Design of an efficient binary phase-shift keying based IEEE 802.15.4 transceiver architecture and its performance analysis

The IEEE 802.15.4 physical layer (PHY) standard is one of the communication standards with wireless features by providing low-power and low-data rates in wireless personal area network (WPAN) applications. In this paper, an efficient IEEE 802.15.4 digital transceiver hardware architecture is designed using the binary phase-shift keying (BPSK) technique. The transceiver mainly has transmitter and receiver modules along with the error calculation unit. The BPSK modulation and demodulation are designed using a digital frequency synthesizer (DFS). The DFS is used to generate the in-phase (I) and quadrature-phase (Q) signals and also provides better system performance than the conventional voltage-controlled oscillator (VCO) and look up table (LUT) based memory methods. The differential encoding-decoding mechanism is incorporated to recover the bits effectively and to reduce the hardware complexity. The simulation results are illustrated and used to find the error bits. The design utilizes less chip area, works at 268.2 MHz, and consumes 108 mW of total power. The IEEE 802.15.4 transceiver provides a latency of 3.5 clock cycles and works with a throughput of 76.62 Mbps. The bit error rate (BER) of 2×10-5 is achieved by the proposed digital transceiver and is suitable for real-time applications. The work is compared with existing similar approaches with better improvement in performance parameters

An Ayurvedic management of Retinal Pigment Epithelial Detachment - A Case Study

Introduction: Retinal pigment epithelial detachments (PEDs) are characterized by separation between the RPE and the inner most aspect of Bruch's membrane. The space created by this separation is occupied by blood, serous exudate, drusenoid material, fibro vascular tissue or a combination. The symptoms of RPE detachment can be considered under Drustigata Rogas mentioned by Sushrutha. This is a case study of a 73year old male patient who was diagnosed with PED with Subretinal fluid in Right eye since 8 months. Materials and methods: The subject who approached Shalakya Tantra OPD of Government Ayurveda Medical College Bengaluru with symptoms of diminished vision for both near and far objects in right eye associated with flashes in front of eye since 8 months, patient underwent two courses of inpatient management, which included Ayurvedic oral medicines, and external therapies for the eyes (Kriyakalpa) and head. Results: Signs of improvement in visual acuity and optical coherence tomography (OCT) were observed at the end of both treatments. Conclusion: The main aim of management was to preserve and give a better quality of vision for the patient. The results indicate the potential of Ayurvedic treatments to manage and maintain vision in REP detachment

The temporal scaling of Caenorhabditis elegans ageing

The process of ageing makes death increasingly likely, but involves a random aspect that produces a wide distribution of lifespan even in homogeneous populations1,2. The study of this stochastic behaviour may link molecular mechanisms to the ageing process that determines lifespan. Here, by collecting high-precision mortality statistics from large populations, we observe that interventions as diverse as changes in diet, temperature, exposure to oxidative stress, and disruption of genes including the heat shock factor hsf-1, the hypoxia-inducible factor hif-1, and the insulin/IGF-1 pathway components daf-2, age-1, and daf-16 all alter lifespan distributions by an apparent stretching or shrinking of time. To produce such temporal scaling, each intervention must alter to the same extent throughout adult life all physiological determinants of the risk of death. Organismic ageing in Caenorhabditis elegans therefore appears to involve aspects of physiology that respond in concert to a diverse set of interventions. In this way, temporal scaling identifies a novel state variable, r(t), that governs the risk of death and whose average decay dynamics involves a single effective rate constant of ageing, kr. Interventions that produce temporal scaling influence lifespan exclusively by altering kr. Such interventions, when applied transiently even in early adulthood, temporarily alter kr with an attendant transient increase or decrease in the rate of change in r and a permanent effect on remaining lifespan. The existence of an organismal ageing dynamics that is invariant across genetic and environmental contexts provides the basis for a new, quantitative framework for evaluating how and how much specific molecular processes contribute to the aspect of ageing that determines lifespan

Environmental Response and Genomic Regions Correlated with Rice Root Growth and Yield under Drought in the OryzaSNP Panel across Multiple Study Systems

Funding: This research was funded by the Generation Challenge Program (GCP) project G3008.06, “Targeting Drought-Avoidance Root Traits to Enhance Rice Productivity under Water-Limited Environments". The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD

KCNT1- related epilepsy: An international multicenter cohort of 27 pediatric cases

ObjectiveThrough international collaboration, we evaluated the phenotypic aspects of a multiethnic cohort of KCNT1- related epilepsy and explored genotype- phenotype correlations associated with frequently encountered variants.MethodsA cross- sectional analysis of children harboring pathogenic or likely pathogenic KCNT1 variants was completed. Children with one of the two more common recurrent KCNT1 variants were compared with the rest of the cohort for the presence of particular characteristics.ResultsTwenty- seven children (15 males, mean age = 40.8 months) were included. Seizure onset ranged from 1 day to 6 months, and half (48.1%) exhibited developmental plateauing upon onset. Two- thirds had epilepsy of infancy with migrating focal seizures (EIMFS), and focal tonic seizures were common (48.1%). The most frequent recurrent KCNT1 variants were c.2800G>A; p.Ala934Thr (n = 5) and c.862G>A; p.Gly288Ser (n = 4). De novo variants were found in 96% of tested parents (23/24). Sixty percent had abnormal magnetic resonance imaging (MRI) findings. Delayed myelination, thin corpus callosum, and brain atrophy were the most common. One child had gray- white matter interface indistinctness, suggesting a malformation of cortical development. Several antiepileptic drugs (mean = 7.4/patient) were tried, with no consistent response to any one agent. Eleven tried quinidine; 45% had marked (>50% seizure reduction) or some improvement (25%- 50% seizure reduction). Seven used cannabidiol; 71% experienced marked or some improvement. Fourteen tried diet therapies; 57% had marked or some improvement. When comparing the recurrent variants to the rest of the cohort with respect to developmental trajectory, presence of EIMFS, >500 seizures/mo, abnormal MRI, and treatment response, there were no statistically significant differences. Four patients died (15%), none of sudden unexpected death in epilepsy.SignificanceOur cohort reinforces common aspects of this highly pleiotropic entity. EIMFS manifesting with refractory tonic seizures was the most common. Cannabidiol, diet therapy, and quinidine seem to offer the best chances of seizure reduction, although evidence- based practice is still unavailable.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154940/1/epi16480_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154940/2/epi16480.pd

The United States COVID-19 Forecast Hub dataset

Academic researchers, government agencies, industry groups, and individuals have produced forecasts at an unprecedented scale during the COVID-19 pandemic. To leverage these forecasts, the United States Centers for Disease Control and Prevention (CDC) partnered with an academic research lab at the University of Massachusetts Amherst to create the US COVID-19 Forecast Hub. Launched in April 2020, the Forecast Hub is a dataset with point and probabilistic forecasts of incident cases, incident hospitalizations, incident deaths, and cumulative deaths due to COVID-19 at county, state, and national, levels in the United States. Included forecasts represent a variety of modeling approaches, data sources, and assumptions regarding the spread of COVID-19. The goal of this dataset is to establish a standardized and comparable set of short-term forecasts from modeling teams. These data can be used to develop ensemble models, communicate forecasts to the public, create visualizations, compare models, and inform policies regarding COVID-19 mitigation. These open-source data are available via download from GitHub, through an online API, and through R packages

Canagliflozin and renal outcomes in type 2 diabetes and nephropathy

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

Potential interaction between LRRK2 and alpha synuclein drives dopaminergic neuron loss

Thesis (M.A.) PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at [email protected]. Thank you.Parkinson’s Disease (PD) is a devastating progressive neurodegenerative disorder second only to Alzheimer's disease in prevalence. Progression is insidious and PD symptomology manifests when approximately half of the DA neurons projecting from the substantia nigra pars compacta (SNpc) to the striatum are lost. PD is histologically characterized by the presence of intracytoplasmic inclusions primarily composed of hyper-phosphorylated and ubiquinated α-synuclein (SNCA), known as Lewy Bodies. Conserved LB pathology in α-synuclein and LRRK2 mediated disease suggests a common pathological pathway in disease progression. In order to address the potential disease-relevant nexus between these two proteins, we generated transgenic C. elegans lines co-expressing LRRK2 (pan-neuronal) and α-synuclein (dopaminergic neuron specific). We report increased and progressive DA-ergic neuron loss in nematodes co-expressing disease linked mutant LRRK2 and α-synuclein compared to nematode lines expressing only α-synuclein. Also, guided by previous CLR network analysis, we implicated mis-regulation of proteostasis machinery in disease progression by demonstrating differential effects of LRRK2 co-expressed with α-synuclein on macroautophagy in our nematode lines expressing LGG, a marker for autophagic flux. Our studies show overexpression of G2019S LRRK2 inhibits autophagy and accelerates age-related dopaminergic neuron toxicity whereas overexpression of WT LRRK2 does not. Cooverexpression of a-synuclein caused increased inhibition of autophagy and showed an increase in DA-ergic neuron degeneration. Although we have no concrete evidence of interaction, we suggest that LRRK2 demonstrates an agedependent interaction with a-synuclein, which potentiates degeneration of dopaminergic neurons.2031-01-0