A new generation photodetector for astroparticle physics: the VSiPMT

The VSiPMT (Vacuum Silicon PhotoMultiplier Tube) is an innovative design we proposed for a revolutionary photon detector. The main idea is to replace the classical dynode chain of a PMT with a SiPM (G-APD), the latter acting as an electron detector and amplifier. The aim is to match the large sensitive area of a photocathode with the performance of the SiPM technology. The VSiPMT has many attractive features. In particular, a low power consumption and an excellent photon counting capability. To prove the feasibility of the idea we first tested the performance of a special non-windowed SiPM by Hamamatsu (MPPC) as electron detector and current amplifier. Thanks to this result Hamamatsu realized two VSiPMT industrial prototypes. In this work, we present the results of a full characterization of the VSiPMT prototype

Management of diabetes mellitus and associated cardiovascular risk factors in Brazil – the Brazilian study on the practice of diabetes care

Abstract\ud \ud \ud \ud Background\ud The Brazilian Study on the Practice of Diabetes Care main objective was to provide an epidemiological profile of individuals with type 1 and 2 diabetes mellitus (DM) in Brazil, concerning therapy and adherence to international guidelines in the medical practice.\ud \ud \ud \ud Methods\ud This observational, cross-sectional, multicenter study collected and analyzed data from individuals with type 1 and 2 DM attending public or private clinics in Brazil. Each investigator included the first 10 patients with type 2 DM who visited his/her office, and the first 5 patients with type 1 DM.\ud \ud \ud \ud Results\ud A total of 1,358 patients were analyzed; 375 (27.6%) had type 1 and 983 (72.4%) had type 2 DM. Most individuals were women, Caucasian, and private health care users. High prevalence rates of hypertension, dyslipidemia and central obesity were observed, particularly in type 2 DM. Only 7.3% and 5.1% of the individuals with types 1 and 2 DM, respectively, had optimal control of blood pressure, plasma glucose and lipids. The absence of hypertension and female sex were associated with better control of type 1 DM and other cardiovascular risk factors. In type 2 DM, older age was also associated with better control.\ud \ud \ud \ud Conclusions\ud Female sex, older age, and absence of hypertension were associated with better metabolic control. An optimal control of plasma glucose and other cardiovascular risk factors are obtained only in a minority of individuals with diabetes. Local numbers, compared to those from other countries are worse.We would like to thank the efforts of the coordinating team and of all the investigators who participated in the study, and the sponsorship by Sanofi-Aventis, that made this research possible.This study was sponsored by Sanofi-Aventis.Álvaro Avezum, Hélio Penna Guimarães, Patrícia Smith, and Lígia Nasi Laranjeira.Adriana Estevam Moretti, Alessandra Uchôa Massad, Álvaro Avezum, Ana Chartuni Teixeira Cury, Ana Claudia Teixeira Jacob Machado, Ana Elizabeth Cabral de Menezes Marinho, Anete Hannud Abdo, Ângela Regina Nasário Sabbag, Aniete Carolina Roma Castro, Antônio Braojos Dantas, Antônio Carlos Lerario, Antônio Tarcísio de Faria Freire, Arnaldo Alves de Mendonça, Bernardo Leo Wajchenberg, Bruno Geloneze Neto, Carlos Frederico Campos, Carlos Gun, Carlos Roberto Netto de Menezes, Carmem Alice Coelho Rezende, Célia Aparecida Uliani Zimmermann, Charles Rodrigues, Christina Lourdes Porto Gaspar Moreira Muniz, Claudia Cozer Leite, Cláudio Guimarães Bernardo, Cleber Rinaldo Favaro, Cristina Figueiredo Sampaio Façanha, Dario Cezar de Vasconcellos, Davis Taublib, Denise Maria Loyola Zolet, Denise Reis Franco, Diógenes Bernardes, Edgar D’Ávila Niclewicz, Edília Maria Ribeiro Dias, Edson da Cunha, Edson Perrotti Santos, Elcio Gomes Junior, Emmanuel de Abreu, Enecy Maria Laborne Brenlha, Erico Paulo Heilbrun, Ernestina Auache, Flávia Ozório Pereira, Francisco José da Cunha Stamato, Freddy Goldenberg Eliaschewitz, Gladys de Jesus Matta, Gláucia Moraes Bastos, Helena Trindade Camargo, Honomar Ferreira de Souza, Ivan Arbex, Ivan dos Santos Ferraz, João Eduardo Nunes Salles, João Paulo Iazigi, José Carlos Aydar Ayoub, José Henrique de Almeida Netto, José Marcio Ribeiro, José Otávio Alquezar Gozzano, José Tasca, Josivan Gomes de Lima, Jucinéia Aparecida de Oliveira, Julio Henrique Bom, Laerte Ferreira Damasceno, Leda Aparecida Daud Lotaif, Levimar Rocha Araújo, Lúcia Helena Silva, Luciano Ricardo Giacaglia, Lucy Mara Gomes Baetas Valente, Luis Cuadrado Martin, Luiz Guilherme Lopes Junior, Marcelo Alexandrino da Silva, Marcelo Eduardo Peralta, Márcia Jablonka Kelman, Márcio Barbosa Guimarães Cota, Márcio Correa Mancini, Marcos André Malta Dantas, Marcos Antonio Lopes, Marcos Antônio Tambascia, Maria da Conceição Carneiro Mamone, Maria Edna de Melo, Maria Isabel Guimarães Favaro, Maria Terezinha Infantosi Vannucchi, Maria Victoria Martinez Descalzo, Mariana Narbot Ermetice, Mariângela Occhioso, Milton Elmor Filho, Mônica Maria Teixeira, Patrícia dos Santos Moniz Martins, Patrícia Smith, Patrícia Teófilo Monteagudo, Paula Fernandes, Paulo de Tarso Freitas, Priscila Lustoza Gomes Sampaio, Rejane Bisacchi Coelho Corrêa de Oliveira, Ricardo Cairo de Camargo, Ricardo da Silva Sá, Roberto Jorge da Silva Franco, Rosangela Maria de Almeida, Rosângela Roginski Réa, Rubens Antunes da Cruz Filho, Samuel Cunha, Sandra Lucia Minanni, Sidney Senhorini, Silvana Maria C P de Souza Queiroz, Silvio Hock de Paffer Filho, Simone Siqueira Meirelles, Tadeu Alencar, Tereza Maria Figueredo Campos Fontes, Vladimir Gomes Oliveira and Walter José Minicucci

The VSiPMT project

Photon detection is a key factor to study many physical processes in several areas of fundamental physics research. Focusing the attention on photodetectors for particle astrophysics, the future experiments aimed at the study of very high-energy or extremely rare phenomena (e.g. dark matter, proton decay, neutrinos from astrophysical sources) will require additional improvements in linearity, gain, quantum efficiency and single photon counting capability. To meet the requirements of this class of experiments, we propose a new design for a modern hybrid photodetector: the VSiPMT (Vacuum Silicon PhotoMultiplier Tube). The idea is to replace the classical dynode chain of a PMT with a SiPM, which therefore acts as an electron detector and amplifier. The aim is to match the large sensitive area of a photocathode with the performances of the SiPM technology. We now present the preliminary study we are performing to realize a 3-inches VSiPMT prototype

Desenvolvimento e implementação de um modelo de gestão do risco num processo de ensino-aprendizagem no pré escolar–Estudo de Caso

A tomada de consciência para a inevitabilidade do risco tem de estar sempre presente quando se realiza qualquer projeto. Realizando uma abordagem processual à gestão de projeto, deverá sempre integrar-se nas várias fases desse processo, a gestão do risco. Assim, a gestão do risco constitui um processo próprio em que, entre outras etapas, uma avaliação precisa do risco se mostra muito importante para uma gestão eficaz. A gestão escolar é influenciada por diversos fatores constituídos no decorrer das relações estabelecidas, tornando-se um desafio aos gestores e também aos educadores. Desta forma, é possível entender os aspetos da formação plena e integrativa, nos ambientes escolares. O processo de gestão deve ser analisado desde a sua conceção, implementação do mesmo na escola até à sua repercussão no processo de ensino-aprendizagem (avaliação dos outputs/outcomes). Este trabalho teve como objetivo a integração da gestão do risco num projeto escolar de terapia da fala, no sentido de melhor apoiar a tomada de decisão, contribuindo para a identificação e levantamento de ações preventivas necessárias a implementar, no sentido de garantir o sucesso da aplicação do referido projeto escolar de terapia da fala.The awareness for the inevitability of the risk must always be present when carry out any project. When conducting a procedural approach to the project management, the risk management must always be integrated in the different stages of the process. Therefore, the risk management represents a unique process that, among other stages, an accurate evaluation of the risk is the key to an effective management. The educational management is influenced by various factors incorporated in the course of the established relationships, becoming a challenge to the managers and also to the educators. In this way, it is possible to understand the aspects of training full and integrated in school environment. The management process must be analyzed since its conception, its complementation in school until its impact in the teaching – learning process (evaluation of outputs/outcomes). The aim of this project was the inclusion of the risk management in the school project of speech therapy, with the purpose to support the awareness, adding to the identification and searching of preventing actions needed to assure the success of the mentioned school project of speech therapy.La conciencia de la inevitabilidad del riesgo siempre debe estar presente al llevar a cabo cualquier proyecto. Tomando un enfoque de procedimiento para la gestión de proyectos, la gestión de riesgos siempre debe integrarse en las diversas etapas de este proceso. Por lo tanto, la gestión de riesgos es un proceso propio en el que, entre otros pasos, la evaluación precisa de riesgos es muy importante para una gestión eficaz. La gestión escolar está influenciada por varios factores constituidos durante las relaciones establecidas, lo que lo convierte en un desafío para los gerentes y también para los educadores. De esta manera, es posible comprender los aspectos de la formación completa e integradora en los entornos escolares. El proceso de gestión debe analizarse desde su concepción, su implementformación en la escuela hasta su repercusión en el proceso de enseñanza-aprendizaje (evaluación de productos / resultados). Este trabajo tuvo como objetivo integrar la gestión de riesgos en un proyecto escolar de terapia del habla, con el fin de apoyar mejor la toma de decisiones, contribuyendo a la identificación y encuesta de acciones preventivas necesarias para implementar, con el fin de garantizar el éxito de la aplicación. del proyecto escolar de logopedia

Association of fruits and vegetables consumption and related-vitamins with inflammatory and oxidative stress markers in prediabetic individuals

Abstract\ud \ud Background\ud Dietary guidelines of 5 servings per day of fruits and vegetables (FV) offer a reasonable amount of vitamins to control organic processes, which may contribute to a favorable cardiometabolic profile. This study aimed at investigating whether the intake of the FV group as well as pro-vitamin A carotenoids and vitamins C and E were associated with circulating markers of oxidative stress, inflammation and insulin resistance in Brazilians individuals at cardiometabolic risk.\ud \ud \ud Methods\ud This cross-sectional study included 205 individuals screened for diabetes prevention program in a healthcare center from the School of Public Health, University of São Paulo, conducted in 2008. Possible associations of consumption of FV group, as well as pro-vitamin A carotenoids and vitamins C and E, with circulating markers of oxidative stress (superoxide dismutase – SOD and oxidized LDL – oxLDL), inflammation (C reactive protein, TNF-α and adiponectin) and insulin resistance (HOMA-IR) were investigated. Pearson correlation coefficient, ANOVA and multiple linear regression were employed.\ud \ud \ud Results\ud The sample (64.7% women) had a mean age of 54.1 ± 12.7 years and body mass index of 30.7 ± 5.7 kg/m2. Dietary, physical activity, anthropometric and laboratory data were obtained. Participants consumed a mean of 3.8 servings/day of FV; their FV intake was categorized into three groups: <2.5, 2.5-5.0 and >5.0 servings/day. Significant trends for lower waist circumference (103.4 ± 13.6 vs. 100.1 ± 12.2 vs. 98.2 ± 12.7 cm, p-trend <0.05) and higher adiponectin concentrations (10.4 ± 1.8 vs. 11.9 ± 1.9 vs. 13.6 ± 2.1 ng/mL, p-trend <0.05) were detected across categories. Associations between SOD concentrations (β 0.172 [0.110-0.688]) with FV consumption and between oxLDL concentrations with vitamins C (β -0.333 [−2.568 – -0.218]) and E (β -0.354 [−1.131– -0.110]) intakes, adjusted for age, gender, BMI, saturated fat intake, smoking and physical activity were found. Similar results were observed for the associations between oxLDL and FV intake, but significance disappeared adding adjustment for saturated fat, smoking and physical activity.\ud \ud \ud Conclusion\ud Our data suggest that the intake of FV or selected vitamins may be useful for identifying the oxidative stress and inflammation involved in the genesis of cardiometabolic diseases and for motivating at-risk patients for changing dietary habits.This work was supported by a grant from The São Paulo Foundation for\ud Research Support – FAPESP and from Coordination for Improvement of\ud Graduate Personnel – CAPES (Brazil)

Clinical, pathological, and prognostic features of rare BRAF mutations in metastatic colorectal cancer: a bi-institutional retrospective analysis (REBUS study)

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Measurement of the atmospheric muon depth intensity relation with the NEMO Phase-2 tower

The results of the analysis of the data collected with the NEMO Phase-2 tower, deployed at 3500 m depth about 80 km off-shore Capo Passero (Italy), are presented. Cherenkov photons detected with the photomultipliers tubes were used to reconstruct the tracks of atmospheric muons. Their zenith-angle distribution was measured and the results compared with Monte Carlo simulations. An evaluation of the systematic effects due to uncertainties on environmental and detector parameters is also included. The associated depth intensity relation was evaluated and compared with previous measurements and theoretical predictions. With the present analysis, the muon depth intensity relation has been measured up to 13 km of water equivalent.Comment: submitted to Astroparticle Physic

All-sky Search for High-Energy Neutrinos from Gravitational Wave Event GW170104 with the ANTARES Neutrino Telescope

Advanced LIGO detected a significant gravitational wave signal (GW170104) originating from the coalescence of two black holes during the second observation run on January 4$^{\textrm{th}}$, 2017. An all-sky high-energy neutrino follow-up search has been made using data from the ANTARES neutrino telescope, including both upgoing and downgoing events in two separate analyses. No neutrino candidates were found within $\pm500$ s around the GW event time nor any time clustering of events over an extended time window of $\pm3$ months. The non-detection is used to constrain isotropic-equivalent high-energy neutrino emission from GW170104 to less than $\sim4\times 10^{54}$ erg for a $E^{-2}$ spectrum

The ANTARES Collaboration: Contributions to ICRC 2017 Part I: Neutrino astronomy (diffuse fluxes and point sources)

Papers on neutrino astronomy (diffuse fluxes and point sources, prepared for the 35th International Cosmic Ray Conference (ICRC 2017, Busan, South Korea) by the ANTARES Collaboratio

The ANTARES Collaboration: Contributions to ICRC 2017 Part III: Searches for dark matter and exotics, neutrino oscillations and detector calibration

Papers on the searches for dark matter and exotics, neutrino oscillations and detector calibration, prepared for the 35th International Cosmic Ray Conference (ICRC 2017, Busan, South Korea) by the ANTARES Collaboratio