deletion impairs sleep-dependent memory consolidation

Sleep abnormality often accompanies the impairment of cognitive function. Both rapid eye movement (REM) and non-REM (NREM) sleep have associated with improved memory performance. However, the role of composition in NREM sleep, consisting of light and deep NREM, for memory formation is not fully understood. We investigated how the dynamics of NREM sleep states influence memory consolidation. Thalamocortical (TC) neuron-specific phospholipase C beta 4 (PLC beta 4) knockout (KO) increased the total duration of NREM sleep, consisting of destabilized light NREM and stabilized deep NREM. Surprisingly, the longer NREM sleep did not improve memory consolidation but rather impaired it in TC-specific PLC beta 4 KO mice. Memory function was positively correlated with the stability of light NREM and spindle activity occurring in maintained light NREM period. Our study suggests that a single molecule, PLC beta 4, in TC neurons is critical for tuning the NREM sleep states and thus affects sleep-dependent memory formation

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field

Scaling the state: Egypt in the third millennium BC

Discussions of the early Egyptian state suffer from a weak consideration of scale. Egyptian archaeologists derive their arguments primarily from evidence of court cemeteries, elite tombs, and monuments of royal display. The material informs the analysis of kingship, early writing, and administration but it remains obscure how the core of the early Pharaonic state was embedded in the territory it claimed to administer. This paper suggests that the relationship between centre and hinterland is key for scaling the Egyptian state of the Old Kingdom (ca. 2,700-2,200 BC). Initially, central administration imagines Egypt using models at variance with provincial practice. The end of the Old Kingdom demarcates not the collapse, but the beginning of a large-scale state characterized by the coalescence of central and local models

Impact of solar energy cost on water production cost of seawater desalination plants in Egypt

Many countries in North Africa and the Middle East are experiencing localized water shortages and are now using desalination technologies with either reverse osmosis (RO) or thermal desalination to overcome part of this shortage. Desalination is performed using electricity, mostly generated from fossil fuels with associated greenhouse gas emissions. Increased fuel prices and concern over climate change are causing a push to shift to alternative sources of energy, such as solar energy, since solar radiation is abundant in this region all year round. This paper presents unit production costs and energy costs for 21 RO desalination plants in the region. An equation is proposed to estimate the unit production costs of RO desalination plants as a function of plant capacity, price of energy and specific energy consumption. This equation is used to calculate unit production costs for desalinated water using photovoltaic (PV) solar energy based on current and future PV module prices. Multiple PV cells are connected together to form a module or a panel. Unit production costs of desalination plants using solar energy are compared with conventionally generated electricity considering different prices for electricity. The paper presents prices for both PV and solar thermal energy. The paper discusses at which electricity price solar energy can be considered economical to be used for RO desalination; this is independent of RO plant capacity. For countries with electricity prices of 0.09 US$/kWh, solar-generated electricity (using PV) can be competitive starting from 2 US$/Wp (Wp is the number of Watts output under standard conditions of sunlight). For Egypt (price of 0.06 US$/kWh), solar-generated electricity starts to be competitive from 1 US$/Wp. Solar energy is not cost competitive at the moment (at a current module price for PV systems including installation of 8 US$/Wp), but advances in the technology will continue to drive the prices down, whilst penalties on usage of fossil fuel will increase electricity costs from conventional non-renewable sources. Solar thermal is cheaper (at a current price of 0.06 US$/kWh) than PV; however, PV is more appropriate for Egypt (for the time being) as it is more applicable to the smaller RO plant sizes found in Egypt (up to 5 MW; 10,000-15,000 m3/d product water capacity). We would expect that there will be a shift towards more centralized RO plants (larger size) in Egypt, to tackle the increasing water shortage, and this would then favor the adoption of solar thermal energy in the near future.