241 research outputs found

    Caracterización geomecánica del macizo rocoso en la ampliación del túnel exploratorio Karen Milagros, región Amazonas, 2016

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    RESUMEN El túnel exploratorio Karen Milagros corresponde a la parte SW del Proyecto Minero Cañón Florida de la empresa MILPO ANDINA PERU SAC, ubicado en el distrito de Shipasbamba, Provincia de Bongará y Departamento de Amazonas. Este Proyecto busca desarrollar la explotación de minerales metálicos a futuro mediante laboreo subterráneo, para lo cual se necesita conocer las condiciones geomecánicas del macizo rocoso presente. Esto ha llevado a desarrollar la tesis titulada “Caracterización Geomecánica del Macizo Rocoso en la Ampliación del Túnel Exploratorio Karen Milagros, Región Amazonas, 2016””, con el objetivo principal de realizar la evaluación geomecánica de los macizos rocosos presentes en en la zona de ampliación deltúnel exploratorio Karen Milagros, mediante el logueo y ensayos de carga puntual y peso específico en testigos de rocas de sondajes diamantinos, cuyos datos analizados estadísticamente, ayudaron a identificar los dominios geomecánicos, así como elaborar cuatro secciones geomecánicas claves NW y un plano geomecánicos del nivel 2370, en base al sistema de clasificación RMR (1989) (Rock Mass Rating). La primera fase comprendió la recopilación de información bibliográfica, posterior a ello se elaboró las secciones en base a 18 sondajes diamantinos de acuerdo al extensión de la zona de interés, los cuales fueron logueados y ensayados, obteniéndose así la data de los cinco parámetros geomecánicos para el cálculo del RMR (1989). Al final se pudo identificar tres Dominios Geomecánicos: Dominio Geomecánico I con macizos rocosos de Buena calidad, Dominio Geomecánico II con macizos rocosos de Regular calidad y Dominio Geomecánico III con Macizos rocosos de mala Calidad; siendo los dos primeros los más predominantes.ABSTRACT The exploratory tunnel Karen Milagros corresponds to the SW part of Florida Canyon Mining Project company MILPO ANDINA PERU SAC, located in the Shipasbamba District, Province of Bongará and Department of Amazonas. This project seeks to develop future exploitation of metallic minerals by underground tilling, for which you need to know the geomechanical conditions of the rock mass present. This has led to develop the thesis entitled "Characterization Geomechanics Rock Mass in the Extension Tunnel Exploratory Karen Milagros, Region Amazonas, 2016" ", with the main objective of making the geomechanical assessment of rock masses present in the area of enlargement deltúnel exploratory Karen Milagros, through logging and testing point load and weight in witnesses rocks diamond drilling, the data statistically analyzed, helped identify the geomechanical domains as well as develop four geomechanical sections key NW and geomechanical level plane 2370, based on RMR classification system (1989) (Rock Mass rating). The first phase involved the collection of bibliographic information, after this the sections were developed based on 18 diamond drilling according to the size of the area of interest, which were logged and tested, thus obtaining the data of the five geomechanical parameters RMR calculation (1989). In the end Geomechanical could identify three domains: Domain I Geomecánico with good quality rock masses, domain Geomecánico II with rock mass quality and Domain Regular Geomecánico III with sleazy rock masses; the first two being the most prevalent

    A deterministic model for highly contagious diseases: The case of varicella

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    [EN] The classic nonlinear Kermack-McKendrick model based upon a system of differential equations has been widely applied to model the rise and fall of global pandemic and also seasonal epidemic by introducing a forced harmonic infectivity which would change throughout the year. These methods work well in their respective domains of applicability, and for certain diseases, but they fail when both seasonality and high infectivity are combined. In this paper we consider a Susceptible-Infected-Recovered, or SIR, model with two latent states to model the propagation and evolutionary history of varicella in humans. We show that infectivity can be calculated from real data and we find a nonstandard seasonal variation that cannot be fitted with a single harmonic. Moreover, we show that infectivity for the present strains of the virus has raised following a sigmoid function in a period of several centuries. This could allow the design of vaccination strategies and the study of the epidemiology of varicella and herpes zoster. (C) 2016 Elsevier B.V. All rights reserved.Acedo Rodríguez, L.; Moraño Fernández, JA.; Santonja, F.; Villanueva Micó, RJ. (2016). A deterministic model for highly contagious diseases: The case of varicella. Physica A: Statistical Mechanics and its Applications. 450:278-286. doi:10.1016/j.physa.2015.12.153S27828645

    Impact of different levels of handling on Solea senegalensis culture: effects on growth and molecular markers of stress

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    [EN] Aquaculture routine practices may cause stress induction on the fish and compromise their welfare affecting the production. This experiment aimed to evaluate the potential links between handling during culture with stress responses and growth on Senegalese sole (Solea senegalensis). We worked with two fish cohorts in terms of initial body weight and culture stage: Trial 1 included specimens in the fattening stage (226 ± 4.96 g) and Trial 2 animals in the pre-fattening stage (27.20 ± 0.44 g). The tested culture protocol, which lasted 6 and 4 months for Trial 1 and 2, respectively, mainly reduced handling-derived stressors in the experimental tanks via lowering routine samplings to a minimum. This decrease of the handling-derived stress was reflected in both trials with lower concentration of circulating cortisol in blood plasma from the experimental fish when compared to controls. Moreover, the proposed protocol promoted higher growth in the fish cultured in the less disturbing protocol in Trial 2. Higher specific growth rates and mean body weight and length were reported. In order to further explore the potential beneficial effects of our protocol, we studied the musculoskeletal from Trial 2 gene expression of key genes regulating glucocorticoid signaling pathway and apoptosis: glucocorticoid receptors 1 and 2 (gr1, gr2), heat shock protein 90 AA (hsp90aa), and caspase 6 (casp6). In line with the cortisol reduced level in this trial, gr1, hsp90aa, and casp6 genes showed lower expression in the samples coming from the experimental group. The findings of this study provide valuable information to the aquaculture industry for the management of Solea senegalensis stress and welfare.SIPublicación en abierto financiada por el Consorcio de Bibliotecas Universitarias de Castilla y León (BUCLE), con cargo al Programa Operativo 2014ES16RFOP009 FEDER 2014-2020 DE CASTILLA Y LEÓN, Actuación:20007-CL - Apoyo Consorcio BUCL

    Calibrating a large network model describing the transmission dynamics of the human papillomavirus (HPV) using a Particle Swarm Optimization (PSO) algorithm in a distributed computing environment

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    [EN] Working in large networks applied to epidemiological-type models has led us to design a simple but e↵ective computed distributed environment to perform a large amount of model simulations in a reasonable time in order to study the behavior of these models and to calibrate them. Finding the model parameters that best fit the available data in the designed distributed computing environment becomes a challenge and it is necessary to implement reliable algorithms for model calibration. In this paper, we have adapted the random PSO algorithm to our distributed computing environment to be applied to the calibration of a Papillomavirus transmission dynamics model on a lifetime sexual partners network. And we have obtained a good fitting saving time and calculations compared with the exhaustive searching strategy we have been using so far.The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work has been partially supported by the Ministerio de Economa y Competitividad Grants MTM2013-41765-P and TIN 2014-54806-R.Acedo Rodríguez, L.; Burgos-Simon, C.; Hidalgo, J.; Sánchez-Alonso, V.; Villanueva Micó, RJ.; Villanueva-Oller, J. (2018). Calibrating a large network model describing the transmission dynamics of the human papillomavirus (HPV) using a Particle Swarm Optimization (PSO) algorithm in a distributed computing environment. International Journal of High Performance Computing Applications. 32(5):721-728. https://doi.org/10.1177/1094342017697862S721728325Acedo, L., Lamprianidou, E., Moraño, J.-A., Villanueva-Oller, J., & Villanueva, R.-J. (2015). Firing patterns in a random network cellular automata model of the brain. Physica A: Statistical Mechanics and its Applications, 435, 111-119. doi:10.1016/j.physa.2015.05.017Acedo, L., Moraño, J.-A., Villanueva, R.-J., Villanueva-Oller, J., & Díez-Domingo, J. (2011). Using random networks to study the dynamics of respiratory syncytial virus (RSV) in the Spanish region of Valencia. Mathematical and Computer Modelling, 54(7-8), 1650-1654. doi:10.1016/j.mcm.2010.11.068Castellsagué, X., Iftner, T., Roura, E., Vidart, J. A., Kjaer, S. K., … Bosch, F. X. (2012). Prevalence and genotype distribution of human papillomavirus infection of the cervix in Spain: The CLEOPATRE study. Journal of Medical Virology, 84(6), 947-956. doi:10.1002/jmv.23282Cortés, J.-C., Colmenar, J.-M., Hidalgo, J.-I., Sánchez-Sánchez, A., Santonja, F.-J., & Villanueva, R.-J. (2016). Modeling and predicting the Spanish Bachillerato academic results over the next few years using a random network model. Physica A: Statistical Mechanics and its Applications, 442, 36-49. doi:10.1016/j.physa.2015.08.032Elbasha, E. H., Dasbach, E. J., & Insinga, R. P. (2007). Model for Assessing Human Papillomavirus Vaccination Strategies. Emerging Infectious Diseases, 13(1), 28-41. doi:10.3201/eid1301.060438González-Parra, G., Villanueva, R.-J., Ruiz-Baragaño, J., & Moraño, J.-A. (2015). Modelling influenza A(H1N1) 2009 epidemics using a random network in a distributed computing environment. Acta Tropica, 143, 29-35. doi:10.1016/j.actatropica.2014.12.008Khemka, N., & Jacob, C. (2010). Exploratory Toolkit for Evolutionary and Swarm-Based Optimization. The Mathematica Journal, 11(3), 376-391. doi:10.3888/tmj.11.3-

    Estrategias financieras para enfrentar las dificultades de liquidez y solvencia producidas por los efectos del Covid-19 en la Cooperativa ACACEMES de R.L. dedicada a la prestación de servicios financieros.

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    Debido a la crisis socioeconómica causada por la pandemia del COVID-19 que se ve arraigada en la actualidad, la economía en El Salvador mantiene una posición deficitaria, dado que por las medidas que tomó el gobierno entre ellas la que más afectó es la cuarentena obligatoria, la que limitó que las personas salieran de sus casas, para lo cual tuvieron que suspender el transporte público entre otras; los ingresos disminuyeron y los costos y gastos mantienen una tendencia creciente, impactando directamente las operaciones de las empresas lo que obliga a buscar vías de soluciones que ayuden a resolver la problemática. Ante los efectos del problema como bajos niveles de liquidez y solvencia se han tomado decisiones financieras que posiblemente no sean las más acertadas perjudicando sus negocios, debido a lo anterior y con el objetivo de mejorar la situación ya mencionada se decidió realizar un trabajo de investigación para poder analizar los resultados que se obtengan y dar soluciones; para lo cual se seleccionó la cooperativa ACACEMES DE R.L. El trabajo contiene estrategias financieras para liquidez y solvencia las cuales se pueden ejecutar de acuerdo con lo que mejor convenga y que contribuya a enfrentar las diferentes dificultades. También se muestran el estudio de los métodos, procedimientos y técnicas para obtener conocimientos y explicación de la problemática que conllevan a una salida; la metodología utilizada en el desarrollo es que se llevó a cabo una investigación basada en un enfoque cualitativo, se realizaron entrevistas una con 16 y la otra con 10 preguntas, las cuales se diseñaron en base a los objetivos establecidos con el fin de conocer las dificultades de liquidez y solvencia ante los efectos del COVID-19 en la cooperativa, luego realizar un análisis el cual está plasmado en una matriz de análisis mostrando las condiciones de lo antes mencionado. ii El diagnóstico describe los efectos producidos por las medidas que el gobierno tomó para contrarrestar el COVID-19, lo cual permite estudiar un plan estratégico que contribuya a incrementar los flujos de efectivo. Las estrategias financieras son obtenidas a partir de la implementación de la herramienta de un flujo de caja e información financiera, con el fin de ayudar a la liquidez y solvencia de la cooperativa, mediante el instrumento de la entrevista y la recopilación de información bibliográfica mencionada anteriormente permite analizar los resultados: a) Se evidenció que la cooperativa necesita un área encargada de elaborar estrategias financieras. b) Se estableció la necesidad de buscar vías de financiamiento e inversión para la obtención de ingresos mediante el uso de diversas estrategias para ayudar a la liquidez y solvencia. c) Se comprobó que en la cooperativa consideran que la liquidez y solvencia es de mucha importancia para la continuidad de sus operaciones y han considerado las dificultades de las mismas. Considerando lo anterior, es recomendable que la cooperativa cuente con un diseño de estrategias financieras para ayudar a enfrentar los problemas de liquidez y solvencia en momentos de crisis económicas. Así mismo que contribuyan en la toma de decisiones

    Epidemic Random Network Simulations in a Distributed Computing Environment

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    We discuss a computational system following the paradigm of distributed computing, which will allow us to simulate the epidemic propagation in random networks with large number of nodes up to one million. This paradigm consists of a server that delivers tasks to be carried out by client computers. When the task is finished, the client sends the obtained results to the server to be stored until all tasks are finished and then ready to be analysed. Finally, we show that this technique allows us to disclose the emergence of seasonal patterns in the respiratory syncytial virus transmission dynamics which do not appear neither in smaller systems nor in continuous systems.This paper has been supported by the Grant from the Universitat Politecnica de Valencia PAID-06-11 ref: 2087 and the Grant FIS PI-10/01433. The authors would like to thank the staff of the Facultad de Administracion de Empresas of the Universidad Politecnica de Valencia, in particular Mara Angeles Herrera, Teresa Solaz, and Jose Luis Real, and the staff of the CES Felipe II of Aranjuez for their help and for letting them use free computer rooms to carry out the Sisifo computations described in this paper. They would also like to acknowledge the BOINC community for its support and the many anonymous volunteers who joined thier project and helped them obtain the results so fast.Villanueva-Oller, J.; Acedo Rodríguez, L.; Moraño Fernández, JA.; Sánchez Sánchez, A. (2013). Epidemic Random Network Simulations in a Distributed Computing Environment. Abstract and Applied Analysis. 2013:1-10. https://doi.org/10.1155/2013/462801S1102013PROULX, S., PROMISLOW, D., & PHILLIPS, P. (2005). Network thinking in ecology and evolution. Trends in Ecology & Evolution, 20(6), 345-353. doi:10.1016/j.tree.2005.04.004Traud, A. L., Mucha, P. J., & Porter, M. A. (2012). Social structure of Facebook networks. Physica A: Statistical Mechanics and its Applications, 391(16), 4165-4180. doi:10.1016/j.physa.2011.12.021Christakis, N. A., & Fowler, J. H. (2008). The Collective Dynamics of Smoking in a Large Social Network. New England Journal of Medicine, 358(21), 2249-2258. doi:10.1056/nejmsa0706154Christakis, N. A., & Fowler, J. H. (2007). The Spread of Obesity in a Large Social Network over 32 Years. New England Journal of Medicine, 357(4), 370-379. doi:10.1056/nejmsa066082Halloran, M. E. (2002). Containing Bioterrorist Smallpox. Science, 298(5597), 1428-1432. doi:10.1126/science.1074674Ahmed, E., & Agiza, H. N. (1998). On modeling epidemics Including latency, incubation and variable susceptibility. Physica A: Statistical Mechanics and its Applications, 253(1-4), 347-352. doi:10.1016/s0378-4371(97)00665-1Martins, M. L., Ceotto, G., Alves, S. G., Bufon, C. C. B., Silva, J. M., & Laranjeira, F. F. (2000). Cellular automata model for citrus variegated chlorosis. Physical Review E, 62(5), 7024-7030. doi:10.1103/physreve.62.7024Hershberg, U., Louzoun, Y., Atlan, H., & Solomon, S. (2001). HIV time hierarchy: winning the war while, loosing all the battles. Physica A: Statistical Mechanics and its Applications, 289(1-2), 178-190. doi:10.1016/s0378-4371(00)00466-0Witten, G., & Poulter, G. (2007). Simulations of infectious diseases on networks. Computers in Biology and Medicine, 37(2), 195-205. doi:10.1016/j.compbiomed.2005.12.002Acedo, L., Moraño, J.-A., & Díez-Domingo, J. (2010). Cost analysis of a vaccination strategy for respiratory syncytial virus (RSV) in a network model. Mathematical and Computer Modelling, 52(7-8), 1016-1022. doi:10.1016/j.mcm.2010.02.041Hethcote, H. W. (2000). The Mathematics of Infectious Diseases. SIAM Review, 42(4), 599-653. doi:10.1137/s0036144500371907Barabási, A.-L., & Albert, R. (1999). Emergence of Scaling in Random Networks. Science, 286(5439), 509-512. doi:10.1126/science.286.5439.509Villanueva-Oller, J., Villanueva, R. J., & Díez, S. (2007). CASANDRA: A prototype implementation of a system of network progressive transmission of medical digital images. Computer Methods and Programs in Biomedicine, 85(2), 152-164. doi:10.1016/j.cmpb.2006.10.002Korpela, E., Werthimer, D., Anderson, D., Cobb, J., & Leboisky, M. (2001). SETI@home-massively distributed computing for SETI. Computing in Science & Engineering, 3(1), 78-83. doi:10.1109/5992.895191Hall, C. B., Powell, K. R., MacDonald, N. E., Gala, C. L., Menegus, M. E., Suffin, S. C., & Cohen, H. J. (1986). Respiratory Syncytial Viral Infection in Children with Compromised Immune Function. New England Journal of Medicine, 315(2), 77-81. doi:10.1056/nejm198607103150201Falsey, A. R., & Walsh, E. E. (2000). Respiratory Syncytial Virus Infection in Adults. Clinical Microbiology Reviews, 13(3), 371-384. doi:10.1128/cmr.13.3.371-384.2000Díez Domingo, J., Ridao López, M., Úbeda Sansano, I., & Ballester Sanz, A. (2006). Incidencia y costes de la hospitalización por bronquiolitis y de las infecciones por virus respiratorio sincitial en la Comunidad Valenciana. Años 2001 y 2002. Anales de Pediatría, 65(4), 325-330. doi:10.1157/13093515ACEDO, L., DÍEZ-DOMINGO, J., MORAÑO, J.-A., & VILLANUEVA, R.-J. (2009). Mathematical modelling of respiratory syncytial virus (RSV): vaccination strategies and budget applications. Epidemiology and Infection, 138(6), 853-860. doi:10.1017/s0950268809991373Weber, A., Weber, M., & Milligan, P. (2001). Modeling epidemics caused by respiratory syncytial virus (RSV). Mathematical Biosciences, 172(2), 95-113. doi:10.1016/s0025-5564(01)00066-9White, L. J., Mandl, J. N., Gomes, M. G. M., Bodley-Tickell, A. T., Cane, P. A., Perez-Brena, P., … Medley, G. F. (2007). Understanding the transmission dynamics of respiratory syncytial virus using multiple time series and nested models. Mathematical Biosciences, 209(1), 222-239. doi:10.1016/j.mbs.2006.08.018Acedo, L., Moraño, J.-A., Villanueva, R.-J., Villanueva-Oller, J., & Díez-Domingo, J. (2011). Using random networks to study the dynamics of respiratory syncytial virus (RSV) in the Spanish region of Valencia. Mathematical and Computer Modelling, 54(7-8), 1650-1654. doi:10.1016/j.mcm.2010.11.068SCHNEEBERGER, A., MERCER, C. H., GREGSON, S. A. J., FERGUSON, N. M., NYAMUKAPA, C. A., ANDERSON, R. M., … GARNETT, G. P. (2004). Scale-Free Networks and Sexually Transmitted Diseases. Sexually Transmitted Diseases, 31(6), 380-387. doi:10.1097/00007435-200406000-00012Lou, J., & Ruggeri, T. (2010). The dynamics of spreading and immune strategies of sexually transmitted diseases on scale-free network. Journal of Mathematical Analysis and Applications, 365(1), 210-219. doi:10.1016/j.jmaa.2009.10.044Fleming, D. M. 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    Antitumoral effect of the aqueous extracts of Bomarea cornigera (Alstroe- meriaceae) on the sarcoma induced in mice

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    Se investigó el efecto antitumoral del extracto acuoso del bejuco Bomarea cornigera. Ratones de la cepa Swiss albina fueron inoculados con la línea tumoral TG-180 por 15 días; luego del cual se separaron en 5 grupos (n=5 por grupo). Se administro intraperitonealmente ciclofosfamida (control positivo), agua destilada (control negativo) y el extracto en concentraciones de 1X, 2X y 4X; se evaluó la morbilidad, mortalidad, el peso y la longitud del sarcoma. Se encontró un efecto inhibidor del extracto de B. cornigera en el desarrollo del tumor sólido en ratones en los cuales se les transplanto el sarcoma TG-180. Las tasas de inhibición fueron 87,44 y 8,52% después de 17 días de tratamiento considerando la dosis 1X (más baja) y 2X (intermedia), respectiva- mente. Estos resultados sugieren que la administración de extracto acuoso de B. cornigera vía intraperitoneal puede ser útil como inhibidor del cáncer.We investigated antitumor effect of aqueous extract of Bomarea cornigera. Swiss albino mice strain were inoculated with tumor cell line TG-180 for 15 days, after which they were separated into 5 groups (n= 5 per group). Cyclophosphamide was administered intraperitoneally (positive control), distilled water (negative control) and the aqueous extract at concentrations of 1X, 2X and 4X; the morbidity, mortality, weight and length of the sarcoma were assessed. We found an inhibitory effect of extract of B. cornigera in the development of solid tumor in mice where the TG-180 sarcoma was transplanted. The inhibition rates were 87.44 and 8.52% after 17 days of treatment, considering 1X dose (lowest) and 2X (intermediate), respectively. These results suggest that administration of aqueous extract of B. cornigera intraperitoneally may be useful as a cancer inhibitor

    Comunidades Docentes de Aprendizaje para una Educación Integral, Transversal y Equitativa Orientada al Progreso Sostenible.

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    Los nuevos modelos de actualización pedagógica del profesorado destacan la importancia de trabajar en comunidades docentes de aprendizaje en las que, a través de un proceso continuo, reflexivo, colaborativo e inclusivo, los profesores orienten su labor académica hacia una formación integral, inclusiva y equitativa. El principal objetivo de este proyecto es [OBJETIVO] diseñar y activar una comunidad que transforme la experiencia docente, facilite el aprendizaje situado y promueva la orientación profesional de los estudiantes hacia el desarrollo sostenible de las empresas y el bien común en la sociedad. [METODOLOGÍA] Mediante una metodología descriptiva y analítica, la reflexión y el diálogo profundo transdisciplinar, en el que han participado [MUESTRA] 120 personas, se ha comprobado que [CONCLUSIÓN] las comunidades docentes de aprendizaje constituyen una vía eficaz para diseñar planes de estudio, organizar la docencia universitaria y propiciar un ecosistema de aprendizaje que responde a la necesidad de orientar los estudios universitarios hacia la formación integral, interdisciplinar, trasversal, justa, inclusiva, equitativa, abierta y global que demanda la sociedad actual.post-print295 K

    Thermophysical Characterization of TFSI Based Ionic Liquid and Lithium Salt Mixtures

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    Este artigo pertence ás actas do The 23rd International Electronic Conference on Synthetic Organic Chemistry.[Abstract] The ionic liquids (ILs) doped with metal salts have become a real alternative as electrolytes for batteries, but the right choice of these compounds for reaching the adequate properties and performance is still a challenge, and strategies are therefore needed for achieving it. The thermophysical properties of IL 1-butyl-1-methylpyrrolidinium bis[(trifluoromethyl)sulfonyl]imide ([bmpyr] [TFSI]) and its mixture with bis-(trifluoromethane)-sulfonimide lithium salt (from 0.1 m to saturation level) were determined in this work. These properties are density (ρ), speed of sound (U), and corresponding derived magnitudes, such as the bulk modulus and the thermal coefficient, as well as electrical conductivity (σ) against temperature. Density shows a linear decreasing dependence with temperature and a clear increase with the addition of salt, whereas the thermal expansion coefficient increases with temperature and salt addition. Speed of sound decreases with both temperature and salt concentration, and the adiabatic compressibility calculated by means of the well-known Laplace equation increases, as expected, with temperature in all the studied cases, although a small variation with concentration was observed. Electrical conductivity increases with temperature following the Vogel–Fulcher–Tammann (VFT) equation and decreases with the addition of salt.This research was funded by the Spanish Ministry of Economy and Competitiveness and FEDER (Fondo Europeo de Desarrollo Regional) Program through the projects MAT2014-57943-C3-1-P, MAT2014-57943-C3-3-P, MAT2017-89239-C2-1-P as well as by Xunta de Galicia through the GRC (Grupo de Referencia Competitiva) ED431C 2016/001 project, and the Galician Network of Ionic Liquids (ReGaLIs) ED431D 2017/06. P. Vallet and J. J. Parajó are thankful for funding support from the FPI (Formación de Personal Investigador) Program from the Spanish Ministry of Science, Education and Universities and I2C postdoctoral Program of Xunta de Galicia, respectively.Xunta de Galicia; ED431C 2016/001Xunta de Galicia; ED431D 2017/0
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