Timing, cause and impact of the late Eocene stepwise sea retreat from the Tarim Basin (west China)

International audienceA vast shallow epicontinental sea extended across Eurasia and was well-connected to the Western Tethys before it retreated westward and became isolated as the Paratethys Sea. However, the palaeogeography and the timing of this westward retreat are too poorly constrained to determine potential wider environmental impacts, let alone understanding underlying mechanisms of the retreat such as global eustasy and tectonism associated with the Indo-Asia collision. Here, an improved chronostratigraphic and palaeogeographic framework is provided for the onset of the proto-Paratethys Sea retreat at its easternmost extent in the Tarim Basin in western China is provided. Five different third-order sea-level cycles can be recognised from the Cretaceous-Palaeogene sedimentary record in the Tarim Basin, of which the last two stepped successively westwards as the sea retreated after the maximum third incursion. New biostratigraphic data from the fourth and fifth incursions at the westernmost margin of the Tarim Basin are compared to our recent integrated bio-magneto-stratigraphic results on the fourth incursion near the palaeodepocentre in the south-western part of the basin. While the fourth incursion extended throughout the basin and retreated at ~ 41 Ma (base C18r), the last and fifth incursion is restricted to the westernmost margin and its marine deposits are assigned a latest Bartonian-early Priabonian age from ~ 38.0 to ~ 36.7 Ma (near top C17n.2n to base C16n.2n). Similar to the fourth, the fossil assemblages of the fifth incursion are indicative of shallow marine, near-shore conditions and their widespread distribution across Eurasia suggests that the marine connection to the Western Tethys was maintained. The lack of diachronicity of the fourth incursion between the studied sections across the southwest Tarim Basin suggests that the sea entered and withdrew relatively rapidly, as can be expected in the case of eustatic control on a shallow epicontinental basin. However, the westward palaeogeographic step between the fourth and fifth incursions separated by several millions of years rather suggests the combined long-term effect of tectonism, possibly associated with early uplift of the Pamir-Kunlun Shan thrust belt. The fourth and fifth regressions are time-equivalent with significant aridification steps recorded in the Asian interior, thus supporting climate modelling results showing that the stepwise sea retreat from Central Asia amplified the aridification of the Asian interior

Factors that can influence the gingival health of children with cerebral palsy

Estudos têm demonstrado que, quanto maior a severidade do dano neurológico em crianças com paralisia cerebral (PC), maior é o risco das doenças orais. Objetivo: Avaliar a influência dos fatores: déficit intelectual, sensibilidade oral, habilidade manual e padrões clínicos da PC sobre a saúde gengival de crianças com PC. Método: Participaram do estudo 106 crianças (10,7 ± 3,6) com PC, que frequentavam um programa de prevenção em Odontologia numa instituição de referência em reabilitação em São Paulo - SP. Os dados relativos ao sexo, desordem do movimento, tipo clínico da PC e uso contínuo de drogas foram coletados dos prontuários. As avaliações clínicas odontológicas incluíram o Índice de Higiene Oral Simplificado (OIHS), o Índice Gengival (IG) e presença do reflexo de mordida. Ainda foram realizadas as avaliações da sensibilidade oral, intelectual pelo Raven test e a habilidade manual pelo Sistema de Classificação da Habilidade Manual (MACS). Foram utilizados os testes t-Student, Qui-quadrado e regressão logística. Fixou-se nível de significância em 5%. Resultados: O grupo 1 (G1) era composto por 47 crianças sem gengivite e o grupo 2 (G2) por 59 crianças com gengivite. As crianças do G2 eram significantemente mais velhas (p = 0,001), com tetraparesia (p = 0,016), em uso de medicamentos (p < 0,001) e com reflexo de mordida (p = 0,025). As crianças do G2 apresentaram valores significantemente maiores para o IHOS (p < 0,001) e IG (p < 0,001); porcentagens significantemente maiores de crianças com percentis inferiores a 10 (p = 0,036) para o teste Raven e com habilidade manual níveis IV e V (p = 0,002) do MACS. A chance de uma criança apresentar gengivite cresce 23,5% para cada ano de idade, até 5 vezes para cada 1 unidade de aumento do IHOS e cerca de 4,5 vezes com utilização de medicamento. Conclusão: O aumento da idade, o acúmulo do biofilme e o uso de medicamentos aumentam o risco de gengivite em crianças com PC.Studies have shown that the greater the severity of neurological damage in children with cerebral palsy (CP), the greater risk of oral disease. Objective: To evaluate the influence of some factors as intellectual disability, oral sensitivity, manual ability and clinical patterns of cerebral palsy (CP) onto gingival health of CP children. Method: One hundred and six children (10.7 ± 3.6) with CP participated of the study. Descriptive data and continuous use of drugs were collected from their medical records. Clinical assessments included the Simplified Oral Hygiene Index (SOHI), the Gingival Index (GI) and the biting reflex. Were also evaluate oral sensitivity, intellectual assessment by Raven test, and manual dexterity by Manual Ability Classification System Manual (MACS). It was used the chi-square, t Student, and logistic regression tests whit a significance level of 5%. Results: Group 1 (G1) consisted of 47 children without and group 2 (G2) by 59 children with gingivitis. Groups were similar regarding gender (p = 0566), but G2 were significantly older (p = 0.001), with quadriplegia (p = 0.016), who used drugs (p < 0.001) and biting reflex (p = 0.025). G2 children presented significantly higher values for SOHI (p < 0.001) and IG (p < 0.001). Significantly higher percentages of children in G2 presented percentiles below 10 (p = 0.036) for Raven test, with manual skill levels IV and V (p = 0.002) of MACS. The chance of a child present gingivitis grows 23.5% for each year of age, and up to 5 times for every 1 unit increase in SOHI. The use of medication increases the chance of children present gingivitis by about 4.5 times. Conclusion: Increasing age, accumulation of biofilm, and use of drugs increase the risk of gingivitis in children with CP

Familial hypercholesterolaemia in children and adolescents from 48 countries: a cross-sectional study

Background: Approximately 450 000 children are born with familial hypercholesterolaemia worldwide every year, yet only 2·1% of adults with familial hypercholesterolaemia were diagnosed before age 18 years via current diagnostic approaches, which are derived from observations in adults. We aimed to characterise children and adolescents with heterozygous familial hypercholesterolaemia (HeFH) and understand current approaches to the identification and management of familial hypercholesterolaemia to inform future public health strategies. Methods: For this cross-sectional study, we assessed children and adolescents younger than 18 years with a clinical or genetic diagnosis of HeFH at the time of entry into the Familial Hypercholesterolaemia Studies Collaboration (FHSC) registry between Oct 1, 2015, and Jan 31, 2021. Data in the registry were collected from 55 regional or national registries in 48 countries. Diagnoses relying on self-reported history of familial hypercholesterolaemia and suspected secondary hypercholesterolaemia were excluded from the registry; people with untreated LDL cholesterol (LDL-C) of at least 13·0 mmol/L were excluded from this study. Data were assessed overall and by WHO region, World Bank country income status, age, diagnostic criteria, and index-case status. The main outcome of this study was to assess current identification and management of children and adolescents with familial hypercholesterolaemia. Findings: Of 63 093 individuals in the FHSC registry, 11 848 (18·8%) were children or adolescents younger than 18 years with HeFH and were included in this study; 5756 (50·2%) of 11 476 included individuals were female and 5720 (49·8%) were male. Sex data were missing for 372 (3·1%) of 11 848 individuals. Median age at registry entry was 9·6 years (IQR 5·8-13·2). 10 099 (89·9%) of 11 235 included individuals had a final genetically confirmed diagnosis of familial hypercholesterolaemia and 1136 (10·1%) had a clinical diagnosis. Genetically confirmed diagnosis data or clinical diagnosis data were missing for 613 (5·2%) of 11 848 individuals. Genetic diagnosis was more common in children and adolescents from high-income countries (9427 [92·4%] of 10 202) than in children and adolescents from non-high-income countries (199 [48·0%] of 415). 3414 (31·6%) of 10 804 children or adolescents were index cases. Familial-hypercholesterolaemia-related physical signs, cardiovascular risk factors, and cardiovascular disease were uncommon, but were more common in non-high-income countries. 7557 (72·4%) of 10 428 included children or adolescents were not taking lipid-lowering medication (LLM) and had a median LDL-C of 5·00 mmol/L (IQR 4·05-6·08). Compared with genetic diagnosis, the use of unadapted clinical criteria intended for use in adults and reliant on more extreme phenotypes could result in 50-75% of children and adolescents with familial hypercholesterolaemia not being identified. Interpretation: Clinical characteristics observed in adults with familial hypercholesterolaemia are uncommon in children and adolescents with familial hypercholesterolaemia, hence detection in this age group relies on measurement of LDL-C and genetic confirmation. Where genetic testing is unavailable, increased availability and use of LDL-C measurements in the first few years of life could help reduce the current gap between prevalence and detection, enabling increased use of combination LLM to reach recommended LDL-C targets early in life

Multidifferential study of identified charged hadron distributions in ZZ-tagged jets in proton-proton collisions at s=\sqrt{s}=13 TeV

Jet fragmentation functions are measured for the first time in proton-proton collisions for charged pions, kaons, and protons within jets recoiling against a $Z$ boson. The charged-hadron distributions are studied longitudinally and transversely to the jet direction for jets with transverse momentum 20 $< p_{\textrm{T}} < 100$ GeV and in the pseudorapidity range $2.5 < \eta < 4$. The data sample was collected with the LHCb experiment at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 1.64 fb$^{-1}$. Triple differential distributions as a function of the hadron longitudinal momentum fraction, hadron transverse momentum, and jet transverse momentum are also measured for the first time. This helps constrain transverse-momentum-dependent fragmentation functions. Differences in the shapes and magnitudes of the measured distributions for the different hadron species provide insights into the hadronization process for jets predominantly initiated by light quarks.Comment: All figures and tables, along with machine-readable versions and any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-013.html (LHCb public pages

Study of the B−→Λc+Λˉc−K−B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-} decay

The decay $B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-}$ is studied in proton-proton collisions at a center-of-mass energy of $\sqrt{s}=13$ TeV using data corresponding to an integrated luminosity of 5 $\mathrm{fb}^{-1}$ collected by the LHCb experiment. In the $\Lambda_{c}^+ K^{-}$ system, the $\Xi_{c}(2930)^{0}$ state observed at the BaBar and Belle experiments is resolved into two narrower states, $\Xi_{c}(2923)^{0}$ and $\Xi_{c}(2939)^{0}$, whose masses and widths are measured to be $$m(\Xi_{c}(2923)^{0}) = 2924.5 \pm 0.4 \pm 1.1 \,\mathrm{MeV}, \\ m(\Xi_{c}(2939)^{0}) = 2938.5 \pm 0.9 \pm 2.3 \,\mathrm{MeV}, \\ \Gamma(\Xi_{c}(2923)^{0}) = \phantom{000}4.8 \pm 0.9 \pm 1.5 \,\mathrm{MeV},\\ \Gamma(\Xi_{c}(2939)^{0}) = \phantom{00}11.0 \pm 1.9 \pm 7.5 \,\mathrm{MeV},$$ where the first uncertainties are statistical and the second systematic. The results are consistent with a previous LHCb measurement using a prompt $\Lambda_{c}^{+} K^{-}$ sample. Evidence of a new $\Xi_{c}(2880)^{0}$ state is found with a local significance of $3.8\,\sigma$, whose mass and width are measured to be $2881.8 \pm 3.1 \pm 8.5\,\mathrm{MeV}$ and $12.4 \pm 5.3 \pm 5.8 \,\mathrm{MeV}$, respectively. In addition, evidence of a new decay mode $\Xi_{c}(2790)^{0} \to \Lambda_{c}^{+} K^{-}$ is found with a significance of $3.7\,\sigma$. The relative branching fraction of $B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-}$ with respect to the $B^{-} \to D^{+} D^{-} K^{-}$ decay is measured to be $2.36 \pm 0.11 \pm 0.22 \pm 0.25$, where the first uncertainty is statistical, the second systematic and the third originates from the branching fractions of charm hadron decays.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-028.html (LHCb public pages

Measurement of the ratios of branching fractions R(D∗)\mathcal{R}(D^{*}) and R(D0)\mathcal{R}(D^{0})

The ratios of branching fractions $\mathcal{R}(D^{*})\equiv\mathcal{B}(\bar{B}\to D^{*}\tau^{-}\bar{\nu}_{\tau})/\mathcal{B}(\bar{B}\to D^{*}\mu^{-}\bar{\nu}_{\mu})$ and $\mathcal{R}(D^{0})\equiv\mathcal{B}(B^{-}\to D^{0}\tau^{-}\bar{\nu}_{\tau})/\mathcal{B}(B^{-}\to D^{0}\mu^{-}\bar{\nu}_{\mu})$ are measured, assuming isospin symmetry, using a sample of proton-proton collision data corresponding to 3.0 fb${ }^{-1}$ of integrated luminosity recorded by the LHCb experiment during 2011 and 2012. The tau lepton is identified in the decay mode $\tau^{-}\to\mu^{-}\nu_{\tau}\bar{\nu}_{\mu}$. The measured values are $\mathcal{R}(D^{*})=0.281\pm0.018\pm0.024$ and $\mathcal{R}(D^{0})=0.441\pm0.060\pm0.066$, where the first uncertainty is statistical and the second is systematic. The correlation between these measurements is $\rho=-0.43$. Results are consistent with the current average of these quantities and are at a combined 1.9 standard deviations from the predictions based on lepton flavor universality in the Standard Model.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-039.html (LHCb public pages

The role of immune suppression in COVID-19 hospitalization: clinical and epidemiological trends over three years of SARS-CoV-2 epidemic

Specific immune suppression types have been associated with a greater risk of severe COVID-19 disease and death. We analyzed data from patients &gt;17 years that were hospitalized for COVID-19 at the “Fondazione IRCCS Ca′ Granda Ospedale Maggiore Policlinico” in Milan (Lombardy, Northern Italy). The study included 1727 SARS-CoV-2-positive patients (1,131 males, median age of 65 years) hospitalized between February 2020 and November 2022. Of these, 321 (18.6%, CI: 16.8–20.4%) had at least one condition defining immune suppression. Immune suppressed subjects were more likely to have other co-morbidities (80.4% vs. 69.8%, p &lt; 0.001) and be vaccinated (37% vs. 12.7%, p &lt; 0.001). We evaluated the contribution of immune suppression to hospitalization during the various stages of the epidemic and investigated whether immune suppression contributed to severe outcomes and death, also considering the vaccination status of the patients. The proportion of immune suppressed patients among all hospitalizations (initially stable at &lt;20%) started to increase around December 2021, and remained high (30–50%). This change coincided with an increase in the proportions of older patients and patients with co-morbidities and with a decrease in the proportion of patients with severe outcomes. Vaccinated patients showed a lower proportion of severe outcomes; among non-vaccinated patients, severe outcomes were more common in immune suppressed individuals. Immune suppression was a significant predictor of severe outcomes, after adjusting for age, sex, co-morbidities, period of hospitalization, and vaccination status (OR: 1.64; 95% CI: 1.23–2.19), while vaccination was a protective factor (OR: 0.31; 95% IC: 0.20–0.47). However, after November 2021, differences in disease outcomes between vaccinated and non-vaccinated groups (for both immune suppressed and immune competent subjects) disappeared. Since December 2021, the spread of the less virulent Omicron variant and an overall higher level of induced and/or natural immunity likely contributed to the observed shift in hospitalized patient characteristics. Nonetheless, vaccination against SARS-CoV-2, likely in combination with naturally acquired immunity, effectively reduced severe outcomes in both immune competent (73.9% vs. 48.2%, p &lt; 0.001) and immune suppressed (66.4% vs. 35.2%, p &lt; 0.001) patients, confirming previous observations about the value of the vaccine in preventing serious disease

Nannofossil biohorizons of the late Oligocene section of ODP Hole 120-748B from the Kerguelen Plateau, Southern Ocean (Table 2)

Palaeoecological changes in nannofossil assemblages in the Southern Ocean during Oligocene times are examined through high-resolution, quantitative analyses of samples from Ocean Drilling Program (ODP) Site 748 (Kerguelen Plateau). We quantitatively characterized the palaeoecological preference of groups of species and compared their general trends with those determined at Maud Rise (ODP Sites 690 and 689) (Persico, D., Villa, G., 2004. Eocene-Oligocene calcareous nannofossils from Maud Rise and Kerguelen Plateau (Antarctica): palaeoecological and palaeoceanographic implications. Marine Micropaleontology 52, 153-179, doi:10.1016/j.marmicro.2004.05.002). We then attempt a correlation between the main assemblage variation and sea-surface temperature (SST) changes in the Southern Ocean at this time. Relatively stable, cool conditions are interpreted to have persisted from earliest to late Oligocene times, when an increase in abundance of temperate-water taxa is recorded, both at Maud Rise and Kerguelen Plateau, before the Mi-1 event. This reveals a climatic event that probably involved both sites, and which is comparable to that indicated by the global oxygen isotope curve ([Miller, K.G., Wright, J.D., Fairbanks, R.G., 1991. Unlocking the Ice House: Oligocene-Miocene oxygen isotopes, eustasy, and margin erosion. Journal of Geophysical Research, 96, 6829-6848, doi:10.1029/90JB02015; Zachos, J., Pagani, M., Sloan, L., Thomas, E., Billups, K., 2001. Trends, rhythms, and aberrations in global climate 65 Ma to present. Science, 292, 686-693, doi:10.1126/science.1059412.]). In the uppermost Oligocene at Site 689, the temperate-water taxa index ([temperate / temperate+cool]*100) increases from 25.2 Ma. Similarly, at Site 748, the temperate-water taxa index indicates an increase in SST in the late Oligocene, from about 26.5 Ma, at the base of Chron C8n.2n, which is offset by about 1 m.y. between the two areas. The reason for this time difference can probably be found in the location of Site 748 with respect to Site 689, and in the palaeoceanographic setting, taking into account that Site 748 lies north of a deep water passage that separates Kerguelen Plateau from Antarctica, and north of the present day front of the Antarctic Circumpolar Current. The presence of warm-water taxa, exclusively at Site 748, corroborates this hypothesis