Análise de relevância da agricultura familiar no estado do Pará.

Este trabalho identificou municípios paraenses nos quais a agricultura familiar apresenta-se com relevância e potencial de desenvolvimento contrastante. Examinando-se as 12 Regiões de Integração (RI) definidas pelo governo do Estado do Pará, foram gerados rankings dos municípios em cada RI para a relevância da agricultura familiar conforme duas variáveis: a porcentagem da área municipal em estabelecimentos da agricultura familiar, e a produção da cultura da mandioca. Constatou-se que a importância da agricultura familiar não deve ser definida apenas a partir de uma variável. Utilizando-se estas duas variáveis para analisar a relevância do segmento, em 24 possíveis situações (12 RI, municípios com maior e menor índice para cada variável) houve coincidência entre rankings de municípios em apenas uma das situações

Co‐existing monophasic teratoma and uterine adenocarcinoma in a female dog

Ovarian teratomas are occasionally reported in dogs; the rarest type is the monophasic teratoma,composed of tissues originating from only one germ layer. Canine endometrial adenocarcinomas are also rare in dogs and mainly affect geriatric females. This report describes case of co-existing ovarian teratoma and uterine adenocarcinoma in a 10-year old nulliparous female Boxer presented with lethargy, anorexia and purulent vaginal discharge. Abdominal ultrasonography evidenced pyometra and a mass in the left ovary. This was composed of a uniform whitish tissue with multiple cystic structures. The histology revealed an atrophy of the ovarian parenchyma, compressed by a proliferation of well-differentiated nervous tissue staining positively to vimentin, S100 and neuronal specific enolase (NSE), and negatively to keratin and inhibin. The left uterine horn, whose diameter was markedly increased, showed foci of endometrial cellular atypia, evident nucleoli and mitoses, at light microscopy. To our best knowledge, this is the first report of a coexisting ovarian monophasic teratoma and endometrial adenocarcinoma, two rare reproductive neoplasia in dogs

A Laplace transform method for energy multigroup hybrid discrete ordinates slab lattice calculations

In typical lattice cells where a highly absorbing, small fuel element is embedded in the moderator, a large weakly absorbing medium, high-order transport methods become unnecessary. In this work we describe a hybrid discrete ordinates (SN) method for energy multigroup slab lattice calculations. This hybrid SN method combines the convenience of a low-order SN method in the moderator with a high-order SN method in the fuel. The idea is based on the fact that in weakly absorbing media whose physical size is several neutron mean free paths in extent, even the S2 method (P1 approximation), leads to an accurate result. We use special fuel-moderator interface conditions and the Laplace transform (LTSN) analytical numerical method to calculate the two-energy group neutron flux distributions and the thermal disadvantage factor. We present numerical results for a range of typical model problems

A Laplace transform method for energy multigroup hybrid discrete ordinates slab lattice calculations

In typical lattice cells where a highly absorbing, small fuel element is embedded in the moderator, a large weakly absorbing medium, high-order transport methods become unnecessary. In this work we describe a hybrid discrete ordinates (SN) method for energy multigroup slab lattice calculations. This hybrid SN method combines the convenience of a low-order SN method in the moderator with a high-order SN method in the fuel. The idea is based on the fact that in weakly absorbing media whose physical size is several neutron mean free paths in extent, even the S2 method (P1 approximation), leads to an accurate result. We use special fuel-moderator interface conditions and the Laplace transform (LTSN) analytical numerical method to calculate the two-energy group neutron flux distributions and the thermal disadvantage factor. We present numerical results for a range of typical model problems

On the violation of a local form of the Lieb-Oxford bound

In the framework of density-functional theory, several popular density functionals for exchange and correlation have been constructed to satisfy a local form of the Lieb-Oxford bound. In its original global expression, the bound represents a rigorous lower limit for the indirect Coulomb interaction energy. Here we employ exact-exchange calculations for the G2 test set to show that the local form of the bound is violated in an extensive range of both the dimensionless gradient and the average electron density. Hence, the results demonstrate the severity in the usage of the local form of the bound in functional development. On the other hand, our results suggest alternative ways to construct accurate density functionals for the exchange energy.Comment: (Submitted on 27 April 2012

A Study of Single- and Double-Averaged Second-Order Models to Evaluate Third-Body Perturbation Considering Elliptic Orbits for the Perturbing Body

The equations for the variations of the Keplerian elements of the orbit of a spacecraft perturbed by a third body are developed using a single average over the motion of the spacecraft, considering an elliptic orbit for the disturbing body. A comparison is made between this approach and the more used double averaged technique, as well as with the full elliptic restricted three-body problem. the disturbing function is expanded in Legendre polynomials up to the second order in both cases. the equations of motion are obtained from the planetary equations, and several numerical simulations are made to show the evolution of the orbit of the spacecraft. Some characteristics known from the circular perturbing body are studied: circular, elliptic equatorial, and frozen orbits. Different initial eccentricities for the perturbed body are considered, since the effect of this variable is one of the goals of the present study. the results show the impact of this parameter as well as the differences between both models compared to the full elliptic restricted three-body problem. Regions below, near, and above the critical angle of the third-body perturbation are considered, as well as different altitudes for the orbit of the spacecraft.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Inst Nacl Pesquisas Espaciais, BR-12227010 Sao Jose Dos Campos, SP, BrazilUniversidade Federal de São Paulo UNIFESP, BR-12231280 Sao Jose Dos Campos, SP, BrazilUniversidade Federal de São Paulo UNIFESP, BR-12231280 Sao Jose Dos Campos, SP, BrazilCNPq: 150195/2012-5CNPq: 304700/2009-6FAPESP: 2011/09310-7FAPESP: 2011/08171-3Web of Scienc

Resonant Orbital Dynamics in LEO Region: Space Debris in Focus

The increasing number of objects orbiting the earth justifies the great attention and interest in the observation, spacecraft protection, and collision avoidance. These studies involve different disturbances and resonances in the orbital motions of these objects distributed by the distinct altitudes. in this work, objects in resonant orbital motions are studied in low earth orbits. Using the two-line elements (TLE) of the NORAD, resonant angles and resonant periods associated with real motions are described, providing more accurate information to develop an analytical model that describes a certain resonance. the time behaviors of the semimajor axis, eccentricity, and inclination of some space debris are studied. Possible irregular motions are observed by the frequency analysis and by the presence of different resonant angles describing the orbital dynamics of these objects.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Universidade Federal de São Paulo UNIFESP, BR-12231280 Sao Jose Dos Campos, SP, BrazilAstron Observ, AMU, PL-60286 Poznan, PolandITA, BR-12228900 Sao Jose Dos Campos, SP, BrazilUniversidade Federal de São Paulo UNIFESP, BR-12231280 Sao Jose Dos Campos, SP, BrazilFAPESP: 2012/24369-0FAPESP: 2012/21023-6CNPq: 303070/2011-0Web of Scienc

Practical guide to single-protein AFM nanomechanical spectroscopy mapping: insights and pitfalls as unraveled by all-atom MD simulations on immunoglobulin G

Atomic force microscopy is an invaluable characterization tool in almost every biophysics laboratory. However, obtaining atomic/sub-nanometer resolution on single proteins has thus far remained elusive - a feat long achieved on hard substrates. In this regard, nanomechanical spectroscopy mapping may provide a viable approach to overcome this limitation. By complementing topography with mechanical properties measured locally, one may thus enhance spatial resolution at the single-protein level. In this work, we perform all-atom molecular dynamics simulations of the indentation process on a single immunoglobulin G (IgG) adsorbed on a graphene slab. Our simulations reveal three different stages as a function of strain: a noncontact regime - where the mechanical response is linked to the presence of the water environment - followed by an elastic response and a final plastic deformation regime. In the noncontact regime, we are able to identify hydrophobic/hydrophilic patches over the protein. This regime provides the most local mechanical information that allows one to discern different regions with similar height/topography and leads to the best spatial resolution. In the elastic regime, we conclude that the Young modulus is a well-defined property only within mechanically decoupled domains. This is caused by the fact that the elastic deformation is associated with a global reorganization of the domain. Differences in the mechanical response are large enough to clearly resolve domains within a single protein, such as the three subunits forming the IgG. Two events, unfolding or protein slipping, are observed in the plastic regime. Our simulations allow us to characterize these two processes and to provide a strategy to identify them in the force curves. Finally, we elaborate on possible challenges that could hamper the interpretation of such experiments/simulations and how to overcome them. All in all, our simulations provide a detailed picture of nanomechanical spectroscopy mapping on single proteins, showing its potential and the challenges that need to be overcome to unlock its full potentialJ.G.V. acknowledges funding from a Marie Sklodowska-Curie Fellowship within the Horizon 2020 framework (Grant No. DLV-795286) and the Swiss National Science Foundation (Grant No. CRSK-2 190731/1). R.P. acknowledges support from the Spanish MINECO (Grant No. MAT2017-83273-R) and from the Ministerio de Ciencia e Innovación (MICINN) through the “María de Maeztu” Programme for Units of Excellence in R&D (Grant No. CEX2018-000805-M). R.G. acknowledges funding from the MICINN (Grant No. PID2019-106801GB-I00) and Comunidad de Madrid Grant No. S2018/NMT-4443 (Tec4Bio-CM). We thankfully acknowledge the computer resources, technical expertise, and assistance provided by the Red Española de Supercomputación (RES) at the Minotauro and CTE-Power9 supercomputers (BSC, Barcelona). We thank Dr. Alejandro Martín-González for fruitful discussion