Emerging hematological targets and therapy for cardiovascular disease: From bench to bedside

Atherosclerotic cardiovascular disease is the leading cause of death and a major part of its pathophysiology remains obscure. Some hematological targets have been related to the development and clinical outcome of this disease, especially soluble cytokines, leukocytes, red blood cells, hemostatic factors and platelets, and bone-marrow vascular progenitors. These emerging factors may be modulated by current antiatherosclerotic pharmacotherapy, target-designed novel drugs or progenitor cell therapy. The aim of current review article is to comprehensively review the role of these antiatherosclerotic targets and therapy

Envejecimiento poblacional y condiciones de vida de los adultos mayores: la situación paraguaya en perspectiva latinoamericana

El objetivo de este documento es analizar la situación sociodemográfica y socioeconómica de la población adulta mayor paraguaya desde una perspectiva regional. Para ello se realiza el estudio comparado de la relación entre el proceso de envejecimiento demográfico y un conjunto de indicadores sociodemográficos seleccionados e indicadores socioeconómicos específicos de la población adulta mayor de Paraguay y de siete países de la región que se encuentran en diferentes fases del proceso de transición demográfica: Argentina, Brasil, Colombia, Cuba, México, República Dominicana y Uruguay. Los indicadores demográficos y sociodemográficos corresponden al periodo 2000-2010 y están elaborados sobre los datos brutos de los censos de población, proyecciones de población o encuestas a hogares, según la disponibilidad de cada uno de los países considerados. Los datos socioeconómicos provienen del procesamiento de las encuestas a hogares cercanos al año 2010. Entre los indicadores que sirven de base para el análisis comparado se incluyen: 1) Composición por edades de las poblaciones: a) envejecimiento demográfico; b) envejecimiento de la población adulta mayor; c) índice de envejecimiento; y d) espe-ranza de vida a los 65; 2) Indicadores sociodemográficos: a) porcentaje de población de 65 años y más analfabeta; b) porcentaje de población de 65 años y más residiendo en áreas rurales; y c) tipo de hogar de la población de 65 años y más según relación de parentesco; 3) Indicadores socioeconómicos: a) condición de actividad de la población de 65 años y más; b) porcentaje de personas de 65 años y más que recibe jubilación o pensión; c) porcentaje de personas de 65 años y más que vive con 2.5 dólares por día —línea de indigencia—; d) calidad de la vivienda en que reside la población de 65 años y más. Abstract: The objective of this paper is to analyse the socio-demographic and socio-economic situation of the Paraguayan elderly population from a regional perspective. We present a comparative study of the relation between the process of demographic ageing and a set of sociodemographic and socio-economic indicators about older people in Paraguay and another seven countries in latinoamerican region that are in different stages of the demographic transition process: Argentina, Brazil, Colombia, Cuba, Mexico, Dominican Republic and Uruguay. The demographic and sociodemographic indicators correspond to the period 2000-2010 and they were calculated with: the censuses of population, population projections, and surveys of households, they were chose depending on the availability of each of the countries involved. Socio-economic data come from surveys to homes close to the year 2010. Indicators that serve as a basis for comparative analysis include: 1) Composition by age of populations: a) demographic ageing, b) ageing of older people, c) index of aging, and d) lifespan at 65; 2) Socio-demographic indicators: a) percentage of population of 65 years and over illiterate, b) percentage of population 65 years and over residing in rural areas, and c) type of household for the population on 65 years by relation of kinship; 3) Socio-economic indicators: a) labor condition of the population on 65 years and over, b) percentage of older people who receives pension, c) percentage of persons 65 years and over who lives with $2.5 dollars per day (indigence line), d) housing quality in which resides the population of 65 years and over

Suborbital Flight: An Affordable and Feasible Option for Mexican Aerospace Development

Suborbital flights are a low-cost option for universities. To perform suborbital missions, it is necessary to design, plan, test, verify, and validate each and every one of the subsystems that integrate the payload without leaving the Earth. In Mexico, some experiments have been carried out since the 1990s to test communication systems in case of disaster and emergency. The Mexican Service Gondola (CSM) from 2015 to date has made suborbital flights in conjunction with the National Polytechnic Institute and the group of Protective Coatings Resistant to Thermal Changes and Cosmic Radiation (CRTCR) to test communication systems and glass-ceramic coatings. Suborbital flights are a great opportunity to explore the national territory and test new communication systems, structures, and materials

Malaria in Gold Miners in the Guianas and the Amazon: Current Knowledge and Challenges

“Purpose of Review Following Paraguay and Argentina, several countries from the Amazon region aim to eliminate malaria. To achieve this, all key affected and vulnerable populations by malaria, including people working on gold mining sites, must be considered. What is the situation of malaria in these particular settings and what are the challenges? This literature review aims to compile knowledge to answer these questions. Recent Findings The contexts in which gold miners operate are very heterogeneous: size and localization of mines, links with crime, administrative status of the mines and of the miners, mobility of the workers or national regulations. The number of malaria cases has been correlated with deforestation (Brazil, Colombia), gold production (Colombia), gold prices (Guyana), or location of the mining region (Peru, Colombia, Venezuela, Guyana). The burden of malaria in gold mines differs between territories: significant in Guyana, French Guiana, or Venezuela; lower in Brazil. Although Plasmodium vivax causes 75% of malaria cases in the Americas, P. falciparum is predominant in several gold mining regions, especially in the Guiana Shield. Because of the remoteness from health facilities, self-medication with under-the-counter antimalarials is frequent. This consti- tutes a significant risk for the emergence of new P. falciparum parasites resistant to antimalarial drugs. Summary Because of the workers’ mobility, addressing malaria transmission in gold mines is essential, not only for miners, but also to prevent the (re-)emergence of malaria. Strategies among these populations should be tailored to the context because of the heterogeneity of situations in different territories. The transnational environment favoring malaria transmission also requires transborder and regional cooperation, where innovative solutions should be considered and evaluated

USO DE APLICACIONES DE LA WEB 2.0 PARA LA EVALUACIÓN DEL APRENDIZAJE SIGNIFICATIVO (USE OF WEB 2.0 APPLICATIONS FOR THE EVALUATION OF SIGNIFICANT LEARNING)

Ante las tendencias tecnológicas y las opciones que brindan las aplicaciones de la Web 2.0 para múltiples dispositivos, se aspira estudiar, si las herramientas de la Web 2.0 incrementan el aprendizaje significativo, contribuyendo a potenciar el rendimiento académico, se utilizaron las Apps Kahoot!, Socrative, Drive y Formularios de la Suite de Google. La investigación es cuantitativa, tipo correlacional y diseño cuasi experimental. Los resultados obtenidos muestran; un incremento en el aprovechamiento de un 9.83%, detectando una mejora en el logro de las competencias establecidas en la unidad de aprendizaje de Tecnologías de la Comunicación y Gestión de Información, a la par se estudiaron aspectos pedagógicos y técnicos de las Apps utilizadas, los resultados prueban que 100% de los estudiantes opinaron de Muy buena (50%) a buena (50%) su evaluación educativa con las aplicaciones implementadas, apoyando la ventaja de utilizar herramientas de la web 2.0 para la evaluación del aprendizaje significativo.Given the technological trends and the options offered by Web 2.0 applications for multiple devices, we aspire to study, if Web 2.0 tools increase meaningful learning, contributing to enhance academic performance, Kahoot! Socrative Apps were used, Drive and Forms of the Google Suite. The research is quantitative, correlational type and quasi-experimental design. The results obtained show; an increase in the use of 9.83%, detecting an improvement in the achievement of the competences established in the Learning Unit of Communication Technologies and Information Management, at the same time pedagogical and technical aspects of the Apps used were studied. results prove that 100% of students rated Very good (50%) as good (50%) their educational evaluation with the applications implemented, supporting the advantage of using Web 2.0 tools for the evaluation of meaningful learning

Galaxy clusters and groups in the ALHAMBRA Survey

We present a catalogue of 348 galaxy clusters and groups with $0.2<z<1.2$ selected in the 2.78 $deg^2$ ALHAMBRA Survey. The high precision of our photometric redshifts, close to $1\%$, and the wide spread of the seven ALHAMBRA pointings ensure that this catalogue has better mass sensitivity and is less affected by cosmic variance than comparable samples. The detection has been carried out with the Bayesian Cluster Finder (BCF), whose performance has been checked in ALHAMBRA-like light-cone mock catalogues. Great care has been taken to ensure that the observable properties of the mocks photometry accurately correspond to those of real catalogues. From our simulations, we expect to detect galaxy clusters and groups with both $70\%$ completeness and purity down to dark matter halo masses of $M_h\sim3\times10^{13}\rm M_{\odot}$ for $z<0.85$. Cluster redshifts are expected to be recovered with $\sim0.6\%$ precision for $z<1$. We also expect to measure cluster masses with $\sigma_{M_h|M^*_{CL}}\sim0.25-0.35\, dex$ precision down to $\sim3\times10^{13}\rm M_{\odot}$, masses which are $50\%$ smaller than those reached by similar work. We have compared these detections with previous optical, spectroscopic and X-rays work, finding an excellent agreement with the rates reported from the simulations. We have also explored the overall properties of these detections such as the presence of a colour-magnitude relation, the evolution of the photometric blue fraction and the clustering of these sources in the different ALHAMBRA fields. Despite the small numbers, we observe tentative evidence that, for a fixed stellar mass, the environment is playing a crucial role at lower redshifts (z$<$0.5).Comment: Accepted for publication in MNRAS. Catalogues and figures available online and under the following link: http://bascaso.net46.net/ALHAMBRA_clusters.htm