Making Change With Mathematics: Youth Conceptions of the Role of Mathematics in Citizenship

This study analyzes the relationship between youths’ conceptions of citizenship and their conceptions of mathematics in order to understand the role that mathematics can play in the development of youth as citizens. The study also explored the possibilities and challenges of a social justice mathematics approach in the development of youth as citizens. Individual interviews were conducted with a total of 38 students from two research settings: a middle-school mathematics class in a public school in a low-income neighborhood serving primarily Black youth, and a mathematics class at an alternative educational program for out-of-school youth obtaining their GED serving primarily a low-income Latino population. An analysis of students’ conceptions of citizenship using Westheimer and Kahne (2004)’s framework highlighted the prevalence of personally responsible conceptions of citizenship across both settings. Having students discuss issues in their communities prompted students to also suggest participatory actions, and engaging in discussions about issues of injustice specifically yielded justice-oriented responses. Personally responsible responses and even participatory responses were often coupled with a sense of powerlessness, as they focused on addressing symptoms of issues by changing or controlling individuals’ behaviors. Students’ conceptions of mathematics also reflected personally responsible conceptions of citizenship. Examining students’ conceptions of mathematics revealed that students have a limited perspective of the role of mathematics in the world, such as in applications involving money, daily tasks, and careers. Students from both settings, but especially those from the alternative education program, also expressed that the mathematics they learn in school primarily serves a credentialing role. Mathematics for social justice offers a promising means to empower youth as justice-oriented citizens by showing them how mathematics can play a key role in learning about and making change in the world. In their reflections about mathematics for social justice lessons, students expressed that mathematics validated their experiences and provided powerful evidence to use in pressing authorities to listen to their issues

A qualitative study of rural and remote Australian general practitioners' involvement in high-acuity patients

This study aimed to understand the experiences, barriers, and facilitators of rural general practitioners’ involvement with high-acuity patients. Semi-structured interviews with rural general practitioners in South Australia who had experience delivering high-acuity care were audio-recorded, transcribed verbatim, and analyzed through content and thematic approaches incorporating Potter and Brough’s capacity-building framework. Eighteen interviews were conducted. Barriers identified include the inability to avoid high-acuity work in rural and remote areas, pressure to handle complex presentations, lack of appropriate resources, lack of mental health support for clinicians, and impacts on social life. Enablers included a commitment to community, comradery in rural medicine, training, and experience. We concluded that general practitioners are a vital pillar of rural health service delivery and are inevitably involved in disaster and emergency response. While the involvement of rural general practitioners with high-acuity patients is complex, this study suggested that with the appropriate system, structure and role supports, rural general practitioners could be better empowered to manage high-acuity caseloads locally

Manufacturing Orgasm: Visuality, Aurality, and Female Sexual Pleasure in Tsai Ming-liang’s The Wayward Cloud

publication-status: Publishedtypes: Article© 2011 by IntellectIn the study of both sex and the city, sound tends to be an aspect that does not receive as much attention as visuality. By examining the sound of sex in Tsai Ming-liang’s 2005 film, The Wayward Cloud, this article will argue that the aural is privileged over the visual and explore its implications for female subjectivity, sexual intimacy and gender politics. It suggests that the film challenges us to think whether it might be possible to forge what Mary Ann Doane calls ‘a political erotics of the voice’, but in a wayward manner that deploys comatose bodies that have no voice, that fragments the unity of voice and body and that privileges the representation of the sonic over the visual in a cinematic tradition that generally dictates otherwise

Health and support service needs of individuals with disability from culturally and linguistically diverse backgrounds : a scoping review protocol

Background: All individuals should have the right to engage meaningfully in occupations that meet their aspirations and life goals as well as promote their health and well-being. For individuals with disability, meaningful engagement in occupations is supported by timely, effective, and adaptive health and support services. However, research has revealed multiple barriers preventing utilization of these services by individuals with disability from culturally and linguistically diverse (CALD) backgrounds. This review aims to identify gaps and solutions in health and support services of individuals with disability from CALD backgrounds to meaningfully engage in occupations. Methods: A scoping review will be conducted in accordance with the Joanna Briggs Institute (JBI) methodology for scoping reviews. A detailed search strategy will be used to search CINAHL, PubMed, Embase, Scopus, PsycInfo, JBI, and Cochrane Library, as well as grey literature in Trove, Mednar, and OpenGrey from January 1974 onwards. Two reviewers will independently screen all citations and full-text articles for eligibility against specific inclusion and exclusion criteria. Potential conflicts will be resolved through discussion. Data will be extracted and presented in a diagrammatic or tabular form accompanied by a narrative summary. Discussion: The scoping review will present the health and support service needs of individuals with disability from CALD backgrounds and will extend the current reviews as it focuses the engagement in meaningful occupation. Findings from this review have the potential to inform local policy discussions and practice-based disability care. Systematic review registration: Open Science Framework (10.17605/OSF.IO/HW2FB)

A hot spot on interferon α/β receptor subunit 1 (IFNAR1) underpins its interaction with interferon-β and dictates signaling

The interaction of IFN-β with its receptor IFNAR1 (interferon α/β receptor subunit 1) is vital for host-protective anti-viral and anti-proliferative responses, but signaling via this interaction can be detrimental if dysregulated. Whereas it is established that IFNAR1 is an essential component of the IFNAR signaling complex, the key residues underpinning the IFN-β-IFNAR1 interaction are unknown. Guided by the crystal structure of the IFN-β-IFNAR1 complex, we used truncation variants and site-directed mutagenesis to investigate domains and residues enabling complexation of IFN-β to IFNAR1. We have identified an interface on IFNAR1-subdomain-3 that is differentially utilized by IFN-β and IFN-α for signal transduction. We used surface plasmon resonance and cell-based assays to investigate this important IFN-β binding interface that is centered on IFNAR1 residues Tyr240 and Tyr274 binding the C and N termini of the B and C helices of IFN-β, respectively. Using IFNAR1 and IFN-β variants, we show that this interface contributes significantly to the affinity of IFN-β for IFNAR1, its ability to activate STAT1, the expression of interferon stimulated genes, and ultimately to the anti-viral and anti-proliferative properties of IFN-β. These results identify a key interface created by IFNAR1 residues Tyr240 and Tyr274 interacting with IFN-β residues Phe63, Leu64, Glu77, Thr78, Val81, and Arg82 that underlie IFN-β-IFNAR1-mediated signaling and biological processes

Pengaruh Kualitas Audit, Debt Ratio, Ukuran Perusahaan dan Audit Lag terhadap Opini Audit Going Concern

Penelitian ini bertujuan untuk menganalisis pengaruh kualitas audit, debt ratio, ukuran perusahaan dan audit lag terhadap opini audit going concern pada perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia (BEI) pada tahun 2015-2017. Populasi dari penelitian ini adalah 147 perusahaan maufaktur yang terdaftar di Bursa Efek Indonesia pada tahun 2015-2017. Dengan menggunakan purposive sampling, sampel dari penelitian ini menjadi 69 perusahaan maufaktur dengan kriteria sampel: perusahaan yang terdaftar di Bura Efek Indonesia pada tahun 2015-2017 dengan data yang lengkap dan tidak mengalami kerugian selama dua tahun berturut-turut. Metode penelitian ini menggunakan pendekatan kuantitatif dengan data di analisis menggunakan regresi logistik. Hasil penelitian yang di peroleh adalah Kualitas Audit dan Ukuran Perusahaan secara parsial berpengaruh signifikan terhadap Opini Audit Going concern pada perusahaan manufaktur yang terdaftar di BEI tahun 2015-2017. Debt ratio dan Audit lag secara parsial tidak berpengaruh terhadap Opini Audit Going concern pada perusahaan manufaktur yang terdaftar di BEI tahun 2015-2017. Kualitas Audit, Debt ratio, Ukuran Perusahaan , Audit lag secara simultan berpengaruh terhadap Opini Audit Going concern pada perusahaan manufaktur yang terdaftar di BEI tahun 2015-2017

The Genomic Impact of Selection for Virulence against Resistance in the Potato Cyst Nematode, <i>Globodera pallida</i>

This work was funded through an AHDB PhD award, the USDA GLOBAL Project and by the Rural and Environmental Science and Analytical Services division of the Scottish Government. Bioinformatics and computational analyses for the generation of the new G. pallida genome assembly were supported by the University of St Andrews Bioinformatics Unit, which is funded by a Wellcome Trust ISSF award (grant 105621/Z/14/Z).Although the use of natural resistance is the most effective management approach against the potato cyst nematode (PCN) Globodera pallida, the existence of pathotypes with different virulence characteristics constitutes a constraint towards this goal. Two resistance sources, GpaV (from Solanum vernei) and H3 from S. tuberosum ssp. andigena CPC2802 (from the Commonwealth Potato Collection) are widely used in potato breeding programmes in European potato industry. However, the use of resistant cultivars may drive strong selection towards virulence, which allows the increase in frequency of virulent alleles in the population and therefore, the emergence of highly virulent nematode lineages. This study aimed to identify Avirulence (Avr) genes in G. pallida populations selected for virulence on the above resistance sources, and the genomic impact of selection processes on the nematode. The selection drive in the populations was found to be specific to their genetic background. At the genomic level, 11 genes were found that represent candidate Avr genes. Most of the variant calls determining selection were associated with H3-selected populations, while many of them seem to be organised in genomic islands facilitating selection evolution. These phenotypic and genomic findings combined with histological studies performed revealed potential mechanisms underlying selection in G. pallida.Publisher PDFPeer reviewe

Mapping the H2 resistance effective against Globodera pallida pathotype Pa1 in tetraploid potato

This work was supported by the Rural & Environment Science & Analytical Services Division of the Scottish Government, the BBSRC, through the joint projects CRF/2009/SCRI/SOP 0929, BB/L008025/1 and BB/K018299/1. Additional funding was obtained through the James Hutton Institute SEEDCORN initiative, AHDB Potato, the Perry Foundation and The Felix Cobbold Trust. Amanpreet Kaur was supported by the Commonwealth Scholarship Commission through a Commonwealth split-site Ph.D. grant.Key message: The nematode resistance gene H2 was mapped to the distal end of chromosome 5 in tetraploid potato. The H2 resistance gene, introduced into cultivated potatoes from the wild diploid species Solanum multidissectum, confers a high level of resistance to the Pa1 pathotype of the potato cyst nematode Globodera pallida. A cross between tetraploid H2-containing breeding clone P55/7 and susceptible potato variety Picasso yielded an F1 population that segregated approximately 1:1 for the resistance phenotype, which is consistent with a single dominant gene in a simplex configuration. Using genome reduction methodologies RenSeq and GenSeq, the segregating F1 population enabled the genetic characterisation of the resistance through a bulked segregant analysis. A diagnostic RenSeq analysis of the parents confirmed that the resistance in P55/7 cannot be explained by previously characterised resistance genes. Only the variety Picasso contained functionally characterised disease resistance genes Rpi-R1, Rpi-R3a, Rpi-R3b variant, Gpa2 and Rx, which was independently confirmed through effector vacuum infiltration assays. RenSeq and GenSeq independently identified sequence polymorphisms linked to the H2 resistance on the top end of potato chromosome 5. Allele-specific KASP markers further defined the locus containing the H2 gene to a 4.7 Mb interval on the distal short arm of potato chromosome 5 and to positions that correspond to 1.4 MB and 6.1 MB in the potato reference genome.Publisher PDFPeer reviewe

Incarceration history and risk of HIV and hepatitis C virus acquisition among people who inject drugs: a systematic review and meta-analysis

Background People who inject drugs (PWID) experience a high prevalence of incarceration and might be at high risk of HIV and hepatitis C virus (HCV) infection during or after incarceration. We aimed to assess whether incarceration history elevates HIV or HCV acquisition risk among PWID. Methods In this systematic review and meta-analysis, we searched MEDLINE, Embase, and PsycINFO databases for studies in any language published from Jan 1, 2000 until June 13, 2017 assessing HIV or HCV incidence among PWID. We included studies that measured HIV or HCV incidence among community-recruited PWID. We included only studies reporting original results and excluded studies that evaluated incident infections by self-report. We contacted authors of cohort studies that met the inclusion or exclusion criteria, but that did not report on the outcomes of interest, to request data. We extracted and pooled data from the included studies using random-effects meta-analyses to quantify the associations between recent (past 3, 6, or 12 months or since last follow-up) or past incarceration and HIV or HCV acquisition (primary infection or reinfection) risk among PWID. We assessed the risk of bias of included studies using the Newcastle-Ottawa Scale. Between-study heterogeneity was evaluated using the I2 statistic and the P-value for heterogeneity. Findings We included published results from 20 studies and unpublished results from 21 studies. These studies originated from Australasia, western and eastern Europe, North and Latin America, and east and southeast Asia. Recent incarceration was associated with an 81% (relative risk [RR] 1·81, 95% CI 1·40–2·34) increase in HIV acquisition risk, with moderate heterogeneity between studies (I2=63·5%; p=0·001), and a 62% (RR 1·62, 95% CI 1·28–2·05) increase in HCV acquisition risk, also with moderate heterogeneity between studies (I2=57·3%; p=0·002). Past incarceration was associated with a 25% increase in HIV (RR 1·25, 95% CI 0·94–1·65) and a 21% increase in HCV (1·21, 1·02–1·43) acquisition risk. Interpretation Incarceration is associated with substantial short-term increases in HIV and HCV acquisition risk among PWID and could be a significant driver of HCV and HIV transmission among PWID. These findings support the need for developing novel interventions to minimise the risk of HCV and HIV acquisition, including addressing structural risks associated with drug laws and excessive incarceration of PWID