“ENSEÑAR O CUIDAR A NIÑOS MALTRATADOS SOCIALMENTE”: EL PROCESAMIENTO DE ESTE DILEMA EN EL MAESTRO DE UN ESPACIO EDUCATIVO ALTERNATIVO

Los estudios institucionales preocupados por las dinámicas institucionales en condiciones críticas advirtieron que la situación de desempeño con niños maltratados socialmente puede configurarse para los docentes bajo el dilema “enseñar o cuidar”. Aquí se presenta el modo en que el maestro de un grado creado para niños que no asisten a la escuela, procesó este dilema.Esta cuestión se inscribe en una investigación que se pregunta por las condiciones y la dinámica de los Espacios Educativos Alternativos que favorecen, en los niños con experiencias de “fracaso escolar”, el desarrollo de las posibilidades y los intereses por aprender.Los resultados del estudio de caso mostraron que una de las condiciones que favorecían el aprendizaje de los niños era el estilo del maestro. El análisis de sus rasgos indica que el procesamiento que efectuó de tal dilema consistió en enfrentar la difícil situación de enseñar a estos niños sosteniendo su proyecto educativo. Este proyecto se orientaba a dar una respuesta educativa de carácter global y el modo de sostenerlo pareció consistir en la coexistencia compleja de la enseñanz

A high burnup model developed for the DIONISIO code

A group of subroutines, designed to extend the application range of the fuel performance code DIONISIO to high burn up, has recently been included in the code. The new calculation tools, which are tuned for UO2 fuels in LWR conditions, predict the radial distribution of power density, burnup, and concentration of diverse nuclides within the pellet. The balance equations of all the isotopes involved in the fission process are solved in a simplified manner, and the one-group effective cross sections of all of them are obtained as functions of the radial position in the pellet, burnup, and enrichment in 235U. In this work, the subroutines are described and the results of the simulations performed with DIONISIO are presented. The good agreement with the data provided in the FUMEX II/III NEA data bank can be easily recognized.Fil: Soba, Alejandro. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Denis, A.. Comisión Nacional de Energía Atómica; ArgentinaFil: Romero, L.. Comisión Nacional de Energía Atómica; ArgentinaFil: Villarino, E.. No especifíca;Fil: Sardella, F.. No especifíca

Evaluating an online well-being program for college students during the COVID-19 pandemic

Introduction: The global COVID-19 pandemic has aggravated challenges involving college students’ mental health and well-being. Some literature suggested developing online programs to address the pandemic’s impact on college students’ mental health and well-being. Thus, this study assessed if significant improvement in well-being among college students can be observed after introducing an online well-being program.Methods: The study utilized a quantitative methodology, mainly using a two-group pretest-posttest design on 178 college students in a private college and state university. The experimental group received 3 months of the well-being program while the control resumed their activities of daily living (ADL). The modified positive emotion, engagement, relationship, meaning, and accomplishment (PERMA) profiler questionnaire was the primary evaluation instrument that measured the participants’ well-being. The first phase gathered the participants’ relevant profile and background, and the last phase concluded with the evaluation of the program. Data were analyzed using SPSS v.21.Results: Based on the post-evaluation PERMA scores, the experimental participants (M = 7.21, SD 1.70) did not differ much from the control (M = 7.07, SD = 1.55) according to a t-test t(176) = –1.07, p = 0.57 as computed using a two-sample independent t-test at a significance level of α = 0.05. The overall PERMA score description is normal functioning. The Pearson correlation of the experimental group’s pre-test and post-test scores (r(91) = 0.01, p = 0.904) and the control (r(83) = 0.04, p = 0.732) group did not indicate an evidence of a significant relationship.Conclusion: The results do not provide evidence of a significant difference and relationship between the experimental participants’ pre-test and post-test PERMA scores after the online well-being program

Comparative Genomics Used to Predict Virulence Factors and Metabolic Genes among Monilinia Species

Brown rot, caused by Monilinia spp., is among the most important diseases in stonefruits, and some pome fruits (mainly apples). This disease is responsible for significant yield losses,particularly in stone fruits, when weather conditions favorable for disease development appear.To achieve future sustainable strategies to control brown rot on fruit, one potential approach will be to characterize genomic variation among Monilinia spp. to define, among others, the capacity to infect fruit in this genus. In the present work, we performed genomic and phylogenomic comparisons of five Monilinia species and inferred differences in numbers of secreted proteins, including CAZy proteins and other proteins important for virulence. Duplications specific to Monilinia were sparse and, overall, more genes have been lost than gained. Among Monilinia spp., low variability in the CAZome was observed. Interestingly, we identified several secondary metabolism clusters based on similarity to known clusters, and among them was a cluster with homology to pyriculol that could be responsible for the synthesis of chloromonilicin. Furthermore, we compared sequences of all strains available from NCBI of these species to assess their MAT loci and heterokaryon Compatibility systems. Our comparative analyses provide the basis for future studies into understanding how these genomic differences underlie common or differential abilities to interact with the host plant.info:eu-repo/semantics/publishedVersio

Induction of Cytotoxic T Lymphocyte Antigen 4 (Ctla-4) Restricts Clonal Expansion of Helper T Cells

Cytotoxic T lymphocyte antigen (CTLA)-4 plays an essential role in immunologic homeostasis. How this negative regulator of T cell activation executes its functions has remained controversial. We now provide evidence that CTLA-4 mediates a cell-intrinsic counterbalance to restrict the clonal expansion of proliferating CD4+ T cells. The regulation of CTLA-4 expression and function ensures that, after ∼3 cell divisions of expansion, most progeny will succumb to either proliferative arrest or death over the ensuing three cell divisions. The quantitative precision of the counterbalance hinges on the graded, time-independent induction of CTLA-4 expression during the first three cell divisions. In contrast to the limits imposed on unpolarized cells, T helper type 1 (Th1) and Th2 effector progeny may be rescued from proliferative arrest by interleukin (IL)-12 and IL-4 signaling, respectively, allowing appropriately stimulated progeny to proceed to the stage of tissue homing. These results suggest that the cell-autonomous regulation of CTLA-4 induction may be a central checkpoint of clonal expansion of CD4+ T cells, allowing temporally and spatially restricted growth of progeny to be dictated by the nature of the threat posed to the host

Dissecting Tissue-Specific Transcriptomic Responses from Leaf and Roots under Salt Stress in Petunia hybrida Mitchell

One of the primary objectives of plant biotechnology is to increase resistance to abiotic stresses, such as salinity. Salinity is a major abiotic stress and increasing crop resistant to salt continues to the present day as a major challenge. Salt stress disturbs cellular environment leading to protein misfolding, affecting normal plant growth and causing agricultural losses worldwide. The advent of state-of-the-art technologies such as high throughput mRNA sequencing (RNA-seq) has revolutionized whole-transcriptome analysis by allowing, with high precision, to measure changes in gene expression. In this work, we used tissue-specific RNA-seq to gain insight into the Petunia hybrida transcriptional responses under NaCl stress using a controlled hydroponic system. Roots and leaves samples were taken from a continuum of 48 h of acute 150 mM NaCl. This analysis revealed a set of tissue and time point specific differentially expressed genes, such as genes related to transport, signal transduction, ion homeostasis as well as novel and undescribed genes, such as Peaxi162Scf00003g04130 and Peaxi162Scf00589g00323 expressed only in roots under salt stress. In this work, we identified early and late expressed genes in response to salt stress while providing a core of differentially express genes across all time points and tissues, including the trehalose-6-phosphate synthase 1 (TPS1), a glycosyltransferase reported in salt tolerance in other species. To test the function of the novel petunia TPS1 allele, we cloned and showed that TPS1 is a functional plant gene capable of complementing the trehalose biosynthesis pathway in a yeast tps1 mutant. The list of candidate genes to enhance salt tolerance provided in this work constitutes a major effort to better understand the detrimental effects of salinity in petunia with direct implications for other economically important Solanaceous specie

Sea surface emissivity observations at L-band: first results of the Wind and Salinity Experiment WISE 2000

Sea surface salinity can be measured by passive microwave remote sensing at L-band. In May 1999, the European Space Agency (ESA) selected the Soil Moisture and Ocean Salinity (SMOS) Earth Explorer Opportunity Mission to provide global coverage of soil moisture and ocean salinity. To determine the effect of wind on the sea surface emissivity, ESA sponsored the Wind and Salinity Experiment (WISE 2000). This paper describes the field campaign, the measurements acquired with emphasis in the radiometric measurements at L-band, their comparison with numerical models, and the implications for the remote sensing of sea salinity.Peer ReviewedPostprint (published version

Plasmodium Impairs Antibacterial Innate Immunity to Systemic Infections in Part Through Hemozoin-Bound Bioactive Molecules

One complication of malaria is increased susceptibility to invasive bacterial infections. Plasmodium infections impair host immunity to non-Typhoid Salmonella (NTS) through heme-oxygenase I (HO-I)-induced release of immature granulocytes and myeloid cell-derived IL-10. Yet, it is not known if these mechanisms are specific to NTS. We show here, that Plasmodium yoelii 17XNL (Py) infected mice had impaired clearance of systemic Listeria monocytogenes (Lm) during both acute parasitemia and up to 2 months after clearance of Py infected red blood cells that was independent of HO-I and IL-10. Py-infected mice were also susceptible to Streptococcus pneumoniae (Sp) bacteremia, a common malaria-bacteria co-infection, with higher blood and spleen bacterial burdens and decreased survival compared to naïve mice. Mechanistically, impaired immunity to Sp was independent of HO-I, but was dependent on Py-induced IL-10. Splenic phagocytes from Py infected mice exhibit an impaired ability to restrict growth of intracellular Lm, and neutrophils from Py-infected mice produce less reactive oxygen species (ROS) in response to Lm or Sp. Analysis also identified a defect in a serum component in Py-infected mice that contributes to reduced production of ROS in response to Sp. Finally, treating naïve mice with Plasmodium-derived hemozoin containing naturally bound bioactive molecules, excluding DNA, impaired clearance of Lm. Collectively, we have demonstrated that Plasmodium infection impairs host immunity to diverse bacteria, including S. pneumoniae, through multiple effects on innate immunity, and that a parasite-specific factor (Hz+bound bioactive molecules) directly contributes to Plasmodium-induced suppression of antibacterial innate immunity